Title:
A method of preparing polyethylene glycol modified interferon alpha 1b
Document Type and Number:
WIPO Patent Application WO/2005/077421
Kind Code:
A1
Abstract:
The invention related to a method of preparing pegylated interferon alpha 1b covalently bounding to actived polyethylene glycol. To achieve the modified interferon alpha 1b protein, where the histidine and lysine on the protein surface were selectively conjugated to PEG the pH value of reaction system was modulated. There were no needs to separate interferon alpha 1b material and intermediate products from reaction system, and the modified interferon alpha 1b still maintained biological activity of original interferon alpha 1b, and excels as pharmacology, immunogenicity, drug metabolism and drug efficiency.
Inventors:
MENG XIANTAI (CN)
PENG YING (CN)
SUN PIAOYANG (CN)
PENG YING (CN)
SUN PIAOYANG (CN)
Application Number:
PCT/CN2005/000168
Publication Date:
August 25, 2005
Filing Date:
February 06, 2005
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
LIANYUNGANG XINYANG PHARMACEUT (CN)
MENG XIANTAI (CN)
PENG YING (CN)
SUN PIAOYANG (CN)
LIANYUNGANG XINYANG PHARMACEUT (CN)
MENG XIANTAI (CN)
PENG YING (CN)
SUN PIAOYANG (CN)
International Classes:
A61K38/21; A61K47/34; A61K47/48; A61P35/00; C07K14/56; C07K17/08; C08G65/00; C12P21/00; C12P21/02; A61K38/00; (IPC1-7): A61K47/48; C07K14/56; C12P21/00; C12P21/02
Foreign References:
| CN1280483A | 2001-01-17 | |||
| CN1261806A | 2000-08-02 |
Other References:
WANG Y.S. ET AL.: "Indentification of the major positional isomer of pegylated interferon alpha-2b.", BIOCHEMISTRY, vol. 39, no. 35, 2000, pages 10634 - 10640
DAVID C. ET AL.: "carboxyalkylated histide is a PH-dependent product of pegylation with SC-PEG.", PHARMACEUTICAL RESEARCH, vol. 18, no. 9, 2001, pages 1354 - 1360
DAVID C. ET AL.: "carboxyalkylated histide is a PH-dependent product of pegylation with SC-PEG.", PHARMACEUTICAL RESEARCH, vol. 18, no. 9, 2001, pages 1354 - 1360
Attorney, Agent or Firm:
JEEKAI & PARTNERS (Jinyu Tower A129 West Xuan Wu Men Street, Beijing 1, CN)
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