Title:
ZINC BINDING FUSION PROTEIN OF GLUTATHIONE S-TRANSFERASE AND METALLOTHIONEIN
Document Type and Number:
WIPO Patent Application WO/2016/146042
Kind Code:
A1
Abstract:
The present invention provides a zinc binding fusion protein that is a fusion protein of glutathione S-transferase (GST) and metallothionein (MT) binding to zinc, which provides an efficacy in preventing or treating a ROS-related disease and heavy metal poisoning.
Inventors:
LIN JER-LI (CN)
TSAI SHENG-HONG (CN)
TSAI SHENG-HONG (CN)
Application Number:
PCT/CN2016/076247
Publication Date:
September 22, 2016
Filing Date:
March 14, 2016
Export Citation:
Assignee:
ACRO BIOTECH CO LTD (CN)
International Classes:
A61K38/16; C07K19/00; A61P39/02; A61P39/06
Foreign References:
| CN101263934A | 2008-09-17 |
Other References:
TOKUDA, E. ET AL.: "Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis.", TOXICOLOGY, vol. 229, no. 1/2, 5 January 2007 (2007-01-05), pages 33 - 41, XP022144238
WARD A.C. ET AL.: "Vectors for Cu2+-inducible Production of Glutathione S-Transferase- Fusion Proteins for Single-step Purification from Yeast.", YEAST, vol. 10, no. 4, 30 April 1994 (1994-04-30), pages 441 - 449, XP008054945
WARD A.C. ET AL.: "Vectors for Cu2+-inducible Production of Glutathione S-Transferase- Fusion Proteins for Single-step Purification from Yeast.", YEAST, vol. 10, no. 4, 30 April 1994 (1994-04-30), pages 441 - 449, XP008054945
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (Tower E3 The Towers, Oriental Plaza,,No.1, East Chang An Avenue, Dongcheng District, Beijing 8, CN)
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