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Matches 1 - 50 out of 2,978

Document Document Title
WO/2022/139675A1
This invention relates to a process for the continuous production of optically pure lactide from an aqueous solution of lactic acid by means of two reactive distillations followed by a main distillation column with a side-draw refluxer. ...  
WO/2022/133772A1
It relates to the medicinal chemistry field, particularly to a process for separating the isomeric compounds comprising a ring-opened thiosuccinimide group and a chiral moiety.  
WO/2022/081473A1
The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)p henyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl- 1,4,7,8,9,10-hexahydro-11,15-...  
WO/2022/014413A1
The purpose of the present invention is to provide a novel method for producing optically active 1,1,3-trimethyl-4-aminoindane by means of a preferential crystallization method using an achiral acid and without using an optically active ...  
WO/2021/181393A1
The present invention relates to a technique for flow crystallization. The system comprises a container having a bottom surface defining a first plane, the container including at least two planar magnetic surfaces being arranged in a spa...  
WO/2021/074078A1
The present invention relates to the diastereomer salts (Va), (Vb), (Vc) and/or (Vd), a process for preparing the diastereomer salts (Va), (Vb), (Vc) and/or (Vd) using a chiral-substituted tartaric acid ester of the formula (IIIa) or (II...  
WO/2021/074077A1
The present invention relates to a process for producing acyloxymethyl esters of (4S)-(4-cyano- 2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-napht hyridin-3-carboxylic acid of formula (IIa) by chiral resolution of the compound ...  
WO/2021/074072A1
The invention relates to the diastereomer salt of formulae (Va), (Vb), (Vc) and/or (Vd), a process for preparing one or more diastereomer salts of the formulae (Va), (Vb), (Vc) and/or (Vd), a process for preparing the compound according ...  
WO/2021/048199A1
The present invention relates to a polymer foam, said polymer foam comprising pores forming an open-cell polymer foam, said polymer foam comprising a supramolecular gel inside pores, and said polymer foam comprising at least one enzyme. ...  
WO/2020/260437A1
The invention relates to perfluorinated polyols and their use for enantiomeric separation of chiral anions. It also relates to a process for preparing such perfluorinated polyols, and to a process for the enantiomeric separation of chira...  
WO/2020/241678A1
Provided are novel chitosan compounds represented by formula (I) and an optical isomer separating agent. In formula (I), the Rs are independent and are a group represented by formula (II) or formula (III), Ra is a C1–5 alkyl group or a...  
WO/2020/213714A1
The present invention provides a method in which when using (+)-dibenzoyl-D-tartaric acid to optically divide (±)-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-piperidinone, an ether-based solvent is added and an extremely high yield of (R)-1-m...  
WO/2020/172506A1
A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The "R-form" compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at...  
WO/2020/161743A1
The present disclosure relates to an improved process for the preparation of bedaquiline fumarate, comprising a step of preparing bedaquiline by reaction of 3-benzyl-6-bromo-2-methoxyquinoline 5 with 3-(dimethylamino)-l-(naphthalen-l-yl)...  
WO/2020/136188A1
The present invention relates to a process for the preparation of a compound (I) or pharmaceutically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disea...  
WO/2020/071418A1
Provided are a novel sphingophospholipid precursor, a production method therefor, and a sphingophospholipid production method, that allow a sphingophospholipid demonstrating optical activity to be produced at a high yield. This sphingoph...  
WO/2020/048986A1
The invention relates to a reactor for carrying out a reaction between two non-miscible fluids of different densities, comprising: an inner chamber formed by a cylindrical, vertically orientated elongated casing, a base and a cover, wher...  
WO/2020/047407A1
The present disclosure relates to solid oral dosage forms comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture the...  
WO/2020/047408A1
The present disclosure relates to pharmaceutical capsules comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture the...  
WO/2020/020365A1
The present invention involves a method for isolating, by means of salt formation and resolution, a single optically active N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxan-6-yl)-2-hydroxy-1- (1-pyrrolidinylmethyl)ethyl]octanamide as shown in f...  
WO/2020/016316A1
The present invention relates to a method for enantiomer enrichment of a mixture made of two enantiomers of a chiral compound, the method comprising: applying the mixture made of two enantiomers of a chiral compound to a surface of a car...  
WO/2019/222565A1
Provided herein are methods of preparing a desired enantiomer 6-[amino(4- chlorophenyl) (1 -methyl- 1H-imidazol-5-yl) methy1]-4-(3-chlorophenyl)-1 -methyl-2(1H)- quinolinone, otherwise known as tipifarnib.  
WO/2019/214467A1
A resolution method for axis chiral enantiomers of Lesinurad (2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazo l-3-ylthio)acetic acid). In said method, inexpensive and readily available quinoline natural products and derivativ...  
WO/2019/160037A1
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...  
WO/2019/127902A1
The present invention relates to a green method for preparing 5R-benzyloxyaminopiperidin-2S-carboxylic acid or derivatives thereof. According to the method, L-glutamic acid, used as a starting raw material, is subjected to esterification...  
