Title:
ZINC-BINDING GROUPS FOR METALLOPROTEIN INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005110399
Kind Code:
A3
Abstract:
The present invention relates to metalloprotein inhibitors comprising: a. an organic backbone molecule (Pep) and at least one zinc binding group (ZBG) covalently attached thereto; or b. at least one ZBG substituted by a side chain that comprises one or more amido and/or amino moieties, wherein the ZBG is of formula (I): wherein the wavy line represents a Pep molecule or a side chain that is an R3 or an R4 group which comprises one or more amido and/or amino moieties, and wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
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Inventors:
PUERTA DAVID T (US)
COHEN SETH M (US)
LEWIS JANA A (US)
COHEN SETH M (US)
LEWIS JANA A (US)
Application Number:
PCT/US2005/009277
Publication Date:
June 15, 2006
Filing Date:
March 21, 2005
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
PUERTA DAVID T (US)
COHEN SETH M (US)
LEWIS JANA A (US)
PUERTA DAVID T (US)
COHEN SETH M (US)
LEWIS JANA A (US)
International Classes:
A61K31/35; A61K31/167; A61K31/435; A61P35/00; C07D213/69; C07D309/36; C07D309/38; C07D309/40
Domestic Patent References:
| WO2004110442A1 | 2004-12-23 |
Foreign References:
| US6552073B1 | 2003-04-22 | |||
| EP1006112A1 | 2000-06-07 | |||
| US4585780A | 1986-04-29 | |||
| US20040063673A1 | 2004-04-01 | |||
| US5981496A | 1999-11-09 |
Other References:
STORR, T. ET AL.: "Vanadyl-thiazolidinedione combination agents for diabetes therapy", BIOCONJIGATE CHEM, vol. 14, no. 1, 2003, pages 212 - 221, XP002364808
WOODS, L.L.: "Mannich bases from kojic acid and aryl amines", J OF THE AMERICAN CHEMISTRY SOCIETY, vol. 68, 1946, pages 2744 - 2745, XP009060665
ATKINSON, J.G. ET AL.: "Kojic amine a novel gamma-aminobutyric acid analogue", J OF MEDICINAL CHEMISTRY, vol. 22, no. 1, 1979, pages 99 - 106, XP002364809
LIM, S.: "Competitive inhibition of tyrosinase by 5-hydroxy-2-phenylalanylaminomethyl-4-pyron", YAKHAK HOECHI, vol. 44, no. 3, 2000, pages 279 - 282, XP009060670
DILSIZ AYTEMIR, M. ET AL.: "Synthesis and evaluation of antimicrobial activity of new 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide derivatives", TURKISH JOURNAL OF CHEMISTRY, vol. 27, no. 6, 2003, pages 757 - 764, XP009060662
PUERTA, D.T. EGT AL.: "Potent, selective pyrone-based inhibitors of stromelysin-1", J AM CHEM SOC, vol. 127, no. 41, 2005, pages 14148 - 14149, XP002364810
WOODS, L.L.: "Mannich bases from kojic acid and aryl amines", J OF THE AMERICAN CHEMISTRY SOCIETY, vol. 68, 1946, pages 2744 - 2745, XP009060665
ATKINSON, J.G. ET AL.: "Kojic amine a novel gamma-aminobutyric acid analogue", J OF MEDICINAL CHEMISTRY, vol. 22, no. 1, 1979, pages 99 - 106, XP002364809
LIM, S.: "Competitive inhibition of tyrosinase by 5-hydroxy-2-phenylalanylaminomethyl-4-pyron", YAKHAK HOECHI, vol. 44, no. 3, 2000, pages 279 - 282, XP009060670
DILSIZ AYTEMIR, M. ET AL.: "Synthesis and evaluation of antimicrobial activity of new 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide derivatives", TURKISH JOURNAL OF CHEMISTRY, vol. 27, no. 6, 2003, pages 757 - 764, XP009060662
PUERTA, D.T. EGT AL.: "Potent, selective pyrone-based inhibitors of stromelysin-1", J AM CHEM SOC, vol. 127, no. 41, 2005, pages 14148 - 14149, XP002364810
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