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WO/2023/227029A1 |
The present invention relates to a novel crystal form of elacestrant (hereinafter referred to as "compound I") dihydrochloride, a preparation method therefor, a pharmaceutical composition containing the crystal form, and uses of the crys...
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WO/2023/224418A1 |
The present invention relates to a method for producing, from fatty alcohols, various monomers that are used in the production of synthetic resins.
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WO/2023/214426A1 |
The present invention discloses a method for resolving cyclohexylphenyl glycolic acid and the preparation of optically active phenylcyclohexyl glycolate esters. More particularly, the invention provides a process for preparation of optic...
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WO/2023/214360A1 |
A method to increase the stability of an aqueous composition comprising an alkanolamine, said method comprising the steps of: - providing a vessel; - adding a pre-determined amount of water into said vessel; - adding a pre-determined amo...
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WO/2023/213713A1 |
Ethanolamines, polyethylenimine and ammonia having a low molar share of deuterium, a process for making ethanolamines, polyethylenimine and ammonia based on non- fossil energy, the use of the molar share of deuterium in hydrogen and down...
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WO/2023/206874A1 |
A sacubitril intermediate, a preparation method therefor, and use thereof. A key intermediate N-Boc amino alcohol represented by formula (10) or formula (10-a) can be efficiently prepared. The intermediate can be used to prepare a neutra...
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WO/2023/209033A1 |
In one aspect, the present invention relates to a method for crystallizing (2R,3R)-3-(3- methoxyphenyl)-N,N,2-trimethylpentan-1-amine or salts thereof (compound I), the method comprising the following steps: (i) mixing compound I with a ...
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WO/2023/197017A1 |
A method for preparing chiral amines useful as pharmaceutical intermediates is provided. The method comprises contacting an ester of formula I in which R1 is a methyl or an ethyl group; R2 is a linear or branched C1 – C4 alkyl group; a...
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WO/2023/187051A1 |
A process for the production of a surfactant is provided, as well as a surfactant composition. Moreover, specific surfactants and compositions thereof are provided, as well as their use in a wide variety of applications such as all purpo...
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WO/2023/191088A1 |
The present invention provides a polysaccharide which has a degree of polymerisation of 16-40 and is composed only of galactose or composed only of galactose and 1-3 molecules of arabinose, the saccharide units of said polysaccharide bei...
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WO/2023/179463A1 |
The present invention relates to a cationic lipid compound, a preparation method therefor and the use thereof, and an mRNA delivery system, which relate to the technical field of medical biology. The problem of there being an urgent need...
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WO/2023/176209A1 |
A tosylic acid anionic ionic liquid represented by formula (1) is a unique compound that is especially stable in supercooled conditions and maintains a liquid state especially easily, even among ionic liquids, and can be handled as a liq...
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WO/2023/173203A1 |
Provided herein is a method for a method for producing an ionizable amino lipid, or a pharmaceutically acceptable salt thereof, the method comprising a nucleophilic displacement of a leaving group L in a compound of Formula (II), wherein...
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WO/2023/171694A1 |
Provided in an embodiment is a core-shell type heterogeneous catalyst provided with a core 1 and a shell 2 positioned on the outside of the core 1, wherein the shell 2 contains a metal complex structure 3 containing a Josiphos ligand.
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WO/2023/149559A1 |
[Problem] The present invention provides a catalyst for hydrogenation reactions, the catalyst having excellent catalyst durability and being capable of selectively hydrogenating only some functional groups and/or unsaturated bonds of an ...
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WO/2023/134145A1 |
The present invention provides a preparation method for a tivozanib key intermediate compound of formula I, 2-chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)-aniline. Compound of formula VI, 4-chloro-6,7-dimethoxyquinoline and compound of for...
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WO/2023/137044A2 |
Described herein are methods of making (Z)-endoxifen, a salt thereof, crystalline forms of endoxifen, and compositions comprising them. Also described herein are crystalline forms of (Z)-endoxifen. A method of making (Z)-endoxifen may in...
