Title:
cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION
Document Type and Number:
WIPO Patent Application WO2000037061
Kind Code:
A3
Abstract:
Treatment of sexual dysfunction by inhalation of a cGMP PDE 5 inhibitor, especially 5-[2-ethoxy- 5-(4-methylpiperazinylsulfonyl )phenyl] -1-methyl- 3-n-propyl-1, 6-dihydro-7H- pyrazolo[4, 3-d]pyrimidin -7-one, 4-phenylmethylamino -6-chloro-2- (1-imidazolyl) quinazoline, 4-phenylmethylamino -6-chloro-2-( 3-pyridyl) quinazoline, 1,3-dimethyl- 6-(2-propoxy- 5-methanesulfonylamidophenyl) -1,5-dihydropyrazolo[ 3,4-d]pyrimidin -4-one or 1- cyclopentyl-3- ethyl-6-( 3-ethoxy-4- pyridyl) -pyrazolo[ 3,4-d]pyrimidin -4-one.
Inventors:
NAEF RETO (CH)
Application Number:
PCT/EP1999/010250
Publication Date:
October 26, 2000
Filing Date:
December 21, 1999
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS ERFIND VERWALT GMBH (AT)
NAEF RETO (CH)
NOVARTIS ERFIND VERWALT GMBH (AT)
NAEF RETO (CH)
International Classes:
A61K9/00; A61K9/72; A61K31/00; A61K31/517; A61K31/519; A61K45/00; A61K9/12; A61P15/00; A61P15/10; A61P43/00; (IPC1-7): A61K31/00; A61K31/517; A61K31/519; A61K9/72; A61P15/00; A61P15/10
Domestic Patent References:
| WO1996028448A1 | 1996-09-19 | |||
| WO1995009636A1 | 1995-04-13 | |||
| WO1994028902A1 | 1994-12-22 | |||
| WO1996016644A1 | 1996-06-06 | |||
| WO1999064004A1 | 1999-12-16 |
Foreign References:
| EP0771799A1 | 1997-05-07 | |||
| US6018046A | 2000-01-25 | |||
| DE4420708A1 | 1995-12-21 | |||
| US5436233A | 1995-07-25 | |||
| EP0636626A1 | 1995-02-01 |
Other References:
ICHINOSE ET AL.: "Selective pulmonary vasodilation induced by aerosolized Zaprinast", ANESTHESIOLOGY, vol. 88, no. 2, February 1998 (1998-02-01), pages 410 - 416, XP000913484
FUJIMURA ET AL.: "Bronchoprotective effect of an intrabronchial administration of cilostazol powder and nebulized PDE1 and PDE4 inhibitor KF19514 in guinea pigs", INT. ARCH. ALLERGY IMMUNOL., vol. 116, no. 3, July 1998 (1998-07-01), pages 220 - 227, XP000913884
FUJIMURA ET AL.: "Bronchoprotective effect of an intrabronchial administration of cilostazol powder and nebulized PDE1 and PDE4 inhibitor KF19514 in guinea pigs", INT. ARCH. ALLERGY IMMUNOL., vol. 116, no. 3, July 1998 (1998-07-01), pages 220 - 227, XP000913884
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