WO/2019/117446A1
The present invention relates to a method for producing a 2-octylglycine ester having optical activity from a racemic 2-octyl-DL-glycine ester and, more particularly, to a method for producing a 2-octyl-L-glycine ester or a 2-octyl-D-gly...  
WO/2019/102240A1
Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR, 10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alky...  
WO/2019/072237A1
Disclosed is a process for preparing an intermediate of anti-tumor drug niraparib and an intermediate thereof. The present invention discloses a process for preparing compound (f), which comprises conducting a cyclization reaction of com...  
WO/2019/060953A1
The present invention relates to chiral auxiliaries and the syntheses thereof and uses thereof.  
WO/2018/212216A1
Provided is a method for producing an optically active isomer, the method including an asymmetry induction step in which an asymmetry-inducing agent is caused to act on chiral molecules having an enantiomeric-excess half-life period less...  
WO/2018/209290A1
A method is provided to conveniently separate racemic (3R,4S)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carb oxamide and (3S,4R)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carb oxamide using selective crystallization with chir...  
WO/2018/191270A1
Provided herein are cinchonium betaine catalysts and methods of promoting asymmetric butenolide isomerization reactions using the same.  
WO/2018/094293A1
Provided herein is a kit for the determination of the absolute configuration of alcohols of a competing enantioselective conversion approach.  
WO/2018/065509A1
The present invention relates to a process for enriching enantiomers from an enantiomer mixture via a fractionating melt crystallization process in a melt crystallization apparatus. The invention specifically relates to a process for pro...  
WO/2018/051972A1
Provided is a method for separating the four optical isomers of Nahlsgen. According to the present invention, a method for producing a mixture of D-2-amino-4-[(Rp)-(3-carboxymethylphenoxy)(methoxy)phosphory l]butanoic acid hydrate and L-...  
WO/2018/035660A1
A porous chiral material of formula [M(L)1.5(A)]+X- wherein M is a metal ion; L is a nitrogen-containing bidentate ligand; A is the anion of mandelic acid or a related acid; and X- is an anion  
WO/2018/001990A1
The present invention relates to methods for the separation of mixtures which contain enantiomers of metal complexes with aromatic and/or heteroaromatic ligands, to metal complexes and to electronic devices, particularly organic electrol...  
WO/2017/181012A1
Provided herein are cinchonium betaine catalysts and methods of promoting asymmetric imine isomerization reactions using the same.  
WO/2017/155025A1
Provided is a method for producing compound (1) or (6) by optical resolution using a specific hydrolase. (In the formula, R represents a protecting group of a carboxy group, R1 and R2 each independently represent a hydrogen atom or a pro...  
WO/2017/156256A1
Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically inclu...  
WO/2017/144635A1
The invention relates to a process for preparing either enantiomer of a compound of formula (I), wherein X, Y and n have the meaning given in claim 1, with high enantiomeric excess (e.e.), by chiral resolution in the presence of a non-ra...  
WO/2017/145124A1
The present disclosure relates to a process for separation of enantiomers of the amino acid from a racemic mixture. The process comprises electrolyzing the first electrolyte having 1 molar solution of lithium perchlorate and 0.01 molar s...  
WO/2017/082396A1
The purpose of the present invention is to provide a method for the industrial production of lacosamide having high optical purity at a high yield, inexpensively, and safely. Provided is a method for the industrial production of lacosami...  
WO/2017/024980A1
Disclosed is a crystallization separation method for a nebivolol hydrochloride intermediate mixture, which comprises the following steps: step 1, adding an alcohol solvent or a mixed solvent of an alcohol and an alkane to a nebivolol hyd...  
WO/2017/002712A1
The present invention provides an industrially practicable method for producing a fluorine-containing cyclopropane carboxylic acid compound that is useful as an intermediate for pharmaceuticals and agrochemicals. A fluorine-containing cy...  
WO/2016/188945A1
The present invention relates to the field of separating chiral isomers from each other. Particularly, it relates to the field of separating of chiral isomers of chromane or chromene compounds, particularly tocopherols, 3,4-dehydro-tocop...  
WO/2016/182083A1
Provided is a separating agent for optical isomers, which is configured of a novel xylan derivative and a carrier. Specifically provided is a separating agent for optical isomers, which is configured of a carrier and a xylan-phenylcarbam...  
WO/2016/100576A9
The invention relates to methods of separating Trolox isomers (R)-Trolox and (S)-Trolox, comprising: (a) contacting a mixture of (R) and (S)-Trolox with a resolving agent selected from the group consisting of (1S,2S)-(+)-Pseudoephedrine,...  
WO/2016/157219A1
The present invention relates to a novel polyfluorene appended with protected glutamic acid of Formula (I) for heterogeneous enantioselective separation and sensing of amino acids, amino alcohol, hydroxyl acid, sugar, aromatic drug and a...  
WO/2016/146299A1
A process to isolate a compound of Formula (2a) or a salt or solvate thereof, comprising a) reacting a mixture of diastereoisomers of Formulae (2a, 2b) with a basic heterocyclic-aldehyde compound and an optically active amine in the pres...  

Matches 1 - 50 out of 2,978