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WO/2023/135035A1 |
A process for the manufacture of alkanolamines and/or a process for the conversion of al-kanolamines wherein the process is performed in one or equipment items, wherein one or more steel parts of the one or more equipment items, which ha...
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WO/2023/117111A1 |
The invention relates to an especially recyclable composite material which consists of at least two material layers (1, 4) bonded by a layer (2) of adhesive. For an easy and clean separation of the two material layers the adhesive consis...
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WO/2023/117112A1 |
The invention relates to a compound material, especially a recyclable composite material which consists of at least two material layers (1, 2) bonded by a layer (2) of adhesive. For an easy and clean separation of the two material layers...
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WO/2023/109213A1 |
A method for preparing a chiral amine compound B or C, which can be used for synthesizing an optically pure repotrectinib intermediate, wherein 2-hydroxy-5-fluorophenylalkylketone compound A is used as a raw material, and a corresponding...
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WO/2023/112939A1 |
A method for purifying a composition that comprises a step for dissolving the composition containing a compound represented by formula(1) [in formula (1): R1 represents -N(R2)-R2 (wherein R2 represents a C1-C4 alkyl group); R3 and R4 rep...
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WO/2023/110929A2 |
The present invention relates to the use of a supported bimetallic catalyst of formula Pd-M/Support, comprising palladium and a metal M on a support, wherein M is Cu or Ag, in the implementation of a method for preparing ethylene glycol ...
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WO/2023/112055A1 |
The present invention relates to a process for preparing a compound of formula I: I. The compound of formula I is useful in anti-doping tests.
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WO/2023/108172A2 |
Disclosed herein are compounds of the formula wherein R1 is methyl; R2 is selected from hydrogen, deuterium, and methyl, or R1 and R2 together with the atom to which they are attached form a cyclopropyl; R3 and R4 independently are selec...
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WO/2023/098203A1 |
Disclosed in the present invention is a production method for 4,4'-diaminodiphenyl ether, which relates to the technical field of the hydrogenation synthesis of aromatic nitro compounds. According to the production method for 4,4'-diamin...
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WO/2023/098670A1 |
Disclosed are a polyphenol antioxidant and a preparation method therefor and an application thereof. An antioxidant molecule designed in the present invention contains a hindered phenol functional group used as a main antioxidant, and fu...
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WO/2023/098592A1 |
The present invention provides a carbon-loaded iron-based catalyst, and a preparation method thereof and a use. The preparation method comprises dissolving ferric chloride in water, adding activated carbon, adding sodium hydroxide at 60-...
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WO/2023/102167A1 |
A method for the synthesis of anhydrous quaternary ammonium hydroxides having the formula (NR1R2R3R4)OH, wherein R1, R2, R3 and R4 are the same as or different from one another and are each individually selected from H, C1-C10 alkyls inc...
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WO/2023/082465A1 |
The present invention relates to the technical field of chemical catalytic reaction. Disclosed are a method for preparing an amino alcohol by asymmetric hydrogenation and an application thereof. A starting raw material of the chemical re...
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WO/2023/077824A1 |
The present invention relates to the technical field of drug synthesis, and relates to a preparation method for dopamine hydrochloride. Specifically, the preparation method for dopamine hydrochloride of the present invention comprises th...
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WO/2023/067624A1 |
The present invention provides a method for the preparation of building blocks of 2,7-dihydroxy-9-fluorenone towards the synthesis of tilorone dihydrochloride salt and other salts (bromide, iodide, fluoride, citrate, oxalate, maleate, ph...
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WO/2023/064364A1 |
A process for preparing alkoxylated ether amines including performing an alkoxylation reaction between a Guerbet alcohol and an epoxide in the presence of a catalyst to obtain an alkoxylated alcohol. Performing an amination reaction on t...
