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Matches 101 - 150 out of 274

Document Document Title
WO/1999/020638A1
The invention relates to novel nitric esters of pentaerythritol of general formula (I) with the meaning of the substituents given in the description. Said substituents can be utilized as pharmaceutical active substances, especially for t...  
WO/1998/025918A1
The invention concerns products of formula (I) in which Ar represents an aromatic monocyclic or bicyclic radical comprising 5 to 10 carbon atoms and optionally 1 or 2 heteroatoms selected among the atoms of nitrogen, oxygen or sulphur, s...  
WO/1998/021193A1
Compounds, or their compositions, of the general formula: A-(X�1?-NO�2?)�to? or their salts, for the preparation of medicaments for antithrombotic application, where: to is an integer equal to 1 or 2; X�1? is an alkylene connecti...  
WO/1998/015521A1
The invention relates to new compound derived from pentaerythritol of the general formula (I), (XIV), (XVI), (XIX) and (XXIII), the subtituents of which have the meaning given in the description, which can be used as pharmaceutical activ...  
WO/1998/009948A2
Use of the following groups of compounds or their compositions for the preparation of medicaments for the treatment of urinary incontinence, such compounds having general formula: A-X�1?-NO�2? or their salts, where A = R(COX)�t? an...  
WO/1998/009937A1
A process for preparing 1,2- and 1,3-dinitrate esters from polyols containing 1,2- or 1,3-diol fragments involves using an alkyl or aryl boronic acid to form a cyclic boronate ester derivative which is then reacted with dinitrogen pentox...  
WO/1997/016405A1
Compounds, or their compositions, of general formula: A - X1 - NO2 or their salts, used as medicaments, wherein: A = R(COX)t; t = 0 or 1; X = O; X0 = X; R being (a) wherein: R1, R2 and R3 are alkyls; X1 is a bivalent linking group chosen...  
WO/1996/034848A1
The invention relates to novel derivatives of acetylsalicylic acid with an NO3 structure. They are therapeutically effective either as intact active agent molecule or after dissociation (NO release). The invention also relates to process...  
WO/1996/032946A1
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising: (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii...  
WO/1995/030641A1
New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A-X1-NO2 or their salts, wherein: A is R(COXu)t, wherein t is zero or 1 and u is zero or 1; and X is O, NH o...  
WO/1995/009831A1
The present invention refers to nitric esters of derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid, 6-methoxy-2-naphthylacetic aci...  
WO/1994/021248A1
The invention pertains to the use of compounds of formula (I) wherein R1 and R2 stand for the constituents indicated in the description, and of their pharmacologically tolerable salts in the preparation of medicines for the treatment of ...  
WO/1994/019338A1
A process for the preparation of (1S,2R)-1,2-epoxy-1,2,3,4-tetrahydronaphthalene having formula (I), which comprises the steps of (a) hydrogenating the compound of formula (II) to form c_i_s_-(1R,2S)-1,2-dihydroxy-1,2,3,4-tetrahydronapht...  
WO/1994/012463A1
Nitric esters with pharmacological activity having general formula (I), their pharmaceutical utilisation and process for their preparation.  
WO/1994/003421A2
A pharmaceutical product for relief of the symptoms of angina pectoris and the like comprises an ester or a combination of an organic nitrate, and a salicylate, or derivative thereof, having anti-platelet activity.  
WO/1992/015555A2
Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are pa...  
WO/1992/001668A1
Compounds of formula (I) wherein X, Y, R¿1? and R¿2? have the meanings specified in the specification, are endowed with cardiovascular activity.  
WO/1991/012230A1
The present invention relates to novel nitric acid esters of cyclohexanol derivatives of formula (I) in which A is a valency line or a C�1?-C�6? alkylene chain and B is the group -NR?1�-CO-Z, -NR?1�-SO�2?-Z or -CO-NR?2�-Z, wh...  
WO/1991/010640A1
The process of the present invention provides a method of obtaining a high yield of water or acid soluble nitrate esters without the use of organic solvents in the nitration reaction or the production of unstable products or by-products....  
WO/1986/006281A1
A pressure-senstive adhesive tape for delivering nitroglycerin to skin, the tape comprising a backing with a layer of inert pressure-sensitive adhesive attached thereto, said pressure-sensitive adhesive layer comprising a pressure-sensit...  
WO/1986/003197A1
2,6-disubstituted 1,4-dihydropyridine derivatives represented by general formula (I) (wherein R1 represents an aryl group or a heterocyclic group optionally having one or more suitable substituents, R2 represents an ester group, R3 repre...  
WO/1984/001770A1
Tertiary organic hyponitrite usable as initiators for polymerizing ethylenically unsaturated compounds are prepared by reacting an alkali metal, alkaline earth, ammonium or substituted ammonium salt of hyponitrate, such as sodium hyponit...  
