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WO/1996/031220A1 |
The present invention provides polyanionic, substituted CDs having cellular growth modulating activity. The invention further provides CDs having anionic groups on one side of the CD molecule. Therapeutic methods for using as well as met...
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WO/1996/030060A1 |
There is provided medical devices for use as cardiac, coronary or vascular prostheses, for example heart valves, coronary artery bypass grafts and arterial grafts. The devices described are at least partially coated or impregnated with a...
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WO/1996/030532A1 |
A method to render in particular endothelial cells capable of inhibiting platelet and leukocyte-mediated injury and inflammation is described, comprising genetically modifying the cells by inserting therein DNA encoding ATP diphosphohydr...
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WO/1996/029102A1 |
A biocompatible material comprising a substrate and a phospholipid moiety covalently attached thereto in an amount and orientation effective to provide an improved nonthrombogenic surface relative to the substrate without the phospholipi...
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WO/1996/028187A1 |
Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic co...
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WO/1996/025960A1 |
An implant for use in the human body has a substrate coated with a material that contains chemical compounds of one or several metals (M) of group IV A of the periodic table, nitrogen (N) and oxygen (O). In the coating material, voids fo...
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WO/1996/024392A1 |
Processes are provided for coating the surfaces of objects with hyaluronic acid, its derivatives or other natural or semisynthetic polymers, for applications in the fields of surgery, health care and diagnostics. The processes make it po...
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WO/1996/023835A1 |
A process for modifying a surface of an article that includes treating the surface with: (a) a first water-soluble polyalkylene amine (b) a water-soluble polymeric anionic compound and (c) a second water-soluble polyalkylene amine in the...
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WO/1996/018423A1 |
A process for the coating of an intraocular lens to impart tissue compatibility thereto, comprising the steps: a) priming said lens using a solution of a polyamine; b) coating the lens treated in step a) above with a solution of a period...
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WO/1996/014887A1 |
Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized, end-capped PEO which is attached at one end to the medical device. The PEO com...
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WO/1996/011668A1 |
The invention involves using a plasma to functionalize a surface of medical devices such as catheters, particularly intracardial catheters, with covalently bound thermochemically reactive groups. The surface is further contacted with a b...
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WO/1996/010427A2 |
A trans-epithelial appliance having a hemidesmosome formation-inducing protein composition derived from rat bladder carcinoma cells deposited thereon. This composition stimulates cell attachment and may be either the cell matrix of a sol...
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WO/1996/009086A1 |
A medical balloon and catheter in which the balloon (14) is wrapped and folded upon itself tortuously and tightly so outer surfaces (12) contact each other for insertion into the body and in whic the balloon is free of bridging and adhes...
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WO/1996/008149A1 |
A biomaterial with a thromboresistant surface and a method for forming same are provided. The thromboresistant surface is comprised of a distinct coating layer of a chitosan-based membrane and a bioactive material. The bioactive material...
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WO/1996/008211A2 |
This invention relates to plasma grafting methods and compounds. More particularly, the present invention relates to a novel plasma grafting process compound for producing a surface suitable for immobilizing bioactive substances.
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WO/1996/004943A1 |
The proposed biologically compatible hydrogel is intended for use in the correction of cosmetic or functional defects (e.g., of the mammary glands, vocal cords, penis, etc., by endoprosthesis), in the creation of interstitial reservoirs ...
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WO/1996/002838A1 |
The invention relates to a novel thiol modified substrate or article with a noble metal or polymer surface on to which glutathione has been immobilized, said novel product possessing an outstanding combination of biological activities ma...
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WO/1995/034332A1 |
The invention concerns treating a biological tissue with a low concentration of cross-linking reagent.
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WO/1995/034669A2 |
Retroviral vectors are disclosed which include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the genes of interest in a wide variety of transfected cell types. Also disclose...
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WO/1995/034251A1 |
The invention provides dental devices (including implants (40), abutments (12), bridges, screws (15), and orthodontic appliances (50, 51, 52)) that are fabricated from low modulus, biocompatible, non-toxic Ti-Nb-Zr alloys. The dental imp...
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WO/1995/033501A1 |
A method of improving mechanical heart valve prostheses and other mechanical parts implanted in the human body, by reducing their tendency to contribute to the formation of thrombi and by improving their mechanical and biocompatible prop...
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WO/1995/031897A1 |
The present invention is directed to methods and means useful for measuring functional characteristics of an organ being perfused at near normal metabolism using an ex vivo warm preservation process/system. The functional characteristics...
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WO/1995/031944A1 |
The present invention is directed to methods and compositions for immunomodifying a graft so that it is nonthrombogenic and substantially nonimmunogenic when transplanted into a recipient. In an ex vivo process, the lumenal surfaces of b...
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WO/1995/029713A1 |
This invention relates to improved blood contact devices such as vascular prostheses rendered antithrombotic through the use of recipient endothelial cells grown on an appropriate subendothelial matrix. The subendothelial matrix layer, w...
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WO/1995/029712A1 |
This invention is directed to improved blood contact devices such as vascular prostheses rendered substantially nonthrombogenic through addition of a preserved layer of extracellular subendothelial matrix. The preserved subendothelial ma...
