Title:
pH RESPONSIVE ORAL POLYMERIC PHARMACEUTICAL DOSAGE FORM
Document Type and Number:
WIPO Patent Application WO/2015/011653
Kind Code:
A9
Abstract:
The disclosure relates to a pH responsive oral polymeric pharmaceutical dosage form for site specific delivery of a pharmaceutically active ingredient to a target site in a human or animal body, the dosage form comprising CHT-PEGDMA-MAA (chitosan-poly(ethylene glycol) dimethacrylate-methacrylic acid) co-polymer particles. In use exposure of the dosage form to media of increasing pH facilitates swelling of the particles, and exposure of the dosage form to media of decreasing pH facilitates constriction and/or aggregation of the particles.
Inventors:
KONDIAH PIERRE P D (ZA)
PILLAY VINESS (ZA)
CHOONARA YAHYA ESSOP (ZA)
MODI GIRISH (ZA)
KUMAR PRADEEP (ZA)
DU TOIT LISA CLAIRE (ZA)
TOMAR LOMAS K (ZA)
TYAGI CHARU (ZA)
PILLAY VINESS (ZA)
CHOONARA YAHYA ESSOP (ZA)
MODI GIRISH (ZA)
KUMAR PRADEEP (ZA)
DU TOIT LISA CLAIRE (ZA)
TOMAR LOMAS K (ZA)
TYAGI CHARU (ZA)
Application Number:
PCT/IB2014/063336
Publication Date:
November 26, 2015
Filing Date:
July 23, 2014
Export Citation:
Assignee:
UNIV WITWATERSRAND JHB (ZA)
International Classes:
A61K9/16; A61K9/19; A61K9/20
Attorney, Agent or Firm:
FIANDIERO, João Achada et al. (2nd Floor34 Fredman Drive ,SANDTON, Johannesburg 2193 Gauteng, ZA)
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