General Methods of Organic Chemistry, Apparatus Therefor

Matches 601 - 650 out of 4,601	< 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 >

Document	Document Title
WO/2003/045878A2	2,W-DIAMINOCARBOXYLIC ACID COMPOUNDS 2,$g(v)-Diaminocarboxylic acid compounds of formula (I), where X, X?1¿, Ar?$g(v)¿, Ar?2¿ and Y are as defined in claim 1, and their use as herbicides, are described.
WO/2003/042135A2	P-CHIRAL PHOSPHOLANES AND PHOSPHOCYCLIC COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYTIC REACTIONS Chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such as, hydrigenation,...
WO/2003/040138A1	DIMERIC COMPOUNDS AND THEIR USE AS ANTI-VIRAL AGENTS The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R?2¿ is acetyl or trifluoroacetyl; and n is an integer from 10 to 18 or a pharmaceutically acceptable derivative thereof, methods for ...
WO/2003/040119A1	ANGIOGENESIS INHIBITORS The invention concerns novel 1-oxa-spiro [2, 5] octan-6-ol of general formula (I), as well as their preparation method, and their use in pharmaceutical compositions for use in human or veterinary medicine, or in cosmetic compositions.
WO/2003/040149A2	ASYMMETRIC CATALYSIS BASED ON CHIRAL PHOSPHOLANES AND HYDROXYL PHOSPHOLANES Chiral phosphine ligands derived from chiral natural products including D-mannitol and tartaric acid. The ligands contain one or more 5-membered phospholane rings with multiple chiral centers, and provide high stereoselectivity in asymme...
WO/2003/035599A1	QUARTERNARY AMMONIUM COMPOUNDS AND THEIR USE AS ANTIMUSCARINIC AGENTS Novel quaternary ammonium compounds of the formula (I) and any stereoisomers thereof, wherein, R1, R2, and R3 independently represent C1−C6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R1, R2 a...
WO/2003/035595A1	NOVEL NORBORNANE AND NORBORNENE DERIVATIVES, USE THEREOF AND PERFUMED PRODUCTS CONTAINING SAME. The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R1 represents: when the dotted line bond is present -CHCH3OH or -CHCH3 OCOR or -CHCH3XCH2CHOHR' or -CHCH3OCHR'CH2OH or f...
WO/2003/033510A1	NOVEL CHIRAL LIGANDS, TRANSITION METAL COMPLEXES THEREOF, AND THE CATALYTIC USE OF THE SAME The invention relates to novel chiral ligands of formula (I), the production thereof and the use of the same in catalytic reactions.
WO/2003/031402A1	PROCESS FOR PREPARATION OF 19−NORVITAMIN D DERIVATIVES A process for preparation of 19−norvitamin D derivatives represented by the general formula (3): (3) [wherein W is hydrogen, halogeno, or the like&semi Z is C1−26 alkyl or the like&semi and X1 and X2 are each independently hydrogen, ...
WO/2003/031401A1	PROCESS FOR PREPARATION OF 19−NORVITAMIN D DERIVATIVES A process for preparation of 19−norvitamin D derivatives represented by the general formula (3): (3) [wherein RA is hydrogen, halogeno, or the like&semi Z is C1−26 alkyl or the like&semi and X1 and X2 are each independently hydrogen,...
WO/2003/031456A2	LIGANDS FOR ASYMMETRIC REACTIONS The invention relates to a process for the manufacture of ligands capable of forming metal complexes and such complexes; novel ligands with new backbones, complexes thereof with transition metals, the use of complexes of said ligands wit...
WO/2003/031428A1	STEREOSPECIFIC PROCESS FOR THE SYNTHESIS OF 2-YL CHROMAN DERIVATIVES This invention provides a process for the stereospecific preparation of 2-yl-chroman and-chromene derivatives of the formula (I). These compounds are useful for the preparation of optically active 2-aminomethyl- and 2-azaheterocyclylmeth...
WO/2003/029259A1	NOVEL DISPHOSPINES, THEIR COMPLEXES WITH TRANSITION METALS AND THEIR USE IN ASYMMETRIC SYNTHESIS The invention concerns novel optically pure or racemic diphosphines of formula (I), wherein: R1 and R2 represent a C5-C7 cycloalkyl group, an optionally substituted phenyl group or a five-membered heteroaryl group; A represents (CH2-CH2)...
