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WO/1993/016074A1 |
A novel isoindolinone derivative of formula (I) in racemic form or in the form of its enantiomers; preparation thereof; and pharmaceutical compositions containing same. The novel product of formula (I) is useful in therapeutics as an anx...
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WO/1993/015039A1 |
A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. In this process: i) a solid racemic mixture of an aliphatic carboxylic acid or ester thereof having formula (I), wher...
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WO/1993/015037A1 |
An improved process for the separation of enantiomers of a mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves adding in inert liquid to the reaction solution formed by: (i) forming a salt s...
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WO/1993/015038A1 |
An improved process for the separation of enantiomers of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves adding a mixture of the aliphatic carboxylic acid to the material forme...
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WO/1993/015040A1 |
An improved process for the separation of enantiomers of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves: (i) forming a salt solution comprising said racemic mixture of a C1 to...
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WO/1993/014056A1 |
A process is disclosed that is useful for separating the enantiomers of a racemic mixture of an aliphatic carboxylic acid having formula (I), where R1 is hydrogen or alkyl, R2, R3 and R4 are independently different and are hydrogen, alky...
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WO/1993/013087A1 |
A process for the resolution of (+-)-alpha-[2-[acetyl(1-methylethyl)amino]ethyl]-alpha-(2-ch
lorophenyl)-1-piperidinebutanamide having structure (I) into its (+) and (-) enantiomers using camphorsulfonic acid.
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WO/1993/013053A2 |
A process for obtaining an isomer of a compound of the general formula (I): R-CH(CN)-R', wherein each of R and R' may be any organic radical linked directly or through a heteroatom to the carbon atom bearing the cyano group provided that...
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WO/1993/013034A1 |
A process for separating a selected amino acid (enantiomer) from a mixture of different compounds including other amino acids is disclosed, in which process the mixture is contacted with a polymer material which is composed of cross-link...
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WO/1993/012054A1 |
This invention relates to certain salts of leukotriene antagonists and the use of a particular amine to form these salts as a means for selectively crystallizing optical isomers of the leukotriene antagonists disclosed herein.
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WO/1993/012062A1 |
A novel multi-step process for preparing the (4S_-enantiomer of 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone in a highly-optically pure form is disclosed. The process involves (1) first esterifying 4-(3,4-dichlorophenyl)-4-keto...
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WO/1993/010118A1 |
Described is a method of preparing (6S)-5-methyl-tetrahydrofolic acid by separation of the racemic mixture, (6R,S)-5-methyl-tetrahydrofolic acid, using a base, characterized in that N-ethyl-2-aminomethylpyrrolidine or one of its optical ...
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WO/1993/008903A1 |
A process is disclosed for separating enantiomers by an electrokinetic process in capillary columns, using surface-immobilized chiral components. The chiral component used may be a polysiloxane to which alkylated cyclodextrine (alpha, be...
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WO/1993/009075A1 |
A method for separating enantiomers of derivatives of aryloxipropanolamines is disclosed. In the method, the derivative is contacted with a chiral solid-phase chromatography material containing molecular imprints of an optically pure ena...
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WO/1993/008162A1 |
The present invention is directed to a compound of formula (I), wherein R represents a hydrogen atom or an acyl, aroyl or cycloalkylcarbonyl radical or a residue of formula (Ia); R1 represents an alkyl radical; R2 represents an aryl or h...
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WO/1993/007135A1 |
3-(N-isopropyl-N-n-propylamino)-5-(N-isopropyl)carbamoylchro
man having formula (I), as racemate, (R)-enantiomer in the form of free base or pharmaceutically acceptable salts thereof. The object of the present invention is to provide com...
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WO/1993/007104A1 |
A carrier and a column for high-performance liquid chromatography having an ability to separate optical isomers. A separating agent for optical isomers is prepared by chemically bonding conalbumin to a carrier such as silica gel or synth...
