Title:
microRNA-143 DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2017/179660
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel miR-143 derivative described herein that can be used as a nucleic acid drug. In the derivative, the first strand is an oligonucleotide comprising the sequence set forth in SEQ ID NO: 3 or a sequence obtained by the substitution, deletion, insertion, or addition of 1 or 2 bases in the sequence set forth in SEQ ID NO: 3, and does not include a 3'-terminal modification, but may include a 5'-terminal modification. The second strand is an oligonucleotide comprising the sequence set forth in SEQ ID NO: 4 or a sequence obtained by the substitution, deletion or insertion of 1 or 2 bases in the sequence set forth in SEQ ID NO: 4, and includes a 3'-terminal modification and may include a 5'-terminal modification. The second strand is alternatively an oligonucleotide comprising the sequence set forth in SEQ ID NO: 5 or a sequence obtained by the substitution or insertion of 1 or 2 bases in the sequence set forth in SEQ ID NO: 5, and which does not include a 3'-terminal modification, and may include a 5'-terminal modification. Here, the 3'-terminal modification is a 1 to 5-mer oligonucleotide derivative that may contain a nucleoside derivative and/or a modified internucleoside bond, or a benzene-pyridine derivative. The 5'-terminal modification is a phosphate site or a group represented by the formula =CQ1-P(=O) (OH)2 (in the formula, Q1 is hydrogen, a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or a substituted or unsubstituted alkyloxy).
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Inventors:
AKAO YUKIHIRO (JP)
KITADE YUKIO (JP)
SEKIGUCHI MITSUAKI (JP)
MITSUOKA YASUNORI (JP)
KUGIMIYA AKIRA (JP)
SASAKI YASUO (JP)
KITADE YUKIO (JP)
SEKIGUCHI MITSUAKI (JP)
MITSUOKA YASUNORI (JP)
KUGIMIYA AKIRA (JP)
SASAKI YASUO (JP)
Application Number:
PCT/JP2017/015153
Publication Date:
October 19, 2017
Filing Date:
April 13, 2017
Export Citation:
Assignee:
UNIV GIFU (JP)
SHIONOGI & CO (JP)
SHIONOGI & CO (JP)
International Classes:
C12N15/09; A61K31/713; A61K48/00; A61P35/00; C12N15/113
Domestic Patent References:
| WO2013065791A1 | 2013-05-10 |
Foreign References:
| JP2008086201A | 2008-04-17 | |||
| JP2011251912A | 2011-12-15 |
Other References:
AKAO, YUKIHIRO ET AL.: "MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers", ONCOLOGY REPORT, vol. 16, no. 4, 2006, pages 845 - 850, XP002463963
See also references of EP 3444345A4
See also references of EP 3444345A4
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (JP)
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