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WO/2014/164905A1 |
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative com...
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WO/2014/158654A1 |
Compounds of formula (II): wherein A, R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well...
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WO/2014/148591A1 |
The present invention provides a method for efficiently producing an optically active 1, 2-diol compound from an olefin. The production method for the optically active 1, 2-diol compound is characterized by including: a step in which an ...
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WO/2014/151232A1 |
Disclosed are salt compositions of lysinol and dicarboxylic acids; and lysinol derived polymers including polyamide, polyimide, polyurea, cross-linked polyurea comprising urethane linkages, polyurea foams, cross-linked polyurea foams, an...
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WO/2014/142218A1 |
Provided is a freshness-keeping film having high antibacterial effect. In this freshness-keeping film, at least one compound selected from the group consisting of palmityldiethanolamine, stearyldiethanolamine, glycerol monolaurate and di...
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WO/2014/143561A1 |
Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may b...
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WO/2014/136795A1 |
A hydrogen transfer reaction can be more efficiently promoted by using a metal complex that is represented by general formula (2). Specifically, a hydrogenation reaction can be caused to proceed with respect to various base materials whi...
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WO/2014/129400A1 |
Disclosed is a liquid for absorbing and collecting carbon dioxide from a gas that contains the carbon dioxide, which contains (A) a secondary amine compound represented by general formula (1) R-NH-(CH2)n-OH, (B) a polyamine compound repr...
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WO/2014/130752A2 |
Disclosed are compounds of Formula (I) and/or a salt thereof; wherein R is -OH or -OP(O)(OH)2. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions ...
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WO/2014/126932A1 |
The present invention relates to alkyne derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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WO/2014/111836A1 |
The present invention provides process for preparation of Fingolimod hydrochloride (I). Formula (I): Fingolimod hydrochloride (I) as Form-β obtained by the process of present invention may be useful as active pharmaceutical ingredient i...
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WO/2014/111949A1 |
The present invention relates to a simple and commercially feasible preparation of Fingolimod hydrochloride with high purity of greater than 99.9%. The.present invention also provides novel intermediates for the preparation of Fingolimod...
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WO/2014/108671A1 |
A method of preparing a 2,6 disubstituted anilines includes, reacting a 2-amino isophtha!ic acid diester with sufficient Grignard reagent R2CH2MgX to form the corresponding diol product, dehydrating the diol product to the corresponding ...
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WO/2014/104789A1 |
The present invention relates to a ternary carbon dioxide absorbent and a carbon dioxide absorption method and separation method using same, the absorbent comprising ternary alkanolamines having different structures, that is, a secondary...
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WO/2014/101460A1 |
Disclosed are a preparation method of a functionalized choline chloride ionic liquid shown in formula I, and use thereof in an electrochemical energy storage device, as an electrolyte material or an additive used in a lithium ion battery...
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WO/2014/106204A1 |
The present invention provides tromethamine salt of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopen
tyl]-hept-5-enoic acid in crystalline and amorphous form. This compound is may also be referred to as "tromethamine salt of ...
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WO/2014/104792A1 |
The present invention relates to the use of an aqueous solution as a carbon dioxide absorbent, the aqueous solution containing a tertiary dialkylalkanolamine as a primary absorbent, a secondary alkanolamine as a speed enhancer, and polya...
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WO/2014/084185A1 |
Disclosed is a diamine represented by the general formula, a polyimide and polyamide obtained by using the diamine as a raw material, a cyclized product of the diamine, and a method for producing the diamine. In the formula, A is a singl...
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WO/2014/084188A1 |
Provided are: an HFIP-group-containing fluorine diamine represented by formula (2) and obtained by introducing an HFIP group to a fluorine diamine compound; and an HFIP-group-containing polymer compound. (In the formula, R1 represents on...
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WO/2014/074778A1 |
The present invention relates to the antimalarial compounds of formula (l)and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such ...
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WO/2014/000629A9 |
The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in g...
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WO/2014/067281A1 |
Disclosed is a tapentadol hydrochloride crystalline form C having high stability and having characteristic peaks at 14.627 (100%), 15.476 (20.7%), 16.710 (33.7%), 18.999 (48.3%), 20.479 (80.7%), 21.790 (27.9%), 25.110 (35.2%), 25.911 (36...
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WO/2014/069846A1 |
The present invention relates to a method for preparing 1-deoxy-1-(2-hydroxyethyl amino)-D-glucitol from D-glucitol by using a borohydride complex as a reducing agent, and to a method for preparing miglitol from the 1-deoxy-1-(2-hydroxye...
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WO/2014/061219A1 |
The present invention relates to a 2-(ethylamino)ethanol production method characterized by subjecting N-ethyldiethanolamine to a disproportionation reaction in the presence of at least one catalyst selected from a group consisting of a ...
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WO/2014/054391A1 |
A compound represented by general formula (1). In general formula (1), R1 represents either one of a protective group for a hydroxy group and a hydrogen atom, and R2 and R3 independently represent a protective group for an amino group.
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WO/2014/036865A1 |
The present invention relates to fingolimod mucate, a crystal form A thereof and a preparation method for the fingolimod mucate and the crystal form A thereof. The crystal form A has characteristic peaks in an X-ray powder diffraction pa...
