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WO/2021/018572A1 |
The present invention relates to air stable, binary Ni(0)-olefin complexes and their use in organic synthesis.
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WO/2020/114150A1 |
A synthesis method for a carbamate using dimethyl sulfoxide ylide, amine and carbon dioxide is provided. The carbamate is obtained by adding dimethyl sulfoxide ylide, an amine and a solvent into a pressure reactor, then adding a catalyst...
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WO/2020/104930A1 |
The present invention relates to an improved asymmetric synthesis of azaspiro or di- azaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the format...
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WO/2020/010228A1 |
Disclosed herein, inter alia, are deconstructive functionalization methods and compounds made using the same.
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WO/2019/238057A1 |
An application of FSO2N3 in preparation of azide. FSO2N3 is used for implementing a diazo transfer reaction, and azide (R-N3, Ar-N3, or RSO2N3) can be quickly and safely prepared from primary amine compounds (comprising a primary alkyl a...
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WO/2019/219942A1 |
Provided is a process for producing an amine via a hydroaminoalkylation reaction of a non-aromatic C-C double bond or C-C triple bond, said process comprising a step of reacting a compound comprising a non-aromatic C-C double bond or C-C...
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WO/2019/196945A1 |
Disclosed is a novel method for synthesizing deuterated amides and deuterated sulfonamides, the steps being as follows: (1) adding a compound M, DMAP, R3-X to a solvent to obtain a compound N after a reaction is complete; (2) adding the ...
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WO/2019/043544A1 |
The present disclosure provides a process for the preparation of ixazomib citrate. An efficient, industrially feasible process for the preparation of ixazomib citrate of Formula I, optionally which the process can occur in a single pot.
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WO/2019/037755A1 |
The present invention relates to a compound represented by general formula (I), as well as a racemate, a stereoisomer, a tautomer, a polymorphic substance, and a solvate thereof, or a pharmaceutically acceptable salt thereof. The present...
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WO/2019/030304A1 |
The invention relates to ylide-functionalised phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.
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WO/2019/018539A1 |
(-)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.
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WO/2017/186615A9 |
In a process for the synthesis of a nitrile by endothermic catalyzed reaction of ammonia with a hydrocarbon using heating obtained by passing an alternating current through a metallic coil, the endothermic reaction between ammonia and th...
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WO/2018/137260A1 |
Disclosed in the present application is a method for preparing a compound I, which is characterized in being prepared and obtained by reacting starting materials which comprise a compound II, which contains a carbon-carbon double bond, a...
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WO/2018/115443A1 |
The invention relates to a method for producing an amine oxide by oxidation of a tertiary amine in a reactor under continuous introduction of tertiary amine in a reaction fluid and export of amine oxide, wherein a suitable surface-to-vol...
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WO/2017/186615A1 |
In a process for the synthesis of a nitrile by endothermic catalyzed reaction of ammonia with a hydrocarbon using heating obtained by passing an alternating current through a metallic coil, the endothermic reaction between ammonia and th...
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WO/2017/137047A1 |
The invention relates to a method for arylation of amines, such as aliphatic amines by reaction of aryl-halogens, e.g. chloro- or fluorobenzene derivatives without strongly electron withdrawing substituents in the presence of a strong base.
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WO/2017/137984A1 |
The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition rea...
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WO/2017/129796A1 |
The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.
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WO/2017/064296A1 |
The present invention concerns a method for synthesising a compound of formula (I) in which: - A is a carbon chain that can contain at least one group comprising one or more heteroatoms preferably chosen from O, N, Si, S and P; - R1 is a...
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WO/2017/050419A1 |
The invention relates to bismuth perfluoroalkylphosphinates as Lewis acid catalysts, the compounds and a method for the production thereof. ArxBi[OP(O)(Rf)2]3 -x (la), Ar3Bi[OP(O)(Rf)2]2 (Ib).
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WO/2016/156932A1 |
Disclosed herein is an efficient, economical, industrially advantageous, straight-through process for the preparation of cyclic amides, also referred as lactams, in substantially pure form and high yield, from the corresponding cyclic ke...
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WO/2016/151464A1 |
The present invention provides an improved process for the preparation of 8-chloro-1-phenyl- 1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione (hereafter referred to as the compound (IV)), which is useful as a key intermediate for the synthesis...
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WO/2016/095860A1 |
Pyrazolyl carboxylic acid and pyrazolyl urea derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds.
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WO/2015/189554A1 |
The present invention provides apalladium(II)complex of formula (1) or a palladium(II) complex of formula (2). R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R18, R19, R20, R21, R22, R23 and R24, m, E and X are described in the speci...
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WO/2015/188401A1 |
Provided is a solvent medium for a diazotization reaction, comprising mutually mixed polyethyleneglycol and water; the molecular weight of the polyethyleneglycol is 200-600; the volume ratio of polyethyleneglycol and water is 1:0.4-1.5. ...
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WO/2015/178847A1 |
There is provided a method for the preparation of an enantiomerically enriched amine by asymmetric hydrogenation of a prochiral oxime.
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WO/2015/178846A1 |
There is provided a method for the preparation of an enantiomerically enriched amine from a prochiral ketone.
