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WO/2001/009065A2 |
The invention relates to a novel method for the nitration of organic compounds, preferably of aromatics and heteroaromatics, using known and novel types of nitration reagents.
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WO/2001/009100A1 |
The invention relates to a novel method of reductively methylating primary and secondary amines, preferably aliphatic, allylic, benzylenic and aromatic amines with methylation reagents that are known in the art.
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WO/2000/069803A1 |
A process for the preparation of nitro compounds by reacting an organic substrate with nitrogen dioxide either in the presence of oxygen or under such conditions that the nitrogen dioxide/organic substrate ratio is less than 1 by mole. T...
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WO/2000/064841A2 |
The present invention discloses new efficient processes for various bond forming reactions, includidng Suzuki reactions and aryl animations. Organic compounds (e.g., ligands), their metal complexes and compositions using those compounds,...
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WO/2000/061608A2 |
The invention relates to peptidic substances, to the production of said substances and to their use as complement inhibitors. In particular, the invention relates to substances with a guanidine or amidine radical as the terminal group, e...
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WO/2000/061574A2 |
The invention relates to a method for producing amidines that are not substituted on the nitrogen atom and salts thereof with inorganic or organic acids. According to said method, the corresponding carboxylic acid amidoximes are reacted ...
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WO/2000/061577A1 |
The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competit...
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WO/2000/058261A1 |
A solid nitrating reagent comprises either a montmorillonite clay or a zeolite material incorporating an amount of gaseous dinitrogen pentoxide. The clay material can be type K10 and suitable zeolites include those designated ZSM-5, zeol...
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WO/2000/050377A1 |
A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of pr...
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WO/2000/050389A1 |
A method of preparing carbamates of the general formula RR'-N-CO¿2?-R'' by reacting an amine with carbon dioxide and an organic electrophile in an anhydrous solvent in the presence of a cesium base, whereby carbamate synthesis is accomp...
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WO/2000/043352A1 |
Mono-substituted and di-substituted alpha-amino acids and derivatives thereof, substituted at the alpha position with one (mono-)or two (di-) substituents (R?2¿ and/or R?3¿) as shown in Formula 1: N(R?4¿R?5¿)C(R?2¿R?3¿)CO(OR?1¿).
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WO/2000/018507A1 |
A method for maufacturing of an improved attrition resistant catalyst having an oxide-rich surface layer involving forming a slurry comprising; catalyst, catalyst precursor or catalyst support particles (e.g., transition metal oxides), a...
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WO/2000/018708A1 |
A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal neutral hydrocarbyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridiu...
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WO/2000/012210A1 |
The invention is directed to a nickel catalyst comprising 0.1 to 12.5 wt.% of at least one structural promoter, selected from the group of oxides of metals and metalloids and combinations thereof, and 87.5 to 99.9 wt.% of nickel, calcula...
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WO/1999/054298A1 |
The invention relates to a new method for producing N-methyl-N- [(1S)- 1-phenyl-2- ((3S)-3- hydroxypyrrolidine- 1-yl)ethyl]- 2,2-diphenyl acetamide or N-methyl- N-[(1R)- 1-phenyl-2- ((3R)-3- hydroxypyrrolidine- 1-yl)ethyl]- 2,2-diphenyl ...
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WO/1999/044991A1 |
A process for preparing a compound of formula (1) in which P?1¿ and P?2¿ are protecting groups; comprising a) reaction of a compound of formula (5) wherein P?1¿ is as defined for formula (1); with a Raney-nickel catalyst in a solvent ...
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WO/1999/032428A2 |
A solid phase method for producing a compound comprising an unsubstituted or substituted diamine moiety, which method comprises: (i) reacting an N-protected amino aldehyde with an amino group attached to a solid resin to produce a resin-...
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WO/1999/029665A1 |
The invention relates to a method for producing salts of cyclic amidines of general formula (I). Known methods for producing salts of compound (I) only produce low yields. According to the invention, the appropriate $g(v)-amino-$g(a)-ami...
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WO/1999/028290A1 |
The transition metal-catalysed amination of aryl halides, in conjunction with an orthogonal protective group scheme, forms the basis of two routes to oligoaniline precursors. The oligoaniline precursors are soluble in a variety of common...
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WO/1999/023061A1 |
According to the invention, a quantity of 0.5 to 20,000 ppm of one or more surface active substances from the group of anionic, cationic, zwitterionic or non-ionic is added to the reaction mixture during the conversion of aromatic compou...
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WO/1999/018064A1 |
The invention concerns a method for functionalizing a phenolic compound bearing an electron-donor group, in said group para position, inter alia a method for the amidoalkylation of a phenolic compound bearing an electron-donor group, and...
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WO/1999/011589A1 |
This invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing method...
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WO/1999/005093A1 |
The invention relates to compounds with general formula (I) in wchich A is a group having formula (a) or (b), and Z is an O or S atom. The invention also relates to their further processing to form new secondary amidoalkyl carbonic acid ...
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WO/1999/005087A1 |
A process for the preparation of a compound of general formula (I), wherein R?1¿ is hydrogen or C¿1?-C¿6? alkyl, C¿2?-C¿6? alkenyl or C¿2?-C¿6? alkynyl, any of which may optionally be substituted with one or more substituents sele...
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WO/1999/001418A1 |
The invention relates to a novel method for aminating mononuclear aromatic compounds and polynuclear compounds containing at least one aromatic ring. The inventive method enables simple separation of the aminated mononuclear aromatic com...
