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WO/2017/156256A1 |
Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically inclu...
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WO/2017/144635A1 |
The invention relates to a process for preparing either enantiomer of a compound of formula (I), wherein X, Y and n have the meaning given in claim 1, with high enantiomeric excess (e.e.), by chiral resolution in the presence of a non-ra...
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WO/2017/145124A1 |
The present disclosure relates to a process for separation of enantiomers of the amino acid from a racemic mixture. The process comprises electrolyzing the first electrolyte having 1 molar solution of lithium perchlorate and 0.01 molar s...
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WO/2017/082396A1 |
The purpose of the present invention is to provide a method for the industrial production of lacosamide having high optical purity at a high yield, inexpensively, and safely. Provided is a method for the industrial production of lacosami...
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WO/2017/024980A1 |
Disclosed is a crystallization separation method for a nebivolol hydrochloride intermediate mixture, which comprises the following steps: step 1, adding an alcohol solvent or a mixed solvent of an alcohol and an alkane to a nebivolol hyd...
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WO/2017/002712A1 |
The present invention provides an industrially practicable method for producing a fluorine-containing cyclopropane carboxylic acid compound that is useful as an intermediate for pharmaceuticals and agrochemicals. A fluorine-containing cy...
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WO/2016/188945A1 |
The present invention relates to the field of separating chiral isomers from each other. Particularly, it relates to the field of separating of chiral isomers of chromane or chromene compounds, particularly tocopherols, 3,4-dehydro-tocop...
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WO/2016/182083A1 |
Provided is a separating agent for optical isomers, which is configured of a novel xylan derivative and a carrier. Specifically provided is a separating agent for optical isomers, which is configured of a carrier and a xylan-phenylcarbam...
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WO/2016/100576A9 |
The invention relates to methods of separating Trolox isomers (R)-Trolox and (S)-Trolox, comprising: (a) contacting a mixture of (R) and (S)-Trolox with a resolving agent selected from the group consisting of (1S,2S)-(+)-Pseudoephedrine,...
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WO/2016/157219A1 |
The present invention relates to a novel polyfluorene appended with protected glutamic acid of Formula (I) for heterogeneous enantioselective separation and sensing of amino acids, amino alcohol, hydroxyl acid, sugar, aromatic drug and a...
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WO/2016/146299A1 |
A process to isolate a compound of Formula (2a) or a salt or solvate thereof, comprising a) reacting a mixture of diastereoisomers of Formulae (2a, 2b) with a basic heterocyclic-aldehyde compound and an optically active amine in the pres...
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WO/2016/116075A1 |
A method of isolation of the E1 and E2 optical isomers, forming an enantiomeric mixture, from a mixture of four optical isomers E1, E2, E3, E4, wherein the enantiomeric mixture of E3 and E4 is first separated from the solution and subseq...
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WO/2016/116073A1 |
A method of performing isolation and purification of bedaquiline (la) from a mixture of stereoisomers of 6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(l-naphth
yl)-l- phenyl-butan-2-ol identified as I-rac, being a mixture of the st...
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WO/2016/088138A1 |
The present invention discloses substituted diphenyloxiranes and process for synthesis thereof. The present invention also provides a process for production of enantiomerically pure anti-3,3'-diphenylmethyloxirane and anti-3,3'-diphenylp...
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WO/2016/047644A1 |
Provided is a production method for an optically active α-trifluormethyl-β-amino acid derivative whereby: a compound indicated by general formula (1) and a compound indicated by general formula (2) are reacted in the presence of a copp...
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WO/2016/039662A1 |
A method for the phase transfer of inorganic colloid semiconductor nanocrystals relates to the field of nanotechnology, and specifically to the enantioselective phase transfer of hydrophobic inorganic nanocrystals from an organic phas...
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WO/2016/031736A1 |
As a result of this pyridine derivative represented by general formula (1), or a salt thereof, a catalyst is provided which is capable of shortening reaction time and achieving high product selectivity in asymmetric Steglich reactions of...
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WO/2016/021711A1 |
The present invention addresses the problem of providing a method for inexpensively, stably and industrially producing, at high yields, lacosamide having high optical purity. The abovementioned problem is solved by providing a method for...
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WO/2016/016196A1 |
The present invention relates to a process for the preparation of an enantiomerically pure of 4-phenyl-6-methyl-2-thiazol-2-yl-1,4-dihydropyrimidine-5-car
boxylic acid ester of formula (la), wherein R1 is phenyl once, twice or more times...
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WO/2015/194157A1 |
[Problem] To provide a technique relating to a novel manufacturing method for a diphenylsulfide derivative. [Solution] An optical resolution method for subjecting a compound represented by general formula (6) to optical resolution using ...
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WO/2015/174377A1 |
The objective of the present invention is to provide a method for producing a compound represented by formula (1) or the like, said compound being a 2-pyridone compound that is useful as a pharmaceutical product or a pharmaceutical inter...
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WO/2015/171003A1 |
The present invention provides a new process for obtaining optically active pirlindole enantiomers, in the form of a free base or in the form of pharmaceutically acceptable salts. The products obtained according to the present invention ...
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WO/2015/152128A1 |
Disclosed is an amino acid that can be prevented from being incorporated into normal cells and selectively incorporated into tumor cells, even when used in a PET diagnostic tracer. Also disclosed are an amino acid precursor, a production...
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WO/2015/145302A1 |
The present invention provides an improved process for the preparation of exametazime, which is used as ligand in preparation of technetium-99m complex. Formula (I)
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WO/2015/118793A1 |
Provided is a method for producing (R)-1,1,3-trimethyl-4-aminoindane, the method including the following steps (A), (B) and (C). (A): A step of optically resolving 1,1,3-trimethyl-4-aminoindane so as to obtain (R)-1,1,3-trimethyl-4-amino...
