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Matches 1 - 50 out of 2,830

Document Document Title
WO/2021/078073A1
Provided are an N-containing derivative of substituted phenol hydroxy acid ester, and the preparation and use thereof. A compound is represented by formula (I). A salt of the compound of formula (I) has good water solubility, and, in viv...  
WO/2021/068943A1
Disclosed in the present invention are a substituted nitrogen heterocyclic compound and anesthetic action thereof. Specifically provided are a chemical compound as shown in formula I, a stereoisomer thereof, a pharmaceutically acceptable...  
WO/2021/067746A1
Provided are liquid ophthalmic compositions containing tetracaine or a pharmaceutically acceptable salt thereof that do not contain a preservative. Also provided are methods of producing surface anesthesia of the eye.  
WO/2021/064186A1
The present invention concerns novel pyridin-2(1H)one derivatives, their process of preparation and their use in therapeutics, in particular as agents for treating and/or preventing pain.  
WO/2021/053047A1
The invention provides a device comprising: at least one biocompatible polymer; and an eutectic composition comprising a first agent and an agent capable of forming a eutectic composition with the first agent; or one or more fatty acids;...  
WO/2020/249695A4
The present invention relates to a hydrogel for in-vivo release of medication comprising at least one medication, wherein the hydrogel comprises (i) a protein-based biopolymer functionalized with a functionalisation agent that is able to...  
WO/2021/037199A1
A transdermal amide local anesthetic-containing pharmaceutical composition and a preparation method therefor. Specifically related is a transdermal pharmaceutical composition, comprising a skin adhesion layer, where the skin adhesion lay...  
WO/2021/025020A1
Provided is a pharmaceutical agent that increases the efficiency of drug absorption through a mucosal epithelial layer. This pharmaceutical agent for transmucosal administration contains, as an active ingredient, a pharmaceutical agent...  
WO/2020/250144A3
The present invention relates to non-aqueous matrix adhesive patch composition. The present invention also relates to a composition of low amount Lidocaine as topical anesthetic and pharmaceutically acceptable excipients for relieving mu...  
WO/2021/011588A1
Systems and methods for tracking sympathetic-driven arousal state (SDAS) including nociception under anesthesia is described herein. The method includes obtaining heart rate variability and electrodermal activity of a subject. Point proc...  
WO/2020/259440A1
Disclosed is a nasal spray of dexmedetomidine. The basic prescription comprises an osmotic pressure regulator, a preservative, a pH regulator, a carrier, and a pharmaceutically effective amount of dexmedetomidine. The nasal spray of dexm...  
WO/2020/259602A1
Disclosed are a benzodiazepine compound, a preparation method therefor, and the use thereof in medicine, with same belonging to the chemical and pharmaceutical field. The benzodiazepine compound is a compound represented by formula I, or...  
WO/2020/210889A9
The present invention relates to the technical field of dyes for marking organic tissue. It relates to a dye whose composition contains pigments, topical anaesthetics and absorption potentiator, used to visually mark a specific area of t...  
WO/2020/262057A1
Provided is a water-based adhesive patch which has basic physical properties required of a water-based adhesive patch that are less apt to deteriorate and in which crystals of l-menthol are less apt to separate out. This water-based adhe...  
WO/2020/248010A1
This invention relates to topical drug delivery formulations, formulated to carry at least one drug, be applied to an open wound, and enable systemic absorption of the at least one drug via the open wound to provide a systemic therapeuti...  
WO/2020/249695A1
The present invention relates to a hydrogel for in-vivo release of medication comprising at least one medication, wherein the hydrogel comprises (i) a protein-based biopolymer functionalized with a functionalisation agent that is able to...  
WO/2020/237749A1
Provided is a compound having a long-acting therapeutic effect. The compound can be used to prepare an antidepressant drug and drugs for anesthesia, analgesia, improvement of cognitive function, lung protection, amyotrophic lateral scler...  
WO/2020/237747A1
Uses of a compound having long-acting therapeutic effects in preparing a medicament. The compound is applicable in preparing a medicament for combating depression, anesthesia, pain relief, improving cognitive function, pulmonary protecti...  
WO/2020/237284A1
A method of treating a subject having a disease caused by a pathogen, preferably an acid-labile pathogen, said method comprising the step of applying to the subject a therapeutically effect amount of a topical composition having biocidal...  
WO/2020/237295A1
A pain relieving aerosol spray (pain relieving and pain preventing aerosol spray) comprising a pain relieving composition and at least one refrigerant, wherein the pain relieving aerosol spray is capable of providing rapid onset local an...  
WO/2020/232539A1
A bioresorbable, sustained release pharmaceutical composition comprising: 1.8 wt% to 3.0 wt% methylcellulose and 0.1 wt% to 3.0 wt% hyaluronan in the form of a gel polymer matrix, and at least one local anesthetic agent, suitably ropivac...  
WO/2020/219823A8
Provided herein are sustained-release biodegradable ocular hydrogel inserts which are useful in the treatment of certain ocular conditions.  
WO/2020/227796A1
The present invention relates to formulations including nanostructured lipid carriers. Specifically, the formulation claimed herein comprises natural nanostructured lipid carriers (NLC) with a strictly natural composition that enables th...  
WO/2019/221853A8
The present technology relates to depot assemblies for the controlled, sustained release of a therapeutic agent. The assembly can include a depot having a therapeutic region comprising a therapeutic agent, and a control region comprising...  