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WO/2014/032627A1 |
Provided is a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ -amino- δ -biphenyl- a -methylalkanoic acid, or acid e...
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WO/2014/013706A1 |
The present invention relates to a method for producing 2-(isopropylamino)ethanol, said method being characterized by comprising carrying out a vapor-phase catalytic reaction of acetone, 2-aminoethanol and hydrogen in the presence of a c...
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WO/2014/005546A1 |
The present invention relates to a preparation method of tapentadol hydrochloride and compounds for preparation of the tapentadol hydrochloride. The preparation method comprises steps using a compound in a formula V or a hydrochloride th...
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WO/2014/007398A1 |
Provided are: a cationic lipid represented by formula (A) or the like, which makes it easier to introduce a nucleic acid into, for example, a cell; a composition which contains the cationic lipid and a nucleic acid; a method for introduc...
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WO/2014/001527A2 |
The present invention relates to a method for the detection of a lipid comprising reacting an alkyne-modified lipid derivative and an azido-modified coumarin compound, purifying the resulting compound using chromatography and detecting t...
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WO/2014/001075A1 |
Many optically active amines are valuable pharmaceuticals and intermediates for preparation of active ingredients. Frequently, only one of the two enantiomers is effective and/or harmless, and so the isolation of this enantiomer from the...
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WO/2013/188829A1 |
The invention relates to substantially pure Desfesoterodine salts, Desfesoterodine salts, solid state forms thereof and pharmaceutical compositions comprising one or more of the Desfesoterodine salts and/or solid state forms thereof.
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WO/2013/185928A1 |
The present invention refers to the preparation of 1-aryl-1-alkyl-2-alkyl-3-dialkylamino-propane compounds, such as tapentadol, using a diastereoselective Eschenmoser-Claisen or Ireland-Claisen rearrangement.
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WO/2013/182023A1 |
The present invention provides a carbon fiber surface modifier, a modified carbon fiber, composites, and preparation methods therefor. The general structural formula of the carbon fiber surface modifier is as represented by formula (I): ...
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WO/2013/172544A1 |
The present invention relates to: a compound which is a novel two-photon absorbing fluorescent substance; a production method for the compound; a fluorescence sensor and molecular probe able to sense various substrates or enzyme activity...
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WO/2013/169531A1 |
This invention relates to methods for making oxetan-3-ylmethanamines having the formula (I) wherein R1? and R2? are as defined herein. The methods of the invention provide the compounds of formula (I) in high yields and under conditions ...
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WO/2013/159570A1 |
Provided are a Mannich base, a preparation method for same, and an application thereof in preparing a detergent and a fuel composition. The Mannich base is represented by structural formula (III), where A and R2 are as defined in the des...
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WO/2013/159571A1 |
The present invention relates to a lubricating oil composition and a preparation method therefor. The lubricating oil composition comprises a Mannich base as represented by structural formula (III) and a lubricating oil base oil, where A...
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WO/2013/152548A1 |
The present invention relates to a catalyst for synthesizing ethylene amine and a method for preparing ethylene amine. The catalyst is formed of a main active component, an auxiliary agent, and a carrier processed by ammonification. The ...
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WO/2013/144500A1 |
The invention relates to a method for synthesizing ivabradine of formula (I) and its addition salts with a pharmaceutically acceptable acid.
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WO/2013/148613A1 |
Described are novel polycationic polyhydroxyl compounds for formula (I) and their uses in personal care compositions:
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WO/2013/141437A1 |
The present invention relates to a method for manufacturing (S)-metoprolol which is used as a depressant, and more specifically, to a novel method for effectively manufacturing high purity (S)-metoprolol, comprising the steps of: carryin...
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WO/2013/129682A1 |
Provided is a production method in which a compound comprising an amino group and/or a hydroxyl group is generated under mild conditions by removing atom groups containing CO or CS from a substrate compound containing such atom groups. A...
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WO/2013/123153A1 |
The present invention provides nonionic surfactants, compositions incorporating these surfactants, and related methods of making and using such surfactants and compositions. The nonionic surfactants demonstrate excellent equilibrium and ...
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WO/2013/120466A1 |
The present invention relates to a crystalline form of tapentadol hydrobromide of formula (i), chemically 3-[(1R,2R)-3-(dimethylamino)-l-ethyl-2-methylpropyl]phenol hydrobromide, which manifests the following characteristic reflection in...
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WO/2013/117013A1 |
A new process for the production of APMMEA (aminopropylmethylethanolamine) is proposed. This process comprises at least 2 steps in which MEAPN (monomethylethanolaminopropionitrile) is first produced from MMEA (monomethylethanol amine) an...
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WO/2013/111823A1 |
[Problem] To provide a method for producing a sphingoid base-containing extract, and a functional food or pharmaceutical composition containing the resulting extract. [Solution] This method for producing a sphingoid base-containing extra...
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WO/2013/105109A1 |
Disclosed herein is a process for the preparation of the compound 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol comprising a) reacting compound (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan
-3-ol with a mixture o...
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WO/2013/087770A1 |
The present invention relates to quinone direct dyes of formula (I) below, organic or mineral acid or base salts thereof,tautomeric forms, optical isomers or geometrical isomers thereof and/or solvates thereof: and also to the use thereo...
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