Title:
NEISSERIA MENINGITIDIS IgtB LOS AS ADJUVANT
Document Type and Number:
WIPO Patent Application WO/2005/107798
Kind Code:
A1
Abstract:
The present invention relates to Neisserial Lipo-Oligo-Saccharides (LOS) that comprise a tri-saccharide outer core that shows increased binding to the DC-SIGN receptor on dendritic cells, as a result of which the Neisserial LOS’s of the invention have increased immunostimulatory activity. The tri-saccharide outer core of the Neiserial LOS’s combined with a Lipid A moiety with reduced toxicity is useful as an adjuvant in vaccine preparations.
Inventors:
STEEGHS LIANA JULIANA JOSEPHIN (NL)
VAN DE WINKEL JOHANNES GERARDU (NL)
VAN DER LEY PETER ANDRE (NL)
VAN DE WINKEL JOHANNES GERARDU (NL)
VAN DER LEY PETER ANDRE (NL)
Application Number:
PCT/NL2005/000358
Publication Date:
November 17, 2005
Filing Date:
May 11, 2005
Export Citation:
Assignee:
NEDERLANDEN STAAT (NL)
STEEGHS LIANA JULIANA JOSEPHIN (NL)
VAN DE WINKEL JOHANNES GERARDU (NL)
VAN DER LEY PETER ANDRE (NL)
STEEGHS LIANA JULIANA JOSEPHIN (NL)
VAN DE WINKEL JOHANNES GERARDU (NL)
VAN DER LEY PETER ANDRE (NL)
International Classes:
A61K39/095; A61K39/39; C07H3/06; (IPC1-7): A61K39/39; A61K39/095; C07H3/06; A61P31/00
Domestic Patent References:
| WO2004014417A2 | 2004-02-19 | |||
| WO2000026384A1 | 2000-05-11 | |||
| WO2004014417A2 | 2004-02-19 | |||
| WO2000026384A1 | 2000-05-11 |
Foreign References:
| NL9101359A | 1993-03-01 | |||
| NL9101359A | 1993-03-01 |
Other References:
LEY VAN DER P ET AL: "MODIFICATION OF LIPID A BIOSYNTHESIS IN NEISSERIA MENINGITIDIS IPXLMUTANTS: INFLUENCE ON LIPOPOLYSACCHARIDE STRUCTURE, TOXICITY AND ADJUVANT ACTIVITY", INFECTION AND IMMUNITY, AMERICAN SOCIETY OF MICROBIOLOGY, WASHINGTON, DC, US, vol. 69, no. 10, October 2001 (2001-10-01), pages 5981 - 5990, XP001055221, ISSN: 0019-9567
STEEGHS LIANA ET AL: "Teasing apart structural determinants of 'toxicity' and 'adjuvanticity': implications for meningococcal vaccine development.", JOURNAL OF ENDOTOXIN RESEARCH, vol. 10, no. 2, April 2004 (2004-04-01), pages 113 - 119, XP009038407, ISSN: 0968-0519
LEY; LEY ET AL., INFECT.IMMUN., vol. 69, 2001, pages 5981 - 5990
STEEGHS ET AL., J. ENDOTOXIN RES., vol. 10, 2004, pages 113 - 119
STEEGHS LIANA ET AL: "Teasing apart structural determinants of 'toxicity' and 'adjuvanticity': implications for meningococcal vaccine development.", JOURNAL OF ENDOTOXIN RESEARCH, vol. 10, no. 2, April 2004 (2004-04-01), pages 113 - 119, XP009038407, ISSN: 0968-0519
LEY; LEY ET AL., INFECT.IMMUN., vol. 69, 2001, pages 5981 - 5990
STEEGHS ET AL., J. ENDOTOXIN RES., vol. 10, 2004, pages 113 - 119
Attorney, Agent or Firm:
Van Westenbrugge, Andries (P.O. Box 29720, LS The Hague, NL)
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