ZINC FINGER PEPTIDE CLEAVAGE OF NUCLEIC ACIDS

Title:

ZINC FINGER PEPTIDE CLEAVAGE OF NUCLEIC ACIDS

Document Type and Number:

WIPO Patent Application WO2000020622

Kind Code:

A9

Abstract:

Selective cleavage of single stranded nucleic acids can be effected by contacting the nucleic acid with a zinc finger peptide in dimeric form. Dimerization results from diminution or elimination of zinc from the peptide, such that easily controllable and highly selective cleavage may be realized.

Inventors:

LIMA WALT F
CROOKE STANLEY T
MANOHARAN MUTHIAH

Application Number:

PCT/US1999/023273

Publication Date:

September 08, 2000

Filing Date:

October 06, 1999

Export Citation:

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Assignee:

ISIS PHARMACEUTICALS INC (US)

International Classes:

C12N15/09; C07K14/47; C12N9/16; C12N9/22; C12N15/10; (IPC1-7): C12P21/06; C07H21/04; C07K1/00; C12N1/00; C12N5/00; C12N15/00

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