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JP4667691B2 |
4-nitroxybutyl ester of the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess of the (S) form higher than or equal to 97%.
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JP2011042690A |
To obtain a naproxen nitroxyalkyl ester having an enantiomeric excess of at least 97%, preferably 98% or higher.A halide of 2-(S)-(6-methoxy-2-naphthyl)-propionic acid of formula A-Hal (wherein A is an acyl residue of an acid) is reacted...
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JP4632138B2 |
Preparation of nitric acid esters (nitrate ester) of univalent alcohols comprises reacting the univalent alcohols or its mixture with nitric acid ester in the presence of sulfuric acid under adiabatic reaction condition.
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JP2011500619A |
The present invention refers to new NO-donors aspirin derivatives, a process for their preparation and pharmaceutical compositions containing them.
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JP2011500519A |
The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy resid...
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JP2010280665A |
To provide a new NSAID (nitrosated nonsteroidal antiinflammatory drug), a composition and a method for using the same.There are provided an NSAID of the formula, its pharmaceutically acceptable salt, and a new composition containing at l...
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JP2010265292A |
To provide new nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and methods for treating inflammation, pain and fever, for treating gastrointestinal disorders, and for facilitating wo...
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JP2010532780A |
The present invention relates to nitrooxyderivative of antioxidant compounds of formula (I) and pharmaceutically acceptable salts or stereoisomers thereof for the treatment of chronic pain, in particular chronic neuropathic pain. The inv...
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JP4558497B2 |
A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
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JP2010531324A |
The present invention relates to a process for the preparation of 1,4-butanediol mononitrate as intermediate for large scale preparation of high purity nitrooxybutyl ester of pharmaceutically active compounds.
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JP4528123B2 |
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independent...
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JP2010521423A |
Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting...
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JP4451595B2 |
Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, Having the following general formula (I): A-X1-L-(W)p-NO2 wherein A contains the radical of a drug, X1 and W are bivalent radicals, L is a cova...
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JP4426840B2 |
In a continuous process for the preparation of alkyl nitrites and dinitrites, an alkanol or dialkanol is first mixed with an aqueous mineral acid, the reaction mixture obtained is then reacted with an inorganic nitrite and the product ob...
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JP4264137B2 |
Compounds or compositions containing compounds of the formula A-(X1-NO2)to or salts thereof, for the preparation of antithrombotic medications wherein "to" is the integer 1 or 2X1 is an alkylene connecting bridge and "A" is the residue o...
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JP2009516719A |
The present invention refers to O-acyl salicylic acid derivatives (I) bearing a NO donor moiety, a process for their preparation and pharmaceutical compositions containing them. (I) wherein: D is ONO2 or (A).
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JP2009057370A |
To provide a process which efficiently produces an ester of nitrous acid with the use of a nitrogen oxide without employing a salt of nitrous acid.A nitrogen oxide (particularly, a nitrogen oxide containing at least N2O3) is reacted with...
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JP2008297261A |
To provide a method of stably separating cyclohexyl nitrate by preventing cyclohexyl nitrate from thermally decomposing in separating cyclohexyl nitrate from an organic substance containing cyclohexyl nitrate by steam distillation.The me...
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JP4134777B2 |
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JP4134761B2 |
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JP2008521770A |
A process for preparing a compound of formula (I) X-(CH2)n-ONO2 (I) wherein: X is a halogen atom selected from Cl, Br, I; n is an integer from 3 to 6; said process comprising the slow addition of a compound of formula (II) X-(CH2)n-...
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JP2008506748A |
The present invention relates to a process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates of compounds having at least an hydroxyl or thiol functional group, according to the following...
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JP4043046B2 |
PCT No. PCT/EP95/01233 Sec. 371 Date Mar. 6, 1997 Sec. 102(e) Date Mar. 6, 1997 PCT Filed Apr. 4, 1995 PCT Pub. No. WO95/30641 PCT Pub. Date Nov. 16, 1995New compounds and their compositions having anti-inflammatory, analgesic and anti-t...
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JP4026350B2 |
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JP4027969B2 |
Tetracyclic compounds having the following structure are described: wherein R1-R10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased uterine weight, antio...
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JP4026521B2 |
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JP2007291127A |
To provide nonsteroidal antiinflammatory drugs preventing, reducing toxicities such as gastrointestinal lesions. Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) ...
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JP2007522253A |
Production of liquid nitrate esters by esterifying alcohols with nitrating acid is effected in a microreactor.
