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WO/2023/169082A1 |
Disclosed in the present invention are a synthesis method and application of a benzoselenazole-1-ketone compound and a derivative thereof. Sulfoximine and the element selenium are used as raw materials, and by means of a rhodium catalysi...
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WO/2023/168827A1 |
The present invention relates to the technical field of chemical intermediates. Disclosed is a synthesis method for a paxlovid intermediate, comprising the following steps: reacting 3,3-dimethyl-4-oxobutyrate with S-substituted sulfinami...
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WO/2023/156972A1 |
Disclosed herein are embodiments of a chiral Pd(0) precatalyst according to Formula I, wherein the Pd atom has an oxidation state of 0 and the A group is a compound comprising at least one olefin moiety capable of coordinating with Pd(0)...
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WO/2023/097690A1 |
A method for preparing a β-nitro or azido alcohol by means of high-selectivity asymmetric catalytic carbonyl reduction. The route of the method is as follows: wherein R1, R2, R3, R4 and R5 are independently selected from any one of H, h...
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WO/2023/097696A1 |
Disclosed is a method for synthesizing (1R)-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-nitroethanol
. The route of the method is as follows: The method is used for synthesizing (1R)-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-nitroethanol...
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WO/2023/077643A1 |
A chiral multidentate ligand and the use thereof in asymmetric hydrogenation. The ligand is flexible and variable, and has a three-dimensional structure, high electrical adjustability and higher universality; the synthesis for the ligand...
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WO/2023/029236A1 |
The present application provides a method for synthesizing a key intermediate II-a of upadacitinib. The asymmetric hydrogenation of unsaturated carboxylic acid I-a can be catalyzed by means of Ru(OAc)2-(R)-OSPD to synthesize chiral carbo...
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WO/2022/222914A1 |
The present invention provides a preparation method for L-nicotine, the method can obtain L-nicotine having an optical purity of more than 99.9%, which is much higher than that of similar products in the current market. The total yield o...
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WO/2022/218391A1 |
The present invention relates to a chiral spiro ammonium salt compound, and a preparation method therefor and an application thereof. Specifically, the compound has the following optical pure or racemic compound represented by structural...
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WO/2022/217013A1 |
Methods for the synthesis of enantiopure (S)-methadone, (R)-methadone, (R,S)-methadone and related analogues starting from optically active or racemic N-substituted cyclic sulfamidates, or N-substituted aziridines with retention of stere...
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WO/2022/186273A1 |
A purpose of the present invention is to provide a novel radioactive compound, in particular a radioactive compound having high biostability.　The present invention relates to a radioactive compound represented by formula (I) or a pharm...
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WO/2022/179557A1 |
A chiral crown ether catalyst and an application thereof. The structure of the catalyst is as shown in formula (VI), wherein R2 and R3 are both phenyl groups, alternatively, R2 and R3 are connected to form an A-ring, and the A-ring is a ...
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WO/2022/107755A1 |
The present invention provides: a novel acridinium salt expressed by formula (I); and a method for producing this novel acridinium salt. (In the formula, R1 represents a C1-C6 alkyl group or a C1-C6 alkyloxy group; R2 represents a hydrog...
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WO/2022/101627A1 |
The present invention provides a method of making an enantiomerically enriched tertiary or quaternary ammonium salt, and the use of a non-racemic chiral compound in the synthesis of an enantiomerically enriched tertiary or quaternary amm...
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WO/2022/085384A1 |
The present invention addresses the problem of providing a novel ruthenium complex, in which addition of a base during catalyst activation is not necessary, which exhibits excellent crystallinity and stability, for which large scale synt...
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WO/2022/073803A1 |
The present invention describes a new synthesis to chiral imidodiphosphoryl compounds, their salts, metal complexes as well as derivatives thereof. Said chiral imidodiphosphoryl compounds can be used as catalysts for Brønsted acid / BrÃ...
