o-SUBSTITUTED ANILINE DERIVATIVE AND ANTIOXIDANT DRUG

Title:

o-SUBSTITUTED ANILINE DERIVATIVE AND ANTIOXIDANT DRUG

Document Type and Number:

WIPO Patent Application WO/2007/052794

Kind Code:

A1

Abstract:

A compound or salt thereof which has antioxidant activity and is effective in the treatment of ischemic organ diseases including arteriosclerosis, heart infarction, and brain infarction, in the treatment of diseases caused by oxidative cellular disorders, such as kidney diseases, and in the inhibition of retinal disorders caused by oxidation due to light, etc. Also provided is an antioxidant drug containing at least one of the compound and salt as an active ingredient. The compound is represented by the formula (1). The antioxidant drug is characterized by containing at least one of the compound and salt as an active ingredient. {In the formula (1), a is 1 or 2, R0 represents (un)substituted amino, R1 to R4 each independently represents hydrogen or alkyl, E represents an (un)substituted alkylene chain, D represents a single bond, oxygen, (un)substituted nitrogen, sulfur, sulfinyl, sulfonyl, carbonyl, carbonylamino, or aminocarbonyl, and A represents an (un)substituted aromatic hydrocarbon group, (un)substituted heterocyclic group, (un)substituted aralkyl, or (un)substituted heteroaralkyl.}

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Inventors:

TSUBOKURA SHIRO (JP)
UMEDA NOBUHIRO (JP)
UCHIDA SEIICHI (JP)

Application Number:

PCT/JP2006/322111

Publication Date:

May 10, 2007

Filing Date:

November 06, 2006

Export Citation:

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Assignee:

NIPPON SODA CO (JP)
TSUBOKURA SHIRO (JP)
UMEDA NOBUHIRO (JP)
UCHIDA SEIICHI (JP)

International Classes:

C07D307/79; A61K31/343; A61K31/4155; A61K31/4178; A61K31/422; A61K31/427; A61K31/439; A61K31/454; A61K31/496; A61P3/10; A61P9/00; A61P9/10; A61P13/12; A61P27/02; A61P39/06; A61P43/00; C07D405/06; C07D405/12; C07D405/14; C07D413/12; C07D417/12; C07D471/08

Domestic Patent References:

WO2004092153A1

2004-10-28

Foreign References:

JPH07112980A	1995-05-02
US3476777A	1969-11-04

Other References:

OHKAWA S. ET AL.: "5-Aminocoumarans: Dual inhibitors of lipid peroxidation and dopamine release with protective effects against central nervous system trauma and ischemia", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 4, 1997, pages 559 - 573, XP002979756
HAMMOND M.L. ET AL.: "Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-y]-2,3-dihydro-5-benzofuranol, a potent tropical anti-inflammatory agent", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 3, 1990, pages 908 - 918, XP000673907
HAMMOND M.L. ET AL.: "2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis", JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 5, 1989, pages 1006 - 1020, XP000673754