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WO/2005/097745A1 |
The present invention provides an asymmetric hydrogenation process for the preparation of chiral cycloalkanoindole DP receptor antagonists of formula I in high enantiomeric excess.
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WO/2005/095416A1 |
It is intended to provide a process for efficiently producing a flavone C glycoside derivative represented by the formula (1) which is an antiallergic substance or its salt, or a flavone C glycoside derivative represented by the formula ...
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WO/2005/095335A1 |
The invention aims at providing ylide compounds represented by the general formula (1) and being useful as herbicide and a process for the production thereof, as well as at providing a process for the preparation of halomethyl ketones kn...
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WO/2005/092902A1 |
An efficient process for producing a folic acid derivative being suitable for formation of a conjugate of anticancer drug and folic acid. There is disclosed a process comprising the step of conducting a reaction between a 2-amino protect...
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WO/2005/092825A1 |
Optically active alcohols are produced by adding a ruthenium complex represented by the following formula (I), RuCl[(S,S)-Tsdpen](p-cymene), and a ketone to a polar solvent and mixing the resulting system in the presence of pressurized h...
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WO/2005/092830A1 |
[PROBLEMS] To provide: a water-soluble transition metal/diamine complex which can be easily separated from reaction products through liquid separation, etc. and is recycleable; an optically active diamine compound constituting the ligand...
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WO/2005/087370A1 |
Materials and methods for preparing (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, whic...
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WO/2005/085178A1 |
A method of preparing L-threo-(2S,3R)-3-(3.4-dihydroxyphenyl)serine or a salt thereof and an immediate obtained in the preparation of the serine derivative are provided. The method includes decomposing an asymmetric aldol condensate of a...
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WO/2005/085171A1 |
A process for producing an optically active fluorochemical represented by the general formula (3), which comprises reacting a specific fluoroamine with an optically active diol; and a process for producing an optically active fluoroalcoh...
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WO/2005/085184A1 |
[PROBLEMS] To provide a process for the synthesis of cyclopentenenitrile derivatives through conjugate addition of a nitrile derivative to an &agr ,β-unsaturated ketone whereby cyclopentenenitrile derivatives, particularly those capable...
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WO/2005/085204A1 |
A method of the intramolecular and intermolecular cyclization of an N-acylhydrazone for obtaining a pyrazoline skeleton or pyrazolidine skeleton under ordinary conditions with high stereoselectivity and in high yield. An N-acylhydrazone ...
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WO/2005/084803A1 |
[PROBLEMS] To provide an asymmetric reaction catalyst which is excellent in yield and stereoselectivity and easy of handling and a process for the production of optically active compounds with the same. [MEANS FOR SOLVING PROBLEMS] An as...
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WO/2005/082842A1 |
A compound (II), compound (IV), compound (VI), and compound (VII); and processes for producing these. Also provided is a process for producing the compound (X) which comprises the steps of (II)→(IV)→(VI)→(VII)→(X).
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WO/2005/082861A1 |
A process for producing an optically active 4-[hydroxy[5-(imidazol-1-yl)-2-methylphenyl]methyl]3,5dime
thylbenzoic acid or an ester thereof, characterized by reacting 4-[5-(imidazol-1-yl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid or ...
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WO/2005/080370A1 |
Provided is a process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols, particularly of (S)-(-)- and (R)-(+)-3-N-methylamino-l-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids ...
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WO/2005/080318A1 |
The invention provides a process permitting easy production in high yield of &agr -aminooxyketones, which are equivalents for the synthesis of monosaccharides or pentoses and equivalents of &agr -hydroxyketones serving as intermediates i...
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WO/2005/080298A1 |
A process for the catalytic asymmetric synthesis of an optically active compound of the formula (la) or (lb): wherein R is an organic group; X is halogen; Rl and R2which may the same or different represents H, or an organic group or Rl a...
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WO/2005/080299A1 |
The invention relates to novel monosulfonylated and carbonylated chiral compounds derived from a diamine or an aminoalcohol and carrying a pyrrolidinyl group, in addition to the preparation thereof, and to the applications of the same in...
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WO/2005/077908A1 |
A guanidine compound which has a bi-aryl skeleton represented by the following general formula (1): [wherein R1, R2 and R3 each independently represents a hydrogen atom, a hydrocarbon group optionally having a substituent or a heterocycl...
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WO/2005/077921A1 |
A guanidine compound which has a bi-aryl skeleton represented by the following general formula (1): [wherein R1, R2 and R3 each independently represents a hydrogen atom, a hydrocarbon group optionally having a substituent or a heterocycl...
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WO/2005/077870A1 |
The invention concerns a method for producing optically active hydroxy-, alkoxy-, amino-, alkyl-, aryl- or chlorine-substituted alcohols or hydroxycarboxylic acids having 3 to 25 carbon atoms or their acid derivatives or cyclization prod...
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WO/2005/077871A1 |
The invention concerns a method for producing optically active hydroxy-, alkoxy-, amino-, alkyl-, aryl- or chlorine-substituted alcohols or hydroxycarboxylic acids having 3 to 25 carbon atoms or their acid derivatives or cyclization prod...
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WO/2005/075073A1 |
The present invention is to provide a recyclable water-soluble transition metal complex catalyst which is a novel metal complex catalyst capable of producing an optically active alcohol from a ketone with good yield and good optical puri...
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WO/2005/075074A1 |
The invention relates to an inorganic solid which is surface modified by transition metal-chelating molecules. According to the invention, a modification site has structure (I), wherein: M = a transition metal or a lanthanide; Y = a liga...
