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WO/2023/185212A1 |
The present invention relates to a mineralized collagen material, a preparation method therefor, and an application thereof. The preparation method comprises: dissolving type I collagen, a calcium source, and acid in a first solvent to o...
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WO/2023/188492A1 |
Provided is a tissue restoration material and a tissue restoration material production method, said tissue restoration material containing crosslinked gelatin and having at least one absorption peak at an absorbance of 0.025 or more in t...
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WO/2023/189485A1 |
The present invention provides a method for evaluating the quality of mesenchymal stem cells, said method including a step for evaluating the cells on the basis of the measured consumption amounts of pyruvic acid, cystine and serine in t...
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WO/2023/192555A1 |
An interbody implant may include a solid, unitary body and one or more porous layers. The interbody implant may include a homogenous interface between the one or more porous layers and a the solid, unitary body. The homogenous interface ...
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WO/2023/191176A1 |
The present invention relates to a bone regeneration composition comprising collagen, thrombin, and albumin, a therapeutic use using same, and a dosage form. The composition and the dosage form, according to the present invention, may no...
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WO/2023/186794A1 |
The present invention relates to an inverse opal (IOPAL) hydrogel formed with poly(ethylene)glycol (PEG) covalently bonded to heparin (Hep). The invention also relates to the use of said hydrogel as well as to the procedure, based in the...
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WO/2023/192343A1 |
Embodiments relate to a method of forming a granular hydrogel scaffold (GHS). The method comprises converting polymers to form hydrogel microparticles (HMP) via a first crosslinking and assembling the HMP to form GHS via non-light-mediat...
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WO/2023/184852A1 |
The present invention relates to the technical field of polymer materials, and in particular to a shape memory polyurethane material and a self-reinforced regular porous polymer film prepared from same. The shape memory polyurethane in t...
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WO/2023/187131A1 |
The present invention relates to an emulsion, a gelled emulsion or a gel, comprising a hydrogel and fat or a fat derivative. In one embodiment, the emulsion further comprises at least one active ingredient, the active ingredient being se...
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WO/2023/192378A1 |
The present invention discloses compositions and methods for modulating the immune system in a subject. The compositions of the present invention comprise a porous scaffold biomaterial comprising active agent. The method of the present i...
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WO/2023/187018A1 |
The present invention relates to regenerative medicine in general, in particular tissue engineering. The present invention provides improved manufacturing methodologies which enables production of complex three-dimensional tissue scaffol...
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WO/2023/183148A1 |
The present invention is constructed or engineered tissue, suitable for isolating, protecting, repairing, and/or regenerating a nerve or a portion thereof. The invention includes a nerve wrap, enclosure, conduit, or tubular shape formed ...
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WO/2023/182916A1 |
An interbody fusion cage (100) comprises a cage body (110) comprising a front wall (120), opposite side walls (130, 140), a back wall (150) and a cage bottom (160) interconnected to enclose an open internal space (180) of the interbody f...
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WO/2023/179139A1 |
The present invention provides a metal prosthetic body bearing modular ceramic and a preparation method therefor. The preparation method for the metal prosthetic body bearing modular ceramic comprises: step S1, preparing a metal support;...
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WO/2023/179544A1 |
Disclosed in the present invention is a 3D-printed bone defect repair scaffold loaded with mesenchymal stem cell extracellular matrixes. Preparation steps are as follows: S1, dissolving gelatin, sodium alginate and 58S bioglass in water ...
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WO/2023/179422A1 |
An elastic porous scaffold, a preparation method therefor and use thereof. The preparation method comprises: dissolving a macromolecule polymer in a solvent, and by means of electrospinning, obtaining a nanofiber membrane; carrying out b...
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WO/2023/179045A1 |
A bionic nerve graft and a preparation method therefor. The bionic nerve graft comprises a spiral stent, a nanofiber membrane, a guide fiber and hBMSC-ECM, wherein the surface of the spiral stent is coated with the nanofiber membrane; th...
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WO/2023/180783A1 |
The present disclosure relates to injectable or implantable compositions that are able to mimic different types of mineralized biological tissues and their uses in mineralized tissues repair and regeneration.
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WO/2023/182700A1 |
The present invention relates to porous inorganic particles, and a composite filler and product using same, the porous inorganic particles comprising: a sintered body of calcium-based particles; and pores distributed in the sintered body...
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WO/2023/179418A1 |
The present invention provides a rotator cuff patch with an orientation structure and a preparation method therefor. The preparation method comprises: adding a natural source matrix material into a solvent to obtain a first mixed liquor ...
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WO/2023/178249A1 |
The present disclosure describes compositions that can be used in the treatment of an ocular injury or disease in a subject in need thereof. Methods of preparing the compositions are also described. The compositions can include one or mo...
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WO/2023/174079A1 |
The present invention provides a ceramic calcium phosphate bone cement and a preparation method therefor. The preparation method for the ceramic calcium phosphate bone cement comprises: preparing a β-TCP ceramic particle; selecting dist...
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WO/2023/173839A1 |
An electrochemical artificial muscle system and an electrochemical artificial muscle testing device. The electrochemical artificial muscle system comprises a working electrode including conductive fibers having a spiral structure; a coun...
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WO/2023/176840A1 |
Provided is an artificial retina in which an organic dye compound is fixed onto a thin sheet, the artificial retina being characterized in that the organic dye compound induces a receptor potential in accordance with an optical stimulus,...
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WO/2023/175590A1 |
An electrode array, such as a cochlear implant electrode array, or a retinal prosthesis array, or a vestibular array, comprising a plurality of electrodes and an electrode carrier carrying the plurality of electrodes. The electrodes can ...