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WO/1993/006080A1 |
The invention relates to a chiral selector useful in separating underivatized enantiomers of non-steroidal anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such s...
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WO/1993/005004A1 |
A compound represented by general formula (I) and a separating agent comprising the same. In formula (I), Ar and Ar' represent each an aromatic group and two substituents on the central benzene ring may be positioned ortho, meta or para ...
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WO/1993/004022A1 |
A method of recovering and reusing a solvent and an optical isomer, characterized by providing a packed bed, which is disposed in the passage for circulating a solvent and packed with a packing material for optical resolution, with a por...
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WO/1993/002079A1 |
Optically pure thiazolidinedione alcohols and ethers, and synthetic intermediates for preparing said alcohols and ethers. These compounds have utility as hypoglycemic and hypocholesterolemic agents.
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WO/1993/001190A1 |
A novel 2-amino naphthyridine derivative having formula (I), optical isomers and salts thereof, and its preparation. The product of formula (I) is particularly useful for preparing the eutomer of the product of formula (II), which has re...
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WO/1993/001156A1 |
A process for obtaining a substantially pure enantiomer of ibuprofen is described. The process utilizes first an enantiomerically enriched mixture of ibuprofen obtained from kinetic resolution, diastereomeric crystallization or asymmetri...
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WO/1993/001167A1 |
Compounds of formule (I), salts thereof, the preparation thereof, and drugs containing same.
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WO/1993/000330A2 |
The present invention relates to novel azanorbornane derivatives having formula (I), wherein R1 through R12 are as defined in the description, and to novel intermediates used in their synthesis. The compounds having formula (I) are usefu...
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WO/1992/020334A1 |
The use of S(-)sodium 2-(4-isobutylphenyl)propionate (the sodium salt of S(+)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described. Preferred compositions comprise S(-)sodium 2-(4-iso...
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WO/1992/019684A1 |
Pyridone dyes of formula (I), wherein R?1� stands for hydrogen or C�1?-C�4? alkyl, R?2� and R?3� may be identical or different and independently stand for hydrogen, optionally substituted C�1?-C�12? alkyl, C�5?-C�7? cyc...
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WO/1992/018455A1 |
A method for resolving (+)-/alpha/-(3-benzoylphenyl)propionic acid is disclosed. The method comprises: (i) converting said propionic acid with (-)-cinchonidine in a solvent comprising a mixture of an aliphatic ester and an alkyl alcohol;...
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WO/1992/016536A1 |
New racemic, optically active phosphorous compounds have the formula (I), in which R stands for lower alkyl, lower alkoxy or a protected hydroxy group; R1 stands for a 5-membered heteroaromatic compound; R2 stands for lower alkyl or lowe...
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WO/1992/016274A1 |
In a continuously operated counter-current chromatography process, relative displacement between the adsorber, composed of a solid phase, and a liquid movable phase, in successively linked chromatography columns, is obtained by successiv...
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WO/1992/015617A1 |
A novel polysaccharide derivative prepared by replacing part or the whole of the hydroxyl or amino groups of a polysaccharide by two or more different substituents, and a separating agent and a separator both containing this derivative. ...
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WO/1992/015616A1 |
A compound prepared by chemically bonding at least one hydroxyl group of the 2-, 3- and 6-hydroxyl groups of a cyclic oligosaccharide derivative to a carrier through a spacer (except one wherein the 6-hydroxyl group is bonded to a carrie...
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WO/1992/013872A1 |
Compounds of general formula (I) in the form of a 22R and 22S epimer, wherein X1 and X2 are the same or different and each represents a hydrogen atom or a fluorine atom, provided that X1 and X2 are not simultaneously a hydrogen atom, pro...
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WO/1992/013823A1 |
A compound of formula (I), or a salt or solvate thereof, in which R1 and R2 each independently represents hydrogen, alkyl, optionally substituted aryl or optionally substituted aralkyl; R3 represents alkyl, optionally substituted aryl or...