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WO/2023/060955A1 |
Provided in the present invention is a synthetic method for cetyl-PG hydroxyethyl palmitamide. The method comprises the following steps: firstly, mixing 1,3-dichloropropanol and hexadecyl alcohol under the action of a catalyst and an alk...
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WO/2023/061999A1 |
The present invention discloses a distinct mode of action of a nickel catalyst to forge C-0 bonds to unlock the mild utilization of N2O as O-atom transfer reagent in the synthesis of complex phenols from the corresponding aryl halides.
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WO/2023/050583A1 |
A method for preparing tris(hydroxymethyl)aminomethane of the present invention, comprising: a process of preparing tris(hydroxymethyl)aminomethane by continuous catalytic hydrogenation of tris(hydroxymethyl)nitromethane is carried out i...
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WO/2023/046768A1 |
The invention relates a method for producing amine N-oxide compounds of the formula (I) or (II), in which the R1 are selected from hydrocarbon groups with 4 to 26 C atoms and optionally at least one O or S atom; R2, R3, and R5 are select...
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WO/2023/048034A1 |
The present invention addresses the problem of providing a method for producing an aromatic compound having an ethynyl group by means of a simple and inexpensive coupling reaction using a halogen-containing aromatic compound. The prese...
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WO/2023/043794A1 |
Described herein are processes for preparing psilocin and psilocybin and chemical intermediates used in the synthetic processes.
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WO/2023/029478A1 |
The present invention relates to a lipid compound, which can be used alone or in combination with other lipid components such as neutral lipids, charged lipids, steroids and/or analogs thereof, and/or polymer-conjugated lipids to form li...
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WO/2023/024532A1 |
Disclosed in the present invention is a one-step method for preparing a C-N coupling product using nitroaromatic hydrocarbon and alkyl or phenylboronic acid. The method comprises: adding nitroaromatic hydrocarbon, alkyl or phenylboronic ...
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WO/2023/025058A1 |
Provided in the present invention are a hydrocarbyl tetralin polyethersulfonate, a preparation method therefor and the use thereof. The hydrocarbyl tetralin polyethersulfonate is represented by formula (I-0). The hydrocarbyl tetralin pol...
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WO/2023/017527A1 |
The present invention relates to an additive comprising stearic acid and ethanolamine. The invention also relates to a process for the preparation of said additive. The present additive significantly improves the silica filler dispersion...
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WO/2023/017323A1 |
In this invention, the active substance of choline chloride is produced using copper and molybdenum based heterogeneous nanocatalysts which is a food supplement for livestock, poultry and aquatic animals and increases productivity. Choli...
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WO/2023/281933A1 |
Provided is a reaction method that includes, in a gas-liquid reaction performed using a solid catalyst, alternately allowing a gaseous raw material 3 that includes a first raw material and a liquid raw material 5 that includes a second r...
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WO/2023/281077A1 |
The present invention relates to a method for obtaining dimethylaminoethyl (meth)acrylate comprising reacting a (meth)acrylic ester with dimethylaminoethanol that is at least partially renewable and non-fossil.
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WO/2022/269041A1 |
The present invention is directed to a method for continuous production of cationic lipids. Said cationic lipids are particularly useful in combination with other lipid components for forming lipid nanoparticles with oligonucleotides (e....
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WO/2022/262350A1 |
The present invention relates to the field of pharmaceutical chemistry, specifically to a class of substituted diaryl compounds of formula (I), and a preparation method therefor, a pharmaceutical preparation containing same, and the medi...
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WO/2022/259265A1 |
The present invention relates to a process for the preparation of 2,3-dichloro-4-hydroxyaniline of formula I from 2,3-dichloronitrobenzene of formula III. The present invention also relates to a process for the purification of 2,3-dichlo...
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WO/2022/253077A1 |
Provided are a pharmaceutical salt of fingolimod, a preparation method therefor, a pharmaceutical composition containing same and the use thereof. The pharmaceutical salt of fingolimod is a salt formed from a fingolimod free base and an ...
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