Title:
ZWITTERIONIC POLYMER, METHOD FOR PRODUCING SAME AND PROTEIN STABILIZER CONTAINING ZWITTERIONIC POLYMER
Document Type and Number:
WIPO Patent Application WO/2019/131757
Kind Code:
A1
Abstract:
Provided is a zwitterionic polymer that has a zwitterion that includes an effect of improving the stability of proteins. This zwitterionic polymer is a polymeric protein stabilizer that exhibits a protein stabilizing effect even at a small addition amount of addition, and at the same time has an antioxidant capability. Also provided is a method for producing this zwitterionic polymer. This problem is solved by a zwitterionic polymer containing a repeating unit represented by formula (1) and having a number-average molecular weight of 1,000 to 1,000,000. (In formula (1), R1 and R2 are each independently selected from a hydrogen atom; linear, branched, or cyclic alkyl groups having 1 to 6 carbons; aromatic groups having 6 to 20 carbons; or alkylene groups having 1 to 6 carbons and formed by linking R1 to R2. R3 represents a hydrogen atom or a methyl group.)
Inventors:
MORI HIDEHARU (JP)
IMAMURA RYUTARO (JP)
IMAMURA RYUTARO (JP)
Application Number:
PCT/JP2018/047836
Publication Date:
July 04, 2019
Filing Date:
December 26, 2018
Export Citation:
Assignee:
UNIV YAMAGATA NAT UNIV CORP (JP)
NOF CORP (JP)
NOF CORP (JP)
International Classes:
C08F20/58; C07C321/18; C08F8/02
Domestic Patent References:
| WO2013148727A1 | 2013-10-03 | |||
| WO1999031144A1 | 1999-06-24 | |||
| WO1998001478A1 | 1998-01-15 |
Foreign References:
| JPH08506030A | 1996-07-02 | |||
| JPH09510963A | 1997-11-04 | |||
| JP2009528440A | 2009-08-06 | |||
| US6153705A | 2000-11-28 |
Other References:
IMAMURA ET AL.: "Synthesis of Zwitterionic Polymers Containing a Tertiary Sulfonium Group for Protein Stabilization", BIOMACROMOLECULES, vol. 20, no. 2, 19 December 2018 (2018-12-19), pages 904 - 915, XP055622315, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01542
TODD EMRICK, J. POLYM. SCI., vol. 55, 2017, pages 83 - 92
J. MORCELLET., MAKROMOL. CHEM., vol. 182, 1981, pages 949
H. MORI, MACROMOLECULAR RAPID COMMUNICATIONS, vol. 33, 2012, pages 1090 - 1107
See also references of EP 3733722A4
TODD EMRICK, J. POLYM. SCI., vol. 55, 2017, pages 83 - 92
J. MORCELLET., MAKROMOL. CHEM., vol. 182, 1981, pages 949
H. MORI, MACROMOLECULAR RAPID COMMUNICATIONS, vol. 33, 2012, pages 1090 - 1107
See also references of EP 3733722A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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