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WO/2010/009630A1 |
Disclosed is a process for preparing chiral pharmaceutical intermediates of R-beta-amino phenylbutyric acid derivatives (I) and the pharmaceutically acceptable salts thereof, which affords the desired object compounds having specific opt...
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WO/2010/000634A1 |
The present invention relates to a process for the isomerization of the Z-isomer I-Z of a semicarbazone compound of the general formula (I) into its E-isomer I-E wherein the variables in formula (I) have the meanings as defined in the de...
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WO/2010/001103A1 |
There is described a process for the manufacture of a racemic 2-aryl propionic acid compound, or a pharmaceutically acceptable salt thereof, which comprises reacting the S- or R- enantiomer of the corresponding 2-aryl propionic acid comp...
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WO/2009/142194A1 |
Disclosed is a production method which enables mass synthesis of an aminoalcohol derivative with high optical purity at low cost. For example, a compound represented by the general formula is recrystallized during the production procedur...
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WO/2009/137853A1 |
An enantioselective zwitterionic ion-exchange material comprising a chiral selector component (SO) comprising at least one cation exchange group and at least one anion exchange group and a carrier, carrying said selector component, where...
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WO/2009/134737A1 |
A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
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WO/2009/119700A1 |
Provided is a manufacturing method for a piperidine-3-ylcarbamate compound in which a pyridine-3-ylcarbamate compound and hydrogen are brought into contact in the presence of a palladium catalyst.
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WO/2009/113428A1 |
Disclosed is a method for producing an optically active ester by highly selectively esterifying one enantiomer of a racemic carboxylic acid, while producing an optically active carboxylic acid which is the other enantiomer. An optically ...
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WO/2009/107571A1 |
Disclosed is a method for optical resolution of an alkylpiperidin-3-yl carbamate, wherein an RS mixture of an alkylpiperidin-3-yl carbamate is brought into contact with an optically active tartaric acid in the presence of a solvent.
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WO/2009/098935A1 |
Disclosed is a method for purifying an optically active 1-(2-trifluoromethylphenyl)ethanol, which includes recrystallization of an optically active 1-(2-trifluoromethylphenyl)ethanol represented by formula [1] (wherein * represents an as...
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WO/2009/094569A2 |
Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamates are disclosed. These carbamates can be coupled to drugs containing amines such as R-baclofen or S-pregabalin.
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WO/2009/090957A1 |
Optically active organosulfonic acid salts of optically active [4-(2-diphenylphosphanylnaphthalen-1-yl)phthalazin-1-yl]-(1-
phenylethyl)amines represented by formula (1) to (4); and a process for production of the same.
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WO/2009/087959A1 |
Disclosed are an optically active 2,2'-biphenol derivative and a method which enables simple and efficient production of the compound. Specifically disclosed are an optically active biphenol derivative represented by Formula (1) or (2); ...
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WO/2009/080708A1 |
Use of enantiopure N-sulphonyl pyroglutamic acid as resolving agent for the separation of enantiomers by crystallization or precipitation.
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WO/2009/075359A1 |
It is intended to achieve a method of separating isomers of chiral substances which is non-contact and does not use a chemical reaction by irradiating chiral substances C with light such as circular polarized light and separating isomers...
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WO/2009/067904A1 |
Methods for resolution of the mixture of the optical isomers, especially the racemate of pinocembrin, using chiral primary amines or chiral sulfenamides. (R)-(+)-pinocembrin obtained by said methods.
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WO/2009/047408A1 |
The invention relates to a method for the continuous crystallisation of a mixture of stereo-isomers and a resolution agent in a solvent, said mixture and resolution agent being injected into a continuously stirred reactor and the crystal...
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WO/2009/025791A2 |
The invention encompasses processes for obtaining pure armodafinil substantially free of disulfide impurities that is suitable for use on an industrial scale. In particular, a processes for purifying armodafinil from bis(diphenylmethyl)d...
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WO/2009/025169A1 |
A method for purification of an optically active α-fluoro- carboxylic acid ester represented by the general formula [1] by removing fluoride ions from the ester to reduce the amount of fluoride ions contained in the ester: [Chemical for...
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WO/2009/016251A1 |
The present invention refers to a process for the resolution into one of its enantiomers of the racemate of compound of formula (I): which comprises separating said one of its enantiomers from a diastereoisomeric salt of formula (II), wh...
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WO/2009/008303A1 |
Disclosed is a process for producing optically active mirtazapine with a high degree of efficiency. Specifically disclosed is a process for producing optically active mirtazapine by optically resolving an R/S mixture of mirtazapine with ...
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WO/2008/155752A1 |
The present invention provides an improved method for obtaining cisatracurium besylate, which preferably includes chromatographically separating cisatracurium besylate from a mixture of (1R,1'R)-atracurium isomers via flash chromatography
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WO/2008/156095A1 |
Disclosed is a method for producing an optically active trans-2-aminocyclohexanol which is characterized in that a trans-2-aminocyclohexanol in a racemic form and an optically active 2-methoxyphenyl acetic acid are reacted and then an op...
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WO/2008/152497A1 |
The present invention relates to a method for differentiating and quantifying the enantiomers, thereby determining the enantiomeric purity, of darifenacin and its intermediate compounds and salts thereof. In addition, the invention relat...
