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WO/2010/098251A1 |
Provided is a novel loxoprofen derivative represented by formula (I) or (II), or a pharmacologically acceptable salt thereof, which avoids side effects such as gastrointestinal disorders and also has excellent antiinflammatory and analge...
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WO/2010/097453A1 |
The invention relates to a method for producing mononitro aromatic compounds and dinitro aromatic compounds wherein a hydrate melt at least of a metal nitrate M(NO3)3 is used as a nitriding medium, wherein M can be the metals Fe, Cr, Y, ...
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WO/2010/089043A1 |
The invention relates to a method for treating wastewaters comprising nitroaromatics and nitrohydroxy aromatics that occur, for example, during the production of nitroaromatics or during the production of nitrohydroxy aromatics, in a two...
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WO/2010/084772A1 |
Disclosed is a process for anti-selectively producing an optically active anti-1,2 –nitroalkanol, which is useful as a precursor of an optically active anti-1,2-amino alcohol, by a catalytic asymmetric reaction. The process comprises a...
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WO/2010/077686A1 |
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorder...
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WO/2010/054462A1 |
A method for making mononitrobenzene using a plug flow reactor train. Benzene, nitric acid and sulfuric acid are introduced into the reactor and produced mononitrobenzene is removed at an outlet end. All of the benzene and at least part ...
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WO/2010/052536A1 |
An improved process for the preparation of p-nitrobenzyl bromide from p-nitrotoluene is disclosed wherein large excess of the reactant in carbon tetrachloride is treated with 2:1 bromide-bromate reagent and the product is isolated effici...
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WO/2010/049228A1 |
The present invention relates to a novel a process for the preparation of 9- dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-
5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiato...
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WO/2010/021093A1 |
Provided are a novel asymmetric organic catalyst with which it is possible to realize a high optically-active yield when said catalyst is used in a small amount, and a method for producing a compound using the same. The asymmetric organi...
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WO/2010/009508A1 |
A compound of Formula (A) wherein Z is an aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the heteroaryl or substituted heteroaryl connected to a 2,4-dinito-6-(trifluoromethyl)phenyl ring via a carbon-carbon bond.
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WO/2010/004957A1 |
Disclosed is a novel chiral iridium aqua complex having good storage stability, which can be easily produced. The chiral iridium aqua complex can achieve a high yield and a high stereoselectivity in an asymmetric transfer hydrogenation ...
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WO/2010/001821A1 |
Disclosed are a compound represented by general formula (I) (wherein R1 and R2 each represents a hydrogen, a lower acyl, a lower alkoxycarbonyl or the like; R3 represents a lower alkyl, a halogenated lower alkyl, a cycloalkyl, a heterocy...
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WO/2009/156359A2 |
The invention relates to a method for producing substituted biphenyls of formula (I), wherein R1 = nitro or amino, R2 = cyano, halide, C1-C4 alkyl halide, C1-C4 alkoxy halide or C1-C4 alkylthio halide, n = 0 to 3 and R3 = hydrogen, cyano...
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WO/2009/157418A1 |
Disclosed is a highly safe agent for treating and/or preventing diabetes or the like, which has excellent activity. Specifically disclosed is a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (...
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WO/2009/149622A1 |
6-Nitro acetophenone compounds of Formula (I), wherein the substituents are defined as the specification, preparation methods, uses in the preparation of 3-substituent-4-hydroxyquinoline and 3-substituent-4-chloroquinoline compounds, and...
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WO/2009/147141A2 |
The invention relates to functionalised diols of diamondoids wherein one of the two hydroxy groups is masked by a protective group, and to methods for producing said functionalised diols. The protective group is a -CHR1R2 group, wherein ...
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WO/2009/147434A1 |
The present invention relates to a novel process for the preparation of γ-amino acids, such 5 as (±)-3-(aminomethyl)-5-methyl-hexanoic acid (1), which is a key intermediate in the preparation of the potent anticonvulsant pregabalin, (S...
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WO/2009/145219A1 |
Disclosed is a means for treating Alzheimer's disease, which utilizes a secretase inhibitor and is highly safe. Specifically disclosed is a compound represented by general formula (I) [wherein A represents a phenyl group or the like; R1...
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WO/2009/145263A1 |
Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an interme...
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WO/2009/145323A1 |
Disclosed is a novel method for oxidizing an alcohol compound. The method for oxidizing an alcohol compound, which is expressed by scheme (1), is characterized by using oxygen in the presence of a polycyclic compound and a nitrous acid c...
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WO/2009/141362A2 |
The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for t...
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WO/2009/137411A1 |
Compounds comprising Formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein J1, J2, U1, B, Y, and A are as described in claims 1-16. Methods, compositions, and medicaments related thereto are also disclosed, fo...
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WO/2009/137412A1 |
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, a dashed line represent the presence or absence of a double bond, are disclosed, wherein J1, J2, U1, B, Y, and A are as described in claims 1-12. Methods, co...
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WO/2003/096987A9 |
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WO/2009/134383A2 |
Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
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WO/2009/129099A1 |
Provided is a process for the formation of 2-nitropropane and/or 2,2-dinitropropane by the nitration of propane with dilute nitric acid.
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WO/2009/129097A1 |
Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compoun...
