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WO/2003/076397A1 |
The present invention relates to a compound formula [I] wherein R1 and R5 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, x is bond,-o-o,-O-CH2-, etc., y is in which Z is bond, -0...
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WO/2003/074572A1 |
The present invention relates to open chain alkoxyamine compounds, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) at least one open chain alkoxyamine compound. Further aspects of the prese...
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WO/2003/072055A2 |
The subject invention provides derivatives of propargylamino indan (PAI) and propargylamino tetralin that selectively inhibit monoamine oxidase (MAO) in the brain, having the structure:, wherein R1 is OC (O) R9 and R2 is H, wherein R9 i ...
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WO/2003/047499A2 |
An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine deri...
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WO/2003/042162A1 |
This invention relates to prodrugs of antidepressants and the use of these prodrugs in a method for therapy and to pharmaceutical compositions comprising the prodrugs of the invention.
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WO/2003/035599A1 |
Novel quaternary ammonium compounds of the formula (I) and any stereoisomers thereof, wherein, R1, R2, and R3 independently represent C1−C6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R1, R2 a...
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WO/2003/022796A1 |
The invention relates to a method for transesterifying methyl methacrylate involving catalysis, particularly zirconium acetylacetonate catalysis. The obtained esters of formula (I) are characterized by having an extremely low content of ...
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WO/2003/008559A2 |
The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease, Alzheimer's disease and related disorders such as...
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WO/2003/008757A1 |
The invention relates to an additive, the use thereof and a method for inhibiting the seeding, growth and/or agglomeration of gas hydrates, whereby an effective amount of an inhibitor is added to a multi-phase mixture, comprising water, ...
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WO/2003/002510A1 |
The invention relates to the B form of ethyl [(7S) 7-[(2R) 2-(3-chlorophenyl)-2-hydroxyethylamino]-5,6,7,8-tetrahydrona
phthalen-2-yloxy] acetate chlorohydrate, applicable as a medicament, with the following particular physical character...
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WO/2002/100817A2 |
The invention relates to a method for producing basic (meth)acrylic acid esters IV by means of transesterification of (meth)acrylic acid alkyl esters I in the presence of a catalyst and by reprocessing the reaction mixture by distillatio...
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WO/2002/100814A1 |
The invention relates to a method for producing (meth)acrylic acid esters IV by means of transesterification of a (meth)acrylic acid ester I with an alcohol R?2¿OH comprising at least one more carbon atom than the alcohol constituents (...
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WO/2002/100813A2 |
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, -CH¿2?-or-CH¿2?CH¿2?-; W is a substituted or unsubstituted alkylene or a substituted or unsubsti...
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WO/2002/100815A1 |
The invention relates to a method for producing higher-molecular (meth)acrylic acid esters IV by the transesterification of a lower-molecular (meth)acrylic acid ester I with a higher-molecular alcohol R?2¿OH in the presence of a stabili...
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WO/2002/096855A2 |
In a preferred embodiment, the subject invention concerns novel analogs of oxybutynin. The present invention also concerns methods for synthesizing the oxybutynin analogs of the present invention. The invention also pertains to methods f...
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WO2001047866A9 |
The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments.
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WO/2002/072068A2 |
This invention pertains to certain lipids and lipid compositions, liposomes and lipoplexes formed therefrom, methods for their synthesis and preparation, compositions and medicaments comprising such liposomes and lipoplexes, and methods ...
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WO/2002/062815A1 |
The invention relates to photo-labile hybrid protecting groups and the application thereof in the synthesis of protected synthons for the light-controlled synthesis of biopolymers, in particular nucleic acids.
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WO/2002/059074A1 |
A compound represented by the general formula (I) (wherein R?1¿ represents C¿1-6? alkyl, etc.; R?2¿ and R?3¿ are the same or different and each represents hydrogen, etc.; R?a¿ represents C¿1-6? alkyl, etc.; Arom represents aryl, et...
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WO/2002/034710A2 |
The invention concerns compounds of formula (1) wherein in particular G represents the -N(CH¿3?)¿2?-, -N(C¿2?H¿5?)¿2?-group or N-pyrrolidine; n is an integer equal to 1 or 2; R¿1?, R¿2? and R¿3?, independently of one another, rep...
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WO/2002/034247A2 |
Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, wher...
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WO/2002/030870A2 |
The invention relates to substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds and the use of substituted C-cyclohexylmethylamine derivatives for producing pharmace...
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WO/2002/026701A2 |
Ionic compounds with a freezing point of up to 100 °C are formed by the reaction of an one amine salt of formula (I) R?1¿ R?2¿ R?3¿ R?4¿ N?+¿ X?-¿, such as choline chloride with an organic compound (II) capable of forming a hydrog...
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WO/2002/014258A2 |
.The invention concerns a method for making an aqueous solution of (meth)acryloyloxyethylbenzyldimethylammonium ((M)ADAMQUAT BZ) chloride, by reacting in the presence of water, N, N-dimethylaminoethyl ((M)ADAME (meth)acrylate with benzyl...
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WO/2002/012165A1 |
A compound of formula (I) wherein x, y, and z are integers from 0 to 3; and the (poly)ethereal amine is at least one selected from compounds of formula II?1¿ through II?5¿.
