Title:
s-TRIAZINE DERIVATIVE AND REMEDY FOR ESTROGEN-DEPENDENT DISEASES CONTAINING THE SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/1993/017009
Kind Code:
A1
Abstract:
An s-triazine derivative represented by general formula (I), or a pharmaceutically acceptable acid addition salt thereof, and a remedy for estrogen-dependent diseases containing the derivative as the active ingredient, wherein: (1) R1 and R3 represent each lower alkyl, and R2 and R4 represent each lower alkyl or phenyl which may be substituted by halogen, nitro or amino; or (2) both of R1 and R2 and/or both of R3 and R4 are combined together to form a cyclic amino group together with the nitrogen atom to which they are bonded. This compound has an aromatase inhibitory effect, i.e., the effect of inhibiting in vivo enzymatic conversion of androgens into estrogens, thus being useful for treating estrogen-dependent diseases such as endometriosis, polycystic ovary, benign mastosis, endometrial carcinoma and mastocarcinoma.
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Inventors:
KOBAYASHI HIDESHI (JP)
KOMATSU TOSHIHIKO (JP)
FUKUDA SEIICHI (JP)
TSUCHIDA YOSHIO (JP)
KATO MASANOBU (JP)
YAGUCHI SHINICHI (JP)
KOMATSU TOSHIHIKO (JP)
FUKUDA SEIICHI (JP)
TSUCHIDA YOSHIO (JP)
KATO MASANOBU (JP)
YAGUCHI SHINICHI (JP)
Application Number:
PCT/JP1993/000240
Publication Date:
September 02, 1993
Filing Date:
February 26, 1993
Export Citation:
Assignee:
ZENYAKU KOGYO KK (JP)
International Classes:
C07D521/00; (IPC1-7): A61K31/53; A61K31/535; A61K31/54; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D413/04; C07D413/14; C07D417/04; C07D417/14
Foreign References:
| JPS62240673A | 1987-10-21 | |||
| JPS5655302A | 1981-05-15 | |||
| JPS4917677B1 | 1974-05-02 | |||
| US3308122A | 1967-03-07 |
Other References:
See also references of EP 0629622A4
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