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WO/2023/223188A1 |
The present invention relates to a process for the preparation of finerenone, a compound of formula I, and intermediates thereof. In particular, the present invention relates to a novel diastereomeric salt of an intermediate of finerenon...
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WO/2023/214426A1 |
The present invention discloses a method for resolving cyclohexylphenyl glycolic acid and the preparation of optically active phenylcyclohexyl glycolate esters. More particularly, the invention provides a process for preparation of optic...
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WO/2023/181054A1 |
The present invention relates to an improved process for the preparation for the stereo-specific preparation of Benazepril intermediate (3S)-3-[[(1S)-1- phenylethyl]amino]-1,3,4,5-tetrahydro-1-benzazepin-2-one of formula (IS). The steps ...
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WO/2023/126186A1 |
Use of a membrane which is permeable to the enantiomers present in a starting racemic or scalemic mixture, for isolating on one side of said membrane a first mixture optically enriched in a first enantiomer and on the other side of the m...
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WO/2023/112051A1 |
The present invention relates to an enantioselective separation of racemic mixtures of amino acids like alanine and leucine using chiral polystyrene microspheres. It provides a simple and efficient separation process by using cost-effect...
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WO/2023/044027A1 |
Provided herein is a process for resolving the (S)- and (R)- enantiomers of a compound of Formula (I), wherein L, R1, and R2 are defined herein.
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WO/2023/032883A1 |
Provided is a microfluidic device characterized by comprising a tunnel-shaped separation flow path, a columnar obstacle which is provided inside the separation flow path, and a ligand which is supported on the surface of the obstacle, wh...
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WO/2022/254457A1 |
The present invention relates to an improved process for the preparation of (4R)-1-[(2R, 4R, 5R)-3,3-difluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one compound of formula-1 and its intermediate compounds. [F...
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WO/2022/139675A1 |
This invention relates to a process for the continuous production of optically pure lactide from an aqueous solution of lactic acid by means of two reactive distillations followed by a main distillation column with a side-draw refluxer. ...
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WO/2022/133772A1 |
It relates to the medicinal chemistry field, particularly to a process for separating the isomeric compounds comprising a ring-opened thiosuccinimide group and a chiral moiety.
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WO/2022/081473A1 |
The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)p
henyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-
1,4,7,8,9,10-hexahydro-11,15-...
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WO/2022/014413A1 |
The purpose of the present invention is to provide a novel method for producing optically active 1,1,3-trimethyl-4-aminoindane by means of a preferential crystallization method using an achiral acid and without using an optically active ...
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WO/2021/181393A1 |
The present invention relates to a technique for flow crystallization. The system comprises a container having a bottom surface defining a first plane, the container including at least two planar magnetic surfaces being arranged in a spa...
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WO/2021/074078A1 |
The present invention relates to the diastereomer salts (Va), (Vb), (Vc) and/or (Vd), a process for preparing the diastereomer salts (Va), (Vb), (Vc) and/or (Vd) using a chiral-substituted tartaric acid ester of the formula (IIIa) or (II...
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WO/2021/074077A1 |
The present invention relates to a process for producing acyloxymethyl esters of (4S)-(4-cyano- 2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-napht
hyridin-3-carboxylic acid of formula (IIa) by chiral resolution of the compound ...
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WO/2021/074072A1 |
The invention relates to the diastereomer salt of formulae (Va), (Vb), (Vc) and/or (Vd), a process for preparing one or more diastereomer salts of the formulae (Va), (Vb), (Vc) and/or (Vd), a process for preparing the compound according ...
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WO/2021/048199A1 |
The present invention relates to a polymer foam, said polymer foam comprising pores forming an open-cell polymer foam, said polymer foam comprising a supramolecular gel inside pores, and said polymer foam comprising at least one enzyme. ...
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WO/2020/260437A1 |
The invention relates to perfluorinated polyols and their use for enantiomeric separation of chiral anions. It also relates to a process for preparing such perfluorinated polyols, and to a process for the enantiomeric separation of chira...
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WO/2020/241678A1 |
Provided are novel chitosan compounds represented by formula (I) and an optical isomer separating agent. In formula (I), the Rs are independent and are a group represented by formula (II) or formula (III), Ra is a C1–5 alkyl group or a...
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WO/2020/213714A1 |
The present invention provides a method in which when using (+)-dibenzoyl-D-tartaric acid to optically divide (±)-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-piperidinone, an ether-based solvent is added and an extremely high yield of (R)-1-m...
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WO/2020/172506A1 |
A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The "R-form" compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at...
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WO/2020/161743A1 |
The present disclosure relates to an improved process for the preparation of bedaquiline fumarate, comprising a step of preparing bedaquiline by reaction of 3-benzyl-6-bromo-2-methoxyquinoline 5 with 3-(dimethylamino)-l-(naphthalen-l-yl)...
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WO/2020/136188A1 |
The present invention relates to a process for the preparation of a compound (I) or pharmaceutically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disea...
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WO/2020/071418A1 |
Provided are a novel sphingophospholipid precursor, a production method therefor, and a sphingophospholipid production method, that allow a sphingophospholipid demonstrating optical activity to be produced at a high yield. This sphingoph...
