Title:
&agr -SUBSTITUTED 2-METHYL-5-NITROIMIDAZOL-1-ETHANOL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2006/058457
Kind Code:
A1
Abstract:
The present invention relates to the &agr -substituted 2-methyl-5-nitroimidazol-1-ethanol derivatives and the preparation method thereof, to the pharmaceutical composition comprising the mentioned derivatives and the use to prepare the medicament for treating anaerobic bacteria.
Inventors:
CEN JUNDA (CN)
ZHONG HUIJUAN (CN)
ZHONG HUIJUAN (CN)
Application Number:
PCT/CN2004/001380
Publication Date:
June 08, 2006
Filing Date:
November 30, 2004
Export Citation:
Assignee:
LIANYUNGANG HENGBANG PHARMACEU (CN)
CEN JUNDA (CN)
ZHONG HUIJUAN (CN)
CEN JUNDA (CN)
ZHONG HUIJUAN (CN)
International Classes:
C07D233/92; A61K31/41; A61P31/10
Other References:
BONE W. ET AL: "Toxicity of ornidazole and its analogs to rat spermatozoa as reflected in motility parameters", INTERNATIONAL JOURNAL OF ANDROLOGY, vol. 20, no. 6, 1997, pages 347 - 355
SKUPIN R. ET AL: "Lipase-catalyzed resolution of both enantiomners of ornidazole and some analogs", TETRAHEDRON: ASYMMETRY, vol. 8, no. 14, 1997, pages 2453 - 2464
ARYA V.P. ET AL: "Nitroimidazoles: Part XV. 1-Methyl-5-nitro-2-oxy(mercapto)imidazoles, 1-methyl-5-nitroimidazole-2-methanol(carboxaldehyde and glyoxalic ester) derivatives and 1-substituted alkyl-2-methyl-5 and -4-nitroimidazoles", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 21B, no. 12, 1982, pages 1078 - 1086
SKUPIN R. ET AL: "Lipase-catalyzed resolution of both enantiomners of ornidazole and some analogs", TETRAHEDRON: ASYMMETRY, vol. 8, no. 14, 1997, pages 2453 - 2464
ARYA V.P. ET AL: "Nitroimidazoles: Part XV. 1-Methyl-5-nitro-2-oxy(mercapto)imidazoles, 1-methyl-5-nitroimidazole-2-methanol(carboxaldehyde and glyoxalic ester) derivatives and 1-substituted alkyl-2-methyl-5 and -4-nitroimidazoles", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 21B, no. 12, 1982, pages 1078 - 1086
Attorney, Agent or Firm:
JEEKAI & PARTNERS (Jinyu Tower A129 West Xuan Wu Men Street, Beijing 1, CN)
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