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WO/1999/047475A1 |
The invention concerns a method for separating $i((d/l)) and $i((meso)) diastereoisomers of bis-[1-phospha- 2,3-diphenyl- 4,5-dimethylnorbornadiene]. The invention also concerns a method for preparing optically active diphosphines of bis...
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WO/1999/047228A1 |
The invention concerns a method for separating from a mixture two optical isomers using a simulated mobile bed, consisting of an assembly of columns (C1,C2,C3,C4, C5,C6,C7,C8) divided into at least three successive zones (I, II, III). Sa...
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WO/1999/043668A1 |
Novel $g(b)-diketone compounds represented by general formula (3); and coordination compounds obtained by modifying the $g(b)-diketone compounds with a metal through coordination. The compounds can be easily synthesized. The compounds ca...
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WO/1999/042192A1 |
The invention relates to capillaries packed with particulate sorbents, having a constant inner diameter along the entire length. The bed of the sorbents is defined by hardened areas generated by thermal treatment. The invention especiall...
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WO/1999/038594A1 |
The invention relates to a method for separating substance mixtures by chromatography using spherical microparticles consisting of chemically and physically unmodified, water-insoluble, linear polysaccharides.
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WO/1999/021811A1 |
A method of separating optical isomers which permits optical resolution of compounds which have been incapable of satisfactory optical resolution under the conventional reversed-phase conditions. Specifically a method of separating optic...
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WO/1999/018052A1 |
A separating agent for optical isomers which has a high suitability for use as a reagent for optical resolution inherent in polysaccharide derivatives and also a solvent resistance and is capable of being produced through short process s...
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WO/1998/054228A2 |
This invention relates to molecularly imprinted polymers (MIPs) using an amide as the hydrogen bonding functional group. The amide MIPs made according to this invention exhibited enantiomeric recognition of the imprinted species when eva...
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WO/1998/049124A1 |
The invention relates to a novel method for producing enantiomer-free biarylketocarboxylic acids, whereby S-phenylethylamine is used as an auxiliary base in racemate resolution. Biarylketocarboxylic acids, specially substituted biaryl-4-...
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WO/1998/045230A1 |
The present invention describes the use of optically active polymers made from N-acryloyl-phenylalanine-neomenthylamide per se, in cross-linked form and/or bonded to a carrier, as stationary phases for chromatographic enantiomer separati...
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WO/1998/045240A1 |
A highly efficient method for enriching the chiral purity of a partially enriched mixture of enantiomers of an optically active compound, a major portion of the partially enriched mixture of enantiomers comprising a first enantiomer of t...
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WO/1998/029398A1 |
A process for preparing optically active piperazinecarboxylic acid derivatives by the resolution of diastereomeric salts wherein an optically active acidic amino acid derivative is used as the agent for optical resolution to thereby enha...
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WO/1998/024741A2 |
A process for the preparation of carbocyclic stereoisomers of formulae (I), (I'), (IIA'), (IIB'), (VA') and (VB'), including enantiomerically pure (IIA'), (I) and (I') utilising fractional crystallisation of salts formed with a chiral ba...
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WO/1998/023559A1 |
The invention concerns a method for splitting 1-amino-alkan-2-ol compounds of general formula (I) in which R can represent a large variety of alkyl groupings using as splitting agent one of the enantiomers R or S of N-tosyl-leucine.
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WO/1998/018770A1 |
The present invention relates to a process for the preparation of (-)-3,4-trans-diarylchromans of formula (I), wherein R?1�, R?4� and R?5� are individually hydrogen, hydroxy, halogen, trifluoromethyl, C�1-6?alkyl, C�1-6?alkoxy ...
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WO/1998/013335A1 |
Process for the preparation of an inorganic salt of an optically active phenylglycine derivative, in which a diastereoisomeric salt of the optically active phenylglycine derivative and an optically active acid is treated with a strong in...
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WO/1998/008787A2 |
Described herein is a novel process to resolve a racemic compound into its optically active isomers without need for chemical transformation such as salt formation. The process advantageously utilizes polymers containing chiral moieties ...
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WO/1998/007671A1 |
The present invention is directed to the separation of optically active compounds into their respective enantiomers. The separation uses imprinted polymers having a desired structure and molecular memory for the corresponding print molec...
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WO/1998/005640A2 |
A process for preparing a compound of formula (I), wherein R�1? represents hydrogen or a protecting group; and R�2? represents hydrogen or benzoyl optionally substituted in the phenyl moiety with halogen, methyl or C�1-4? alkoxy; w...
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WO/1998/000425A1 |
A process for separating the enantiomers of a racemic mixture of trans-2-(2-pyrimidinyl)-7-(hydroxymethyl)octahydro-2H-pyrido
[1,2-a]pyrazine comprising reacting the racemic mixture with D-(-) or L-(+) tartaric acid and separating the re...
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WO/1997/049733A1 |
The invention essentially relates to thermally crosslinked polysaccharide derivatives which contained no polymerizable functional groups prior to crosslinking and which are used in particular as support materials for the chromatographic ...
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WO1997047617A1 |
The invention relates to processes for the chromatographic separation of enantiomeric esters from 2-alkanoyl-chromane derivatives of the formula (I) in which Z is -(CH2)n1-(CHA)n2-(CH2)n3, where n1 = 0, 1, 2 or 3, n2 = 0 or 1, n3 = 0, 1,...
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WO/1997/046538A1 |
A process for producing D(+)-2-[4-(6-chloro-2-quinoxalyloxy)phenoxy]propionic acid, which comprises reacting an alkali metal salt of 4-(6-chloro-2-quinoxalyloxy)phenol with an alkali metal salt of L-2-chloropropionic acid in an aromatic ...
