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Matches 1 - 50 out of 6,713

Document Document Title
WO/2021/070658A1
Provided is a method for producing a cyclopentane compound, the method allowing easy synthesis of a cyclopentane compound in a diastereoselective manner and, as necessary, in an enantioselective manner, the compound having multiple asymm...  
WO/2021/066043A1
The present invention provides a method for producing a trione compound, said method being characterized by producing a trione compound represented by formula (IV) (wherein R1 and R2 are as defined in formula (I); and R3 and Ar are as de...  
WO/2021/039023A1
The present invention provides, inter alia, a novel method for producing a compound represented by formula (I) and a novel method for producing a compound represented by formula (B) or a salt thereof, which are intermediates in the produ...  
WO/2021/007141A1
This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R...  
WO/2020/238559A1
Disclosed are a de-C2-symmetric diphenylamine-type chiral bisoxazoline ligand as shown in formula 3, a synthesis method therefor and the use thereof in an asymmetric catalytic reaction. The C2-symmetry of the ligand is removed by introdu...  
WO/2020/202205A4
The invention provides a novel and practical route of synthesis the substituted diol intermediates, 1,1-dialkylethane-1,2-diols, useful for the preparation of various 6-nitro-2,3-dihydroimidazo[2,1-b]oxazole containing drugs. Specificall...  
WO/2020/215357A1
The present invention provides a method for preparing a chiral β-hydroxycarboxylate compound: first, under nitrogen protection, dissolving [Ir(COD)Cl]2, a ligand, and an alkaline additive in a solvent, and stirring same at room temperat...  
WO/2020/218173A1
The present invention provides a novel fluorodinitrophenyl compound, a method for producing the fluorodinitrophenyl compound, and a use of the fluorodinitrophenyl compound. The present invention relates to: a compound represented by form...  
WO/2020/213714A1
The present invention provides a method in which when using (+)-dibenzoyl-D-tartaric acid to optically divide (±)-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-piperidinone, an ether-based solvent is added and an extremely high yield of (R)-1-m...  
WO/2020/202205A1
The invention provides a novel and practical route of synthesis the substituted diol intermediates, 1,1-dialkylethane-1,2-diols, useful for the preparation of various 6-nitro-2,3-dihydroimidazo[2,1-b]oxazole containing drugs. Specificall...  
WO/2020/189540A1
The present invention provides a method for efficiently preparing various optically active aromatic amino acid derivatives by performing a reaction, in the presence of a catalyst, on a specific ester compound by using an aromatic halide ...  
WO/2020/177654A1
The present invention discloses a phosphine ligand and a preparation method thereof, and an application in catalytic synthesis of ortho-tetra-substituted biaromatics. The phosphine ligand of the present invention has a structure of formu...  
WO/2020/171073A1
The present application discloses a method for producing (R)-4-methyl-1-(2-methyl-4-(3-methyl-1H-pyrazol-1-yl)benzoyl )-5-oxo-2, 3, 4, 5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester by methylating 1-(2-methyl-4-(3-methyl-1...  
WO/2020/156022A1
Provided herein are enantioselective organocatalytic methods for preparing chiral tetraaryl methanes.  
WO/2020/137545A1
A method for producing an amide, wherein after causing a dehydration condensation of carboxylic acids or a reaction between a carboxylic acid and a halogenated formic acid ester, a first base is reacted therewith and an amine is reacted ...  
WO/2020/088949A1
The present invention relates to a process for preparing benzylic amidesof formula (I) wherein the variables are as defined in the specification, and the shown enantiomer has at least 50 % ee; by condensation of a ketone o formula (II) w...  
WO/2020/073657A1
Provided by the present invention are carbohydrate monophosphines represented by general formula Ia, Ib, IIa or IIb, comprising mixtures represented by Ia and Ib having different phosphorus atom configurations, or mixtures represented by...  
WO/2020/050339A1
Provided is an industrially useful method for manufacturing (1R,2S)-2-{[((2,4-dimethylpyrimidine-5-yl)oxy}methyl]-2-(3-f luorophenyl)-N-(5-fluoropyridine-2-yl)cyclopropane-1-carboxa mide. In the present invention, (1R,2S)-2-{[((2,4-dimet...  
WO/2020/048991A1
The invention relates to a reactor for carrying out a gas-liquid two-phase high-pressure reaction with a foaming medium, comprising: an interior, which is formed by a cylindrical, vertically oriented elongate jacket, a bottom and a hood,...  
WO/2020/048986A1
The invention relates to a reactor for carrying out a reaction between two non-miscible fluids of different densities, comprising: an inner chamber formed by a cylindrical, vertically orientated elongated casing, a base and a cover, wher...  
WO/2020/048998A1
The invention relates to a method for carrying out a continuous gas/fluid two-phase high-pressure reaction, wherein a gas and a liquid are introduced into a back-mixed zone of a reactor, and the gas is dispersed into the liquid in the ba...  
WO/2020/032038A1
The present invention provides a compound represented by formula (I), which has high specificity and high selectivity for monoamine oxidase B, and which is capable of imaging monoamine oxidase B with a good sensitivity, or a pharmaceutic...  
