Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 100,866

Document Document Title
WO/2021/088219A1
Provided is an application of a TRPC1 peptide molecule in preparation of a drug for treating inflammation caused by viral infection, relating to the technical field of biomedicine. Studies show that a third extracellular domain polypepti...  
WO/2021/089790A1
The present invention relates to compounds having a lipid affinity of less than 15% by weight of the compound (such as a logP of -0.75 or less) for use in targeting mitochondria to reduce, inhibit or prevent the formation of mitochondria...  
WO/2021/088957A1
Disclosed are a novel aromatic heterocyclic compound as an ATX (Autotaxin) inhibitor, a pharmaceutical composition containing the compound, and a use of the compound and the composition in treatment of a disease having a pathological cha...  
WO/2021/091238A1
The present invention relates to a small molecule TNF-α inhibitor and, more specifically, to: a compound for inhibiting the formation of a TNF-α homotrimer by specifically binding to the binding cavity of a TNF-α homodimer; a composit...  
WO/2021/092515A1
Disclosed herein include methods, compositions, and kits suitable for use in the spatial and temporal delivery of payload molecules to a target site of a subject. Disclosed herein include hydrogel compositions (e.g., particles) comprisin...  
WO/2021/091009A1
The present application discloses a method for screening an inflammatory bowel disease therapeutic agent on the basis of a mechanism in which RORα inhibits NF-κB transcriptional activity in the bowels, thereby inhibiting the expression...  
WO/2021/089782A1
The present invention relates to a compound of formula (I) for use in the treatment or prevention of an autoinflammatory disorder such as cryopyrin-associated periodic syndrome (CAPS), tumor necrosis factor receptor associated periodic s...  
WO/2021/089783A1
The present invention relates to a compound of formula (I) for use in the treatment or prevention of arthritis.  
WO/2021/067628A3
Described are conformation-specific antibodies or antigen-binding fragments that specifically bind to the trans conformation of phosphorylated-Threonine254-Proline (pThr254-Pro) of the p65 subunit of nuclear factor kappa-light-chain-enha...  
WO/2021/092336A1
Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The compounds may...  
WO/2021/089850A1
The invention relates to combination therapy involving two or more antibodies, wherein the Fc regions of the two antibodies have been modified such that hetero-oligomerization between the antibodies is strongly favored over self-oligomer...  
WO/2021/089306A1
This invention relates to a cosmetic composition, especially one which provides synergistic anti-dandruff efficacy. This is achieved through a judicious combination of anti-dandruff agent piroctone olamine and a vitamin B3 compound. Disc...  
WO/2021/084266A1
Provided are compounds of the Formula (I), and salts and solvates thereof: (Formula (I)) wherein R2, R3, X1, L, A, R6, R7 and Z are defined in the specification. The compounds are inhibitors of salt-inducible kinase (SIK), particular SIK...  
WO/2021/082889A1
Disclosed is an environmentally-friendly method of preparing a composition containing an anti-inflammatory ingredient, and an application thereof. The method comprises: S1, weighing a specific volume of water, adjusting the pH thereof, a...  
WO/2021/083191A1
The present invention provides a keratin BD-2, an encoding nucleic acid molecule thereof, an expression vector thereof, a host cell thereof, and a pharmaceutical composition comprising the keratin. The keratin BD-2 can be used for prepar...  
WO/2021/084166A1
The invention relates to a gold nanoparticle comprising as active ingredients the antioxidants anti-catalase, superoxide oxidase, glutathione, in combination with adenosine triphosphate, optionally combined with a polymer; a food, cosmet...  
WO/2021/084498A1
The present invention discloses compounds formula (I): (I) wherein X is CH; R2 is (AA) R3 is (BB) The present compounds of formula (I) are dihydroorotate dehydrogenase (DHODH) inhibitors, and are useful for the treatment of inflammatory ...  
WO/2021/084068A1
The present invention relates to the compound (3S,4S)-1-Cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)- isoxazole-3-carbonyl]-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide: (Formula) and its use as modulator of ...  
WO/2021/083201A1
Provided in the present invention are a keratin BD-10, an encoding nucleic acid molecule thereof, an expression vector, a host cell, a preparation method for the keratin BD-10, and a pharmaceutical composition comprising the keratin BD-1...  
WO/2021/083206A1
Provided are a keratin BD-17, a nucleic acid molecule encoding the keratin BD-17, an expression vector containing the nucleic acid molecule, a host cell which contains the expression vector or in which the genome integrates the nucleic a...  
WO/2021/083193A1
Provided are keratin BD-4, an encoding nucleic acid molecule thereof, an expression vector, a host cell, and a pharmaceutical composition containing the keratin. The keratin BD-4 can be used for preparing drugs having antipyretic and ana...  
WO/2021/083205A1
The present invention provides keratin BD-15, an encoding nucleic acid molecule thereof, an expression vector, a host cell, a preparation method for the keratin BD-15, and a pharmaceutical composition containing same. Further provided is...  
WO/2021/082882A1
Disclosed is a method for anchoring and modifying a nano-drug on the surface of a living cell. The method comprises: introducing an active reaction group to the surface of a living cell by means of a hydrophobic tail chain of a cell memb...  
WO/2021/083192A1
The present invention provides keratin BD-3, a nucleic acid molecule encoding same, an expression vector thereof, a host cell thereof, a preparation method therefor, and a pharmaceutical composition containing same. The keratin BD-3 can ...  
WO/2021/083200A1
Provided are a keratin BD-6, a nucleic acid molecule encoding the keratin BD-6, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrating the nucleic acid molecule, a pr...  
