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WO/2004/093806A2 |
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherei...
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WO/2004/093799A2 |
Thyroid receptor ligands are provided which have the general formula (I), wherein: R1 is formula (II); R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4 carbons or cycloalkyl of 3 to 5 carbons, provided that ...
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WO/2004/089885A1 |
The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
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WO/2004/080377A2 |
This invention relates to compounds of the general formula (I) useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.
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WO/2004/078144A2 |
The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering...
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WO/2004/076459A1 |
A quaternary ammonium bifluoride compound; and a process for stereoselectively producing a nitroalcohol with the compound. The quaternary ammonium bifluoride compound is represented by the following formula (I). In the presence of the co...
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WO2004017920B1 |
Novel biphenyl and biphenyl-like cannabinoid compounds are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, result in a sufficiently high level of that compound in the indivi...
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WO/2004/067623A2 |
The present invention relates to a polyimide resin for non-rubbing vertical alignment material and a preparation method thereof, and more particularly to a method for preparing a branched diamine compound offering a uniform and high pret...
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WO/2004/063129A2 |
A novel, convenient and efficient method for trifluoromethylation of substrate compounds is disclosed. Particularly, alkoxide and hydroxide induced nucleophilic trifluoromethylation of carbonyl compounds, disulfides and other electrophil...
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WO/2004/063148A1 |
The present invention relates to a compound of the formula ((I): in which: n is an integer chosen from 1, 2 and 3; Y represents O; N-OR9, in which R9 represents H or a saturated hydrocarbon-based aliphatic group; CR10R11, in which R10 an...
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WO/2004/058391A2 |
The invention relates to a method for the synthesis of biopolymers by step-by-step construction using protected synthesis units carrying two-stage protective groups. Said two-stage protective groups are activated by a first irradiation s...
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WO/2004/058164A2 |
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/...
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WO/2004/058392A2 |
The invention relates to novel photoactivatable protective groups having a quantum yield which can be significantly increased by means of an intramolecular sensitizer. The invention also relates to the use of said groups in the synthesis...
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WO/2004/056738A1 |
The invention relates to the use of derivatives of cyclopentenone for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more spe...
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WO/2004/056365A2 |
A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing...
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WO/2004/055066A1 |
Polymer-immobilized formamides characterized by being represented by the general formula: (wherein R1 is an optionally substituted hydrocarbon chain which may have a cyclic moiety or a heteroatom; R2 is an optionally substituted hydrocar...
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WO/2004/052939A2 |
One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-ca...
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WO/2004/052816A1 |
Compounds of formula (I), wherein A1 and A2 are each independently of the other a bond or a C1-C6alkylene bridge; A3 is a C1-C6alkylene bridge; X1 and X2 are each independently of the other fluorine, chlorine or bromine; Y is O, NR7, S, ...
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WO/2004/052844A1 |
The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA anal...
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WO/2004/052847A2 |
The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula...
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WO/2004/050603A1 |
A process for producing 1,5-diaminonaphthalene which comprises dehydrogenating a 5-substituted 1-tetralone to produce a naphthol compound and then aminating the hydroxy group of the naphthol compound. Thus, the target compound can be pro...
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WO/2004/046081A1 |
The present invention relates to beta-nitrostyrene compounds, and pharmaceutically acceptable salts and hydrates thereof having the following formula (I) and showing anticancer activity. Formula (I) wherein R1 to R5 are each independentl...
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WO/2004/043884A2 |
Novel acylating agents useful for preparing activated nucleophiles such as terminally activated polymers are disclosed. In preferred aspects, the acylating agents are formula (I) and formula (II) and they used to prepare activated polyme...
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WO/2004/041771A1 |
A protective against ultraviolet which contains as an active ingredient a compound functioning to protect against ultraviolet and represented by the general formula (I'): (I') wherein X represents NH or oxygen&semi Y' represents vinyl su...
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WO/2004/037765A1 |
The present invention relates to a process for the preparation of 3,4,5-trifluoronitrobenzene of the formula (1). The process involved straightforward transformations and eventually culminated in consistent preparation of the title compo...
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WO/2004/035520A1 |
An industrial and economical process for producing an acetylenic compound useful as an intermediate of drugs from 4-nitrofluorobenzene, specifically, a process for the production of the acetylenic compound (3): (3) characterized by react...
