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WO/2009/047905A1 |
Disclosed is a selective ester production process of an alcoholic hydroxyl group, which proceeds under chemically mild conditions, while having adequate environmental suitability, operability and economical efficiency. Specifically discl...
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WO/2009/044278A1 |
The present invention provides a novel amorphous form of fesoterodine fumarate, process for preparation, pharmaceutical compositions, and method of treating thereof.
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WO/2009/042013A1 |
The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1S, 2S, 4R)-2-hydroxy-4-{7H-pyrrolo[2/3-d]pyrimidin-7- yl}cyclopentyl)methyl sulfamates, which are El activating enzyme inhibitors,...
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WO/2009/037569A2 |
Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of Fesoterodine or a pharmaceutically acceptable salt thereof in high yield and purity. Disclosed also herein is an improved a...
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WO/2009/037707A2 |
ABSTRACT Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of pota...
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WO/2009/018389A1 |
Described herein are cannabidiol prodrugs, methods of making cannabidiol prodrugs, formulations comprising cannabidiol prodrugs and methods of using cannabidiols. One embodiment described herein relates to the transdermal or topical admi...
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WO/2009/014829A2 |
Biocompatible polymers having polymer backbones with at least one pendant reactive secondary amine suitable for diazeniumdiolation are disclosed. Specifically, methods for providing secondary amines-containing polymers using epoxide-open...
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WO/2008/132679A1 |
The invention relates to compounds of formula (I), wherein R1, R2, R1a, R2a, R3, R4, A, B, X, W and n are as defined in the description, and pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium chann...
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WO/2008/107797A2 |
Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of substantially pure Lercanidipine intermediate, 1,1,N- trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate. The inter...
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WO/2008/105964A1 |
Provided is an adjuvant for agricultural pesticides comprising at least one dialkyl alkanolamine such as dimethyl ethanolamine, at least one derivative thereof, or a combination thereof. A pesticide composition comprising glyphosate herb...
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WO/2008/098375A1 |
The invention emcompasses polyunsaturated fatty acid monoglycerides and derivatives thereof, having the formulae (I), (II), (III) and (IV), pharmaceutically acceptable salts thereof, compositions thereof and processes of preparing said c...
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WO/2008/087736A1 |
A process for producing an aromatic amine compound having an aralkyloxy or heteroaralkyloxy group, in which under mild conditions, through convenient procedure, an aromatic nitro compound having an aralkyloxy or heteroaralkyloxy group is...
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WO/2008/080680A1 |
The invention relates to compositions which are suitable as fabric softeners, particularly for softening fabrics that have been washed with highly concentrated detergents. Said compositions are obtainable by esterification of a C6 - C22 ...
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WO/2008/074154A1 |
A hyperbranched polyglycidol polymer with zwitteπon endgroups of quaternary nitrogen and phosphate or phosphonate are described, as well as methods to prepare said polymers The zwitteπon endgroups allow the polymer to interact with pro...
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WO/2008/071948A2 |
A compound of formula (1 ) Including pharmaceutically acceptable salts thereof, wherein: R1 is aryl or heteroaryl optionally substituted with R8; R2 is H or alkyl or CH2 (when forming part of a ring with R3, R4 or R5); R3 is H, alkyl, CH...
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WO/2008/073350A2 |
The invention relates to radiolabeled compounds and their use in methods of imaging amyloid deposits, as well as to methods of their manufacture. The invention also relates to compounds for inhibiting the aggregation of amyloid proteins ...
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WO/2008/068444A1 |
The subject of the invention is a method for the synthesis of (meth)acrylic esters by transesterification in the presence of a catalyst corresponding to the formula [(R'O)3TiO]xR'' in which R' is a linear or branched alkyl radical having...
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WO/2008/061466A1 |
Disclosed are synthetic methods of formula (V) compounds: wherein R1-R7 are same or different and respectively selected from hydrogen and C1-4 alkyl; and n is an integer of 1-4. Said methods can be carried out as one-pot processes. Synth...
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WO/2008/056808A1 |
Disclosed is a polyimide which is obtained by reacting a tetracarboxylic acid component with a diamine component containing a diamine compound represented by the following general formula (1). (In the formula, A represents a biphenylene ...
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WO/2008/037433A1 |
The invention relates to a process for making the compound of general formula (I), or an acid addition salt wherein the dotted line indicates a carbon-carbon bond on the asymmetric carbon, which process comprises the steps of a) the reac...
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WO/2008/037503A2 |
The invention relates to a process for making the compound of general formula (I), or an acid addition salt wherein the dotted line indicates a carbon-carbon bond on the asymmetric carbon, which process comprises the steps of a) the reac...
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WO/2008/022541A1 |
Disclosed are a series of esters containing 2,6-diisopropylphenyl and tert-amine, the water-soluble derivatives thereof (II) through reaction with acid, and preparation method thereof. The method uses 2,6-diisopropylphenol (I) as a raw m...
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WO/2008/012046A1 |
The present invention relates to an improved process for the preparation of 3- [(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride.
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WO/2007/147252A1 |
The present invention provides the use of prodrugs of pelorol and homopelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIPl activity. A compound or a pharmaceutical composition of the present invention...
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WO/2007/144091A1 |
The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, ch...
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WO/2007/140965A1 |
This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof , comprising the following steps: a)...