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WO/2009/125606A1 |
Provided is a compound represented by formula (I) having a PAI-1 inhibiting action. [In formula (I), R1 represents an optionally substituted C6-10 aryl group etc., T represents a single bond etc., m is 0 or 1, when m is 0 G represents -N...
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WO/2009/114329A2 |
Polyols or polyisocyanates, or both, are treated to reduce aldehyde impurities before being reacted together to form a polyurethane. Polyols are treated by adding certain aminoalcohols to them, preferably in the presence of a tertiary am...
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WO/2009/107133A1 |
The invention provides a process for preparing bronopol, which process comprises charging a reaction vessel with water, bromopicrin, nitromethane and paraformaldehyde, gradually feeding a base into said reaction vessel under stirring, br...
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WO/2009/102043A1 |
Disclosed is a method for producing an optically active 4-amino-3-(3,4-dichlorophenyl)butan-1-ol, wherein an optically active 3-(3,4-dichlorophenyl)-4-nitrobutanal is obtained by reacting 3-(3,4-dichlorophenyl)acrylaldehyde with nitromet...
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WO/2009/096409A1 |
Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time. Specifically disclosed is a catalyst which is composed...
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WO/2009/087650A2 |
A novel process of preparation of racemic pregabalin from comprising an intermediate of structure III comprising reductive ring opening to form a structure IV followed few alternative routes that yield racemic pregabalin that is resolved...
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WO/2009/086277A1 |
Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are described.
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WO/2009/084031A2 |
The present invention relates to an improved, cost effective, eco-friendly and easy t handle process to manufacture substantially pure form of (2E)-2-Cyano-3-(3,4-dihydroxy-5 nitrophenyl)-N,N-diethyl-2-propenamide or (E)- N,N-diethyl-2-c...
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WO/2009/069523A1 |
Disclosed is a polymeric compound having a constituent unit represented by formula (1a), wherein ring A and ring B independently represent an aromatic hydrocarbon ring which may have a substituent; R1 represents a group represented by fo...
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WO/2009/070736A1 |
A composition for and methods of preserving a topical cosmetic, toiletry or pharmaceutical formulation against microbiological contamination or growth are described in which the compositions used herein include at least one hydroxamic ac...
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WO/2009/067597A1 |
Compounds of the formula: (I) are disclosed. The compounds act as phosphodiesterase-4 modulators, and useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions. Other embodiments are also disclosed.
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WO/2009/054202A1 |
A method of organic-compound reaction and a process for producing an organic compound. By the method and process, high reaction selectivity and a high yield of a target substance can be ensured according to purposes. At least two fluids ...
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WO/2009/046992A1 |
The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy resid...
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WO/2009/044803A1 |
A process for producing a product of the asymmetric-catalyst Michael reaction. By the process, an α,ß-unsaturated aldehyde can be reacted with a nitroalkane such as nitromethane to obtain the corresponding Michael addition product in a...
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WO/2009/034258A1 |
The invention relates to tri-amino-pyrimidine derivatives of the general formula (I) in which Y, R3, W, R4a, R5a, R4b, R5b, n and m are variable. These compounds have a phosphatase CDC25 inhibiting activity and can thus be used as drugs ...
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WO/2009/026961A1 |
Processes for the preparation of pancratistatin and pancratistatin analogues. The key step is the reaction of a 1,3-dioxan-5-one and a nitroolefine in the presence of an amine. The process may take place in an enantioselective way when a...
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WO/2009/028719A1 |
Disclosed is an alkali metal fluoride dispersion substantially comprising an alkali metal fluoride and an aprotic organic solvent, which is produced by carrying out Step (A) mentioned below, subsequently carrying out Step (B) mentioned b...
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WO/2009/017091A1 |
Disclosed is a method for producing a β-nitrostyrene compound wherein a benzaldehyde derivative represented by the formula (I) below and nitromethane are condensed in an acetic acid solvent in the presence of a primary amine. This metho...
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WO/2009/010426A1 |
The present invention relates to a process for preparing dinitrotoluene. The process of the invention for preparing dinitrotoluene from mononitrotoluene, which comprises carrying out a mononitrotoluene nitration reaction using a nitratin...
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WO/2009/000651A1 |
A method of producing 2-phenoxyacetals of the general formula (Ia) is likewise described in which R1 is hydrogen, a branched or unbranched C1-C12-alkyl moiety, a low-electron, halogen-NO2-, -CN, -CF3-, acyl- or branched or unbranched alk...
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WO/2009/002734A1 |
A method for producing nitrobenzene is disclosed which comprises forming a dispersion comprising benzene-containing droplets or particles dispersed in a mixture of concentrated nitric acid and concentrated sulfuric acid, wherein said par...
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WO/2008/148608A1 |
The present invention relates to a process for preparing mixtures of diphenylmethane diisocyanates and polyphenyl polymethylene polyisocyanates by sequential reaction of benzene to nitrobenzene to aniline to polyphenyl polymethylene poly...
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WO/2008/146277A1 |
A continuous process of preparing bromopicrin is disclosed. The process is effected by transferring a continuous flow of a first mixture and a continuous flow of a second mixture into a first reactor, the first mixture containing nitrome...
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