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WO/1998/054115A1 |
The invention relates to the use of a rhodium catalyst for inter- or intra-molecular hydroamination and/or inter- or intra-molecular oxidative amination of aryl-substituted olefins using primary or secondary amines, said rhodium catalyst...
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WO/1998/053910A1 |
The invention relates to a moulded, activated metallic fixed-bed catalyst having a pore volume of 0.05-1 ml/g and an outer, activated shell consisting of a sintered, small-particle catalyst alloy as well as optional catalyst promoters. T...
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WO/1998/047871A1 |
The invention encompasses a process for making compounds of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases.
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WO/1998/041504A1 |
The invention relates to a method for producing 5-aminomethyl-2-chloropyridines by reacting a mixture of 5-chloromethyl-2-chloropyridine and 5-dichloromethyl-2-chloropyridine with substituted amines. Said mixture of 5-chloromethyl-2-chlo...
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WO/1998/037057A1 |
A process is disclosed for preparing acid amides by reacting an acid with an aliphatic amine in molten urea. Also disclosed is a process for metallising compounds which can be bonded to a metal ion by reacting the compound with a metal i...
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WO/1998/030329A1 |
At least one functional group selected between nitro and carboxyl groups can be introduced into a substrate by bringing the substrate into contact with at least one reactant selected from among (i) nitrogen oxides and (ii) carbon monoxid...
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WO/1998/019978A1 |
A process for the nitration of an aromatic or heteroaromatic compound with a nitrating agent comprising nitric acid or a mixture of nitric and sulphuric acids, characterised in that nitration is performed in a solvent comprising at least...
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WO/1998/013331A1 |
The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon mul...
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WO/1998/009950A1 |
The invention concerns a process for preparing amidines and their salts with inorganic or organic acids. According to this process, the corresponding nitrile is reacted with ammonia, a C�1?-C�6? alkylamine or hydrazine in the presenc...
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WO/1998/008786A1 |
This invention relates to a new nitration system, and a new method for nitration of aromatic compounds. The nitration system comprises dinitrogen pentaoxide dissolved in an organic solvent, and after having generated an intermediate ther...
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WO/1998/007763A1 |
This invention relates to methods for preparing novel, solid-phase transfer reagents, specifically phosgenated oxime resins and non-symmetrical ureas, that are useful as supports in combinatorial synthesis for the creation of libraries o...
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WO/1998/005666A1 |
Hexaazaisowurtzitane derivatives of general formula (I): WA�n?N(�6-n?) [wherein n is 4 or 5; As are each independently C�1?-C�10? acyl; N is nitro; and W is a hexavalent hexaazaisowurtzitane residue of general formula (II)] havin...
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WO/1998/004515A1 |
The invention concerns the production of compounds containing NH�2?-groups by hydrogenating compounds containing at least one unsaturated carbon-nitrogen bond with hydrogen in the presence of a catalyst at temperatures not below room t...
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WO/1998/002408A1 |
The invention concerns a method of nitrosation of a phenolic compound substituted by an electro-attracting group.The invention also concerns a method of nitration of a phenoic compound substituted by an electro-attracting group. The nitr...
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WO/1997/038955A1 |
A process for the selective hydrogenation of aliphatic or aromatic substrates under supercritical or near critical conditions. Hydrogenation is effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritic...
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WO/1997/034872A1 |
The invention concerns a process for preparing pyridyl-substituted N-phenylhydroxylamines of formula (II) by catalytically hydrogenating the corresponding nitro compounds in the presence of an N-substituted morpholine compound and rearra...
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WO/1997/030967A1 |
This invention concerns a method for catalytic hydrogenation of aromatic nitrocompounds to aromatic amines by applying a supercritical or near-critical state solvent. The aromatic nitro compound, hydrogen gas and the solvent are mixed to...
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WO/1997/019954A1 |
This invention is in the field of the chemistry of targeting anticancer anthracycline derivatives. More particularly, it concerns doxorubicin (DOX) or its daunosamine modified derivatives (DM-DOX) linked covalently to analogs of peptide ...
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WO/1997/003946A1 |
The invention relates to the production of organic nitrogen compounds, especially aminoalkanes, alkyloximes, alkylnitrons or mixtures thereof having only one nitrogen-functional grouping and no alcoholic hydroxyl groups in the molecule, ...
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WO/1996/036588A1 |
The present invention provides a process for the preparation of substituted aromatic amino compounds which are substituted by at least one -CN multiple bond or a carbonyl group on the aromatic radical or in side chain, by catalytic hydro...
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WO/1996/028250A1 |
A titanium catalyst for use in the reaction between unsaturated carbon-to-carbon bonds and a compound having an electrophilic functional group or an electrophilic agent, which catalyst comprises a titanium compound represented by the gen...
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WO/1996/024061A1 |
The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that spec...
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WO/1996/020232A1 |
A process to make an allyl ether, allyl thioether or allyl amine comprising the step of reacting an active-hydrogen-containing compound containing at least one hydroxyl, thiol, ester or amine group with a compound containing an allyl car...
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WO/1996/020233A1 |
Epoxy-containing compounds are prepared by: (1) providing an allyl reagent; (2) allylating one or more compounds containing at least one active-hydrogen atom per molecule using the allyl reagent from step (1), whereby an allyl ether, all...
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WO/1996/011915A1 |
A process is disclosed for preparing acid amides, including isocyanate-functional 1,3,5-triazines and isocyanate-based 1,3,5-triazine derivatives, from the reaction of (Si, Ge or Sn substituted amino)-1,3,5-triazines and acid halides.
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