Title:
ZERO ORDER RELEASE AND TEMPERATURE-CONTROLLED MICROCAPSULES AND PROCESS FOR THE PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO2001080831
Kind Code:
A3
Abstract:
A microcapsule composition comprising a core material in a matrix of polymorphic shell material, releases said core material in an aqueous environment in accordance with zero order linear release profile. A preferred composition comprises a core material having a degree of water solubility entrapped in a beta crystalline matrix of water insoluble shell material which matrix may, optionally, be surrounded by a contiguous core material-free layer of water insoluble shell material. Also disclosed is a process for the preparation of microcapsules comprising subjecting a flowable mixture of core material and a first amount of water insoluble shell material to a pressure force to form a pressure-treated mixture, and passing said pressure-treated mixture through a spray nozzle into a chilling zone to form a solidified composition. A special embodiment of the method providing for the long term moisture stability of the resulting microcapsules subjects the microcapsules prepared in the first step to a second coating with a second amount of water insoluble shell material.
Inventors:
VAGHEFI FARID (US)
LEE JEFFRY (US)
NALAMOTHU VIJENDRA (US)
LEE JEFFRY (US)
NALAMOTHU VIJENDRA (US)
Application Number:
PCT/US2001/013646
Publication Date:
March 21, 2002
Filing Date:
April 27, 2001
Export Citation:
Assignee:
VERION INC (US)
VAGHEFI FARID (US)
LEE JEFFRY (US)
NALAMOTHU VIJENDRA (US)
VAGHEFI FARID (US)
LEE JEFFRY (US)
NALAMOTHU VIJENDRA (US)
International Classes:
A61K9/16; A61K9/52; A61K47/02; A61K47/44; B01J2/00; B01J2/02; B01J3/00; B01J13/04; B01J13/22; A61K9/50; (IPC1-7): B01J13/04; B01J13/22
Foreign References:
| US5130171A | 1992-07-14 | |||
| US5204029A | 1993-04-20 |
Other References:
DATABASE WPI Section Ch Week 198649, Derwent World Patents Index; Class A97, AN 1986-323902, XP002181611
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 06 22 September 2000 (2000-09-22)
PATENT ABSTRACTS OF JAPAN vol. 012, no. 056 (C - 477) 19 February 1988 (1988-02-19)
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 06 22 September 2000 (2000-09-22)
PATENT ABSTRACTS OF JAPAN vol. 012, no. 056 (C - 477) 19 February 1988 (1988-02-19)
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