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Patent Searching and Data


Matches 501 - 550 out of 2,245

Document Document Title
WO/2004/010950A2
This invention relates to aryl substituted hydantoins of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein n, A, A', R, R1 and R2, are defined in the specification. The invention is also directed to t...  
WO/2004/009064A1
The invention relates to the use of neurotoxic substances which have a toxic effect, particularly for the axons and nociceptive nerve endings and to the production of a means for the treatment of joint pain.  
WO/2004/000296A1
Pharmaceutical compositions comprising (2S)-2-amino-4-&lcub [2-(ethanimidoylamino) ethyl]thio&rcub butanoic acid: (Formula I); a pharmaceutically acceptable bulking agent and one or more antioxidants or chelating agents are described.  
WO/2004/000369A2
There is described a method of magnetically manipulating a cell in vivo which comprises the association of a magnetisable particle with a cell. More particularly, there is described a method of magnetically manipulating a cell which comp...  
WO/2003/105779A2
Novel guanidine compounds having the formula (I) in which Rl, R2 and R4 are as defined, are effective as sodium channel blockers in neuronal mammalian cells and as anesthetics and/or analgesics, particularly local spinal and/or epidural ...  
WO/2003/105872A1
Xenon or xenon-containing gases and optionally an NO source find application as anti-spasmodics. The anti-spasmodic is preferably a medicament for the treatment of vasospasms, in particular for the treatment of cerebral vasospasms or cor...  
WO/2003/092652A1
This invention relates to substantially anhydrous warming, non-toxic and nonirritating lubricating compositions containing polyhydric alcohols and an insulating agent as well as gel and jelly compositions related thereto. The invention a...  
WO/2003/092651A1
This invention relates to substantially anhydrous warming, non-toxic and nonirritating lubricating compositions containing polyhydric alcohols and an insulating agent. The invention also relates to methods of using such compositions for ...  
WO/2003/086413A1
The present invention is directed to pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering the prodrug. In one aspect, a method of inducing and/or maintaining a generalized anesthetic stat...  
WO2003007802A9
Disclosed in certain embodiments is a pharmaceutical composition comprising from 10 to 40 mg of oxycodone or a pharmaceutically acceptable salt thereof and 0.65 to 0.90 mg naloxone or a pharmaceutically acceptable salt thereof.  
WO/2003/080557A1
The invention relates to substituted 4-aminocyclohexanols, to methods for producing them, to drugs containing said compounds and to the use of substituted 4-aminocyclohexanols in the production of drugs for the treatment of various indic...  
WO/2003/076414A2
This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aryl-substituted pyrimidine compounds of Formula (I): or a pharmaceutically acceptable salt, or solvate thereof, where...  
WO2003051333B1
The invention can be summarized as follows. The present invention provides a reverse-micellar delivery system for enhanced absorption of an agent of interest across biological membranes such as the gastro-intestinal tract of mammals. The...  
WO/2003/072544A1
A process for preparing an anhydrous benzoate salt in crystallineform having formula (I) and the corresponding benzoate monohydrate in crystalline form. The benzoate salts and pharmaceutical compositions thereof are selective kappa-recep...  
WO/2003/070177A2
Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.  
WO/2003/068200A2
The invention relates to a mixture of products A, B, C, D, comprising a local anaesthetic, butamben, mixed with a eugenate compound from eugenol and zinc oxide powder and a product D, being the red food colourant lycopene from tomato ole...  
WO/2003/068197A1
A method for systemically delivering a pharmaceutical composition to a human or animal, said method comprising forming an orifice in a nail of a human or animal by means of a laser-based device and applying a pharmaceutical composition i...  
WO/2003/066595A2
A compound of formula (I) (wherein X is O or S and R1-R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (each being a 'Piperazine Compound'), pharmaceutical compositions comprising a Piperazine Compound and methods f...  
WO/2003/066599A1
The invention relates to 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols of general formula (1) wherein the radicals R1, R2, R3, R4, R5, R6, R7, R8 and R9 can have the designations cited in the description and in the claims. The in...  
WO/2003/063898A2
A method of treating pain in provided. The method comprises administering to the intrinsic spinal muscles of a mammal an amount of a toxin sufficient to paralyze the muscles. This prevents the muscles from shortening and can allow healin...  
WO/2003/063824A2
This invention relates to a pharmaceutical compositio n containing an inclusion complex of propofol and a water soluble cyclodextrin, in freeze dried form. The invention also relates to a process for producing the composition and the com...  
WO/2003/063779A2
The invention provides a method for producing a selective analgesic effect outside the brain (e.g. via opioid receptors in the spinal cord) of a mammal, comprising administering to the mammal, an effective analgesic dose of a compound th...  
WO/2003/061634A1
A sustained release composition including at least one growth and/or reproduction-associated pharmaceutical component; analogue thereof or derivative thereof; and a non-silicone pharmaceutical carrier therefor, in a unit dosage form.  
WO/2003/059255A2