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WO/2007/140986A1 |
The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C1-C6 alkyl group or an aryl group which may optionally be substituted. Thi...
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WO/2007/140611A1 |
Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are partic...
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WO/2007/138440A1 |
The invention provides a process for the production of a compound of formula (I), wherein Y is selected from CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i) reacting a compound of formula (II), wherein OX is hydroxy or O...
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WO/2007/137799A1 |
The present disclosure relates to a process for the preparation of 2-(3-diisopropylamino-l-phenylpropyl)-4-(hydroxymethyl) phenol or its phenolic monoesters or salts thereof, characterized by the steps of a) reacting a compound of formul...
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WO/2007/134421A1 |
The present invention relates to the preparation of 2-vinyl indoles from ortho-gem-dibromovinylaniline compounds and alkene reagents using a palladium pre-catalyst, a base, and, in some instances, a ligand or additive. The present invent...
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WO/2007/127639A2 |
This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula (I) wherein (II) is a biologically-active moiety comp...
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WO2006097421A9 |
The present invention relates to a method of removing SO2 contaminants from dimethyl sulfate (DMS) by treatment with an oxidizing agent, and to a process for the preparation of odour free fatty acid trialkanolamine esters quaternized wit...
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WO/2007/090567A1 |
A fabric softening composition comprising from 1 to 80% by weight of ester-linked quaternary ammonium fabric softening material comprising a quaternised mixture of mono- di- and tri-ester of alkanolamine in which the tri-ester content of...
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WO/2007/092020A1 |
A fabric conditioning active composition comprising an esterquat mixture of quaternised mono- di- and tri-esters of alkanolamine in which the tri-esterquat content of the quaternised esterquat mixture is from 25 to 50% by weight of said ...
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WO/2007/071452A1 |
This invention provides compounds having the structural formula: wherein:- R1 is an acyl or sulfonyl group, - R2 is an acyl group selected from the group consisting of acyl groups derived from cycloaliphatic, aromatic or heterocyclic mon...
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WO/2007/068929A1 |
Compounds of formula (I) have muscarinic M3 receptor modulating activity; formula (I) wherein R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group -R5, or a group, -Z-Y-R5, or a group -Z-NR9R10, or a group -Z-N(R9)C...
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WO/2007/057120A1 |
The invention relates to a process in which a compound R1COOR3 (I) is made by a transesterification reaction of an ester compound R1COOR2 (II) with an alcohol R3OH (III) in the presence of a transesterification catalyst, wherein R1 is H ...
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WO/2007/059350A2 |
Embodiments of the process for the preparation of alkoxyamines of the present invention are directed to conducting a coupling reaction in a reaction medium initially comprising at least one transition metal catalyst, an ATRP initiator an...
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WO/2007/022030A2 |
The present invention provides methods of carrying out the safe and reliable preparation of lipids comprising quaternary amines. Such lipids are especially suited for introducing therapeutic agents into cells or organisms. In particular,...
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WO/2007/017670A1 |
Compounds of formula (I) have muscarinic M3 receptor modulating activity; Formula(I) wherein A is an oxygen atom or group -N(R12)-;(i) R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group -R5, -Z-Y-R5 -Z-NR9R10; -Z-...
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WO/2006/133652A1 |
Compounds of the general formula (I), optical isomers, pharmaceutically acceptable salts, preparation process and uses thereof in which R1, R2, R3 and R4 are as defined in specification are disclosed. Such compounds can be optical isomer...
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WO/2006/135694A2 |
Disclosed herein are novel aromatic-containing compounds and methods for using various aromatic-containing compounds for treatment and prevention of diseases and disorders related to the Urotensin II receptor.
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WO/2006/121187A1 |
The present invention provides: an acrylicester compound having a structure represented by General Formula (1) or (2) below ; a latent electrostatic image forming member includes a cured material obtained through a radical polymerization...
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WO/2006/111233A1 |
The invention relates to the use of compounds of formula (I), comprising radicals as defined in the description, which are used as antioxidants, corresponding novel compounds and preparations, in addition to a corresponding production me...
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WO/2006/111234A1 |
The invention relates to the use of compounds which do not display any essential UV-absorption in the UV-A- or UV-B-ranges, but are reactive under conditions of application, in order to produce UV-A- or UV-B- protection during applicatio...
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WO/2006/100225A2 |
Benzoic acid ester compounds of formula (I) wherein R and R1-R5 have the meanings explained in the description, methods for producing them and use thereof in cosmetic, pharmaceutical, personal care and industrial preparations as sunscree...
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WO/2006/056312A1 |
The invention relates to DOTAP chloride that is devoid of enantiomers, in addition to stable crystalline modifications of (2R,S)-, (2S)- and (2R)-DOTAP chloride. The invention also relates to a method for producing said modifications and...
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WO/2006/040332A1 |
The instant invention relates to the use of compounds derived from the esterification reaction of alkoxylated amines and fatty acids, optionally quaternised with an alkylating agent, and of the cationic surfactants and esterquats obtaina...
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WO/2006/040470A1 |
The invention concerns a method for preparing (meth)acrylic esters or anhydrides from acrylic acid of formulae (I), wherein R is H or Me, and R' is alkyl and R'' is alkyl or ethyl substituted by dialkylamino whereof the alkyls can form w...
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