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Patent Searching and Data


Matches 1 - 50 out of 16,989

Document Document Title
WO/2021/087136A1
Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.  
WO/2021/081130A1
The present disclosure provides methods for treating and preventing foot pain, muscle soreness, inflammation or an inflammatory-related disorder, and itch with the administration of compositions comprising pine resin. Also provided are m...  
WO/2021/078120A1
Provided herein are a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical composi...  
WO/2021/081315A1
Cryptosporidium is a leading contributor to early childhood mortality, and fully effective treatment for this important infectious disease is lacking. A bicyclic azetidine compound series is disclosed having potent in vitro activity agai...  
WO/2021/073586A1
Disclosed are a decoquinate liposome, a preparation method therefor and a use thereof. The preparation raw materials for the decoquinate liposome comprise the following components in parts by weight: 1 part of decoquinate and 2-20 parts ...  
WO/2021/076922A1
This disclosure features niclosamide compounds (or pharmaceutically acceptable salts and/or co-crystals thereof, e.g., niclosamide), having one or more properties that include, but are not limited to: a particular purity (e.g., a chemica...  
WO/2021/037289A3
Disclosed are a recombinant fusion polypeptide, a preparation method therefor, and a use thereof. A recombinant fusion polypeptide, said recombinant fusion polypeptide being expressed as the following general formula: X-linker1-Y, Y-link...  
WO/2021/037291A3
Provided is a fusion polypeptide having multifunctional activities, the amino acid sequence of the fusion polypeptide being: Pro-Arg-Cys-X-Y-Gly-Glu-Gly-Gly-Gly-Gly-Ile-Val-Arg-Arg-Ala- Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp...  
WO/2021/074452A1
The present invention relates to pharmaceutical preparations containing as active ingredients 3-N-formylhydroxylaminopropylphosphonic acid derivatives or 3-N-acetylhydroxylaminopropylphosphonic acid derivatives in combination with clinda...  
WO/2021/069569A1
The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, Y, R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions com...  
WO/2021/068080A1
Described herein is an immunogenic fusion protein comprising: an immunogenic peptide or an immunogenic variant thereof, the immunogenic peptide comprising the following motifs: - KQPAa; QPAKa; PAKQa; or AKQPa; - NPDPb; PNPDb; DPNPb; or P...  
WO/2021/069567A1
The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, Y, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositio...  
WO/2020/051408A8
The present disclosure is directed to methods for preventing or treating helminth (e.g., filarial) diseases in animals. The methods are accomplished by administering to the animal a therapeutically effective amount of an inhibitor of UDP...  
WO/2021/065885A1
A compound represented by general formula (I) or a salt thereof. (In the formula, R1 to R5, X, Y, Q1 and Q2 are as defined in the description.)  
WO/2021/064217A1
The present document discloses methods and means for treating and/or preventing ectoparasite infestations and/or gill parasite infection in teleosts by the administration of probiotic bacteria to the teleosts.  
WO/2021/067261A1
Provided are conjugates comprising a knottin peptide comprising an engineered loop that binds to a cell surface molecule, and an immunostimulant conjugated to the knottin peptide via a linker. According to some embodiments, the immunosti...  
WO/2021/067967A1
The present invention relates to pyrazolo[3,4-b]pyridine compounds. The present invention further relates to methods for inhibiting Plasmodium comprising contacting Plasmodium with pyrazolo[3,4-b]pyridine compounds described herein. Also...  
WO/2021/067801A1
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or prodrug, and/or tautomer, and/or drug combination of the compound) that inhibit (e.g., antagoniz...  
WO/2021/067791A1
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes...  
WO/2021/060862A1
The present invention relates to a composition containing fucoidan as an active ingredient and, more specifically, to: a pharmaceutical composition for preventing or treating malaria, containing fucoidan as an active ingredient; and a di...  
WO/2021/047210A1
Provided is an immunization-purpose suspending agent, comprising the following raw materials in parts by weight: 15-40 parts of sodium alginate, 5-20 parts of guar gum, 2-10 parts of blow-dried powder, 1-10 parts of a surfactant, and 12-...  
WO/2021/049596A1
The present invention addresses the problems of: damage by pests still being extensive in crop production such as agriculture and horticulture; the need to develop and provide a novel agricultural and horticultural insecticide due to the...  
WO/2021/047565A1
A method for preparing and detecting an (R) or (S) configuration of 1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid, and a composition thereof, and for preparing (R)-praziquantel and a key intermediate thereof. An (R) or (S) acid is pr...  
WO/2021/049597A1
The present invention addresses the problem of developing and providing a novel insecticide agent for agricultural or horticultural use on the basis of factors in the production of agricultural and horticultural crops, such as the fact t...  
WO/2021/049595A1
Pests still cause major damage, and pests occur that resistant to existing pesticides, so the present invention addresses the problem in crop production, including agriculture and horticulture, of developing and providing a novel agricul...  
WO/2021/042194A1