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WO/2015/070995A1 |
The present invention relates to a process for the preparation of optically pure ( R) -1-aminoindan by a diastereomeric resolution of 1-aminoindan using N-acetyl-L-glutamic acid as a resolving agent. In another aspect, the invention rela...
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WO/2015/064453A1 |
The present invention addresses the problem of providing a simple method for producing, at a high yield, an optically active D-form and/or L-form amino acid derivative having a thiol group in a side chain. Provided are: a method for prod...
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WO/2015/030010A1 |
The present invention provides a method for producing an atropisomer of a pyrrole derivative having an exceptional mineralocorticoid receptor antagonizing effect, and an intermediate thereof. A method for producing an atropisomer of a py...
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WO/2015/005298A1 |
The purpose of the present invention is to provide a high purity optically active bicyclic γ-amino acid derivative. The means for accomplishing this purpose is a method for producing a compound represented by general formula (VII), or a...
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WO/2015/001868A1 |
According to the present invention, a ketone derivative (I) and a sulfur ylinde are reacted in a hydrocarbon solvent to obtain an oxirane derivative (II), whereby selectivity to one geometric isomer is improved.
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WO/2014/196623A1 |
Provided is (+)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin-1(2H)-y
l)methyl]imidazolidine-2,4-dione or a salt thereof. Also provided is a drug containing as the active ingredient (+)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin...
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WO/2014/157607A1 |
Provided is a method for improving the optical purity of optically active 2-hydroxycarboxylic acids that are useful as raw materials in the manufacture of drugs, agricultural chemicals, and industrial products. A method for improving the...
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WO/2014/147395A1 |
The present invention relates to materials, methods and kits for detecting and identifying glycated species, in particular methods in which glycated species are first labelled and then subjected to a separation step, following which the ...
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WO/2014/139086A1 |
The present invention relates to the field of chemical synthesis, and discloses a preparation method of ambrisentan. In the preparation method, using (S)-phenethylamine as a resolving agent, to form two diastereomers with 2-[(4,6-dimethy...
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WO/2014/128523A1 |
The present invention relates to a process for the preparation of a key intermediate (as described herein) used in the synthesis of (+)-trans enantiomer of pyrrolidine substituted flavones, represented by the compounds of formula (1) or ...
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WO/2014/126028A1 |
The present invention pertains to an optically active poly(diphenylacetylene) compound represented by formula (I) (the symbols in the formula are as indicated in the description), a preparation method therefor, an optical isomer separati...
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WO/2014/125667A1 |
The present invention provides an optical isomer separating agent and a preparation method therefor. Specifically, the present invention pertains to a single-handed helical poly(diphenylacetylene) compound represented by formula (I) (the...
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WO/2014/119731A1 |
Provided is a method for producing D-alloisoleucine in a fewer steps and with high yield by an asymmetric transformation reaction of L-isoleucine. A method for producing D-alloisoleucine, involving a step of allowing a tartaric acid deri...
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WO/2014/103998A2 |
The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin receptor 1 MT1 antagonist, and a method for efficiently manufacturing a specific m-tyrosine derivative in which an iodine atom is i...
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WO/2014/087937A1 |
Provided is a separating agent which comprises a carrier and a ligand that is supported on the surface of the carrier by means of a chemical bond. This separating agent is characterized in that: the carrier is a core-shell particle that ...
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WO/2014/046172A1 |
A method that enables isoxazolidine compounds to be produced at high yields is provided. A compound (1) is converted into a compound (2) in the presence of a tertiary amine catalyst having a hydrogen bond donor site within a molecule. (E...
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WO/2014/034957A1 |
A method for producing a methanol solvate of a D-tartrate of (R)-1,1,3-trimethyl-4-aminoindane characterized by including the following steps (a), (b), and (c) and by mixing water into the reaction system prior to step (c). Step (a): a s...
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WO/2014/009964A1 |
The invention discloses a process for enantiomeric enrichment of 2',6'-pipecoloxylidide using a chiral carbamoyl benzoic acid to provide (S)-enantiomer in high yield and high enantiomeric purity. The invention also discloses novel interm...
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WO/2013/160926A1 |
The invention concerns a procedure for the separation of optical isomers or for the production of an enantiomeric excess from a racemic mixture or from a mixture having any composition of D and L enantiomers, through direct crystallizati...
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WO/2013/154066A1 |
The problem addressed by the present invention is to efficiently produce an optically active bicyclic compound. The present invention efficiently produces an optically active bicyclic compound using an enzyme.
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WO/2013/089189A1 |
An optically active bicyclic compound is efficiently produced by performing optical resolution using an optically active amine.
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WO/2013/089188A1 |
An optically active bicyclic compound is efficiently produced by performing optical resolution using an optically active amine.
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WO/2013/081087A1 |
A method for preparing trans-{4-[({2-[({1-[3,5-bis(tri- fluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]- pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}- (ethyl)amino)methyl]cyclohexyl}acetic acid having a high optical pu...
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WO/2013/069025A1 |
The invention discloses a novel process for preparation of dexmedetomidine in higher yield and with enantiomeric purity more than 99%.
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WO/2013/061515A1 |
[Problem] The present invention provides: a composition for imparting a cooling sensation, which contains 3-menthoxy propanol; and a method for producing 3-menthoxy propanol with high selectivity and high yield using 3-menthoxy-1,2-epoxy...
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