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WO/1996/002535A1 |
A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles as well as of other structurally related sulp...
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WO/1996/001995A1 |
A separating agent comprising a polysaccharide derivative having a molecular weight distribution of 1 to 3 in terms of Mw/Mn (wherein Mw and Mn represents, respectively, weight-average and number-average molecular weights thereof in term...
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WO/1995/033749A1 |
A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofo...
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WO/1995/032178A1 |
The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-hydroxyben
zoate using di-toluoyltartaric acid. The invention further relates to...
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WO/1995/031420A1 |
A separating agent which, when used as the packing material for reversed-phase liquid chromatography, is excellent in the stability of the base line in the mobile phase and is increased in the number of the steps of the detected peak in ...
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WO/1995/031436A1 |
A process and diastereomeric salts useful for the optical resolution of racemic 'alpha'-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmeth
yl)-1-piperidinebutanol, 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybuty
l]-'alpha'...
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WO/1995/029142A1 |
A method of separating optical isomer, by which optical resolution of an optical isomer mixture can be efficiently conducted by using a packing material which is inexpensive per se and has an excellent ability to separate optically activ...
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WO/1995/026950A1 |
Substituted phenyl compounds endowed with chain extension activity for formulations such as polyurethanes are disclosed, and which have general formula (I) wherein n is 1-1000 and m is 1-100; and R1 and R2 are each independently selected...
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WO/1995/023805A1 |
The title compounds are obtained by racemic resolution of D, L-homoalanin-4-yl-(methyl)phosphinic acid by precipitating out one of the diastereomeric salts with chiral bases such as quinine or cinchonine. The yield of desired enantiomers...
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WO/1995/022521A1 |
An optically active compound represented by general formula (1), a racemate thereof, and a pharmaceutically acceptable acid-addition salt thereof, wherein R represents either a C1-C5 (un)saturated linear or branched aliphatic group, or a...
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WO/1995/022390A1 |
Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis and chromatography. The macrocyclic antibiotics include ansamacrolides, macro...
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WO/1995/020590A1 |
The subject invention provides chiral receptor molecules useful for the purification of enantiomers of amino acid derivatives and other compounds. The subject invention also provides methods of preparing said receptor molecules.
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WO/1995/018833A1 |
Polysaccharide derivatives containing unsaturated substituents and aromatic substituents, and their use for preparing stationary chiral phases suitable for separating isomers of chemical compounds, are disclosed.
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WO/1995/017433A1 |
The use of mono-3,6-anhydro-cyclodextrins for solubilising a hydrophobic compound and monitoring the purity of an enantiomer is disclosed. Said mono-3,6-anhydro-cyclodextrin has formula (I), wherein n is 5, 6 or 7, preferably 6. The hydr...
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WO/1995/015953A1 |
The invention relates to novel substituted oxazolidines of formula (I) wherein R1 and R2 are simultaneously hydrogen or both together are the identical lower alkyl radical, and to the salts thereof in racemic and chiral form, to a proces...
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WO/1995/014934A1 |
A chiral shift reagent comprising a sugar derivative for 1H-NMR and 13C-NMR spectrometry, of which the starting material is readily available and the synthesis is easy and which has good performance. An analytical method which comprises ...
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WO/1995/009907A1 |
Disclosed is a method of separating a compound from a solution comprising passing the solution through at least one crystal of a biological macromolecule capable of selectively binding the compound.
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WO/1995/008529A1 |
Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using micellar capillary electrophoresis is disclosed. A chiral surfactant having general formula (I) is described. R1 is th...
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WO/1995/008522A1 |
A method of optical enantiomer resolution by preferential crystallization involves entering, each time crystallization starts, the two-phase domain containing excess enantiomer and the saturated solution, and cooling according to a well-...
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WO/1995/005879A1 |
A process for separating enantiomeric mixtures by liquid chromatography using a stationary phase that includes cellulose or amylose derivative and a mobile phase that includes methanol and pentane, the concentration of methanol in the mo...
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WO/1995/000492A1 |
Optical isomers of 4-(5-fluoro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole and pharmaceutically acceptable salts thereof, their use and preparation are described. Both isomers are potent in the treatment of cognitive disorders.
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WO/1995/000463A1 |
A polysaccharide derivative is immobilized on a carrier such as silicagel by cross-linking only the derivatives with each other by using a polyfunctional cross-linking agent. The optical isomer separating agent thus obtained is excellent...
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WO/1994/028040A1 |
Optically-active, amphiphilic, free-radical addition copolymers having an optically-active hydrophobic portion and an ionic hydrophilic portion are effective resolving agents. This utility is based on a unique combination of properties, ...
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WO/1994/027963A1 |
This invention relates to a process for the preparation of optically pure alkylated oxindoles which are useful in the preparation of enantiomers of physostigmine and physostigmine-like compounds having pharmaceutical activity.
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WO/1994/020493A1 |
A method for preparing N-methyl-2-(3-pyridyl) (1R,2R)-2-tetrahydrothiopyrancarbothioamide-1-oxide of formula (I) from a sel of a mixture of trans isomers (1S,2S) and (1R,2R) with an optically active acid.
