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WO/2009/005794A2 |
Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and ...
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WO/2009/005024A1 |
Disclosed is a method for producing a chiral amine, which is characterized in that an imine compound is subjected to a hydrogen transfer-type asymmetric reduction in the presence of an iridium (III) complex having a chiral proline amide ...
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WO/2009/003589A1 |
The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and g...
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WO/2009/004914A1 |
Disclosed are: a PET probe compound having an alkoxy group substituted by a fluorine and a hydroxy group, which is useful for the early diagnosis of a conformational disease; a pharmaceutical composition for the treatment and/or preventi...
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WO/2008/155613A1 |
A process for the preparation of famciclovir a compound of Formula (I) and its intermediates.
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WO/2008/153159A1 |
It is intended to provide a novel amine compound represented by the following general formula (I), a pharmaceutically acceptable acid addition salt thereof, a hydrate thereof or a solvate thereof, which has an excellent peripheral blood ...
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WO/2008/151179A2 |
Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
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WO/2008/148057A2 |
The disclosure provides adjuvants, immunogenic compositions, and methods useful for vaccination and immune response. In particular, the disclosure provides a class of adjuvants comprising cationic lipidxo-lipid mixtures and methods for d...
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WO/2008/142088A1 |
The invention relates to a process for preparing α-aminoacetals substantially in racemic form, comprising a step of oxidizing optically enriched α-aminoacetals to the corresponding oximes, in the presence of a catalyst, and a step of r...
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WO/2008/140859A1 |
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disor...
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WO/2008/138639A1 |
This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper- proliferative and/or angiogenesis disorde...
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WO/2008/139987A1 |
Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabet...
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WO/2008/137470A1 |
There are provided multi-chain lipophilic polyamine compounds and derivatives thereof, pharmaceutical formulations comprising the same, method of making and using said compounds or formulations.
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WO/2008/134327A1 |
The present invention is a method comprising: (a) providing an N-alkenylphthalimide; (b) converting the alkenyl group to an aldehyde by hydroformylation; (c) reacting the aldehyde with an alcohol or alkyl diol to form two alkoxy groups o...
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WO/2008/133269A1 |
Disclosed is an ionic liquid comprising a cation having a quaternary nitrogen atom and an alkoxyalkyl group on the nitrogen atom (i.e., a cation represented by the formula (1)) and an ion represented by the formula: (CH3O)(R)PO2 - [where...
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WO/2008/128129A1 |
This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and...
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WO/2008/123821A1 |
The present invention relates to new compounds of formula (I), as a free base or salts thereof, to pharmaceutical compositions containing said compounds and to the use of said compounds in therapy. The present invention further relates t...
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WO/2008/119015A2 |
A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic sche...
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WO/2008/117759A1 |
Disclosed is a novel diamine which has an effect of increasing the pretilt angle of a liquid crystal when used as a raw material for a liquid crystal aligning agent. This diamine enables to vertically align a liquid crystal even when use...
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WO/2008/117760A1 |
Disclosed is a novel diamine which has an effect of increasing the pretilt angle of a liquid crystal when used as a raw material for a liquid crystal aligning agent. This diamine enables to vertically align a liquid crystal even when use...
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WO/2008/110281A2 |
The jinvention relates to 3,4-disubstituted phenoxyphenylamidines of geenral formula (I), a method for production thereof, and use of said amidines for preventing undesired microorganisms and an agent for said purpose, comprising said ph...
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WO/2008/110280A2 |
The invention relates to 3-substituted phenoxyphenylamidines of general formula (I), a method for production thereof and use of said amidines for preventing undesired microorganisms and an agent for said purpose, comprising said phenoxya...
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WO/2008/110314A1 |
The invention relates to fluoroalkylphenylamidines of general formula (I), a method for production thereof and use of said amidines for preventing undesired microorganisms and an agent for said purpose, comprising said phenoxyamidines. T...
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WO/2008/110315A1 |
The invention relates to 4-cycloallkyl or 4-aryl substituted phenoxyphenylamidines of general formula (I), a method for production thereof and use of said amidines for preventing undesired microorganisms and an agent for said purpose, co...
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WO/2008/110279A1 |
The invention relates to dihalophenoxyphenylamidines of general formula (I), a method for production thereof, the use of said amidines to prevent undesired microorganisms, and an agent for said purpose comprising said phenoxyamidines. Th...
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WO/2008/107878A1 |
Novel cannabinoid-derived quinone derivatives (quinonoid derivatives) having a substituted hydroxyl group, pharmaceutical compositions comprising same and uses thereof as anti-proliferative agents, are provided.
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WO/2008/107879A1 |
Novel derivatives of cannabidiol, having one or two of the hydroxyl groups substituted, exhibiting improved production yield, solubility, stability and bioavailability, are provided. Also provided are pharmaceutical compositions comprisi...
