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WO/2018/170476A1 |
The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions, in which aldehyde toxicity is implicated in the pathogenesis, by the administration of small molecule t...
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WO/2018/159834A1 |
Provided are a donor-acceptor type compound having a novel structure and an application of the donor-acceptor type compound. This enamine compound is represented by general formula (1) (in the formula: R1 represents an electron-accepting...
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WO/2018/103239A1 |
Disclosed is a preparation method for a compound shown by formula (E), a Velpatasvir intermediate shown by formula (K) and an analogue thereof. The method of the present invention uses inexpensive and easily available materials, and a si...
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WO/2018/074411A1 |
Provided is an efficient and economical method for producing a nitrogen-containing compound. In this method for producing a compound represented by the formula R3C(O)CH=CHNR1R2, a six-fold molar excess of a compound represented by the fo...
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WO/2018/059213A1 |
Provided are compounds interfering with SAICAR synthesis, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain co...
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WO/2017/067497A9 |
Disclosed are a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, preparation method therefor, and uses thereof. In the present invention, the amphiphilic hypocrellin derivative having substituted functional groups s...
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WO/2018/013682A1 |
Covalent organic frameworks (COFs) usually crystallize as insoluble powders and their processing for suitable devices has been thought to be limited. Here, it is demonstrated that COFs can be mechanically pressed into shaped objects havi...
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WO/2017/211129A1 |
A method for manufacturing an ephedrine or pseudoephedrine intermediate, comprising: using 2-chloropropionyl chloride and benzene as starting raw materials and performing a Friedel-Crafts reaction using a Lewis acid catalyst to generate ...
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WO/2017/137955A1 |
The present invention relates to novel chiral 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylprop
an-1-amine (5) and racemic 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylprop
an-1-amine () and its use in improved and ...
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WO/2017/077550A1 |
The present invention discloses a novel metal free process for the regioselective synthesis of α-substituted carbonyl compounds of formula I from alkene, X is selected from the following compounds (A, B).
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WO/2017/057460A1 |
Provided is a method for producing an organic compound, wherein the organic compound is an industrially useful compound, and a deodorization step, for removing from a reaction solution odorants that are generated in or remaining after a ...
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WO/2017/054112A1 |
The present invention relates to a method of preparing a 3-fluoroalkyl-1-methylpyrazole-4-carboxylic acid comprising the following steps: Step 1, performing a condensation reaction on the fluoroacetyl halide derivative shown in formula I...
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WO/2017/035224A1 |
Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are ...
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WO/2016/207252A1 |
A method of preparing a compound represented by general formula (3) : Formula (3). R1 and R2 are each independently an alkyl group. The method includes reacting a compound represented by general formula (2) : Formula (2) with an alkylami...
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WO/2016/202254A1 |
Provided are a preparation method for synthesizing a pyrazolecarboxylic acid derivative of the following formula (I), which is suitable for industrial production, and an intermediate as shown by the following formula (II). The method is ...
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WO/2016/150208A1 |
Disclosed are a pharmaceutical composition and dosage form containing a glaucocalyxin A derivative as represented by the formula (I) or salt thereof, and a preparation method and use of said composition and dosage form; the anti-autoimmu...
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WO/2016/150206A1 |
Disclosed is a glaucocalyxin A derivative -- dimethylamino glaucocalyxin A hydrochloride salt -- and two crystalline forms thereof. The dimethylamino glaucocalyxin A hydrochloride salt provided by the present invention has good water sol...
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WO/2016/150207A1 |
Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fig...
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WO/2016/152886A1 |
The present invention provides a novel method for producing pyrazole derivatives useful as intermediates of pharmaceuticals and agricultural chemicals, as well as novel intermediate compounds in this method. The present invention pertain...
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WO/2016/071249A1 |
The present invention relates to a novel method for producing substituted biphenylamines.
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WO/2016/057770A1 |
The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an amine; and...
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WO/2016/035609A1 |
The present invention provides a method for producing a benzaldehyde in which an amino group is bonded in the 2 position, a halogeno group or an alkoxy group is bonded in the 3 position, and a hydrogen atom, an alkyl group, a halogeno gr...
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WO/2015/198608A1 |
[Problem] To provide: a method for manufacturing a reaction product in which there is employed a phase interface reaction that makes it possible to efficiently bring about a reaction between a plasma-form substance (ozone, nitrogen plasm...
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WO/2015/170124A1 |
Graphene is chemically modified by a process resulting in the introduction of functional groups located only at an edge of the graphene plane. The functionalised graphene finds uses in numerous applications and further chemical synthesis...
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WO/2015/109963A1 |
Disclosed are an o-phenyl chalcone compound and preparation method and use thereof The o-phenyl chalcone compound is capable of inhibiting the aggregation assembly of microtubules in tumour cells and influencing the mitosis of the cells,...
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WO/2014/207761A1 |
The present invention relates to transition-metal-free process for the synthesis of tertiary arylamines comprises coupling reaction between arynes and N,N-dimethyl aniline compounds in presence of 18-crown-6, KF and THF.
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WO/2014/118038A1 |
The invention relates to novel phosphorus ligands and to a chemoselective and regioselective method for the hydroaminomethylation of olefins with at least one primary or secondary amine, with the addition of H2 and CO under catalytic con...