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WO/2022/014414A1 |
The purpose of the present invention is to provide a method for more efficiently producing specific optically active compounds including optically active 1-acetyl-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline.　The present invention provi...
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WO/2021/177287A1 |
The present invention addresses the problem of providing a catalyst which exhibits high reusability and is capable of reducing the amount of residual metals in a reaction liquid in a process wherein an optically active reduction product ...
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WO/2021/160649A1 |
Disclosed is a method for preparing compound S-1, from compound S-5; wherein compound S-5 is prepared by treating compound 2 with a tertiary amine and a hydrogen source in the presence of a chiral complex.
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WO/2021/117760A1 |
A compound (A) according to the present invention is represented by formula (1). (In formula (1), each R1 independently represents a hydrogen atom or a group represented by formula (2), and each R2 independently represents a hydrogen ato...
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WO/2021/117764A1 |
A compound (A) according to the present invention is represented by formula (1).　(1): R1O―R2―OR1. (In formula (1), R1s each independently represent a group represented by formula (2) or a hydrogen atom, and R2 represents a linear o...
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WO/2021/097139A1 |
Disclosed herein are methods for preparing tertiary alcohols from an optionally substituted phenyl ketone or an optionally substituted pyridinyl ketone that includes the use of a chiral ligand and boron trifluoride diethyl etherate. Tert...
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WO/2021/070658A1 |
Provided is a method for producing a cyclopentane compound, the method allowing easy synthesis of a cyclopentane compound in a diastereoselective manner and, as necessary, in an enantioselective manner, the compound having multiple asymm...
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WO/2021/066043A1 |
The present invention provides a method for producing a trione compound, said method being characterized by producing a trione compound represented by formula (IV) (wherein R1 and R2 are as defined in formula (I); and R3 and Ar are as de...
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WO/2021/039023A1 |
The present invention provides, inter alia, a novel method for producing a compound represented by formula (I) and a novel method for producing a compound represented by formula (B) or a salt thereof, which are intermediates in the produ...
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WO/2021/007141A1 |
This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R...
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WO/2020/238559A1 |
Disclosed are a de-C2-symmetric diphenylamine-type chiral bisoxazoline ligand as shown in formula 3, a synthesis method therefor and the use thereof in an asymmetric catalytic reaction. The C2-symmetry of the ligand is removed by introdu...
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WO/2020/215357A1 |
The present invention provides a method for preparing a chiral β-hydroxycarboxylate compound: first, under nitrogen protection, dissolving [Ir(COD)Cl]2, a ligand, and an alkaline additive in a solvent, and stirring same at room temperat...
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WO/2020/218173A1 |
The present invention provides a novel fluorodinitrophenyl compound, a method for producing the fluorodinitrophenyl compound, and a use of the fluorodinitrophenyl compound. The present invention relates to: a compound represented by form...
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WO/2020/213714A1 |
The present invention provides a method in which when using (+)-dibenzoyl-D-tartaric acid to optically divide (±)-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-piperidinone, an ether-based solvent is added and an extremely high yield of (R)-1-m...
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WO/2020/202205A1 |
The invention provides a novel and practical route of synthesis the substituted diol intermediates, 1,1-dialkylethane-1,2-diols, useful for the preparation of various 6-nitro-2,3-dihydroimidazo[2,1-b]oxazole containing drugs. Specificall...
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WO/2020/189540A1 |
The present invention provides a method for efficiently preparing various optically active aromatic amino acid derivatives by performing a reaction, in the presence of a catalyst, on a specific ester compound by using an aromatic halide ...
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WO/2020/177654A1 |
The present invention discloses a phosphine ligand and a preparation method thereof, and an application in catalytic synthesis of ortho-tetra-substituted biaromatics. The phosphine ligand of the present invention has a structure of formu...
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WO/2020/171073A1 |
The present application discloses a method for producing (R)-4-methyl-1-(2-methyl-4-(3-methyl-1H-pyrazol-1-yl)benzoyl
)-5-oxo-2, 3, 4, 5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester by methylating 1-(2-methyl-4-(3-methyl-1...
