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WO/2005/042034A1 |
A generic structure for the peptides of the present invention includes A - X - B -C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. Th...
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WO/2005/037363A2 |
An applicator for facilitating radiation treatment in a body cavity, particularly post resection, provides for superior wound closure management, with an integrated drain and a flexible main shaft (24) that permits further treatment at i...
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WO/2005/023367A2 |
Radioactive sources (10) are manufactured for treating a tumor or cancerous area occurring around a conduit or duct in the body by emitting X-rays to destroy or reduce the tumors. The sources (10) contain ytterbium which is substantially...
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WO/2005/023180A2 |
Disclosed herein are methods for identifying cancer cells and monitoring anticancer therapy in the body of a mammal by systemically delivering Sindbis viral vectors. The vector can specifically target and identify tumor cells in mice gro...
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WO/2005/011793A1 |
The present finding relates to a catheter (1) for cerebral treatment with therapeutic radioactive substances including a proximal portion (2), an intermediate portion (3) and a distal portion (4), said distal portion (4) comprising an in...
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WO/2004/101026A2 |
A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated strand made of material, which is bio-absorbable in living tissue and a plurality of radioacti...
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WO/2004/101737A2 |
A composition for eliciting an immunce response to an immunogen comprises an immunogen in combination with a mast cell membrane activator such as compound 48/80. Any suitable immunogen may be employed, such as an antibody-inducing determ...
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WO/2004/098711A2 |
Devices, systems, and methods are provided for transporting implants. In one embodiment, the implants are radioactive seeds contained within substantially transparent sleeves that can be sealed at both ends. Multiple sleeves can be place...
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WO/2004/098523A2 |
An ocular brachytherapy device, generally comprising a catheter (10) and wire (12), impregnated with radioactive material, are provided. The wire (12) is formed having a desired treatment shape and size such that it can be placed near an...
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WO/2004/091714A2 |
An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymeric release region comp...
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WO/2004/083902A2 |
The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocomp...
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WO/2004/082762A1 |
A radioactive member for use in brachytherapy comprising a hollow elongate bioabsorbable suture member with radioactive seeds and spacer members without different coloration and diameter from the radioactive seeds alternately disposed th...
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WO/2004/073640A2 |
Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and coval...
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WO/2004/071571A1 |
The present invention is directed toward a method for preparing and purifying a conjugate of a radioiodinated aminopolycarboxylate-appended peptide and a targeting M agent. The method involves (A) providing a solution comprising (i) unbo...
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WO/2004/071580A1 |
An apparatus in one example comprises a terminus-spacer component that comprises a first end and a second end portion. The first end portion is configured to form a coupled connection with an implantation seed. The second end portion ser...
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WO/2004/069159A2 |
The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor bin...
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WO/2004/069337A1 |
The invention provides magazines or radioactive brachytherapy seeds. The seed magazines provide herein include housing, seed holder, and pusher components, and optionally have a slidable shield to protect a user from radiation.
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WO/2004/060205A2 |
A device for percutaneously implanting an object in a patient includes a handle (210), a cannula (240) projecting outwardly from the handle, and an actuator (230) movably disposed relative to the handle. The cannula can be configured to ...
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WO/2004/050168A2 |
The present disclosure provides radiopharmaceutical macroaggregates for the treatment of abnormal tissue comprising particles having a minimum size of one micron, wherein the particles comprise iron, gadolinium, or calcium, and one or mo...
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WO/2004/044227A2 |
The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor angioge...
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WO/2004/041098A1 |
A medical appliance through an endoscope, wherein a plurality of medical treatment items including a flexible guide unit are lockingly inserted into and extracted from a sheath through the endoscope selectively inserted into body cavitie...
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WO2003015864B1 |
A brachytherapy seed (100) includes a magnetized or magnetizable material (106). To locate seeds (100) which have been implanted into an organ, the organ is exposed to an oscillating magnetic field, which causes them to vibrate. Doppler ...
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WO/2004/032708A2 |
Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of blood vessels, by administering to a subject a therapeutically effective amount peptide AM(11-...
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WO/2004/024236A1 |
Apparatus, systems and methods for delivering brachytherapy to a target tissue region of a human or other mammalian body. In some embodiments, a flexible brachytherapy device is implanted that includes a therapy delivery portion having o...
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WO/2004/017905A2 |
The present invention relates to assessing and measuring endothelial functions. A vasodilating stimulant is provided to a patient to stimulate hemodynamic activity in a selected region of the patient's body. In an embodiment, endothelial...
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WO/2004/014215A2 |
Disclosed is a brachytherapy seed deployment system for use in any of a variety of medical procedures such as radiation treatment of the prostate gland. In one embodiment, the system includes a number of brachytherapy seed deployment nee...
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WO/2004/003121A1 |
The invention relates to the preparations used for disinfecting and applied in national economy, medicine, laboratories of all types. The preparation contains a chelating metal complex compound with a monodentate bidentate or polydentate...