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WO/2014/082581A1 |
Disclosed is an α-(3, 5-dimethoxy benzylidene)-α'-hydrocarbyl methylene cyclic ketone, having a structure as represented by (I) or (II), wherein R is an aryl or alkyl; a preparation method is: mixing cyclic ketone and morpholine, and a...
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WO/2014/037444A1 |
Disclosed is a novel process for the reduction of nitro groups to amino derivatives, based on the use of trichlorosilane and an organic base, which is efficient from the chemical standpoint and of wide general applicability.
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WO/2014/005546A1 |
The present invention relates to a preparation method of tapentadol hydrochloride and compounds for preparation of the tapentadol hydrochloride. The preparation method comprises steps using a compound in a formula V or a hydrochloride th...
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WO/2013/121997A1 |
The purpose of the present invention is to provide: a method for obtaining hydrogen or deuterium with high efficiency or hydrogenating or deuterating an organic compound; a device for use in the method; and others. Provided are: a method...
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WO/2013/095301A1 |
Present invention relates to a method of preparing a chiral α- or β-substituted ketone from the corresponding β- or γ-substituted aldehyde, wherein the ketone has formula (I), (III) or (V), and the corresponding aldehyde has formula ...
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WO/2013/077720A1 |
Methods for producing methadone and its resolution to produce (R)-6-dimethylamino-4,4-diphenylheptan-3-one ((R)- methadone). Such methods producing first the precursor compound 4-(dimethylamino)-2,2-diphenylpentanitrile. Oxidation of 4-(...
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WO/2013/054181A1 |
Disclosed herein is a continuous tubular reactor based conversion of acetophenones to amino substituted acetophenones wherein the nitration is carried out at -10 to 10 °C followed by reduction to m-nitrophenone resulting in uniform outp...
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WO/2013/008247A1 |
The invention discloses a process for preparation of (dl)-norepinephrine salt by reacting 3,4-dihydroxy-a-haloacetophenone with hexamethylenetetramine to provide hexamine salt; followed by hydrolysis and hydrogenation. The invention also...
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WO/2012/136121A1 |
An amino phenylpropanoid compound, or a geometric isomer thereof, or a pharmaceutically acceptable salt or hydrate thereof as represented by Formula I, a preparation method therefor, and a pharmaceutical composition containing the compou...
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WO/2012/137741A1 |
A method for purifying an organic material, which can sublimate and purify an organic material having a high sublimation temperature and high heat resistance within a short time with high purity and high yield. The method comprises: redu...
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WO/2012/081031A1 |
A substantially pure crystalline form A of tetrabenazine compound of structural formula I and processes for the preparation thereof is provided.
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WO/2012/076165A1 |
The present invention relates to a method for synthesising substituted aminocyclohexanone derivatives, comprising the following step (b) reaction of a compound of general formula (II) with an organolithium compound to form a compound of ...
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WO/2012/062041A1 |
Disclosed are aromatic ketone compounds with para- or meso-substituted multifunctional groups as represented by the general formulae I-III, preparation methods thereof, and free-radical polymerization photoinitiators comprising the compo...
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WO/2010/139482A1 |
A compound of formula (I) R-L-CO-X (I) (wherein R is a C10-24 unsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups of heteroatoms selected from S, O, N, SO, SO2, said hydrocarbon group comprising at l...
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WO/2010/004386A2 |
The present invention provides an amorphous bupropion hydrobromide and an amorphous bupropion hydrobromide granulates with at least one pharmaceutically acceptable carrier, and a process for its preparation.
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WO/2010/000856A1 |
The present invention relates to a method for producing substituted aminobiphenylene, in particular 2-aminobiphenylene, and a method for producing (het)acrylic acid amides of such aminobiphenyenes, in particular 2-aminobiphenyene.
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WO/2009/143714A1 |
Disclosed is a new 2,4-dihydroxyl chalcone derivative having the structure of general formula i and a pharmaceutically acceptable salt thereof, in which each group has the same meaning as defined in the specification, and a process for p...
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WO/2009/100996A2 |
The present invention provides innovative strategies for synthesizing pyrazole ring- functionalized benzodiazepinones. Alternative intermediates and high conversion strategies for forming alpha-aminobenzophenone intermediates involve a c...
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WO/2008/117054A2 |
The present invention provides P-chiral compounds of general formulae (II) and (III): in formula (II) at least one of R21, R25, R26and R30 is independently selected from CM alkyl, CF3, C1 -4 alkoxy, phenyl and benzyloxy and the remaining...
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WO/2008/111515A1 |
Disclosed is a simple and highly efficient process for producing an aromatic carbonyl compound, which can produce an aromatic carbonyl compound having a substituent introduced to an aromatic ring adjacent to a carbonyl group. The process...
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WO/2008/099418A2 |
The present invention relates to an improved process for preparing Bupropion Hydrochloride of formula (I). The present invention also provides a process for purification of Bupropion hydrochloride.
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WO/2008/067752A1 |
Disclosed is a process for preparing of optical pure milnacipran and its pharmaceutically accepted salts, wherein racemic milnacipran is used as raw material and the resolution is carried out with tartaric acid derivatives or their compo...
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WO/2008/043798A1 |
A process for the preparation of for the preparation of β-amino aldehydes and derivatives thereof, in particular β-amino acids and Υ-amino alcohols, by reacting carbamate-protected imines and unmodified aldehydes in the presence of an...
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