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WO/2008/098527A1 |
A method for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-indole of formula (1) by reaction of 2-bromo-4'-benzyloxypropiophenone and 4-benzyloxyaniline hydrochloride, in which high purity of the product is achieved by...
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WO/2008/099730A1 |
Disclosed is a novel optical resolving agent for an amine compound, which can be produced on an industrial scale in a simple manner and at low cost. An optically active 2-(aroyloxy)propionic acid can be used as an optical resolving agent...
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WO/2008/093142A1 |
The present invention relates to a novel process for the preparation of O-desmethyl 5 venlafaxine (ODV).
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WO/2008/093686A1 |
Disclosed is a salt, particularly an ionic liquid, of a nonsteroidal anti-inflammatory drug (NSAID) comprising a carboxylic acid and an organic amine compound, which has properties required for a preparation for external application (e.g...
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WO/2008/087736A1 |
A process for producing an aromatic amine compound having an aralkyloxy or heteroaralkyloxy group, in which under mild conditions, through convenient procedure, an aromatic nitro compound having an aralkyloxy or heteroaralkyloxy group is...
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WO/2008/087421A2 |
A compound having formula (I). R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkyl...
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WO/2008/083708A1 |
The present invention relates to an improved process for the preparation of essentially pure Venlafaxine Hydrochloride. Particularly, the process for the preparation of Venlafaxine Hydrochloride comprises the following steps: i) Preparat...
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WO/2008/081811A1 |
Disclosed is a conductor having high conductivity and electrochemical stability, which is in a solid state over a practically wide temperature range. Specifically disclosed is a plastic crystal containing a compound represented by the fo...
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WO/2008/081477A1 |
Present invention relates to novel 3-aryloxy 3-substituted propanamines of formula (I), method of preparing the same and to their use in inhibiting serotonin and norepinephrine reuptake wherein A is a phenyl which is optionally substitut...
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WO/2008/074227A1 |
Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the...
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WO/2008/069518A1 |
The present invention relates to a new use of alkylcarbamoyl naphthalenyloxyprophenylhydroxybenzamide derivatives for controlling the function of sphingosylphosphorylcholine.
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WO/2008/065681A2 |
The present invention provides a process for preparing Ivabradine of formula (I) or its pharmaceutically acceptable salts, solvates, hydrate thereof, by reacting 3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trie
n-7-yl]methyl}...
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WO/2008/062469A2 |
The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta(TR-Beta). Further, the present invention relates to processes o...
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WO/2008/062138A1 |
The invention relates to an in situ or one-pot method for preparing compounds of the formula (I). The method provides a compound of the formula (I) and comprises: a) hydrogenation of a nitrile function of the compound of the formula (II)...
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WO/2008/062473A1 |
The present invention relates to the process for preparing Atomoxetine hydrochloride which is a selective norepinephrine reuptake inhibitor. Atomoxetine HCl is chemically known as (-)-iV-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydroch...
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WO/2008/059525A2 |
A novel single step process for the synthesis of venlafaxine of formula I and N-desmethylvenlafaxine of formula II from 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile [cyano-intermediate] of formula V V comprising reacting 2-(1-...
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WO/2008/054154A1 |
The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.
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WO/2008/053652A1 |
A process for producing 1-hydroxy-4-aminoadamantane shown below. wherein R1 and R2 independently represent a hydrogen, a halogen, a carboxy, a nitro, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylsulfonyl...
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WO/2008/053285A1 |
The present invention relates to new synthetic methods for preparing 2- methoxyisobutylisonitrile and metal isonitrile complexes, such as tetrakis(2- methoxyisobutylisonitrile)copper(I) tetrafluroroborate, which are used in the preparati...
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WO/2008/047382A2 |
The present invention relates to a process for the preparation of 4-[2-[[3-(4-hydroxyphenyl)-1- rnethylpropyl]amino]ethyl]-1,2-benzenediol, a compound of formula (I), and its pharmaceutically acceptable salts. The compound of formula (I)...
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WO/2008/046745A1 |
The present invention relates to a process for the synthesis of aryloxypropylamine and heteroaryloxypropylamine of formula (I) where: A is aryl or heteroaryl, where the aryl is preferably a phenyl, optionally substituted, selected from b...
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WO/2008/047839A1 |
Disclosed is a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof, which can act as a 5-HT1A receptor agonist (serotonin 1A agonist) and is useful as a therapeutic or prophylactic agent for a mood disor...
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WO/2008/046598A1 |
The present invention provides a Compound of formula (I), wherein: R1 is a group selected from -CH2OH,-NH(CO)H; and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the c...
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