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WO/2008/148912A1 |
The invention relates to a novel method and a device for producing crystals from a substance. According to said method: (i) a saturated dissolution of the substance to be crystallised is prepared in a suitable solvent in a reaction vesse...
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WO/2008/150000A1 |
Disclosed is a novel method for producing an optically active form of etodolac. Specifically disclosed is a method for producing an optically active form of etodolac at a high productivity rate, at a low cost and in a simple manner. The ...
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WO/2008/146826A1 |
A process for efficiently and economically producing an optically active styrene oxide compound having a target configuration. The process for producing an optically active styrene oxide compound comprises subjecting a racemate of a styr...
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WO/2008/143925A1 |
A process for separating the diastereomers of a compound such as dihydrodecafluoropentane by using an ionic liquid to increase separation efficiency. The process may involve separation of thethreo and erythro diastereomers of HFC-4310mee...
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WO/2008/144198A1 |
High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrop...
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WO/2008/140074A1 |
Disclosed is a method for producing an optically active carboxylic acid ester directly from a racemic secondary alcohol and a carboxylic acid. Also disclosed is a method for optically resolving a racemic secondary alcohol in the same met...
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WO/2008/136527A1 |
Disclosed is a method for purifying an optically active dioxopyrrolidine derivative represented by the general formula (I): (I) wherein R1 represents a lower alkyl which may have a substituent; X represents a hydrogen atom or R2NH- [wher...
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WO/2008/117271A1 |
Provided is a method for separating cisatracurium from a mixture of atracurium isomers, which method includes eluting from a Reverse Phase (RP) stationary phase with a mobile phase in which the isomers are stable. The method of the prese...
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WO/2008/111631A1 |
Disclosed is an important production intermediate for an optically active phthalazinone derivative [1], which is useful as a pharmaceutical product, or a pharmaceutically acceptable salt thereof. Also disclosed are a method for producing...
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WO/2008/107887A2 |
The present invention provides an improved method of chromatographically separating the isomers of (lR,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably p...
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WO/2008/102920A1 |
Disclosed is an optical isomer separating filler having separation performance/separation characteristics different from those of conventional optical isomer separating fillers, which is capable of separating an optical isomer which cann...
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WO/2008/102720A1 |
The invention is directed to a method for producing optically active 3-aminopiperidine or a salt thereof, in which racemic nipecotamide is converted into optically active nipecotamide and optically active nipecotic acid by stereoselectiv...
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WO/2008/102671A1 |
Disclosed is a method for easily isolating/purifying and separating/removing (2S,3R,4S)-4-hydroxyisoleucine with high purity and high yield. Specifically disclosed is a method for purifying (2S,3R,4S)-4-hydroxyisoleucine or a chemically ...
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WO/2008/099730A1 |
Disclosed is a novel optical resolving agent for an amine compound, which can be produced on an industrial scale in a simple manner and at low cost. An optically active 2-(aroyloxy)propionic acid can be used as an optical resolving agent...
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WO/2008/072773A1 |
Disclosed is a production method comprising the steps (A)-(E) below, which enables to commercially and safely produce (1R,2R)-2-amino-1-cyclopentanol or a hydrochloride thereof.
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WO/2008/070909A1 |
The present invention relates to a process for obtaining the R-enantiomer of salbutamol from a mixture of the enantiomers of salbutamol by a crystallization of said R-enantiomer as its salt with R-ibuprofen from a solution or slurry of a...
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WO/2008/053652A1 |
A process for producing 1-hydroxy-4-aminoadamantane shown below. wherein R1 and R2 independently represent a hydrogen, a halogen, a carboxy, a nitro, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylsulfonyl...
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WO/2008/038300A1 |
The present invention provides an organic-inorganic hybrid chiral sorbent for chiral resolution of various racemic compounds viz. racemic mandelic acid, 2- phenyl propionic acid, diethyl tartrate, 2,2'-dihydroxy-1,1 '-binaphthalene (BINO...
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WO/2008/029785A1 |
Disclosed is a polysaccharide derivative containing a structure wherein hydrogen atoms in a hydroxy group or amino group at the 2-position and the 3-position of a structural unit of polysaccharide are substituted with different substitue...
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WO/2008/019055A2 |
Optically pure 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is prepared. The 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is particularly useful for preparing solifenacin succinate.
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WO/2008/015689A1 |
A process for the preparation of optically pure R (-) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate...
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WO/2008/012047A1 |
The present invention relates to a process for the preparation of (1 R,2R)-3- dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
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WO2007092264B1 |
The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 12, 24, 48, 96 or more samples is ...
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WO/2007/111706A2 |
The present invention relates to a process for the synthesis of (S)-2'[2-1-(methyl-2-piperidyl) ethyl] cinnamanilide (I) or salts or pharmaceutically acceptable prodrugs thereof.
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WO/2007/105729A1 |
Disclosed are: a process for production of 3-amino-2-hydroxyhexanoic acid cyclopropylamide with high efficiency, which is suitable for the production in an industrial scale; an intermediate compound useful for the process; and a process ...
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WO/2007/103221A2 |
The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the ...
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