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WO/1994/014746A1 |
The invention relates to a method for separating the ortho- and para-isomers of hydroxymandelic acid or a salt thereof. For that purpose the starting material is a solid mixture of these ortho- and para-isomers in the alkali metal salt f...
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WO/1994/014742A1 |
Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally s...
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WO/1994/012451A1 |
A process is provided whereby S(+)-ibuprofen or R(-)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity of L-lysine is not more than about a mola...
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WO/1994/012460A1 |
A process is disclosed for the production of a product which is enriched in a desired enantiomer of a phenylpropionic acid selected from ibuprofen and flurbiprofen, or their pharmaceutically acceptable salts, which comprises the followin...
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WO/1994/012275A1 |
Optically active adsorbents based on network polymerised derivatives of dicarboxylic acids, diamines or diols which are chemically bonded to a carrier. The derivatives can be polymerised by radical polymerisation or through hydrosilylati...
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WO/1994/011337A1 |
The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary ...
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WO/1994/011364A1 |
A process for preparing (+)-6-[(4-chlorophenyl)(1H_-1,2,4-triazol-1-yl)methyl]-1-met
hyl-1H_-benzotriazole comprising the resolution of (U)-6-[(4-chlorophenyl-hydrazinomethyl)-1-methyl-1H_-benzotr
iazole and converting the appropriate en...
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WO/1994/008937A1 |
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture of the aryl-substituted aliphatic carboxylic acid obta...
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WO/1994/008935A1 |
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process combines an aryl substituted aliphatic carboxylic acid, a base and water in an inert solvent to make a hyd...
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WO/1994/008934A1 |
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture of the aryl-substituted aliphatic carboxylic acid obta...
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WO/1994/008936A1 |
A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. In this process, the aryl-substituted aliphatic carboxylic acid is reacted with an inorganic base in the presence of a...
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WO/1994/007814A1 |
Proposed is a process for separating enantiomers from a racemic mixture by countercurrent extraction using at least two liquids of mutually differing chiralities, said liquids being wholly miscible and separated from each other by a phas...
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WO/1994/006743A1 |
The invention concerns compounds which are effective anti-epileptica but have only a low sedative or teratogenic action and which have formulae (I), (II), (III) or (IV), the compounds of formulae (I) and (II) may also have multiple unsat...
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WO/1994/006747A1 |
A method for resolving (U)-/alpha/-(3-benzoylphenyl)propionic acid is disclosed. The method comprises: i) converting said propionic acid with (-)-cinchonidine in a solvent comprising a mixture of an aliphatic ester and an alkyl alcohol; ...
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WO/1994/003457A1 |
A process for the preparation of (-)-eserethole, of formula (I) starting from (U)-eserethole, or from mixtures of (+)-and (-)-eserethole in which the latter enantiomer prevails, by treating (U)-eserethole or mixtures of (+)- and (-)-eser...
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WO/1994/002226A1 |
Solid substrates with free hydroxyl groups as phosphorylated by thermolysing a solution of phosphoramidate of formula (I), in the presence of the substrate, whereby metaphosphate is generated which phosphorylates the substrate.
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WO/1994/000408A1 |
A high performance chiral selector having formula (I) whereinAr is a monocyclic or ortho-fused polycyclic aromatic moiety having up to 10 ring carbon atoms, either of which may be unsubstituted or substituted with one or more C1 to C6 al...
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WO/1994/000455A1 |
The present invention relates to a composition having general formula (I), wherein each of A, B, C, X, Y, and Z is independently O, NH, N(CH2)mCH3, N(C=O)(CH2)mCH3, CH2, S, or Se; each of R1, R2, and R3 is indepently phenyl, 4-hydroxyphe...
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WO/1993/023394A1 |
The object of the present invention is a process for producing optically pure S-timolol or its derivatives wherein racemic R,S-timolol, or its racemic derivative, at elevated pressure and dissolved in carbon dioxide is periodically fed t...
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WO/1993/022269A1 |
3(S)-methylheptanoic acid is prepared by fractional crystallization of the salt of racemic 3-methylheptanoic acid with (S)-alpha-methylbenzyl amine followed by acidification.
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WO/1993/021176A1 |
Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cy...
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WO/1993/020052A1 |
(S)-$g(a)-phenyl-2-pyridineethanamine, and its pharmaceutically acceptable derivatives, are useful in the treatment of neurodegenerative disorders, and exhibit linear pharmacokinetics.
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WO/1993/017022A1 |
The (6S_) stereoisomer of folinic acid is obtained in high optical purity by salification of (R, S) folinic acid with di- or polyamines and subsequent selective crystallization of the desired diastereomeric salt.
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WO/1993/017055A1 |
Polymer particles having a hydrophobic core and various surface functional groups, particularly hydrophilic and chiral surface functional groups, are produced by adding a non-emulsified functional polymerizable monomer to the aqueous pha...
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WO/1993/016035A1 |
The method proposed for separating racemates of verapamil is characterized in that the free base of the compound is reacted with optically active dibenzoyltartaric acid or ditoluoyltartaric acid in the molar ratio 1:1 to 1:2 in a mixture...
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