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WO/2020/048986A1 |
The invention relates to a reactor for carrying out a reaction between two non-miscible fluids of different densities, comprising: an inner chamber formed by a cylindrical, vertically orientated elongated casing, a base and a cover, wher...
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WO/2020/047407A1 |
The present disclosure relates to solid oral dosage forms comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture the...
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WO/2020/047408A1 |
The present disclosure relates to pharmaceutical capsules comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture the...
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WO/2020/020365A1 |
The present invention involves a method for isolating, by means of salt formation and resolution, a single optically active N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxan-6-yl)-2-hydroxy-1-
(1-pyrrolidinylmethyl)ethyl]octanamide as shown in f...
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WO/2020/016316A1 |
The present invention relates to a method for enantiomer enrichment of a mixture made of two enantiomers of a chiral compound, the method comprising: applying the mixture made of two enantiomers of a chiral compound to a surface of a car...
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WO/2019/222565A1 |
Provided herein are methods of preparing a desired enantiomer 6-[amino(4- chlorophenyl) (1 -methyl- 1H-imidazol-5-yl) methy1]-4-(3-chlorophenyl)-1 -methyl-2(1H)- quinolinone, otherwise known as tipifarnib.
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WO/2019/214467A1 |
A resolution method for axis chiral enantiomers of Lesinurad (2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazo
l-3-ylthio)acetic acid). In said method, inexpensive and readily available quinoline natural products and derivativ...
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WO/2019/160037A1 |
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...
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WO/2019/127902A1 |
The present invention relates to a green method for preparing 5R-benzyloxyaminopiperidin-2S-carboxylic acid or derivatives thereof. According to the method, L-glutamic acid, used as a starting raw material, is subjected to esterification...
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WO/2019/117446A1 |
The present invention relates to a method for producing a 2-octylglycine ester having optical activity from a racemic 2-octyl-DL-glycine ester and, more particularly, to a method for producing a 2-octyl-L-glycine ester or a 2-octyl-D-gly...
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WO/2019/102240A1 |
Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR, 10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alky...
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WO/2019/072237A1 |
Disclosed is a process for preparing an intermediate of anti-tumor drug niraparib and an intermediate thereof. The present invention discloses a process for preparing compound (f), which comprises conducting a cyclization reaction of com...
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WO/2019/060953A1 |
The present invention relates to chiral auxiliaries and the syntheses thereof and uses thereof.
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WO/2018/212216A1 |
Provided is a method for producing an optically active isomer, the method including an asymmetry induction step in which an asymmetry-inducing agent is caused to act on chiral molecules having an enantiomeric-excess half-life period less...
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WO/2018/209290A1 |
A method is provided to conveniently separate racemic (3R,4S)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carb
oxamide and (3S,4R)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carb
oxamide using selective crystallization with chir...
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WO/2018/191270A1 |
Provided herein are cinchonium betaine catalysts and methods of promoting asymmetric butenolide isomerization reactions using the same.
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WO/2018/094293A1 |
Provided herein is a kit for the determination of the absolute configuration of alcohols of a competing enantioselective conversion approach.
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WO/2018/065509A1 |
The present invention relates to a process for enriching enantiomers from an enantiomer mixture via a fractionating melt crystallization process in a melt crystallization apparatus. The invention specifically relates to a process for pro...
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WO/2018/051972A1 |
Provided is a method for separating the four optical isomers of Nahlsgen. According to the present invention, a method for producing a mixture of D-2-amino-4-[(Rp)-(3-carboxymethylphenoxy)(methoxy)phosphory
l]butanoic acid hydrate and L-...
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WO/2018/035660A1 |
A porous chiral material of formula [M(L)1.5(A)]+X- wherein M is a metal ion; L is a nitrogen-containing bidentate ligand; A is the anion of mandelic acid or a related acid; and X- is an anion
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WO/2018/001990A1 |
The present invention relates to methods for the separation of mixtures which contain enantiomers of metal complexes with aromatic and/or heteroaromatic ligands, to metal complexes and to electronic devices, particularly organic electrol...
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WO/2017/181012A1 |
Provided herein are cinchonium betaine catalysts and methods of promoting asymmetric imine isomerization reactions using the same.
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WO/2017/155025A1 |
Provided is a method for producing compound (1) or (6) by optical resolution using a specific hydrolase. (In the formula, R represents a protecting group of a carboxy group, R1 and R2 each independently represent a hydrogen atom or a pro...
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WO/2017/156256A1 |
Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically inclu...
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WO/2017/144635A1 |
The invention relates to a process for preparing either enantiomer of a compound of formula (I), wherein X, Y and n have the meaning given in claim 1, with high enantiomeric excess (e.e.), by chiral resolution in the presence of a non-ra...
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WO/2017/145124A1 |
The present disclosure relates to a process for separation of enantiomers of the amino acid from a racemic mixture. The process comprises electrolyzing the first electrolyte having 1 molar solution of lithium perchlorate and 0.01 molar s...
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