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WO/2023/131349A1 |
A treprostinil coupled nitric oxide (NO) donor drug as shown in formula I below, a pharmaceutical composition thereof and a use thereof.
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WO/2022/183263A1 |
The present patent relates to chemical compounds, the function of which is to act as additives for reducing the compression ignition time of alternative fuels in the diesel cycle, i.e., to act as cetane improvers. Such compounds can be d...
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WO/2022/167070A1 |
The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hept
en-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-prope
n-1-yl ester of formula (I)....
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WO/2021/214146A1 |
The invention relates to a safe and efficient process for the for the acylation of an α,ω-alkanediol, which can be used in the manufacture of ω-nitrooxy-C3-10alkane-1-ols. The process is safer to operators and allows to obtain advanta...
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WO/2021/214145A1 |
The invention relates to a safe and efficient process for the nitrate ester formation of an α,ω-C3-10alkanediol monoacylate. The process is safer to operators and allows to obtain advantageous yields on industrial scale.
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WO/2021/214144A1 |
The invention relates to a safe and efficient process for the hydrolysis of α,ω-C3-10alkanediol mononitrate monoacylates. The process is safer to operators and allows to obtain advantageous yields on industrial scale.
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WO/2021/214143A1 |
The invention relates to a safe and efficient process for the solvent removal and recovery by distillation in a process for the preparation of ω-nitrooxy-C3-10alkane-1-ols. The process is safer to operators and allows to obtain advantag...
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WO/2021/188448A1 |
A composition comprising a complex of a cyclodextrin with a nitroalkene.
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WO/2021/047978A1 |
The present invention relates to a process for the preparation of α-methyl-[4-(nitro)-2- (trifluoromethyl)]-benzyl nitrate and to the α-methyl-[4-(nitro)-2-(trifluoromethyl)]-benzyl nitrate.
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WO/2021/034678A1 |
This disclosure relates to compositions and methods of making an additized fuel composition comprising a base fuel composition and a randomly branched nitrate composition. The randomly branched nitrate composition includes a plurality of...
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WO/2020/257336A1 |
Disclosed herein are formulations and methods for reversing one or more symptoms of cannabinoid hyperemesis syndrome (CHS) or one or more symptoms thereof, comprising parenterally administering a CB1 antagonist in an amount sufficient to...
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WO/2020/231333A1 |
Provided herein are compounds, extracted from Wrightia antidysenterica, that are potent inhibitors of tyrosinase and melanogenesis, which can be used as skin whitening agents. Provided also are compositions comprising the compounds and m...
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WO/2020/221805A1 |
The present invention relates to fatty acid esters of formula (I) as well as the use thereof as for inhibiting the methane production in ruminants and/or for improving ruminant performance.
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WO/2020/109420A1 |
The present invention relates to a novel process for the synthesis of mono- and bis-nitrosylated propanediols, as well as novel compositions and pharmaceutical formulations comprising said compounds. The process proceeds by reacting a co...
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WO/2020/103556A1 |
The present invention relates to a nitric acid reduction conversion process, the process involving bringing a raw material gas that is rich in nitric oxide into contact with a raw material liquid containing nitric acid and methanol in a ...
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WO/2020/082194A1 |
A process for producing an alkyl nitrite is provided, comprising: mixing oxygen and a circulating gas in a pre-reactor, mixing the oxidized circulating gas and an alkyl alcohol liquid in a first esterification tower to generate alkyl nit...
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WO/2020/053193A1 |
The invention relates to a safe and efficient process for the manufacture ω-nitrooxy-C3-10alkane-1-ols.
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WO/2020/053194A1 |
The invention relates to a process for the preparation of ω-nitroxyC3-1 0 alkane-1-ols comprising the nitration of an α,ω-C 3-10 alkanediol with a nitration agent, optionally in the presence of a nitrite trapping agent, characterized ...
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WO/2019/206892A1 |
The present invention relates to novel dicarboxylic diesters as well as the use thereof as for inhibiting the methane production in ruminants.
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WO/2019/031774A1 |
The present invention relates to a method for preparing latanoprostene bunod, and an intermediate therefor. According to the preparation method of the present invention, latanoprostene bunod can be efficiently and economically prepared w...
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WO/2018/179808A1 |
Provided is a method for producing alkyl nitrite by bringing an aqueous solution containing nitric acid and an alkanol into contact with a gas containing nitrogen monoxide to generate alkyl nitrite, wherein the reaction temperature is 60...
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WO/2018/096504A1 |
Compounds of Formula (I), including stereoisomers and salts thereof, and compositions, methods of treatment and prevention, and methods of preparing, the same: Formula (I) wherein X is O or a direct bond; wherein when X is O, R1 and R2 a...
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WO/2017/097969A1 |
Described is a method for preparing a salt consisting of cations of an arene-transition metal sandwich complex and anions of a Brönsted acid.
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WO/2017/079721A1 |
Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided.