WO/2020/221322A1
A ketamine transdermal patch and a preparation method therefor, comprising the following preparation steps: carrying out de-crystallization on ketamine to obtain de-crystallized powder; dispersing the de-crystallized powder into choleste...  
WO/2020/218249A1
This patch is bioequivalent to existing formulations even with higher concentrations of lidocaine, is highly safe, and contains lidocaine or a salt thereof, lactic acid, and hydroxy acid with 4-6 carbons; the skin penetration rate of the...  
WO/2020/219823A1
Provided herein are sustained-release biodegradable ocular hydrogel inserts which are useful in the treatment of certain ocular conditions.  
WO/2020/211762A1
A lipid pharmaceutical preparation and application thereof. The lipid pharmaceutical preparation comprises local anesthetics and lipid substances. The mass percentage of the local anesthetic in the lipid pharmaceutical preparation is 2%-...  
WO/2020/210889A1
The present invention relates to the technical field of dyes for marking organic tissue. It relates to a dye whose composition contains pigments, topical anaesthetics and absorption potentiator, used to visually mark a specific area of t...  
WO/2020/211787A1
A pharmaceutical preparation, a system comprising same, a preparation method therefor and an application thereof. The pharmaceutical preparation comprises water and a local anesthetic; the local anesthetic in the pharmaceutical preparati...  
WO/2020/193693A1
The present invention relates to a benzodiazepine or pharmaceutically acceptable salt thereof for use in inducing and/or maintaining a MOAA/S score of ≤ 1 in a human patient selected from an infant, a child and a patient with a cogniti...  
WO/2020/197576A1
There is disclosed a method for treating pain, comprising administering an analgesic oral dosage form comprising desmetramadol substantially free of tramadol.  
WO/2020/191506A1
A composition comprising capsaicin or a capsacinoid is used in a method for postoperative pain control. The composition is administered to a site intended for surgery in a patient at least one day before surgery is actually performed.  
WO/2020/184208A1
The purpose of present invention is to provide a local anesthetic-containing patch that is practical as a pharmaceutical in terms of skin permeability, aggregation power, and adhesiveness. The patch according to the present invention is ...  
WO/2020/176568A1
Provided is a pharmaceutical composition for use in treating postsurgical pain. The pharmaceutical composition comprises a lipid-based complex. The lipid-based complex comprises an amide-type anesthetic and at least one lipid, wherein a ...  
WO/2020/170198A1
The invention relates to an infusion container comprising a sterile, ready-to-use, stable aqueous solution of Midazolam or a pharmaceutically acceptable salt thereof, suitable for direct intravenous infusion to a patient in need thereof....  
WO/2020/168213A1
Disclosed herein are methods and compositions for reversing the effects of a sedation agent or general anesthetic agents. The methods are useful for example for assessing a patient during a surgical procedure or a patient' s physiologic ...  
WO/2020/156359A1
Disclosed in the present invention are a quaternary ammonium salt compound and a preparation method therefor and a use thereof, relating to the field of medicinal chemistry. Disclosed in the present invention is the compound shown in for...  
WO/2020/159565A1
Methods of treating post-surgical pain are provided. The methods include administering to an individual a therapeutically effective amount of a compound of Formula I (Compound 1). The method can be used to treat post-surgical pain arisin...  
WO/2020/143198A1
Ketamine derivatives and pharmaceutical compositons thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used ...  
WO/2020/130084A1
The present invention provides: an external preparation composition including lidocaine lactate that is composed of lidocaine and a lactic acid component, and diclofenac or a salt thereof, wherein the lactic acid component is composed of...  
WO/2020/109254A1
The present invention relates to novel topical compositions and uses there of which are useful in tissue local anaesthesia, in particular in the context of the prevention and/or treatment of pain and/or a premature ejaculation.The invent...  
WO/2020/110118A1
Described herein are compositions comprising an effective amount of a local anesthetic agent for blocking neural transmission at the superficial inguinal ring or canal, for treatment of symphysiolysis. The compositions may be for adminis...  
WO/2020/093256A1
Disclosed are a clear propofol injection and a preparation method therefor, wherein the injection comprises the following components: propofol, cyclodextrin, stabilizer, pH regulator, and water for injection, and the pH value of the inje...  
WO/2020/095496A1
[Problem] To provide a method for reducing the pain associated with childbirth without using epidural anesthesia. [Solution] In this method for reducing pain, a medical instrument 100 includes an inner cavity 14 and an injection needle 2...  
WO/2020/092698A1
An injectable formulation for a sustained-release of a local anesthetic is provided. The formulation comprises a pharmaceutically effective amount of a local anesthetic encapsulated into polymeric particles having a diameter from about 1...  
WO/2020/076017A1
A multifunctional microstructure patch is provided. The multifunctional microstructure patch, according to one embodiment of the present invention, comprises: a base layer having an opening part formed in the center thereof; a plurality ...  
WO/2020/051543A1
Disclosed herein are compositions and methods for treating post-surgical pain in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a NK-1 receptor antagonist and a pain medication.  
WO/2020/047277A1
A sustained release pharmaceutical formulation for pain management comprises an active ingredient, and a water-miscible and hygroscopic network-forming material, the active ingredient being dispersed within the water-miscible and hygrosc...  
WO/2020/046973A1
The present technology relates to depot assemblies for the controlled, sustained release of a therapeutic agent. The assembly can include a depot having a therapeutic region comprising an analgesic, and a control region comprising a bior...  

Matches 1 - 50 out of 2,830