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WO/2023/176501A1 |
A biocompatible member according to an embodiment of the present invention has multiple fibers containing a biocompatible material. The adjacent fibers are covalently bonded to each other at multiple places in the direction in which the ...
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WO/2023/177601A1 |
A microfabricated droplet dispensing structure is described, which may include a MEMS microfluidic fluidic valve, configured to open and close a microfluidic channel. The opening and closing of the valve may separate a target particle an...
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WO/2023/143335A9 |
Disclosed is a hydrophilic electrostatic spinning implant for inducing the regeneration of skin tissues. The implant is prepared from raw materials comprising a fibrinogen complex and a polylactic acid-polycaprolactone copolymer by means...
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WO/2023/176906A1 |
This transplantation medium has a viscosity of 1.5 to 4 mPa∙s at a shear speed at 25°C of 2 (1/s), contains a hyaluronic acid and a pharmaceutically acceptable aqueous liquid, and is for subretinal transplantation of retinal pigment e...
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WO/2023/172751A1 |
Device and methods for treating wounds or surgical sites are provided. The devices and methods include use of antifibrinolytic agents such as tranexamic acid to reduce exudate and improve wound healing. Embodiments provide for the timed ...
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WO/2023/170424A1 |
The present invention relates to formulations, comprising SBF and collagen, and methods that form a bone-like coating on the surface of a substrate. These coated substrates can be used in cell culture experiments to investigate the bone ...
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WO/2023/170557A1 |
The present invention relates to a method of manufacturing a medical device that is produced with poly lactic acid (PLA) and hydroxyapatite (HA) aimed at repairing bone fractures or injuries of considerable size using 3D printing techniq...
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WO/2023/170316A1 |
The present invention refers to a method for the preparation of a hydrogel suitable to produce artificial tissues. The present invention also covers a biomaterial or artificial tissue obtained by implementing said method. Finally, the pr...
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WO/2023/172686A1 |
Embodiments herein relate to thromboresistant coatings, coated devices, and related methods. In an embodiment, a thromboresistant implantable, partially implantable, or wearable medical device is included having a substrate, a non-foulin...
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WO/2023/169074A1 |
The present disclosure relates to the technical field of medical materials, and provides a bone adhesive, a preparation method therefor and an application thereof. According to the bone adhesive, levodopa (L-DOPA) is grafted on polyvinyl...
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WO/2023/168921A1 |
Provided is the use of human platelet-apoptotic vesicles in the preparation of a formulation for promoting osteogenic differentiation of mesenchymal stem cells. Further provided is a bone defect repair formulation, comprising a PLGA scaf...
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WO/2023/165194A1 |
The present application provides a biodegradable magnesium alloy free of rare earth elements, wherein the magnesium alloy comprises the following elements in percentage by mass: 1.0%-5.0% Zn; 0.1%-1.0% Mn; 0.1%-1.0% Ca; 0.1-1.0% Sr; 0.1%...
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WO/2023/166513A1 |
Bioink compositions comprising a plurality of aromatic peptides and a matrix-forming material, formulations and kits for preparing same, additive manufacturing (bioprinting) processes utilizing same and three-dimensional objects obtained...
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WO/2023/168153A1 |
Embodiments of the present disclosure concern administration of a cell population to an individual for regeneration of a tissue. The cell population may comprise fibroblasts and/or immune cells, either of which may be modified or unmodif...
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WO/2023/167122A1 |
The present invention mainly addresses the problem of providing a novel method for rapidly inducing growth factor-producing cells from somatic cells, that is, a novel production method that allows rapid production of growth factor-produc...
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WO/2023/166161A1 |
Present invention relates to a novel composition and treatment regimen in treatment of bacterial infections.
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WO/2023/167402A1 |
The present invention relates to a method for producing an artificial scalp model using a 3D printing-based multi-point multi-nozzles, and an artificial scalp model manufactured by using same, in which a dermal mimetic body can be create...
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WO/2023/168387A1 |
This disclosure provides cryoprotectant compositions containing one or more cryoprotective agents encapsulated by one or more stimulus-responsive nanoparticles or microparticles, kits containing the compositions, and methods of using the...
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WO/2023/164799A1 |
An umbilical cord Wharton's jelly product is prepared by the following two methods: (1) taking Wharton's jelly from an umbilical cord, treating the Wharton's jelly with an antifreeze agent before performing cryopreservation, and thawing ...
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WO/2023/164824A1 |
The present application provides an X-ray imageable identification element for an implant, comprising a body and an identification pattern, wherein the identification pattern is formed on the body or embedded in the body, and the materia...
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WO/2023/161828A1 |
Described herein are compositions of EDTA having activity against planktonic and biofilm cells of clinically relevant pathogens. The compositions generally include EDTA and are capable of inhibiting the growth and proliferation of microb...
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WO/2023/162926A1 |
This medical coating agent comprises a polymer including a structural unit (A) derived from an ethylenic unsaturated monomer having a urea bond. The polymer contained in the medical coating agent satisfies Condition (i) in a case where a...
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WO/2023/161352A1 |
A bioink is described. The bioink comprises coral particles and biocompatible polymer, wherein the concentration of coral particles in the bioink is 25 to 85 weight % of the total weight of the bioink.
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WO/2023/160588A1 |
The present invention provides a tissue engineering cartilage particle graft and a preparation method therefor. Specifically, the present invention provides injectable cartilage particles prepared from chondrocytes by means of amplificat...
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WO/2023/159885A1 |
The present invention discloses a preparation method for a slowly-degradable high-purity magnesium anchor. The preparation method comprises the following steps: 1) dissolving disodium ethylenediaminetetraacetate, potassium dihydrogen pho...
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