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Matches 1 - 50 out of 50,771

Document Document Title
WO/2021/092564A1
Provided herein are methods for generating cultivated autologous limbal epithelial cell grafts for the treatment of various disorders caused by limbal stem cell deficiency. This invention relates to methods and compositions for treating ...  
WO/2021/092499A1
Active agents that bind to VEGF or a VEGF receptor and reduce the severity of a condition associated with BLB disruption and/or angiogenesis, for example anti-VEGF antibodies or tyrosine kinase inhibitor small molecules, can be locally, ...  
WO/2021/092470A1
The present disclosure relates to therapeutic compositions and therapies for use in the treatment of diseases and disorders of the eye. The present disclosure relates to curved, multilayer controlled-release ocular implant devices which ...  
WO/2021/048779A3
The present invention provides a method of treating ocular disorders by administering a suitable amount of VEGF inhibitors in a patient in need thereof, wherein the suitable amount of VEGF inhibitor is determined with respect to the body...  
WO/2021/091718A1
This invention relates to methods and compositions useful for treatment of subjects with dry age-related macular degeneration or geographic atrophy secondary to dry age-related macular degeneration. The methods involve administration of ...  
WO/2021/090911A1
Provided are: a method for selectively killing protein aggregate-containing cells; a kit therefor; a therapeutic drug for protein misfolding diseases; and a drug product for removing protein aggregates from a blood product. The method fo...  
WO/2021/084021A1
The invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of an COCH associated condition.  
WO/2021/084522A1
The invention relates to topical ophthalmic preparations in eye drops containing bimatoprost as an active ingredient at the concentration of 0.1 mg/ml, wherein the presence of benzalkonium chloride is limited to the indispensable minimum...  
WO/2021/087360A1
Embodiments of the present invention generally relate to novel immunostimulatory compositions of use to stimulate non-specific immune responses in a subject. In certain embodiments, immunogenic compositions disclosed herein can be direct...  
WO/2021/086077A1
The present invention relates to an isoquinolinone derivative, a preparation method therefor, and a pharmaceutical composition, comprising same as an active ingredient, for prevention or treatment of a poly(ADP-ribose)polymerase-1 (PARP-...  
WO/2021/087408A1
Provided herein are methods for preventing and/or reducing the severity of drug induced ototoxicity. Provided herein are methods for recovery from hearing loss due to drug-induced ototoxicity.  
WO/2021/081826A1
Disclosed are applications of a PTBP1 inhibitor in preventing and/or treating retinal diseases. Specifically, provided are uses of an inhibitor of PTBP1 gene or an encoded protein thereof, for use in preparing a composition or preparatio...  
WO/2021/084013A1
New treatment regimen for the treatment of neurological diseases or conditions It relates to a compound of formula (I), or a pharmaceutically or veterinary acceptable salt thereof, or any stereoisomer or mixtures of stereoisomers, either...  
WO/2021/081348A1
The present disclosure provides methods for treating, preventing, or inhibiting diseases in patients having one or more CFI mutations.  
WO/2020/097369A8
Provided herein are compositions that include one or more adeno-associated virus (AAVs) vectors and methods of inducing differentiation of a hair cell using these vector(s).  
WO/2021/080206A1
The present invention provides a composition containing a sweet potato stem and/or leaf extract for prevention, alleviation, or treatment of an ear disease. The composition according to the present invention can suppress hearing loss by ...  
WO/2021/081206A1
Neurotrophin receptor binding conjugate compositions for delivering an active agent to nerve cells are provided. Conjugate compositions of the present disclosure according to certain embodiments include a one or more active agent compoun...  
WO/2021/079536A1
This composition for lysis of Staphylococcus aureus or this composition for prevention or therapy of diseases caused by Staphylococcus aureus contains as active ingredients: at least one bacteriophage selected from the group consisting o...  
WO/2021/079962A1
A problem addressed by the present invention is to provide a pharmaceutical composition for the prevention and/or treatment of hearing loss. The present invention relates to a pharmaceutical composition for the prevention and/or treatm...  
WO/2021/079986A1
A composition for lysing Staphylococcus aureus or a composition for preventing or treating a disease caused by Staphylococcus aureus, said composition comprising, as active ingredients, at least one bacteriophage selected from the group ...  
WO/2021/079435A1
This composition is for lysing Staphylococcus aureus or treating or preventing diseases caused by Staphylococcus aureus, and contains, as active ingredients, at least one bacteriophage selected from the group consisting of the bacterioph...  
WO/2020/097372A8
Provided herein are compositions that include at least two different nucleic acid vectors that, when introduced into a primate cell, the at least two different vectors undergo concatamerization or homologous recombination with each other...  
WO/2021/079984A1
The present invention provides a novel compound having an excellent β-lactamase inhibitory effect. The present invention provides: a compound which has an excellent β-lactamase inhibitory effect, and is represented by formula (1a), (1b...  
WO/2021/050744A3
A method of inhibiting neutrophil activation in retinal pigment epithelial (RPE) cells comprising administering an inhibitor of interferon (IFN) λ to a subject in need thereof, as well as a method of restoring lysosomal function of RPE ...  
WO/2021/074782A1
An ophthalmic solution based on hyaluronic acid and arabinogalactan in synergistic amounts is used, alone or in combination with panthenol, vitamin E-D-α—polyethylene-glycol (TGPS) and trehalose, in the treatment of dry-eye syndrome, ...  