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WO/2017/046118A1 |
The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are...
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WO/2016/128147A1 |
Disclosed is an apparatus for producing polyethylene glycol dinitrate. The apparatus includes providing continuously an acid composition and a glycol composition to a reaction apparatus; reacting the acid composition and the glycol compo...
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WO/2015/155234A1 |
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
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WO/2015/134703A1 |
A process for synthesizing isooctyl nitrate in a continuous flow reactor comprises flowing a H2SO4-HNO3 mixture within a flow reactor, flowing isooctyl alcohol into said flow reactor so as to mix the isooctyl alcohol with the H2SO4-HNO3 ...
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WO/2015/044177A1 |
The present invention refers to compounds of formula: (formula A), wherein R1 is selected from (formula I), (formula II), (formula (III), (formula IV), (formula V), or (formula B), and wherein R2, R3, R4 and R5 are as defined in the clai...
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WO/2015/022110A1 |
The invention relates to a method and to a device for removing contaminants arising during the production of aliphatic or alicyclic nitric acid esters, in particular for removing contaminants from nitrated crude nitric acid esters, which...
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WO/2014/170262A1 |
The present invention relates to nitric oxide donor compounds having a quinone based structure of formula (I), wherein R1 to R6, m, n and p are as defined in claim 1, to processes for their preparation and to their use in the treatment o...
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WO/2014/169976A1 |
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role...
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WO/2014/111957A1 |
The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the prep...
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WO/2014/086065A1 |
Provided is a method for producing an alkyl nitrate, using a centrifugal extraction device as a separator for the esterification reaction, feeding a mixed acid solution containing sulfuric acid and nitric acid from a heavy phase inlet of...
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WO/2013/150840A1 |
A method for producing a nitrous acid ester whereby nitric oxide, oxygen, and an alcohol are reacted to produce a nitrous acid ester, the method for producing a nitrous acid ester including: a step for supplying the bottoms liquid from t...
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WO/2013/060673A1 |
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role...
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WO/2012/152438A1 |
The present invention relates to a one-step process for the synthesis of nitric acid esters or 15N isotopically labeled nitrate esters of organic compounds starting from the correspondent alcohols. Formula (I).
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WO/2011/132171A1 |
The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups ...
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WO/2011/120695A1 |
Organic nitrates are prepared from mono-, di- or polyhydric alcohols by (i) simultaneously feeding a first continuous-flow microreactor unit with (a) concentrated nitric acid, (b) acetic anhydride, (c) optionally, a catalytic amount of a...
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WO/2011/101245A1 |
The invention relates to nitrooxyderivatives of Gamma- aminobutyric acid analogs (GABA analogs) for treating neuropathic pain and in particular diabetic neuropathy. The invention also relates to pharmaceutical formulation comprising such...
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WO/2011/098839A2 |
The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di...
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WO/2011/058162A1 |
This invention relates to a new process for preparing 4-nitro-oxy-methyl- benzoic acid, comprising the following steps: a) reaction of 4-chloromethyl-benzoic acid with silver nitrate and in the presence of an acid as a catalyst in aceton...
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WO/2011/032936A1 |
The present invention relates to the novel compounds of the formula (I), as well as to their manufacture and use and compositions comprising them. The invention also relates to a change in oxidation reactions of hydrocarbons admixed to t...
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WO/2011/012400A2 |
The present invention relates to a novel nitric oxide releasing naproxen derivative, its use for the treatment of diseases associated with pain and inflammation. This NO releasing naproxen derivative shows a surprisingly improved gastroi...
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WO/2010/134679A2 |
Disclosed is a novel bicycloheptane-based compound. A cetane number improver containing the bicycloheptane-based compound and diesel fuel containing the cetane number improver are also provided. This cetane number improver has lower toxi...
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WO/2009/153668A2 |
The present invention relates to a method for purifying naproxcinod comprising the steps of : a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or tw...
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WO/2009/153670A2 |
Antibodies against various domains of laminin-332 are discussed herein. The antibodies reduce the adhesion and matrix binding properties of laminin-332, inhibiting tumor growth and metastasis in vivo. Pharmaceutical compositions and meth...
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WO/2009/149053A2 |
Processes for the preparation of naproxcinod and its purification, solid dispersions of naproxcinod with a pharmaceutically acceptable carrier, and processes for making dispersions. Also provided is crystalline 2-(S)-(4-chlorobutyl)-2-(6...
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WO/2009/127398A2 |
A conjugated linoleic acid (CLA) derivative having the structure (I) wherein n is an integer from 1 to 10; and wherein the broken lines at positions 9 and 11, or at positions 10 and 12, are each double bonds separated by a single bond, a...
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WO/2009/089493A2 |
The present invention is directed to methods and compositions which include nitrate amino acid chelates that can increase the metabolic activity or metal concentration in animals and that can increase metabolic activity and nitrogen cont...
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