JP2022513153A
The present invention relates to novel processes for synthesizing mono and bisnitrosylated propanediols, as well as novel compositions and pharmaceutical formulations containing such compounds. This process proceeds by reacting the corre...  
JP2022001558A
To provide a nitrogen compound conversion device capable of effectively utilizing NOx that is generated with combustion treatment of fossil fuel or waste.A nitrogen compound conversion device 100 comprises: a stationary boiler 101; a flo...  
JP6980315B2
The present invention relates to a process for preparing latanoprostene bunod and an intermediate therefor. In accordance with the preparation process of the present invention, latanoprostene bunod can be efficiently and cost-effectively...  
JP2021504303A
The present disclosure provides adamantyl compounds having one or more amino groups and one or more nitrate groups. Aminoadamantyl nitrate compounds can be used to treat diseases of the central nervous system, including neurodegenerative...  
JP2020536874A
Activity-based probes that can be used to selectively identify and characterize enzymes involved in various phases of foreign body metabolism in the host and its microbiota population (s) are described. The activity-based probes describe...  
JP6668508B2
The present invention discloses a terpinenol compound as well as its preparation method and use; structure of such terpinenol compound is as shown in Formula (I) or (II); in Formula (I), R is independently selected from C 12 ˆ¼C 16 alk...  
JPWO2018179808A1
In the manufacturing method of an alkyl nitrite which contacts solution containing nitric acid and alkanol, and the gas containing nitric oxide, and makes an alkyl nitrite generate, the manufacturing method of an alkyl nitrite whose reac...  
JP6449519B2
The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are...  
JP6306148B2
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.  
JP2018505221A
The present invention is a device for manufacturing a polyethylene-glycols Jinit rate. The process at which a device feeds an acid constituent and a glycol constituent into a reaction apparatus continuously, The process of making an acid...  
JP6189543B2
The invention relates to a method and to a device for removing contaminants arising during the production of aliphatic or alicyclic nitric acid esters, in particular for removing contaminants from nitrated crude nitric acid esters, which...  
JP6158194B2
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role...  
JP6070695B2  
JP6027723B2
The present invention relates to a process for producing C1-C4 alkyl nitrite, comprising loading a resin catalyst layer and/or a porous filler layer into a reactor, passing nitrogen oxide, oxygen and C1-C4 alkanol as raw materials throug...  
JP5800554B2
A process of producing C1-C4 alkyl nitrite, comprising the following steps: a) firstly feeding nitrogen oxide and oxygen into Reactor I, contacting with an aluminosilicate catalyst, and reacting to produce an effluent I containing NO2 an...  
JP5191477B2
Organic nitrites can be produced from a compound which is a mono/polyhydric alcohol or an aldehyde- or ketone-derivate thereof after de-aeration of the same, using NO gas, and stored in an environment saturated with gaseous NO. Organic n...  
JP2013510827A
This invention relates to a new process for preparing 4-nitro-oxy-methyl-benzoic acid, comprising the following steps: a) reaction of 4-chloromethyl-benzoic acid with silver nitrate and in the presence of an acid as a catalyst in acetoni...  
JP2012509875A
A compound having the structure wherein Y is selected from the group consisting of -C(O)OR2, -C(O)NHR8, -C(CH2)1-2OR3, OH, and or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.  
JP4771659B2
The present invention relates to a new process for the preparation of the (S)-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for the ma...  
JP2011524892A
The present invention relates to a method for purifying naproxcinod comprising the steps of: a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two...  
JP4685996B2
In the invented process for producing a nitro compound, an organic substrate and nitrogen dioxide are reacted in the presence of oxygen or are reacted in a molar ratio of nitrogen dioxide to the organic substrate of less than 1 to yield ...  
JP4667691B2
4-nitroxybutyl ester of the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess of the (S) form higher than or equal to 97%.  
JP2011042690A
To obtain a naproxen nitroxyalkyl ester having an enantiomeric excess of at least 97%, preferably 98% or higher.A halide of 2-(S)-(6-methoxy-2-naphthyl)-propionic acid of formula A-Hal (wherein A is an acyl residue of an acid) is reacted...  
JP4632138B2
Preparation of nitric acid esters (nitrate ester) of univalent alcohols comprises reacting the univalent alcohols or its mixture with nitric acid ester in the presence of sulfuric acid under adiabatic reaction condition.  
JP2011500619A
The present invention refers to new NO-donors aspirin derivatives, a process for their preparation and pharmaceutical compositions containing them.  
JP2011500519A
The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy resid...  
JP2010280665A
To provide a new NSAID (nitrosated nonsteroidal antiinflammatory drug), a composition and a method for using the same.There are provided an NSAID of the formula, its pharmaceutically acceptable salt, and a new composition containing at l...  
JP2010265292A
To provide new nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and methods for treating inflammation, pain and fever, for treating gastrointestinal disorders, and for facilitating wo...  

Matches 101 - 150 out of 274