WO/2021/074606A1
The present disclosure provides compositions comprising an opsin polypeptide and an arrestin polypeptide and their use thereof. Exemplary embodiments provide a composition including an opsin polypeptide, or an opsin polypeptide and an ar...  
WO/2021/075536A1
The present disclosure provides a therapy for diabetes that targets abnormal stem cells in combination with stem cell migration. In one embodiment, the present disclosure provides a therapy for diabetes and/or diabetes-related diseases a...  
WO/2020/063696A8
Provided are a preparation of a semicarbazide-sensitive amine oxidase inhibitor and the use thereof. In particular, dislosed are a compound as shown in formula I, or a stereoisomer or racemate or pharmaceutically acceptable salt thereof....  
WO/2021/071864A1
Provided herein are pharmaceutical compositions comprising a bacterial consortium and one or more pharmaceutically acceptable excipients. Such pharmaceutical compositions can be orally administered to a subject for prevention and/or trea...  
WO/2021/069523A1
The present invention relates to therapeutic use of calreticulin in treatment of angiogenic eye diseases. Different treatment methods and pharmaceutical compositions comprising calreticulin are disclosed.  
WO/2021/071835A1
Provided herein are pharmaceutical compositions comprising a recombinant adeno-associated virus (AAV), salt excipient or buffer agent, sugar and surfactant. Also provided herein are methods for treating or preventing a disease in a subje...  
WO/2021/069750A1
A system for and method of monitoring/measuring the level of receptoral action/blockade and intra-ocular penetration/concentration of an eye medication and determining an optimal treatment regime based on the level of receptoral action/b...  
WO/2021/068203A1
Use of chloroquine or a derivative thereof hydroxychloroquine in the preparation of a medicament for the treatment of Graves' oculopathy. Chloroquine or the derivative thereof hydroxychloroquine has a significant inhibitory effect on the...  
WO/2021/069553A1
The current invention concerns liver progenitor or stem cells, lysates thereof, and/or conditioned medium obtainable by culturing liver progenitor or stem cells in said medium for use in the treatment of diseases and/or conditions caused...  
WO/2021/071413A1
A yeast cell for use in the treatment and/or alleviation of allergy and/or symptoms caused by allergy, wherein the yeast cell has been treated with electromagnetic waves in the range of 1 GHz to 300 GHz, or said yeast cell has been grown...  
WO/2021/070181A1
The present invention provides humanized antibodies and antigen binding fragments thereof that bind to human poliovirus (PVR). The antibodies are useful in the treatment of tumors or cancers.  
WO/2021/072265A1
Provided herein are methods of treating eye disorders by administering an anti-VEGF antibody and/or conjugate to a subject having an eye disorder. The anti-VEGF antibody of the present disclosure may be an anti-VEGF antibody conjugate th...  
WO/2020/023251A8
This invention relates to exosome compositions and methods of using them.  
WO/2021/065050A1
The purpose of the present invention is to provide a formulation technique pertaining to an aqueous liquid formulation that contains brimonidine and/or a salt thereof. This aqueous liquid formulation contains brimonidine and/or a salt ...  
WO/2021/066144A1
This disclosure provides a means for treating dry eye. This disclosure can provide: a composition for treating dry eye; and a use thereof. The composition includes (E) -2-(7-trifluoromethyl-chroman-4-yllidene)-N-(7-hydroxy-5,6,7 ,8-tet...  
WO/2021/066672A1
The inventions relate to the pharmaceutical and medical industry and are applicable in medicine, and more particularly relate to the use of a biologically active extract of the plant Alhagi pseudalhagi for new purposes and to a pharmaceu...  
WO/2021/062007A1
The present disclosure provides a method of treating mitochondrial and age-related diseases and disorders with exercised blood products. The blood products include circulating factors whose production or secretion into the blood is stimu...  
WO/2021/058636A1
The present invention relates to antibodies and fragments thereof that target the A-domain of Neuropilin-1 (Nrp1A). More specifically, anti-Nrp1A antibodies and methods of use for the treatment of various diseases or disorders are disclo...  
WO/2021/059267A1
Pharmaceutical compositions comprising specific tetrapeptides, for use in treating, preventing, minimizing, diminishing or reversing degenerative, age-related and trauma- induced disorders, particularly of the eye, are provided.  
WO/2021/061980A1
Compositions, methods, and kits are provided for diagnosing and treating uveitis. In particular, biomarkers have been identified that can be used to distinguish infectious uveitis from noninfectious uveitis, and further discriminate amon...  
WO/2021/061000A1
The subject-matter of the invention is a composition of a dietary supplement and/or a nutritional additive for food, a unitary dosage form of said composition, and their use for the improvement of the quality of visual performance includ...  
WO/2021/034418A3
Cell penetrating peptides that target many cells types including cells of the retina and cornea with high efficiency are provided herein. These peptides can be used to deliver cargo molecules across a plasma membrane, without the need fo...  
WO/2021/061823A1
The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as Janus kinase (JAK) inhibi...  
WO/2021/060460A1
Provided are a novel repair agent for biological tissue damage, having a markedly higher repairing effect on biological tissue damage than a conventional repairing agent for biological tissue damage, and a method for manufacturing said r...  
WO/2021/055013A1
This invention relates to methods and compositions for detecting, identifying and treating glaucoma diseases. In addition, this invention discloses compositions and methods for affecting intraocular pressure and increasing ocular outflow...  

Matches 1 - 50 out of 50,771