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WO/2004/031124A1 |
The invention provides salts of formula (I) wherein X is a basic counterion selected from a group I or group II metal and a primary, secondary or tertiary amine; n is 0, 1 or 2; and Rl, Rla, R2, R2a, R3, R3a, R4 and R4a are independently...
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WO/2004/027078A2 |
This invention relates to novel fluorinated dendrons and to a universal strategy for producing functional fluorinated dendrons programmed to self-assemble into supramolecular nanocylinder compositions containing pstacks of high electron ...
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WO/2004/026808A1 |
The present invention relates to a new process for the preparation of NO-donating compounds using a sulfonated intermediate. The invention relates to new intermediates prepared therein suitable for large scale manufacturing of NO-donatin...
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WO2003055446A9 |
The antifungal and cancer cell growth inhibitory activities of 1-(3', 4', 5'-trimethoxyphenyl)-2-nitro-ethylene (TMPN) were examined. TMPN was fungicidal for the majority of 132 reference strains and clinical isolates tested, including t...
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WO/2004/016348A1 |
The invention provides systems and methods for conducting reactions in which a reactant contacts a tethered catalyst and/or tethered chiral auxiliary in a microchannel and is converted to product.
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WO/2004/014550A2 |
The invention relates to novel monocarbene complexes of nickel, palladium or platinum containing electron-deficient olefin ligands, to their production and to the use thereof in the homogeneous catalysis of organic reactions (Formula II ...
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WO/2004/013094A2 |
One aspect of the present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond b...
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WO/2004/013077A2 |
A compound of formula (I) or (II): wherein A is hydrogen or CR1R2; Y and Z are each, independently, hydrogen or a halogen; X is -NR4R5, or R7; R1 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1-4 carbon...
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WO/2004/011410A1 |
Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11$g(b)HSD1 are described.
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WO/2004/007424A1 |
The invention relates to a method of preparing a high-purity nitrophenol and, more specifically, p-nitrophenol from a nitrohalobenzene. The inventive method comprises the following steps: (a) hydrolysis of a nitrohalobenzene compound by ...
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WO/2004/005229A1 |
The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1-R25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of an...
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WO/2004/004648A2 |
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound ...
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WO/2004/002947A1 |
Compounds of formula (I), wherein R01 is hydrogen, C1-C8alkyl, C3-C8alkenyl or C3-C8alkynyl; or R01 is phenyl or phenyl-C1-C6alkyl, it being possible for the phenyl rings in turn to be mono- to penta-substituted by halogen and/or mono-, ...
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WO/2004/003331A2 |
A chloride free amphoteric surfactant obtained by reacting an amine with a carbonyl compound, the amphoteric surfactant being particularly useful as a foamer for treating gas wells to enhance production.
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WO/2004/000778A1 |
Provided is a use as a coupling agent for condensation reactions of a compound of formula (I): wherein each of R1, R2, and R3 is independently H, hydrocarbyl, or hydrocarbyloxy, provided that not more than one of R1, R2, and R3 is H ; an...
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WO/2003/104178A1 |
Where Y, R¿1?-R¿8? and R¿101?-R¿108? are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting M...
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WO/2003/104203A1 |
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of t...
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WO/2003/104184A1 |
The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.
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WO/2003/103686A1 |
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a huma...
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WO/2003/097568A1 |
A process for producing a 4-phenyl-4-oxo-2-butenoic ester derivative, characterized by simultaneously or continuously reacting a sulfuric ester, aromatic hydrocarbon, and maleic anhydride derivative. By the process, a 4-phenyl-4-oxo-2-bu...
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WO2003006570B1 |
New, efficient methods for making novel platform molecules and polymerizable mesogens are provided, as well as the novel mesogens and methods of using same.
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WO/2003/093237A1 |
The present invention concerns 2,6-quinolinyl and 2,6-naphthyl derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals for the treatment of VLA-4 dependent in...
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WO/2003/090926A1 |
A method for preparing a ruthenium-carrying alumina which comprises suspending alumina in a solution containing a tri-valent ruthenium, and then adding a base to the resultant suspension. A ruthenium-carrying alumina is useful as a catal...
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WO/2003/088927A2 |
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agent...
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