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WO/1997/043244A1 |
The invention relates to an improved process for the separation of racemic 2-)o-chlorophenyl)-2-methyl aminocyclohexanone (ketamine).
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WO/1997/041084A1 |
The invention relates to a process for the production of enantiomerically-pure AzeOH which comprises selective crystallisation of a diastereomerically-pure AzeOH-tartrate salt from a homogeneous solution of AzeOH, optically-active tartar...
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WO/1997/035841A2 |
A method for preparing optically substantially pure (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phe
nyl]hydrazono]propanedinitrile from racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone intermediate is descri...
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WO/1997/033895A1 |
The invention relates to isolated RNA molecules with high affinity for particular amino acids, processes for isolating these, and uses thereof. Via a process which includes various washing and heating steps, one isolates these RNA molecu...
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WO/1997/028271A1 |
Specific optically active (S)-amines are obtained as follows: in a first stage, suitable racemic amines are allowed to react, in the presence of lipase from Candida antarctica and optionally in the presence of a diluting agent, with an e...
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WO/1997/021663A1 |
The disclosure relates to a process for obtaining optically active L-'alpha'-aminocarboxylic acids from the corresponding racemic D,L,'alpha'-aminocarboxylic acids. The following steps are involved: (a) the D,L,'alpha'-aminocarboxylic ac...
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WO/1997/012881A1 |
The invention pertains to a process for the continuous production of basic cyclic optically active 'alpha'-amino acids of general formula (I) by continuous racemate splitting via diastereomeric salt pairs with re-racemisation of the resi...
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WO/1997/011927A1 |
Described is a method of resolving racemic mixtures of compounds of the formula (I) in which a, A, B, D, E, F, M, Q and R are as defined in the description. The method is carried out using prior art techniques but using the enantiomers o...
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WO/1997/004011A1 |
The invention relates to substantially photochemically cross-linked polysaccharide derivatives that do not contain photopolymerisable functional groups prior to the cross-linking, which can be used as carrier materials for the chromatogr...
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WO/1996/040617A1 |
A method of making (U)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with (II) to form primarily (III); reacting the (III) with a cyanide source to form (IV); decarboxylating the (IV) to form (V); hydro...
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WO/1996/037465A1 |
The invention relates to a chiral compound of general formula (I), wherein the groups R are the same or different but preferentially the same and are aliphatic C1-10 groups or optionally substituted aromatic groups or that both groups R ...
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WO/1996/037527A1 |
A suspension polymerization technique is provided for molecular imprinting based on the use of a perfluorocarbon liquid as the dispersing phase that does not interfere with the interactions between functional monomers and print molecules...
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WO/1996/036584A1 |
A process for the full or partial resolution of a mixture of enantiomers of a genus of chiral carboxylic acids is disclosed. The process uses a pure enantiomer of 1-aminoindan-2-ol as the resolving agent and achieves separation of the di...
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WO/1996/036606A1 |
New process for the preparation of ropivacaine hydrochloride monohydrate adapted for production in the plant, which process includes three steps.
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WO/1996/034842A1 |
There is provided a process for preferential conversion of a racemic 'alpha'-aryl propionic acid into an optically pure S-(+) or R-(-)-'alpha'-aryl propionic acid. An illustrative process is disclosed to prepare S-(+)-ibuprofen involving...
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WO/1996/033173A2 |
This invention relates to the preparation of racemic and enantiomeric 1-(pyridyl)-2-cyclohexylethylamine and, in particular, the separation of (+)-(S)- or (-)-(R)-1-(2-pyridyl)-2-cyclohexylethylamine from a racemic mixture of -1-(R,S)-(2...
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WO/1996/028402A1 |
The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catal...
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WO/1996/027639A1 |
The invention relates to a process for the preparation of polysaccharide-N-arylcarbamates in suitable form as supports for chromatography, which process comprises adding to polysaccharide carbamates, which may be substituted in the aryl ...
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WO/1996/027615A1 |
The present invention relates to photochemically cross-linked polysaccharide derivatives of general formulae (IA) and (IB), wherein R is a polysaccharide radical in which the OH groups have been esterified as OR' groups or converted into...
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WO/1996/023764A1 |
A process is disclosed for separating racemates of phenyl acetonitriles having the formula (I), in which R1, R2, R3 and n have the meaning given in the description. The process consists in dissolving the racemates (I) in a polar solvent,...
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WO/1996/022959A1 |
A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process comprises: (i) forming a diastereomeric salt by reaction comprising said racemic mixture of a C1 to C6 li...
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WO/1996/022272A1 |
The present invention relates to a process for producing optically active 2-halogen propionic acids in which the corresponding optically active 2-halogen propionic acid alkyl ester is reacted at high temperature with a carboxylic acid in...
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WO/1996/020158A1 |
This invention relates to derivatives of 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds which are useful for treating allergic and inflammatory diseases.
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WO/1996/012692A1 |
The proposal is for a process for producing derivatives of 4a,5,9,10,11,12,-hexahydro-6H-benzofuro[3,2-ef][2]benzazepin
e facilitating in particular the production of galanthamine (6) via the novel bromine-N-demethyl galanthamine (4) and...
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WO/1996/012699A1 |
Levobupivacaine or an analogue thereof is prepared by reaction with a tartaric acid resolving agent in a solvent, in the presence of water and/or less than 0.5 equivalents of the resolving agent.
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WO/1996/011894A1 |
Proposed is a process for separating enantiomers from a racemic mixture by countercurrent extraction using at least two substances, one of them a liquid in which the racemic mixture to be separated is present, the other containing a chir...
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WO/1996/009290A1 |
A process for the racemisation of an optically-enriched piperidine-2-carboxanilide compound, comprises heating the compound in the presence of an alkanoic or arylalkanoic acid. A process for the asymmetric transformation of such a compou...
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