WO/2003/029190A1	PROCESSES AND COMPOSITIONS FOR THE PRODUCTION OF CHIRAL AMINO-NITRILES Processes for the efficient production of chiral amino nitriles are disclosed. Generally, the processes include the esterification of the alcohol of an amino protected alcohol followed by nucleophilic substitution of the ester with a cya...
WO/2003/029267A2	METHOD OF PRODUCING 17β-(SUBSTITUTED)-3-OXO-&Dgr 1,2-4-AZASTEROIDS AND INTERMEDIATES The invention relates to the production of 17β-(substituted)-3-oxo-&Dgr 1,2-4-azasteroids (I), wherein R1 is a C1-C4 alkyl, OR2, wherein R2 is a C1-C4 alkyl, or NR3R4, wherein R3 and R4, which may be identical or different, denote hydro...
WO/2003/024981A2	METHOD FOR THE PRODUCTION OF OPTICALLY-ACTIVE COMPOUNDS CONTAINING HYDROXY GROUPS Optically-active compounds containing hydroxy groups are advantageously produced from a carbonyl compound with hydrogen in the presence of a catalyst and a base, whereby a catalyst is used which contains a support-bonded Ru (II) complex,...
WO/2003/018569A1	PROCESS FOR ASCORBIC ACIDS USING ALKALINE EARTH SILICATE CATALYSTS Disclosed is a process for the preparation of ascorbic acids from 2-keto-hexonic acids or 2-keto-hexonic acid derivatives using alkaline earth silicate catalysts. The process may be carried out in water, alcohols, or in a variety of pola...
WO/2003/018191A1	CATALYSTS A zeolite-immobilised Lewis acid e.g. copper catalyst for performing carbonyl-ene and iminoene reactions is described. The catalyst can readily be separated from the reaction mixture and re-used in further reactions with minimal reductio...
WO/2003/018572A1	3−&lpar N−ALKOXYCARBONYL−N−METHYL&rpar AMINO−1−ALKOXYCARBONYL− OXY−&lpar 2−THIENYL&rpar PROPANES AND PROCESS FOR PREPARING 3−&lpar N− METHYLAMINO&rpar −1−&lpar 2−THIENYL&rpar −PROPAN−1−OL WITH THE SAME Optically active 3−(N−alkoxycarbonyl−N−methyl)amino−1− alkoxycarbonyloxy−(2−thienyl)propanes, which are novel compounds of the general formula (I), can be prepared by reacting optically active 3−(N,N−dimethylamino)−...
WO/2003/014133A1	ISOXAZOLINE DERIVATIVES AS P, N LIGANDS The invention relates to novelligands of the phosphanylbenzothiophenyl-dihydroisoxazoline, phosphanyl-dihydrooxazolyl-indole and phosphanyl-dihydrooxazolyl-benzofuran type, especially compounds of formula (I) and mixtures of such compoun...
WO/2003/014068A1	PROTECTED 3.5-DIHYDROXY-2.2-DIMETHYL-VALERONITRILES FOR THE SYNTHESIS OF EPOTHILONES AND DERIVATIVES AND METHOD FOR THE PRODUCTION AND USE THEREOF The invention relates to 3.5-dihydroxy-2.2-dimethyl-valeronitriles for the synthesis of epothilone and epothilone derivatives and a method for producing said novel intermediate products in the synthesis and the use thereof in the product...
WO/2003/013542A1	ASYMMETRIC SYNTHESIS OF KAVALACTONES This invention relates to preparation of enantio-enriched compounds, and more particularly to enantio-enriched kavalactone compounds and derivatives thereof. The methods provide compounds that are useful as reagents, or building blocks, ...
WO/2003/011799A1	KINETIC RESOLUTIONS OF CHIRAT 3- AND 3-SUBSTITUTED CARBOXYLIC ACIDS One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing cataly...
WO/2003/011852A1	NOVEL MODIFICATIONS OF THE TROMETAMOL SALT OF R-THIOCTIC ACID AND METHOD FOR PRODUCING THE SAME The invention relates to novel modifications of the trometamol salt of R-thioctic acid of formula (I), to methods for producing the same, to pharmaceutical preparations containing said modifications, and to the medical application thereof.