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WO/1992/012152A1 |
Azabicyclo[2.2.2]octan-3-imines of general formula (I), wherein R1, R2 and R3 are as defined herein are prepared by reacting a compound of formula (II) with a compound of formula (III), wherein A is MgCl, MgBr or Li.
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WO/1992/012180A1 |
Novel cyclodextrin and epichlorohydrin based polymers are obtained by adding an epoxy-ammonium salt to a cyclodextrin-epichlorohydrin polycondensate wherein the ratio of cyclodextrin to epichlorohydrin is 1:3 to 1:10 and the proportion o...
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WO/1992/012135A1 |
Optically substantially pure (-) enantiomer of [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]
hydrazono]propanedinitrile or pharmaceutically acceptable salt thereof, intermediates and a process for the preparation are descr...
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WO/1992/008702A1 |
A method for resolving chiral hydantoins having general formula (I), wherein R1 is a lower alkyl radical having 1-5 carbon atoms in a linear or branched chain; and R2 is a phenyl radical which is optionally mono-, di- or trisubstituted b...
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WO/1992/005151A1 |
This invention relates to salts of formula (I) where, A is 1 and X is 1 or 2; R1 is C8 to C13 alkyl, C7 to C12 alkoxy, C7 to C12 alkylthio, C10 to C12 1-alkynyl, 10-undecynyloxy, 11-dodecynyl, phenyl-C4 to C10 alkyl, phenyl-C3 to C9 alko...
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WO/1992/003404A1 |
Process for transforming (benzoyl-3 phenyl)-2 propionic-R(-) acid into an S(+) isomer through the action of a base either in situ during the splitting of racemic ketoprofen or on the crystallization mother liquor of a (benzoyl-3 phenyl)-...
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WO/1992/002283A1 |
The media is an ether derivative of cyclodextrin such as a permethylated hydroxy ether of cyclodextrin or a dialkyl trifluoroacetyl ether derivative of cyclodextrin and is used in capillary gas chromatographic columns. Particular benefit...
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WO/1992/000965A1 |
1R-cis,1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis-(1,2,3,4-tetrah
ydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium) salt, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis...
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WO/1992/000275A1 |
The description relates to a process for producing enantiomer-pure $g(a)-hydroxypropionoaldehyde derivatives of the general formula (I) in which: R¿1? is the substituent Q which may be a hydrocarbon radical interrupted by oxygen atoms, ...
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WO/1991/018878A1 |
Novel processes are disclosed for the preparation and resolution of substituted piperidines of formula (I), wherein R1 and R2 are defined as below, and related compounds, as well as novel intermediates used in such processes.
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WO/1991/018910A1 |
A compound of general formula (I), in which each of R1, R2, R3 and R4 independently represent a hydrogen atom or a group -(CO)nR5 in which n is 0 or 1 and R5 represents an alkyl, aryl, cycloalkyl, alkaryl or aralkyl group, or R1 or R2 to...
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WO/1991/017816A1 |
The invention relates to a process for the high yield, cost efficient means of separating enantiomers. The process utilizes a supported liquid membrane and a chiral carrier which selectively complexes with one of the two enantiomeric opt...
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WO/1991/017977A1 |
Process for the stereoselective preparation of phenylisoserin derivatives of general formula (I) from benzylamine. In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is a hydroxy function protective group.
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WO/1991/017159A1 |
(-)-4-Amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyr
imidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulations thereof, methods for its preparation and its use as an antiviral agent are described.
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WO/1991/015471A1 |
A process is disclosed for the isolation of an enantiomerically enriched alcohol from a first mixture of an enantiomerically enriched alcohol and an enantiomerically enriched ester. The process includes the steps of: (a) contacting the m...
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WO/1991/015472A1 |
A process is disclosed for the separation of an enantiomerically enriched 1-tosyloxy-2-acyloxy-3-butene and an enantiomerically enriched 1-tosyloxy-2-hydroxy-3-butene from a first mixture containing both compounds. The process includes t...
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