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WO/2003/099374A2 |
An apparatus for producing a radionuclide comprising a target chamber (T) having a fluid to hold a target liquid (TL) which is illuminated by a particle beam (PB) created at particle beam source (PBS) to produce a radionuclide in said fl...
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WO/2003/099210A2 |
The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubu...
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WO/2003/099381A2 |
The invention features brachytherapy applicators for delivering radioactive seeds to a patient. Specifically, the invention provides brachytherapy applicators in which a seed magazine is removably held within a chuck by a magazine retain...
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WO/2003/099208A2 |
An apparatus for producing a radionuclide includes a target chamber, a particle beam source operatively aligned with the target chamber, and a regenerative turbine pump for circulating a target fluid through the target chamber via first ...
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WO/2003/092814A1 |
The present invention relates to an apparatus and method for loading radioactive brachytherapy seeds into a seed cartridge for use with an applicator. Embodiments of the apparatus according to the present invention may include a number o...
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WO/2003/090865A1 |
Methods and apparatus are provided for loading therapeutic materials into brachytherapy needles (16). The apparatus (30) comprises an apparatus with chambers (46 and 48), and radioactive seed and spacer cartridges (34 and 36) received th...
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WO/2003/088269A2 |
A device for producing a fluid containing a radioactive constituent, comprising a shielded chamber (5) with an opening for receiving an isotope container (6) housing a radioactive isotope (7); a chamber closure (18) adapted for cooperati...
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WO2002036199A9 |
A radioactive member for use in brachytherapy comprising a molded elongate, bioabsorbable carrier material with spaced radioactive sources disposed therein, and methods for the manufacture thereof. The radioactive members may be used in ...
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WO/2003/059397A2 |
A method and compositions are described for labeling a targeting agent with Ga-68, in which eluate from an acid-eluted Ge-68/Ga-68 generator is combined with a macrocycle-containing targetable agent. The labeling method and compositions ...
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WO/2003/055379A2 |
Nonlinear optical−active species which are analogues of fluorescent labels, markers, tags, contrast agents and targeting constructs used for imaging or detection by a surface−selective nonlinear optical technique are disclosed. A sur...
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WO/2003/053509A2 |
The present invention relates to a method for implantation of Xe isotopes in a matrix for production of ?125¿I sources that do not shed radioactive atoms. ?125¿Xe implanted at 12kV in steel, titanium and gold does not evol ve after mor...
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WO/2003/039463A2 |
A delivery system and method for interstitial brachytherapy using hollow seeds (21) on a wire (24).
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WO/2003/039654A2 |
A delivery system and method for interstitial radiation therapy uses a seed strand composed of a plurality of radioactive seeds (12) having projections (13) or indentations connected by a polymer. The seed strand is axially stiff and rad...
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WO/2003/039643A2 |
A delivery system and method for brachytherapy having an elongate member made of two half-shells (201A and 201B) having seeds (206) and spacers (209).
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WO/2003/039655A2 |
A delivery system and method for interstitial radiation therapy having a substantially axially stiff and longitudinally flexible elongated member (12) carrying radioactive seeds (14).
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WO/2003/028808A2 |
A needle assembly (10) including a cannula (12) having a sharpened distal end (20a), a line of elements (28) n the cannula (12) extending reward from the distal end (20a). A yieldable positioner (32) positions the elements (28) more prox...
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WO/2003/026480A2 |
Method and apparatus (20) employing ionizing radiation for forming lines of ablation or lesions in cardiac tissue to treat atrial fibrillation or other electrophysiological problems with the heart. The apparatus (20) may include a cathet...
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WO/2003/022350A1 |
A pellet implant system and method of implanting a plurality of implants that include at least one pharmaceutical pellet implant and at least one non-pharmaceutical device implant in an animal or human in a single combined procedure. The...
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WO/2003/020369A2 |
The invention relates to a radioactive implant consisting of a stainless steel substrate (composition in the text) and a radioactive isotope. The aim of the invention is provide one such implant, to which the isotope is applied by coatin...
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WO/2003/015870A2 |
A radiolabeled implantable device includes a base, a first layer including Cu and a radioactive isotope on the base, and a second layer including Sn on the first layer. Preferably, the base is formed of stainless steel and the radioactiv...
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WO2001072202A9 |
Methods and apparatus are provided for brachytherapy treatment of prostate disease for use in conjunction with needles containing a plurality of radioactive seeds (60). The apparatus comprises a housing (102) and plunger (104) assembly o...
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WO/2003/011161A1 |
Tissue marking apparatus for marking a tissue mass of interest within the body of a patient are disclosed. The tissue marking apparatus include a handle, a tube operatively coupled to a distal end of the handle, a push rod disposed withi...
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WO2002041762A9 |
An automated implantation system assists the implantation of low dose radioisotope seeds in a patient as part of a brachytherapy procedure. A Z-axis automated motion control system and an X-Y axis automated motion control system control ...
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