WO/2003/008399A1	SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
WO/2003/006458A1	BENZO [G] QUINOLINE DERIVATIVES FOR TREATING GLAUCOMA AND MYOPIA The invention provides a compound of formula I wherein A, B, X, Y and R¿1? are as defined in the description, and a process for preparing them. The compounds of formula I are useful as pharmaceutical agents for the treatment of glaucoma...
WO/2003/006151A1	MICROENCAPSULATED CATALYST, METHODS OF PREPARATION AND METHODS OF USE THEREOF A microencapsulated catalyst is prepared by dissolving or dispersing a catalyst in a first phase (for example an organic phase), dispersing the first phase in a second, continuous phase (for example an aqueous phase) to form an emulsion,...
WO/2003/004157A2	OPTICALLY ACTIVE CATALYSTS CONTAINING A SALEN LIGAND AND VANADIUM (IV), PRODUCTION THEREOF AND USE OF THE SAME FOR PRODUCING CYANOHYDRINS The invention relates to an optically active catalyst containing a salen ligand of formula (II) and vanadium at oxidation stage (IV), wherein the groups R, R' and R' of the salen ligand independently of one another represent hydrogen, br...
WO/2003/003972A2	KINETIC RESOLUTION OF A INTERMEDIATE USEFUL IN THE PRODUCTION OF BENAZEPRIL AND ANALOGUES THEREOF The present invention provides an efficient synthetic process for making benazepril and analogues thereof by having an intermediate compound undergo epimerization and kinetic resolution.
WO/2003/004455A2	PROCESS FOR THE PREPARATION OF 7-AMINO SYN 3,5-DIHYDROXY HEPTANOIC ACID DERIVATIVES, INTERMEDIATES THEREOF AND METHODS FOR THEIR PREPARATION The invention relates to synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to synthesis methods of the intermediate of formula (VI) wherein R¿a?' and R¿...
WO/2003/004450A1	PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF STATIN DERIVATIVES ESPECIALLY 7-AMINO 3,5-DIHYDROXY HEPTANOIC ACID DERIVATIVES, AND INTERMEDIATES THEREOF The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N...
WO/2003/004456A1	PROCESS FOR THE PREPARATION OF 7-AMINO SYN 3,5-DIHYDROXY HEPTANOIC ACID DERIVATIVES VIA 6-CYANO SYN 3,5-DIHYDROXY HEXANOIC ACID DERIVATIVES The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein R¿a...
WO/2003/005010A2	METHOD FOR PRODUCING OPTICALLY ACTIVE CYANOHYDRINS The invention relates to a method for producing optically active cyanohydrins and the corresponding $g(a)-hydroxycarboxylic acids, starting from an aldehyde, hydrogen cyanide and an optically active vanadyl-salen catalyst, whereby the re...
WO/2003/002582A1	NEW CHIRAL SALEN CATALYST AND METHODS FOR THE PREPARATION OF CHIRAL COMPOUNDS FROM RACEMIC EPOXIDES BY USING NEW CATALYST There are provided new chiral salen catalyst, and methods for the preparation of chiral compounds from racemic epoxides by using new catalyst. More particularly, there are provided new chiral compounds from racemic epoxides by using new ...
WO/2003/002255A1	HYDROXYLATION OF BETA-DICARBONYLS WITH ZIRCONIUM CATALYSTS The present invention pertains to a process for preparing a compound of Formula I that is achiral, racemic or enantiomerically enriched at the hydroxylation center indicated by comprising contacting a compound of Formula II with an oxida...
WO/2003/000698A1	$g(b)-BENZYLOXYASPARTATE DERIVATIVES WITH AMINO GROUP ON BENZENE RING L-threo-$g(b)-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1): wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl portion optionally subs...
WO/2002/102764A2	METHOD FOR PRODUCING CHIRAL AMINO ACID DERIVATIVES The invention relates to a method for producing chiral amino acid derivatives, characterised in that free carboxylic acid groups in an amino acid derivative are first converted into nitro ketones, and said nitro ketones are then converte...
WO/2002/102707A2	TRANSITION METAL OXO, SULFIDO AND AMIDO COMPLEXES AS CATALYSTS OF NUCLEOPHILIC ADDITION REACTIONS Methods are provided for carrying out nucleophilic addition reactions using oxo, sulfido or amido complexes of transition metals as reaction catalysts. Exemplary catalysts are oxo complexes of Group 7 transition metals, with rhenium (V) ...