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WO/2005/073156A1 |
[PROBLEMS] To provide catalysts permitting the progress of asymmetric hydroxymethylation with high asymmetric selectivity and processes for the production of optically active hydroxymethylated compounds with the catalysts. [MEANS FOR SOL...
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WO/2005/070876A1 |
An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthi...
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WO/2005/058917A2 |
A chiral ligand represented by the formula and its enantiomer: Formula (I) wherein A, X, Y and Z are as defined in the specification is provided. Also provided is a process of making the chiral ligands and catalysts prepared from these l...
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WO/2005/058805A1 |
A process for producing an optically active amine compound (IV), characterized in that nucleophilic addition of nucleophilic agent (III) to imine compound (II) is carried out in the presence of asymmetric urea compound (I). An advantageo...
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WO/2005/056526A1 |
Provided are a process for the production of intermediates from which optically active cyclopropylamine derivatives (6) can be easily synthesized by a short operation without optical resolution; and such intermediates. A process for the ...
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WO/2005/056609A1 |
A cationic oligomer of a saccharide, wherein the saccharide is functionalized by a cationic group, for example an ammonium, phosphonium, imidazolium, or pyridinium group. In a preferred embodiment, the cationic oligomer of a saccharide i...
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WO/2005/051964A1 |
The invention relates to a method for asymmetric synthesis in the presence of a chiral catalyst, comprising at least one complex of a metal of subgroup VIII of the periodic system with ligands that are capable of dimerizing via non-coval...
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WO/2005/049557A1 |
A process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by comprising causing cells of a microorganism or a product of treatment of the cells, the microorganism having the ability to stereoselectively...
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WO/2005/049570A1 |
The invention relates to a method for preparing optically active piperidines by the hydrogenation of pyridines using a suitable catalyst. Said method enables the preparation of a plurality of piperidine derivatives with high optical puri...
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WO/2005/040096A1 |
A process for the production of asymmetric alkyl compounds which is characterized by comprising the step of mixing a reaction solution containing a glycine imine ester, an alkyl halide, and an asymmetric catalyst having an ability to mak...
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WO/2005/037765A1 |
Disclosed is a method for producing &agr -alkylated aldehydes and/or ketones. According to said method, an aldehyde or ketone of general formula R1-CO-CH-R2R3, wherein R1 represents H, linear or branched, optionally substituted C1-C30 al...
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WO/2005/028419A2 |
The present invention relates to a process for producing amino acid derivatives such as optically active β-amino acid in short steps with good yield and high optical purity, which comprises reacting a keto acid of the formula (1): where...
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WO/2005/028413A1 |
A process for producing an optically active cyclopropane compound represented by the formula (4): (4) (wherein R3, R4, R5, and R6 are the same or different and each represents hydrogen, halogeno, (un)substituted alkyl, etc.; R7 represent...
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WO/2005/023821A1 |
A process for producing a penicillanic acid compound represented by the formula (2), characterized by reacting a halogenated penicillanic acid compound represented by the formula (1) with (b) a metal having a lower standard oxidation-red...
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WO/2005/021562A2 |
Compounds of the formulae (I) and (Ia) where X1 is secondary phosphino; R3 is a hydrocarbon radical having from 1 to 20 C atoms, a heterohydrocarbon radical which has from 2 to 20 atoms and at least one heteroatorn selected from the grou...
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WO/2005/016866A2 |
The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention...
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WO/2005/016331A1 |
[MEANS FOR SOLVING PROBLEMS] A preventive and/or therapeutic agent for neuropathic pains, characterized by containing a compound represented by the following formula (I), an optically active isomer thereof, or a pharmaceutically acceptab...
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WO/2005/012209A2 |
Enantioselective catalytic reactions that operate directly on unactivated alkenes for the preparation of chiral organic building blocks and new materials. More particularly, a catalyzed enantioselective reaction that operates on an unsat...
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WO/2005/007622A2 |
[PROBLEMS] To provide (1) an optically active quaternary ammonium salt which, when used as an asymmetric-axis-containing spiro type phase-transfer catalyst for the asymmetric alkylation of a glycine derivative, shows high stereoselectivi...
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WO/2005/000792A1 |
A process for producing an N-acylated amino acid derivative by which various intermediates useful biologically or as a medicine can be yielded. It comprises subjecting an N-acylimino ester and a silyl enol ether or alkyl vinyl ether deri...
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WO/2004/111063A2 |
The invention relates to biarylbisphosphines and intermediates thereof. Furthermore, the invention relates to catalysts produced from the biarylbisphosphines and the use thereof in asymmetric syntheses.
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WO/2004/111065A1 |
A substituted paracyclophane is described of formula (I) wherein Xl and X2 are linking groups comprising between 2 to 4 carbon atoms, Y1 and Y2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalk...
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WO/2004/110977A1 |
A process for producing an optically active, 1-alkyl-substituted 2,2,2-trifluoroethylamine represented by the formula [3] (wherein R represents C1-6 alkyl and * indicates asymmetric carbon) or a salt of the compound. These compounds are ...
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WO/2004/106269A1 |
The invention relates to a method for producing substituted shiral diols and the derivatives thereof of formula (I), wherein R is H or possibly substituted C5-C20-aryl-, C5-C20-heterocycle or C1-C20 alkyl radical or R1 is possibly substi...
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WO/2004/103560A1 |
The present invention concerns a catalytic composition comprising a catalyst effective for catalysing asymmetric hydrogenation reactions, which catalyst requires acid activation, an acidic material effective for activating the catalyst, ...
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WO/2004/104014A2 |
The invention relates to chiral phosphorus compounds and their transition metal complexes, in addition to the use of said transition metal complexes, in particular in asymmetric syntheses.
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