Despite recent efforts to eradicate malaria worldwide, this parasitic disease is still considered to be a major public health issue, with a total of 219 million cases of malaria and 435,000 deaths in 2017. However, after a decade of use,...  
WO/2021/037289A2
Disclosed are a recombinant fusion polypeptide, a preparation method therefor, and a use thereof. A recombinant fusion polypeptide, said recombinant fusion polypeptide being expressed as the following general formula: X-linker1-Y, Y-link...  
WO/2021/038250A1
There is discussed nematode antigens capable of causing an immune response in a host such that a protective effect is provided to the host in relation to the nematode. Antigens, compositions for the treatment of parasitic nematode infect...  
WO/2021/037291A2
Disclosed is a use of a fusion polypeptide having multifunctional activities. The fusion polypeptide having multifunctional activities is characterized in that the polypeptide comprises the following domain: Pro-Arg-Cys-X-Y-Gly-Glu, wher...  
WO/2021/014415A3
The present invention relates to compounds of formula (I). The compounds may be used to modulate the acetyl coenzyme A synthetase short chain2(ACSS2) protein and may thereby treat, ameliorate or prevent a disease selected from cancer, ba...  
WO/2021/032687A1
A series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives, and analogues thereof, substituted in the 6-position by an arylcarbonylaminophenyl or heteroarylcarbonylaminophenyl moiety, being potent inhibitors of the growth and propa...  
WO/2021/032861A1
The invention relates to combinations of urolithins with therapeutic agents, particularly combinations of urolithins with immunotherapy treatments, such as immune checkpoint blockage therapies, such as PD-1 antagonists. The invention als...  
WO/2021/034963A1
T. gondii proteins MIC1 and MIC4 are components of excretory/secretory antigens (ESA) that elicit delayed type hypersensitivity (DTH) responses in infected animals. These antigens are capable of inducing IFN- g secretion by splenic T cel...  
WO/2021/033159A1
The present disclosure relates to pyrazino [1,2-b]quinazoline-3,6-diones compounds, in particular it relates to pyrazino [1,2-b]quinazoline-3,6-diones compounds having antibacterial activity and/or antimalarial activity.  
WO/2021/028479A1
The present invention relates to a composition comprising tigolaner and, optionally endoparasiticidal agents, a method for its manufacture and its use as a medicament for controlling parasites.  
WO/2021/028696A1
Described herein are pharmaceutical compositions and contact lens solutions comprising an Acanthamoeba encystation inhibitor such as a cationic quaternary ammonium compound and a physiologically or pharmaceutically acceptable carrier or ...  
WO/2021/027502A1
Methods of treating malaria comprising administration of compounds of Formula (I') or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. It also provides uses of the com...  
WO/2021/030162A1
The present invention relates to salt forms of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3'-(3-(((R)-3-hydroxypyrrolidin-1-yl)meth yl)-1,7-naphthyridin-8-ylamino)-2,2'-dimethylbiphenyl-3-yl)b enzo[d]oxazol-5-yl)methyl)pyrrolidine-3-car...  
WO/2021/026884A1
Methods for treating malaria comprises administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. It also provides uses of the comp...  
WO/2021/023886A1
Liquid dressing compositions liquid for veterinary use in the treatment or prevention of infection and/or wounds are described that comprise shellac, an anti-infective metal active and a solvent. The compositions are capable of forming a...  
WO/2021/025020A1
Provided is a pharmaceutical agent that increases the efficiency of drug absorption through a mucosal epithelial layer. This pharmaceutical agent for transmucosal administration contains, as an active ingredient, a pharmaceutical agent...  
WO/2021/023885A1
Liquid dressing compositions liquid for use in the treatment or prevention of infection and/or wounds are described that comprise shellac, an anti-infective metal active and a solvent. The compositions are capable of forming a barrier wh...  
WO/2021/017475A1
Disclosed is an ophthalmic pharmaceutical composition containing a cyclosporine, a preparation method and use thereof. The ophthalmic pharmaceutical composition expressed by weight percentages comprises 0.01%-0.5% of a cyclosporine, 0.2%...  
WO/2021/019506A1
The present invention relates to a composition comprising at least one amino acid, (ii) a controlled release lipid matrix, and optionally (ill) at least one acceptable pharmaceutical or food grade additive and/or excipient. Furthermore, ...  
WO/2021/019067A1
The invention relates to a veterinary composition comprising paromomycin or a pharmaceutically acceptable salt thereof for use in the prevention and/or treatment of cryptosporidiosis in a non-human mammal, wherein the composition is admi...  
WO/2021/019510A1
The present invention relates to a composition for use in a method for the treatment of an amino acid deficiency to a non-mammalian monogastric animal, such as a poultry animal, a fish or a crustacean, wherein said composition comprises ...  
WO/2021/018839A1
The present invention covers new isoquinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compou...  
WO/2021/014415A2
The present invention relates to compounds of formula (I). The compounds may be used to modulate the acetyl coenzyme A synthetase short chain 2 (ACSS2) protein and may thereby treat, ameliorate or prevent a disease selected from cancer, ...  
WO/2021/016509A1
An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NPDPNANPNVDPNAN (amino acids 5-19 of SEQ ID NO:1) linked to the ...  
WO/2021/013720A1
The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations a...  

Matches 1 - 50 out of 16,989