WO2002036261B1	CATALYST COMPRISING A CHIRAL CATIONIC METAL-LIGAND COMPLEX IMMOBILISED ON A MESOPOROUS ALUMINO-SILICATE SUPPORT, ITS PREPARATION AND USE IN ASYMMETRIC HYDROGENATION A solid catalyst for asymmetric hydrogenation reactions is disclosed comprising a chiral cationic metal-ligand complex immobilised on a mesoporous alumino-silicate support. The catalyst is formed by ion exchange with the acid sites of th...
WO/2002/101003A2	STEREOSELECTIVE PREPARATION OF CYCLIC L-AMINO ACIDS The invention concerns a method for producing a cyclic L-amino acid of formula (I), characterised in that it consists in reacting a L-diamino acid of formula (II) or an enantiomeric mixture comprising such a L-diamino acid and a correspo...
WO/2002/098854A2	PROCESS FOR PREPARING CHIRAL DIOL SULFONES AND DIHYDROXY ACID HMG COA REDUCTASE INHIBITORS A process is provided for preparing chiral diol sulfones of the structure (I) where R¿3? is preferably (II) or (III) where R¿4a? is preferably aryl such as phenyl, and R¿1a? is preferably alkyl such as t-butyl, which are intermediates...
WO/2002/096898A2	PROCESS FOR THE PREPARATION OF PROSTAGLANDINS AND ANALOGUES THEREOF Disclosed are processes for the synthesis and purification of prostaglandins and analogues thereof, especially analogues of PGF¿2$g(a)?.
WO/2002/096899A1	SYNTHESIS OF CANNABINOIDS The present invention relates to a process for the production of compound (A) comprising reacting compound (B) with compound (C). A further ring closure reaction may be necessary. The invention further relates to certain novel compounds ...
WO/2002/094761A1	STEREOSELECTIVE SYNTHESIS OF 2-HYDROXY-4-PHENYLBUTYRIC ACID ESTERS A process is described for the stereospecific preparation of an ester of formula (I): wherein *signifies the (R) stereoisomer; R?1¿ is selected from C¿1-6? alkyl, preferably ethyl; and R?2¿ is hydrogen, a protecting group or a leaving...
WO/2002/094849A2	PROCESS FOR THE PRODUCTION OF 6, 7 − DIHYDROXY STEROID COMPOUNDS BY ALLYLIC OXIDATION OF STEROID − 5 − ENE COMPOUNDS TO STEROID − 5 − ENE − 7 − ONE COMPOUNDS FOLLOWED BY HYDROBORATION AND OXIDATION AND INTERMEDIATES OF THIS PROCESS Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding &agr , β−unsaturated ketone using copper iodide and t−butyl hydroperoxide. A steroid compound containing the &agr , β−unsaturated ketone struc...
WO/2002/092204A2	METHOD FOR ACTIVATING AND IMMOBILIZING CATIONIC TRANSITION METAL CATALYSTS USING IONIC FLUIDS AND COMPRESSED CO¿2? The invention relates to a novel method for activating cationic transition metal catalysts using a solvent mixture containing one or several ionic fluids and compressed CO¿2?. The cationic transition metal catalyst can also be immobiliz...
WO/2002/092572A1	METHOD FOR PREPARATION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE An efficient and high-yielding method for the preparation of optically pure (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-car boxamide and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-car boxamide by resolution of ...
WO/2002/092562A2	ENANTIOSELECTIVE REACTIONS USING TWO-COMPONENT CHIRAL PHASE TRANSFER CATALYSTS IN MULTIPHASIC SYSTEMS The present invention provides multiphasic systems comprising at least one chiral selector and an achiral phase transfer catalyst, wherein said system can be used to effect enantioselective reactions or asymmetric induction reactions.
WO/2002/088146A2	ANTIDEPRESSANT INDOLETETRAHYDROPYRIDINE DERIVATIVES OF 2,3-DIHYDRO-7H-[1,4]DIOXINO[2,3-e]INDOLE Compounds of the formula (I) are useful in the treatment of central nervous system disorders including depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction, eating disorders and addic...
WO/2002/088047A1	POLYMER-BOUND CATALYST FOR THE ENANTIOSELECTIVE CLEAVAGE OF PRO-CHIRAL ANHYDRIDES The invention relates to the use of catalysts comprising the structures of general formulas (I), (II) or (III), for the asymmetric cleavage of anhydrides.

Matches 601 - 650 out of 4,601	< 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 >