WO/2020/019911A1
Disclosed are a boron nitrogen ligand based on a chiral 1,2-ethylenediamine backbone, and a preparation method and use thereof. The boron nitrogen ligand has a structural formula as shown in formula (I), wherein R1, R2, and R3 are respec...  
WO/2019/233209A1
A catalyst and a method for preparing S-indoxacarb using the catalyst. The catalyst is prepared using 3-tert-butyl-5-chloromethyl salicylaldehyde and cyclohexanediamine as raw materials, where an original quinine catalyst such as cinchon...  
WO/2019/233211A1
The present invention relates to the field of asymmetric catalytic synthesis, and in particular to a preparation method for a high optical indoxacarb intermediate. The present invention comprises reacting 5-chloro-2-methoxycarbonyl-1-ind...  
WO/2019/213987A1
Disclosed are a monophosphine ligand based on a tetramethyl spirobiindane skeleton and an intermediate thereof, and a preparation method therefor and the use thereof. The monophosphine ligand is a compound having the structure represente...  
WO/2019/208710A1
The present invention provides: a method for producing 3-hydroxymethyltetracyclo[4. 4. 0. 12, 5. 17, 10]dodecane, which is characterized by subjecting tetracyclo[4. 4. 0. 12, 5. 17, 10]-3-dodecene to a hydroformylation reaction and subse...  
WO/2019/180084A1
The present invention relates to the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds. The present invention provides a process for the synthesis of compound of formula (I). This process...  
WO/2019/176732A1
[Problem] To provide a production method capable of easily synthesizing a compound having a structure in which a plurality of tetrahydroisoquinoline rings are linked together, using a reduced number of steps. [Solution] It was found that...  
WO/2019/160037A1
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...  
WO/2019/119516A1
Disclosed are a tetramethylspiroindene skeleton-based bisoxazoline ligand compound, an intermediate thereof, a preparation method therefor, and a use thereof. The bisoxazoline ligand compound is a compound having a structure as shown in ...  
WO/2019/115597A1
Enantiopure terphenyl presenting two ortho-located chiral axes having the following structural formula (I) : their process of synthesis and their use as mono or bidentate ligands for asymmetric organometallic reactions, as organocatalyst...  
WO/2019/075084A1
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-l...  
WO/2019/060953A1
The present invention relates to chiral auxiliaries and the syntheses thereof and uses thereof.  
WO/2019/035775A1
A method for the preparation of tapentadol in the form of a base or its hydrogen chloride, which involves the preparation of a salt (III) from a mixture of diastereomers (II) by means of crystallization-induced asymmetric transformation ...  
WO/2019/035453A1
Provided is a catalyst represented by general formula (1). In general formula (1), R1-R14 each independently represent a hydrogen atom or a substituent.  
WO/2019/008358A3
The present invention provides a metallocenyl compound of formula (I). Ra, Rb, Rc, Rd, Re, Rf, M, m, n, j, k, Y and Z and * are as described in the specification. The invention also provides a process for the preparation of the complexes...  
WO/2018/207888A1
The present invention provides a method for simply and efficiently producing ramelteon, which is a sleep-inducing agent. According to the present invention, ramelteon can be produced through a few steps including a step in which (E)-2-[1...  
WO/2018/209243A1
The present disclosure provides methods for enantioselective synthesis of acyclic α- quaternary carboxylic acid derivatives via iridium-catalyzed allylic alkylation.  
WO/2018/189107A1
The present invention is related to a new chiral biphenyl diphosphine ligand of formula (I), wherein R1, R2, and R3 are independently H, alkyl or aryl; R6 and R7 is independently a substituent; and A is independently aryl or heteroaryl, ...  
WO/2018/189060A1
The invention comprises novel chiral metal complex compounds of the formula (I) wherein M, PR2, R3 and R4 are outlined in the description, its stereoisomers, in the form as a neutral complex or a complex cation with a suitable counter io...  
WO/2018/143165A1
The present invention provides a method for producing a compound represented by formula (VII), the method including reacting a compound represented by formula (VI) with a malonic acid derivative in the presence of a base and an asymmetri...  
WO/2018/106746A3
This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands  
WO/2018/106746A2
This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands  
WO/2018/106621A1
This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.  
WO/2018/099146A1
Disclosed is a method for asymmetrically synthesizing aspidosperma alkaloid. In this method, a key intermediate of formula (4) is obtained by 6 steps of reactions, including [4+2] cycloaddition of the compound of formula (1a) and the com...  
WO/2018/086197A1
The present invention relates to the field of organic syntheses, and provides a catalytic asymmetric synthesis method for a chiral SPINOL derivate, comprising: using chiral phosphoric acid as a catalyst and reacting same with a compound ...  
WO/2017/036577A8
The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound (I) a...  
WO/2018/021508A1
The present invention is a production method for a compound represented by formula [I] or a pharmaceutically acceptable salt thereof, or a hydrate of said compound or salt.  
WO/2017/197670A1
Disclosed in the present application is a method for synthesizing a 1,2-dimethylene cyclobutane chiral compound. The 1,2-dimethylene cyclobutane chiral compound is synthesized from an allenylamine compound in the presence of a rhodium co...  

Matches 1 - 50 out of 6,713