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WO/2002/004402A1 |
Compounds of the general formula (|), which exhibit selective muscarinic M¿3? receptor antagonism, little have side effects, and are suitable for administration by inhalation and useful as therapeutic agents for respiratory system disea...
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WO/2002/004434A1 |
The invention relates to colchinol derivatives of the formula 1: wherein the substituents are as defined in the description or a pharmaceutically-acceptable salt, solvate or pro-drug thereof. The invention also relates to processes for p...
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WO/2002/000603A1 |
The use of pamoic acid or of one of its derivatives is described with general formula (I), in which groups R1 and R5 are as indicated in the description, or of one of their pharmaceutically acceptable salts, for the preparation of a medi...
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WO/2001/098254A1 |
The invention relates to a method for preparing amino alkyl(meth)acryrlates by means of transesterification from C1-C4 alkyl(meth)acrylates and amino alcohols. The transesterification is carried out in the presence of at least one distan...
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WO/2001/095720A1 |
The present invention relates to the use of an amino compound, which is an esteramine or an amidoamine surfactant with improved biodegradability, as an adjuvant for agrochemically active compounds such as pesticides or fertilisers. The a...
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WO/2001/093653A2 |
The invention relates to ester quaternary mixtures, containing (c) ester quaternaries with an acyl component which is derived from C¿6?-C¿18? fatty acids and (d) ester quaternaries with an acyl component which is derived from C¿18?-CÂ...
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WO/2001/094357A1 |
New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR', SH, SR', SOR', SO¿2?R', NO¿2?, NH¿2?, NHR', N(R')¿2?, CN, halogen, C(=O)H, C(=O)CH¿3?,...
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WO/2001/092198A1 |
The invention relates to a method for the production of an ester of an unsaturated carboxylic acid by reaction of an ester formed from the unsaturated carboxylic acid and a C¿1?-C¿4? alkanol with an alcohol R?3¿OH in the presence of a...
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WO/2001/087299A1 |
The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is admin...
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WO/2001/085668A1 |
The use of the optically active forms of 5,6-dihydroxy-2-methylaminotetralin and acyl esters thereof as medicaments for cardiovascular diseases a process for the preparation thereof and their use in pharmaceutical compositions.
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WO/2001/081296A1 |
Choline derivatives useful in the treatment of the diseases related with central cholinergic deficit.
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WO/2001/074301A1 |
The present invention provides a dental material that includes a hardenable resin system and a first initiator system capable of hardening the hardenable resin.
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WO/2001/062706A1 |
The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases usin...
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WO/2001/055088A2 |
The invention concerns compounds of formula (I) prepared by quaternizing a compound (II) with at least a compound R?3¿ - X?-¿ wherein: R?1¿ = H or -CH¿3?; R?2¿ = -CH¿3?; -C¿2?H¿5?; -C¿2?H¿7? or - C¿4?H¿9?; and the compound (I...
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WO/2001/055081A2 |
Esters derived from fatty acids and juvenoid alcohols of the general formula (I), in which X means the oxygen atom or the NH group, Y means the NH group or the oxygen atom, R means methyl, ethyl, 1-propyl, 2-methylethyl or propargyl and ...
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WO/2001/055089A2 |
The invention concerns a method for preparing compound (I), which consists in introducing a quaternizing agent R?3¿ - X?-¿ in a solution, in a organic solvent or a mixture of organic solvents, of a compound of formula (III), at a tempe...
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WO/2001/049650A1 |
The invention concerns novel esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclocyclohexyl)phenyl, Tramadol analogs, method for obtaining said esters and to the utilization of said compounds for the p...
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WO/2001/044218A1 |
In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including...
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WO2001035957A1 |
The invention relates to highly pure, crystalline, stable compounds of 3,3-diphenylpropylamine derivatives, in the form of their salts, a method for their production and highly pure, stable, intermediate products. The method is particula...
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WO/2001/030734A1 |
The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a cat...
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WO/2001/021577A2 |
A melanin-concentrating hormone antagonist which comprises a compound of formula (I) wherein Ar?1¿ is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main c...
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WO/2001/021601A1 |
The invention concerns an oxazolin-2 compound of formula (I) wherein: R represents a phenyl group; R1 represents an ethyl group; and R2 represents an alkyl or aryl group; and its use for preparing trimebutine. More particularly, the inve...
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WO/2001/012584A2 |
Compounds or their salts of general formula (I): A$m(Y)B$m(Y)N(O)¿s? wherein: s is an integer equal to 1 or 2; A = R$m(Y)T¿1?-, wherein R is the drug radical and T¿1? = (CO)¿t? or (X)¿t'?, wherein X = O, S, NR¿1c?, R¿1c? is H or a...
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WO/2001/009082A1 |
The invention relates to a process for preparing an esterquat composition comprising (a) reacting a tertiary amine according to formula (I) wherein R?1¿ represents a C¿3?-C¿6? hydrocarbon group, R?2¿ represents a C¿3?-C¿6? hydrocar...
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WO/2000/078846A1 |
Degradable cross-linkers which are used to form polymer networks which degrade under aqueous conditions are described. These cross-linkers comprise a monodispersed central polyacid, monodispersed monomeric or monodispersed oligomeric deg...
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