Title:
iPS CELL HAVING DIFFERENTIATION PROPENSITY FOR CORNEAL EPITHELIUM
Document Type and Number:
WIPO Patent Application WO/2012/144582
Kind Code:
A1
Abstract:
The main purpose of the present invention is to provide a method for inducing the differentiation into a corneal epithelial stem cell and/or a corneal epithelial cell, which can be utilized for the production of a corneal epithelial cell sheet that has higher safety from the viewpoint of the possibility of occurrence of vascularization and the like and that can be produced readily. A method for inducing the differentiation of a pluripotent stem cell into a corneal epithelial stem cell and/or a corneal epithelial cell, which comprises a step of culturing the pluripotent stem cell in the presence of a stromal cell or an amnion-derived factor.
Inventors:
HAYASHI RYUHEI (JP)
NISHIDA KOHJI (JP)
NISHIDA KOHJI (JP)
Application Number:
PCT/JP2012/060667
Publication Date:
October 26, 2012
Filing Date:
April 20, 2012
Export Citation:
Assignee:
UNIV OSAKA (JP)
HAYASHI RYUHEI (JP)
NISHIDA KOHJI (JP)
HAYASHI RYUHEI (JP)
NISHIDA KOHJI (JP)
International Classes:
C12N5/071; C12N5/10; C12N5/0735
Domestic Patent References:
| WO2010134619A1 | 2010-11-25 | |||
| WO2012073238A1 | 2012-06-07 | |||
| WO2007069666A1 | 2007-06-21 | |||
| WO2001088100A1 | 2001-11-22 |
Foreign References:
| JP2007524411A | 2007-08-30 | |||
| JP2005333904A | 2005-12-08 | |||
| JP2004261533A | 2004-09-24 | |||
| JP2005333904A | 2005-12-08 |
Other References:
RYUHEI HAYASHI ET AL.: "'Ishoku Iryo ni Okeru iPS Saibo Kenkyu no Impact' iPS Saibo o Mochiita Kakumaku Johi Saisei Chiryoho no Kaihatsu", JAPANESE JOURNAL OF TRANSPLANTATION, vol. 44, no. 3, 2009, pages 226 - 230, XP008171630
KAZUHIRO SUDO ET AL.: "Kansaibo o Sasaeru Kankyo II. Feeder no Yakuwari to Feederless-ka eno Challenge, Amnion as a promising source of feeder cells for regenerative medicine", REGENERATIVE MEDICINE, vol. 8, no. 2, 2009, pages 195 - 200, XP008171942
OKANO,H. ET AL.: "Differentiation of induced pluripotent stem cells into corneal epithelial cells", DIFFERENTIATION, vol. 80, 2010, pages S44 - S45, XP055137049
WANG,Z. ET AL.: "Differentiation of embryonic stem cells into corneal epithelium", SCIENCE IN CHINA. SERIES C, LIFE SCIENCES / CHINESE ACADEMY OF SCIENCES, vol. 48, no. 5, 2005, pages 471 - 480, XP009122403
HOMMA,R. ET AL.: "Induction of epithelial progenitors in vitro from mouse embryonic stem cells and application for reconstruction of damaged cornea in mice", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 45, no. 12, 2004, pages 4320 - 6, XP055082514
NISHIDA K. ET AL., TRANSPLANTATION, vol. 77, 2004, pages 379 - 385
NISHIDA K. ET AL., N ENGL J MED, vol. 351, 2004, pages 1187 - 1195
KAWASAKI H. ET AL., NEURON, vol. 28, 2000, pages 31 - 40
See also references of EP 2700709A4
KAZUHIRO SUDO ET AL.: "Kansaibo o Sasaeru Kankyo II. Feeder no Yakuwari to Feederless-ka eno Challenge, Amnion as a promising source of feeder cells for regenerative medicine", REGENERATIVE MEDICINE, vol. 8, no. 2, 2009, pages 195 - 200, XP008171942
OKANO,H. ET AL.: "Differentiation of induced pluripotent stem cells into corneal epithelial cells", DIFFERENTIATION, vol. 80, 2010, pages S44 - S45, XP055137049
WANG,Z. ET AL.: "Differentiation of embryonic stem cells into corneal epithelium", SCIENCE IN CHINA. SERIES C, LIFE SCIENCES / CHINESE ACADEMY OF SCIENCES, vol. 48, no. 5, 2005, pages 471 - 480, XP009122403
HOMMA,R. ET AL.: "Induction of epithelial progenitors in vitro from mouse embryonic stem cells and application for reconstruction of damaged cornea in mice", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 45, no. 12, 2004, pages 4320 - 6, XP055082514
NISHIDA K. ET AL., TRANSPLANTATION, vol. 77, 2004, pages 379 - 385
NISHIDA K. ET AL., N ENGL J MED, vol. 351, 2004, pages 1187 - 1195
KAWASAKI H. ET AL., NEURON, vol. 28, 2000, pages 31 - 40
See also references of EP 2700709A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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