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WO/1995/029714A1 |
This invention relates to improved vascular prostheses derived from mammalian blood vessels. The prostheses are fabricated from arterial segments from which the donor endothelium has been removed. A key aspect of this invention is the pr...
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WO/1995/028184A1 |
The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylact...
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WO/1995/026993A1 |
The present invention relates to novel polymeric compositions of matter and their use. Said polymeric compositions of matter are surface active endgroup-containing polymers that comprise a linear base polymer having covalently bonded sur...
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WO/1995/026169A1 |
The present invention provides methods for modifying surfaces of metal alloy and/or UHMWPE (ultra-high molecular weight polyethylene), preferably surfaces which are frictionally engaged, e.g., in an orthopaedic implant. The methods reduc...
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WO/1995/025751A1 |
Provided are sulfated derivatives of polysaccharides such as hyaluronic acid and hyaluronic acid esters exhibiting anticoagulant, antithrombotic, and angiogenic activity, for use in the biomedical area.
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WO/1995/021869A1 |
Film-forming block polymer material comprising an antithrombogenic glycosaminoglycan component and having general structure (I), wherein R1 and R2, which are the same or different, are each a hydrogen atom or a C1-C4 alkyl group; R3 is O...
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WO/1995/020407A1 |
New materials having improved biocompatibility have novel zwitterionic groups at the surface. The zwitterion is characterised by having at least one monovalent substituent at the atom carrying the cationic charge which is an aryl group. ...
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WO/1995/019796A1 |
A biocompatible implant having improved host tissue ingrowth capability and enhanced blood compatibility comprises at least one tissue-contacting surface of an electrically charged material. The electrically charged material can be furth...
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WO/1995/020008A1 |
Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane ...
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WO/1995/018840A1 |
A method for modifying the plastic surface of an article adapted for contacting living tissue by the gamma or electron beam irradiation induced chemical graft coating thereon of: (1) a neutral or ionic water-soluble, hydrophilic monomer ...
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WO/1995/016735A1 |
Surface treated articles of polyethylene terephthalate (PET) are disclosed having low self-adhesion and high bondability to other surfaces. The articles comprise oriented PET and about 100-5000 ppm of a particulate additive uniformly dis...
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WO/1995/013313A1 |
Plasma polymerized membranes comprising polymerized aliphatic hydrocyclosiloxane monomers optionally copolymerized with co-monomers and methods for their preparation are described. These methods may be used to coat substrates to impart p...
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WO/1995/013103A2 |
A method for growing epithelial cells in vitro using soluble proteins secreted by 804G rat bladder carcinoma cells. These proteins are able to stimulate cell attachment and hemidesmosome formation in cells grown in contact with the prote...
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WO/1995/009883A1 |
Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to ...
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WO/1995/007691A1 |
This invention relates to the use of nitric oxide adducts to prevent platelet deposition and thrombus formation, on artificial surfaces which come into contact with blood. Suitable nitric oxide adducts include nitroglycerin, sodium nitro...
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WO/1995/006487A2 |
An intravascular medical device (10) having a structure (11) shaped and sized for introduction into the vascular system of a patient, the structure having biologically inert properties and a thrombolytic agent (13) or an antithrombogenic...
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WO/1995/005408A1 |
New polymers formed from ethylenically unsaturated monomers having pendant zwitterionic groups and pendant urethane units are used to increase the biocompatibility, especially hemocompatibility, of polymeric, especially polyurethane, sub...
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WO/1995/004839A2 |
This invention relates to a new technique for preparing metal devices such as guide wires for the subsequent attachment of hydrophilic coatings. The invention also relates to guide wires and other devices made according to that method. I...
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WO/1995/003075A1 |
A medical material comprising a polymer or copolymer of a polar vinyl derivative and containing an antithrombocytic agent. Since it can release the antithrombocytic agent in an effective concentration for long, it has a high anticoagulan...
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WO/1995/003083A1 |
The invention features a catheter (1) for delivering drugs to tissue at a desired location of the wall of a body lumen (2). The catheter (1) has a catheter shaft (3) and an expandable portion (4) mounted on the catheter shaft (3). The ex...
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WO/1995/000017A1 |
About 0.01 % to 10 % of an antifoam silicone oil having a predetermined viscosity of at least about 100 cp is dispersed in an aqueous solution of a water-soluble gum having a viscosity within about 20 % of the predetermined viscosity of ...
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WO/1994/027651A1 |
A medical implant made of polymeric material having an increased oxidation resistance is formed by a method including the steps of placing a resin powder in a sealed container. A substantial portion of the oxygen is removed from the seal...
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WO/1994/026321A1 |
The present invention relates to a bioactive conjugate adapted to coat a metal implant outer surface, which have the following structural formula (I): -R-X-P wherein, R is O or S, adapted to be covalently attached to an implant surface; ...
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WO/1994/026399A1 |
The present invention concerns surface modified biocompatible membranes used in contact with body fluids or tissue and a method of preparing polymer surface modified biocompatible membranes with functional groups incorporated into the me...
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WO/1994/025081A1 |
Vascular grafts, shunts, patches or valves are formed of material tolerated by the body and are lined or coated with gold to form a non-thrombogenic surface. Methods of manufacture are also disclosed.
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