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WO/2015/164699A1 |
Disclosed is a method for hydrogenating a dinitrile to form a diamine in the presence of liquid or supercritical ammonia, in particular the preparation of hexamethylenediamine (HMD) from adiponitrile (ADN) and of 2-methylpentamethylenedi...
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WO/2015/086793A1 |
The present invention relates to the field of catalysis, more particularly to the field of organocatalysis and to polymer supported chiral phosphoric acid catalysts. It also relates to the use of these compounds in the preparation of chi...
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WO/2015/067450A1 |
The invention relates to a method for producing amines, comprising the following steps: a. reacting a (i) carboxylic acid amide of general formula (I) or (ii) carboxylic acid diamide of general formula (II) or (iii) di-, tri-, or polypep...
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WO/2015/067448A1 |
The present invention relates to a process for the preparation of amines, comprising the following steps: reaction of a (i) amide acetal of the general formula (I), or (ii) ketene N,O-acetal of the general formula (II), or (iii) ester im...
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WO/2015/060657A1 |
The present invention relates to a method for preparing an intermediate of iopromide, and more particularly, to a method for preparing an intermediate of iopromide, in which 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid dichloride i...
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WO/2015/022282A1 |
The invention relates to a process for hydrogenating halogen-substituted nitro-aromatic compounds or functional nitro-aromatic compounds using nitrogendoped carbon nanotubes (NCNTs).
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WO/2015/000753A1 |
A method for the methylation of amines, amides and imines comprises the step of reacting these compounds with CO2 and H2 in the presence of a Ruthenium-phosphine complex.
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WO/2014/083109A3 |
A process for the selective removal of a component from a liquid phase and subsequently returning the component to a liquid phase is disclosed. A novel compound of formula (I) [SUP]-[[L]-[G]]a (I) in which L is a linking group, G is an a...
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WO/2014/118038A1 |
The invention relates to novel phosphorus ligands and to a chemoselective and regioselective method for the hydroaminomethylation of olefins with at least one primary or secondary amine, with the addition of H2 and CO under catalytic con...
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WO/2014/006637A3 |
Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and ...
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WO/2014/055440A1 |
Provided herein are compositions comprising co-crystals of GGA or a GGA derivative (including salts and tauotomers thereof) with urea or thiourea, and processes related to such co-crystals. Also provided herein are methods, compounds, an...
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WO/2014/037444A1 |
Disclosed is a novel process for the reduction of nitro groups to amino derivatives, based on the use of trichlorosilane and an organic base, which is efficient from the chemical standpoint and of wide general applicability.
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WO/2014/034124A1 |
Provided is a chemical reaction which omits or simplifies treatment after reaction. This problem is solved by a method for producing a product by a chemical reaction which comprises: (A) a step of producing a product by reacting a substa...
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WO/2014/016241A1 |
The invention relates to a process for preparing primary amines by alcohol amination of alcohols with ammonia to eliminate water, wherein the alcohol amination is conducted under homogeneous catalysis in the presence of at least one comp...
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WO/2014/013512A1 |
Disclosed is one pot process of the preparation of 2,3-dihydroxy benzonitrile from 2,3-dialkoxy benzoic acid without prior isolation of the intermediates. Further disclosed is the preparation of 2,3-dihydroxy benzonitrile by dealkylation...
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WO/2013/181096A1 |
The invention provides a method of forming a phosphonate diester compound from a ligand hydrolysis product (LHP) of a phosphite ligand used in a nickel-phosphite hydrocyanation catalyst, such as for conversion of 3-pentenenitrile to adip...
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WO/2013/152548A1 |
The present invention relates to a catalyst for synthesizing ethylene amine and a method for preparing ethylene amine. The catalyst is formed of a main active component, an auxiliary agent, and a carrier processed by ammonification. The ...
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WO/2013/133508A1 |
The present invention relates to a novel diamine compound in which two substituents are asymmetrically introduced, and a polymer using the diamine compound. The diamine compound has sufficient solubility in an organic solvent even after ...
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WO/2013/129682A1 |
Provided is a production method in which a compound comprising an amino group and/or a hydroxyl group is generated under mild conditions by removing atom groups containing CO or CS from a substrate compound containing such atom groups. A...
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WO/2013/089241A1 |
The present invention relates to a method for removing Fmoc groups, the method comprising a step for mixing a compound represented by formula (I): HS-L-COOH (where L is an optionally substituted C1-8 alkylene group), a compound having am...
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WO/2013/082656A1 |
The present invention relates to compounds that are useful as metal ligands and which can be bound to a biological entity such as a molecular recognition moiety and methods of making these compounds. Once the compounds that are bound to ...
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WO/2013/033862A1 |
Provided are derivates substituted with urea associated with 4-substituted-(3-substituted-1H-pyrazole-5-amino)-pyrimidine
-2-amino of formula (I), wherein these compounds may selectively regulate or inhibit an information transmission pr...
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WO/2013/026903A1 |
The invention relates to a method for continuous production of reaction products by addition reactions based on a Michael reaction, wherein at least one compound (B) having at least one nucleophilic functional group is added to at least ...
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