WO/2021/083203A1
Provided are a keratin BD-13, a coding nucleic acid molecule, expression vector, and host cell thereof and a preparation method therefor, and a pharmaceutical composition containing said keratin. Keratin BD-13 can be used to prepare anti...  
WO/2021/084139A1
Disclosed herein is a method for the preparation of an amorphous solid dispersion (ASD) comprising the steps of providing an aqueous suspension comprising nano-particles having a solubility in the aqueous suspension of less than 10g/l, w...  
WO/2021/084500A1
The present invention discloses compounds formula (I): (I) wherein X is CH; The present compounds of formula (I) are dihydroorotate dehydrogenase (DHODH) inhibitors, and are useful for the treatment of inflammatory disorders, autoimmune ...  
WO/2021/085295A1
The present invention addresses the problem of clarifying the immune response mechanism of IL-17-producing cells, said immune response mechanism inducing pathological conditions such as psoriasis, to thereby provide an immune response su...  
WO/2021/083198A1
Provided are keratin BD-5, an encoding nucleic acid molecule thereof, an expression vector, a host cell, and a pharmaceutical composition containing the keratin. The keratin BD-5 can be used for preparing drugs having antipyretic and ana...  
WO/2021/083202A1
Provided are keratin BD-11, an encoding nucleic acid molecule thereof, an expression vector, a host cell, a preparation method, and a pharmaceutical composition containing the keratin. The keratin BD-11 can be used for preparing drugs ha...  
WO/2021/081642A1
The present disclosure relates to methods of ameliorating an inflamed state in a cell or tissue by subjecting an inflamed cell or tissue to a biophotonic composition, illuminating the biophotonic composition for a time sufficient for the...  
WO/2021/083204A1
Provided are keratin BD-14, a nucleic acid molecule encoding keratin BD-14, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a genome integrated with the nucleic acid molecule, a ...  
WO/2021/085252A1
The present invention provides a medicine for an inflammatory pulmonary disease that is capable of effectively preventing and/or treating an inflammatory pulmonary disease. More specifically, the present invention pertains to a prophylac...  
WO/2021/083190A1
Provided is a keratin BD-1, a nucleic acid molecule encoding the keratin BD-1, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrating the nucleic acid molecule, and a...  
WO/2021/083209A1
Provided are a compound of formula (I') or (I), a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of SSAO, a pharmaceutical composition comprising a compound of...  
WO/2021/082502A1
Provided is a Lactobacillus casei producing short-chain fatty acids in a high yield, a culture method therefor and an application thereof. Lactobacillus casei LC89 capable of producing short-chain fatty acids in a high yield is preserved...  
WO/2021/048195A3
This invention relates to the delivery of a composition, preferably a pharmaceutical composition, comprising D-pinitol, D-Chiro inositol or myo-inositol or any pharmaceutically acceptable salt thereof, for use in the treatment or prevent...  
WO/2021/078022A1
Provided in the present invention is a small molecule compound, which is characterized in that it is a compound or a stereoisomer, geometric isomer, tautomer, racemate, hydrate, solvate, metabolite, and pharmaceutically acceptable salt o...  
WO/2021/081130A1
The present disclosure provides methods for treating and preventing foot pain, muscle soreness, inflammation or an inflammatory-related disorder, and itch with the administration of compositions comprising pine resin. Also provided are m...  
WO/2021/080257A1
The present invention relates to a composition for preventing or treating inflammatory bowel disease, comprising sulglycotide as an active ingredient. A group to which sulglycotide, an active ingredient of the present invention, was admi...  
WO/2021/077889A1
Disclosed are a paracetamol sustained-release preparation and a 3D printing preparation method therefor. Specifically, disclosed are a paracetamol sustained-release tablet and a method for preparing the paracetamol sustained-release tabl...  
WO/2021/080500A1
The invention relates a pharmaceutical composition comprising from 0.001 to 2 % (w/v) of propane-1,2- diol as the only anti-inflammatory agent and at least one bioadhesive polymer. The pharmaceutical composition can be used in ameliorati...  
WO/2021/078020A1
The present invention provides a small molecule compound, having a structure represented by the following molecular general formula (I), wherein X1 and X2 are selected from carbon or nitrogen; one or more carbons in A1, A2, A3, A4, and A...  
WO/2021/080037A1
The present invention relates to a pharmaceutical composition comprising mesenchymal stem cells derived from joint fluids of a subject suffering from rheumatoid arthritis for treatment or prevention of rheumatoid arthritis. Particularly,...  
WO/2021/078937A1
The present invention relates to a pharmaceutically compatible iron chelator or prodrug thereof for use in treating and/or preventing a disease caused or aggravated by STAT3 hyperactivity in effector cells in a subject; and to methods, k...  
WO/2021/078274A1
The present invention relates to a pyridazinone or pyridazine compound and a derivative and a pharmaceutical composition thereof. Specifically, the present invention provides a pyridazinone or pyridazine compound as shown in formula (I) ...  
WO/2021/078023A1
Provided is a small molecule compound, which is characterized in having the structure represented by the following molecular formula: (I), wherein X1 and X2 are selected from carbon or nitrogen; G1 is a carbocyclic ring or heterocyclic r...  
WO/2021/078553A1
The present invention relates to an aqueous composition for intranasal administration by spray comprising a mixture of (a) sufentanil, a salt and/or analogs thereof and (b) ketamine, a salt and analogs thereof in solution. The present in...  
WO/2021/078349A1
The present invention relates to compositions and dosage forms for the treatment of fibromyalgia, rheumatoid arthritis, systemic lupus erythematosus and autoimmune diseases associated with pain and inflammation of the muscles and joints,...  

Matches 1 - 50 out of 100,866