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JP2007521961A |
A process for treating liquids is carried out in one or more micro-reactors and/or micro-mixers. The liquid to be treated is continuously mixed with a washing fluid, and the liquid / washing liquid mixture flows into a container with upp...
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JP2007519641A |
The invention is directed to a method for treating a cyclooxygenase-2 mediated disease or condition in a mammalian patient at risk of a thrombotic cardiovascular event, wherein the patient is on aspirin therapy to reduce the risk of the ...
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JP2007513114A |
The present invention relates to β-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y—ONO2)s and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing ...
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JP2007509842A |
Compounds comprising nitric oxide derivatives of stilbenes, polyphenols and flavonoids and methods of their use are provided for treating patients suffering from any of hypercholesterolemia, vascular oxidative stress and endothelial dysf...
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JP2007509035A |
Compounds and methods are provided for treating patients suffering from health condition associated with an expression state of a gene such as fertility disorders, cancer, proliferative diseases, vascular diseases, wounds requiring thera...
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JP3880067B2 |
PCT No. PCT/EP36/04696 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Oct. 29, 1996 PCT Pub. No. WO97/16405 PCT Pub. Date May 9, 1997Compounds and their compositions, of general formula: A-X1-NO2 are used as medicam...
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JP3807124B2 |
To provide a method for stably producing a nitrous ester by effectively removing heat of reaction by specifying the amount of an alcohol and the circulation amount or the like of a bottom liquid when the alcohol is reacted with nitrogen ...
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JP3775796B2 |
PCT No. PCT/EP94/03182 Sec. 371 Date Apr. 5, 1996 Sec. 102(e) Date Apr. 5, 1996 PCT Filed Sep. 23, 1994 PCT Pub. No. WO95/09831 PCT Pub. Date Apr. 13, 1995This invention is directed to nitric esters of derivatives of propionic acid, 1-(p...
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JP2006506418A |
A process for the preparation of compounds of formula HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disclosed. The process is safer to ope...
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JP2006500409A |
The present invention relates to a new process for the preparation of NO-donating compounds using a sulfonated intermediate. The invention relates to new intermediates prepared therein suitable for large scale manufacturing of NO-donatin...
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JP2005539089A |
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound ...
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JP2005536559A |
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independent...
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JP2004290948A |
To provide a method capable of easily oxidizing hydrocarbons, hetero element-containing compounds and alcohols at low temperature.In the method for oxidizing hydrocarbons, hetero element-containing compounds and alcohols in the presence ...
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JP2004529204A |
Colchicine derivatives represented by the formula (I) with a halogen or nitric ester group, or pharmaceutically acceptable salts thereof, are described. Pharmaceutical compositions containing the same as effective components are also des...
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JP3541720B2 |
To provide a method for recovering methyl nitrite, capable of solving recovery and safety problems accompanied by the recoveries of the methyl nitrite and nitrogen monoxide contained in a purged gas recovered from a zone for producing th...
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JP2004512303A |
The present invention provides compositions useful for the treatment of inflammation in humans, and related methods of treatment for the same. In one embodiment the composition isIn another embodiment, the composition isAdditional altern...
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JP2004511456A |
Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B)b0-(C)c0-NO2 wherein A contains the radical of a drug having an antiinflammatory or analgesic activity, B is a bivalent linking ...
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JP2003529576A |
The invention concerns a method for preparing alkyl nitrites of formula (I) R ONO (I) ONO wherein R represents a C1-C20, advantageously C2-C10 linear or branched alkyl group. The invention is characterised in that it consists in graduall...
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JP2003261515A |
To provide a method for efficiently producing an alkyl nitrite in higher yield by reaction between nitrogen dioxide and an alkanol.The method for producing the alkyl nitrite comprises feeding a reaction column with the alkanol and water ...
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JP2003519176A |
Use of certain nitrate ester compounds or pharmaceutically acceptable salts thereof in the manufacture of a medicament for treating pain or providing analgesia.
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JP2003515526A |
Compounds or their salts of general formula (I): A-B-N(O)2 wherein: A is a drug radical selected from ferulic acid and sulindac; B= -O-R1B-X-R2B-O- wherein R1B and R2B, equal to or different from each other, are linear or branched C1-C6 ...
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JP2003504352A |
A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives of formula (I) wherein R1 is the OCOR3 group characterized in that it comprises the following steps: a) reaction of a halide of a salicylic acid derivativ...
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