A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing wate...  
WO/2003/057153A2
The present invention is directed to aqueous based formulations of water−soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water−soluble prodrug of propofol and an effective amount o...  
WO/2003/055465A1
The invention relates to a preparation having a local anaesthetic action, for dermal application. Said preparation contains a local anaesthetic and is in the form of a microemulsion. The invention also relates to a method for producing a...  
WO/2003/051819A1
The invention relates to substituted 1,5-diaminopentan-3-ol compounds, methods for production and use thereof for the production of medicaments and medicaments comprising the same.  
WO/2003/051855A1
The invention relates to N,N'-disubstituted piperazine compounds, to methods for the production thereof, to pharmaceuticals containing said compounds, and to the use of said compounds for producing pharmaceuticals.  
WO2003030920A9
The present invention provides an antispasmodic agent spaced drug delivery system comprising an immediate release composition and timed pulse release composition releasing predetermined amounts of oxybutynin as a pulse initially and at p...  
WO/2003/051888A1
The invention relates to the compounds of formula (I) which are useful as highly active analgesics.  
WO/2003/049768A1
The present invention relates to the use of GABA¿A? receptor $g(b)3 selective anesthetic agents for the manufacture of medicaments for providing anesthesia; to transgenic animals of use in the testing of such agents; and to methods for ...  
WO/2003/041648A2
A composition comprising lidocaine-containing liposomes wherein the weight concentration of lidocaine in said composition is greater than 10 %. The composition is prepared by mixing water with an oil phase comprising lidocaine, a C¿14?-...  
WO/2003/037873A1
The invention relates to substituted benzo[b]azepin-2-one compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments.  
WO/2003/037863A2
The invention relates to substituted indoles, method for production thereof, medicaments containing said compounds and use of said compounds for the production of medicaments.  
WO/2003/037879A1
The invention relates to substituted (1H)-quinoxalin-2-one compounds, methods for production thereof, medicaments containing said compounds and the use of said compounds for the production of medicaments. The invention further relates to...  
WO/2003/034900A2
An intradermal patch having a permeable backing coated with a polyvinylpyrrolidone-based hydrogel and containing one or more local anesthetics. The patch is breathable, non-irritating upon application and removal, soothing, and sterile. ...  
WO/2003/034988A2
The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipoph...  
WO/2003/035684A1
The invention relates to (i) DNA sequences, (ii) expression vectors, comprising said DNA sequences, (iv) host cells, comprising said expression vectors, (v) genetic products, coded by said sequences, (vi) transgenic animals, altered with...  
WO/2003/032985A2
This invention relates to novel compositions, methods of use, regimens and kits for treating local fungal and bacterial infections that are susceptible to treatment administered either locally or topically and systemically. The methods o...  
WO/2003/033048A2
Inhalant anesthetics are developed with a number of properties including rapid onset and recovery, controllability, and, ideally, a broad safety profile. The efficacy of these agents is measured by their ability to create anesthesia with...  
WO/2003/030941A1
Compositions and methods for in vivo delivery of pharmacologically active agents associated with polymeric biocompatible materials. Compositions comprising a first, negatively charged pharmacologically active agent such as an oligonucleo...  
WO/2003/030862A2
An inhalation anaesthetic formulation comprising a suspension of the anaesthetic agent in aqueous solution.  
WO/2003/026479A2
Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific ...  
WO/2003/026632A2
The invention provides substituted phenol compounds and pharmaceutical compositions containing substituted phenol compounds which are useful for inducing or maintaining anesthesia or sedation in a mammal. This invention also provides met...  
WO/2003/022285A1
This invention relates to aryl substituted pyridines of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: Ar is selected from the group consisting of Ar¿1?, Ar¿2?, Ar¿3? and Ar¿4?, wherein Ar¿1?...  
WO/2003/022276A1
This invention relates aryl substituted pyridines of Formula (I),or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R¿1?-R¿4? are set in the specification. The invention is also directed to the use of com...  
WO/2003/020037A1
A topical delivery composition which employs a multivesicular emulsion in combination with a pharmaceutically/pharmacologically active agent is disclosed. The multivesicular emulsion is formed from a quaternary amine salt emulsifier such...  
WO/2003/017977A1
Propofol solubilised in aqueous micellar preparations of poloxamers and containing local anaesthetic is associated with reduced levels of pain on injection.  
WO2002074200B1
An injectable formulation of a sedative hypnotic drug, such as the anesthetic drug propofol, that is pharmaceutically stable and demonstrates a reduced incidence of pain upon injection. The formulation of the present invention employs a ...  
WO/2003/015699A2
Topical compositions and methods for treating pain. The invention provides oil-in-water emulsions comprising an antidepressant; an NMDA-receptor antagonists; a lipophilic component; water; and a surfactant. The compositions induce a loca...  

Matches 501 - 550 out of 2,245