Title:
m-SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING INTEGRIN$g(a)¿v?$g(b)¿3? ANTAGONISM
Document Type and Number:
WIPO Patent Application WO/2001/027090
Kind Code:
A1
Abstract:
m-Substituted benzoic acid derivatives represented by general formula (I) and exhibiting integrin alpha v beta 3 antagonism; and intermediates for preparing the same [wherein A is an optionally substituted mono- or bi-cyclic heterocycle group containing two nitrogen atoms, or the like; D is a bond, >NR<4>, >CR<5>R<6>, -NR<4>-CR<5>R<6>-, or the like; X is CH or N; R<7> to R<9> are each hydroxyl, alkyl, or the like; Q is >C=O or the like; J is a bond or alkylene; and R<10> is optionally substituted hydroxyl, amino, or the like]. These derivatives are useful in the treatment or prevention of cardiovascular diseases, vascularization-related diseases, cerebrovascular diseases, cancers and metastases thereof, immunologic diseases, bone diseases, and so on.
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Inventors:
AJITO KEIICHI (JP)
ISHIKAWA MINORU (JP)
KUBOTA DAI (JP)
MURAKAMI SHOICHI (JP)
YAMAMOTO MIKIO (JP)
YAHATA NAOKAZU (JP)
FUJISHIMA KAZUYUKI (JP)
OYAMA MAKOTO (JP)
ISHIKAWA MINORU (JP)
KUBOTA DAI (JP)
MURAKAMI SHOICHI (JP)
YAMAMOTO MIKIO (JP)
YAHATA NAOKAZU (JP)
FUJISHIMA KAZUYUKI (JP)
OYAMA MAKOTO (JP)
Application Number:
PCT/JP2000/007031
Publication Date:
April 19, 2001
Filing Date:
October 10, 2000
Export Citation:
Assignee:
MEIJI SEIKA KAISHA (JP)
AJITO KEIICHI (JP)
ISHIKAWA MINORU (JP)
KUBOTA DAI (JP)
MURAKAMI SHOICHI (JP)
YAMAMOTO MIKIO (JP)
YAHATA NAOKAZU (JP)
FUJISHIMA KAZUYUKI (JP)
OYAMA MAKOTO (JP)
AJITO KEIICHI (JP)
ISHIKAWA MINORU (JP)
KUBOTA DAI (JP)
MURAKAMI SHOICHI (JP)
YAMAMOTO MIKIO (JP)
YAHATA NAOKAZU (JP)
FUJISHIMA KAZUYUKI (JP)
OYAMA MAKOTO (JP)
International Classes:
A61P7/02; A61P9/00; A61P9/02; A61P19/00; A61P35/00; C07C229/54; C07C229/60; C07D239/14; C07D239/42; C07D401/12; (IPC1-7): C07D239/42; C07D239/14; C07D401/04; C07D403/04; C07D211/52; C07C229/54; A61K31/606; A61P7/02; A61P9/00; A61P19/00; A61P35/00
Domestic Patent References:
| WO1999052872A1 | 1999-10-21 | |||
| WO1999038849A1 | 1999-08-05 |
Foreign References:
| US4032676A | 1977-06-28 |
Other References:
K.C. NICOLAOU ET AL.: "Design, synthesis and biological evaluation of nonpeptide integrin antagonists", BIOORG. MED. CHEM., vol. 6, no. 8, 1998, pages 1185 - 1208, XP002935433
TAYLOR E.C. ET AL.: "A convenient synthesis of 1-aryl-4-piperidones", SYNTHESIS, no. 8, 1981, pages 606 - 608, XP002935434
SU TSANN LONG ET AL.: "Synthesis of 4-((1,3-diamonipyrrolo(3',4':4,5)pyrido(2,3-d)pyrimidin-8-yl)benzoyl)-L-glutamic acid as a potential antifolate", J. HETEROCYCL. CHEM., vol. 30, no. 5, 1993, pages 1437 - 1443, XP002935435
TAYLOR E.C. ET AL.: "A convenient synthesis of 1-aryl-4-piperidones", SYNTHESIS, no. 8, 1981, pages 606 - 608, XP002935434
SU TSANN LONG ET AL.: "Synthesis of 4-((1,3-diamonipyrrolo(3',4':4,5)pyrido(2,3-d)pyrimidin-8-yl)benzoyl)-L-glutamic acid as a potential antifolate", J. HETEROCYCL. CHEM., vol. 30, no. 5, 1993, pages 1437 - 1443, XP002935435
Attorney, Agent or Firm:
Sato, Kazuo (Fuji Bldg. 2-3 Marunouchi 3-chome Chiyoda-ku, Tokyo, JP)
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