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WO/2020/156022A1 |
Provided herein are enantioselective organocatalytic methods for preparing chiral tetraaryl methanes.
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WO/2020/137545A1 |
A method for producing an amide, wherein after causing a dehydration condensation of carboxylic acids or a reaction between a carboxylic acid and a halogenated formic acid ester, a first base is reacted therewith and an amine is reacted ...
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WO/2020/088949A1 |
The present invention relates to a process for preparing benzylic amidesof formula (I) wherein the variables are as defined in the specification, and the shown enantiomer has at least 50 % ee; by condensation of a ketone o formula (II) w...
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WO/2020/073657A1 |
Provided by the present invention are carbohydrate monophosphines represented by general formula Ia, Ib, IIa or IIb, comprising mixtures represented by Ia and Ib having different phosphorus atom configurations, or mixtures represented by...
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WO/2020/050339A1 |
Provided is an industrially useful method for manufacturing (1R,2S)-2-{[((2,4-dimethylpyrimidine-5-yl)oxy}methyl]-2-(3-f
luorophenyl)-N-(5-fluoropyridine-2-yl)cyclopropane-1-carboxa
mide. In the present invention, (1R,2S)-2-{[((2,4-dimet...
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WO/2020/048991A1 |
The invention relates to a reactor for carrying out a gas-liquid two-phase high-pressure reaction with a foaming medium, comprising: an interior, which is formed by a cylindrical, vertically oriented elongate jacket, a bottom and a hood,...
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WO/2020/048986A1 |
The invention relates to a reactor for carrying out a reaction between two non-miscible fluids of different densities, comprising: an inner chamber formed by a cylindrical, vertically orientated elongated casing, a base and a cover, wher...
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WO/2020/048998A1 |
The invention relates to a method for carrying out a continuous gas/fluid two-phase high-pressure reaction, wherein a gas and a liquid are introduced into a back-mixed zone of a reactor, and the gas is dispersed into the liquid in the ba...
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WO/2020/032038A1 |
The present invention provides a compound represented by formula (I), which has high specificity and high selectivity for monoamine oxidase B, and which is capable of imaging monoamine oxidase B with a good sensitivity, or a pharmaceutic...
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WO/2020/019911A1 |
Disclosed are a boron nitrogen ligand based on a chiral 1,2-ethylenediamine backbone, and a preparation method and use thereof. The boron nitrogen ligand has a structural formula as shown in formula (I), wherein R1, R2, and R3 are respec...
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WO/2019/233209A1 |
A catalyst and a method for preparing S-indoxacarb using the catalyst. The catalyst is prepared using 3-tert-butyl-5-chloromethyl salicylaldehyde and cyclohexanediamine as raw materials, where an original quinine catalyst such as cinchon...
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WO/2019/233211A1 |
The present invention relates to the field of asymmetric catalytic synthesis, and in particular to a preparation method for a high optical indoxacarb intermediate. The present invention comprises reacting 5-chloro-2-methoxycarbonyl-1-ind...
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WO/2019/213987A1 |
Disclosed are a monophosphine ligand based on a tetramethyl spirobiindane skeleton and an intermediate thereof, and a preparation method therefor and the use thereof. The monophosphine ligand is a compound having the structure represente...
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WO/2019/208710A1 |
The present invention provides: a method for producing 3-hydroxymethyltetracyclo[4. 4. 0. 12, 5. 17, 10]dodecane, which is characterized by subjecting tetracyclo[4. 4. 0. 12, 5. 17, 10]-3-dodecene to a hydroformylation reaction and subse...
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WO/2019/180084A1 |
The present invention relates to the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds. The present invention provides a process for the synthesis of compound of formula (I). This process...
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WO/2019/176732A1 |
[Problem] To provide a production method capable of easily synthesizing a compound having a structure in which a plurality of tetrahydroisoquinoline rings are linked together, using a reduced number of steps. [Solution] It was found that...
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