Document |
Document Title |
WO/1993/001158A1 |
Acid addition salts of arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and strong acid in a dipolar aprotic solvent.
|
WO/1992/019586A1 |
Disclosed is a process for the preparation of 1-amino-4-bromoanthraquinones by the bromination of the corresponding 1-aminoanthraquinone wherein a 1-amino-anthraquinone is contacted with elemental bromine in the presence of a carboxylic ...
|
WO/1992/018564A2 |
A method of manufacturing 3-amino-2-cyclohexene-1-one by hydrogenating m-phenylenediamene to produce a novel intermediate salt of 3-amino-2-cyclohexene-1-imine followed by hydrolysis to produce 3-amino-2-cyclohexene-1-one. The novel inte...
|
WO/1992/015319A1 |
The invention relates to HIV protease inhibitors wherein the compounds have a 2,4-dihydroxy isostere wherein the hydroxyl group in the 2-position is further substituted to create a tertiary alcohol. Also disclosed are pharmaceutically ac...
|
WO/1991/007371A1 |
The present invention relates to a method for the preparation of alpha,beta-unsaturated ketones represented by general formula (II) (where R is a heterocyclic group with nitrogen atom in the ring or a phenyl group with electron donative ...
|
WO/1990/009368A1 |
A method for producing amines, comprising contacting at reactive conditions at least one alcohol, aldehyde or ketone, or a mixture thereof, with an aminating agent in the presence of a catalyst, is improved by employing as the catalyst a...
|
WO/1990/006299A1 |
New phenylethanolamines of general formula (I), in which A is a straight-chain or branched alkylene group, B is a bond, an alkylene group, a carbonyl or hydroxymethylene group, R1 is a hydrogen atom, a halogen atom or a trifluormethyle g...
|
WO/1989/003382A1 |
The invention comprises cyclobutarene ketoaniline monomers and the process for preparing them. The monomers can be used to graft and/or endcap a monomer or polymer having at least 1 amino-reactive functionality. The grafted and/or endcap...
|
WO/1986/001502A1 |
A process for the production of amino compounds from hydroxyl compounds (Voelter reaction), according to which a hydroxyl compound is converted with trifluormethanesulphonic acid anhydride in water-free conditions, the corresponding trif...
|
JP2024015334A |
[Problem] The present disclosure provides (2R,6R)-hydroxynorketamine (HNK) and (2S, A method for synthesizing the free base form of 6S)-hydroxynorketamine is provided. In one embodiment, (2R,6R)-hydroxynorketamine (HNK ) was synthesized ...
|
JP2023182866A |
[Object] To provide a cross-coupling reaction method in which a wide variety of compounds can be used as starting materials and a reaction product can be obtained in high yield in a short time, and a novel compound obtained by the method...
|
JP7404795B2 |
To provide a metal catalyst that can be used as a catalyst capable of efficiently and selectively promoting a chemical reaction while using polysaccharide such as an environmentally friendly cellulose as a catalyst carrier.There is provi...
|
JP7379567B2 |
The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketam-ine (HNK) includes preparation of (R)-norket-amin...
|
JP7345806B2 |
To provide an intrinsic black polyimide that has good light shielding performance and excellent mechanical properties, thermal stability, and dielectric properties.An anthraquinone derivative tetraamine monomer has a structure represente...
|
JP2023525590A |
The present invention relates to a method of purifying 2-(4'-diethylamino-2'-hydroxybenzoyl)benzoic acid hexyl ester that provides high purity and low content of dialkyl phthalate. [Selection figure] None
|
JP2023054399A |
To provide methods for producing trifluoromethyl ketone and pentafluoroethyl ketone in economical, safe and industrial manners.An ester compound represented by the general formula (1) is supplied and mixed with a base and trifluoromethan...
|
JP2023052420A |
To provide small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of Aβ42 oligomers in a subject, and methods of producing the same.A pharmaceutical composition compris...
|
JP7254297B2 |
Provided are a donor-acceptor type compound having a novel structure and its use.An enamine compound represented by general formula (1)(in the formula:R1represents an electron-withdrawing group;A represents a divalent aromatic hydrocarbo...
|
JP7244134B2 |
[Problem] To provide a novel means capable of generating highly stereoselective and/or highly efficient amidation reactions in a variety of substrates having a carboxyl group and an amino group, and capable of producing amide compounds.[...
|
JP2023017733A |
To provide a novel method for synthesizing 2,4-dimethylpyrimidine-5-ol, a novel intermediate for the method, and use of a product in the synthesis of lemborexant.The present invention provides a novel method for synthesizing 2,4-dimethyl...
|
JP7193178B2 |
The present invention relates to an aromatic compound and a preparation method therefor and the use thereof. Specifically, disclosed are a compound as shown in the following general formula (I), or a tautomer, an enantiomer, a diastereom...
|
JP7152403B2 |
The present invention relates to a novel process for the preparation of a nitrogen containing biopolymer-based catalyst and to the novel nitrogen containing biopolymer-based catalysts obtainable by this process. In particular, the invent...
|
JP6999039B2 |
The present invention provides a photoinitiator containing fluorine fluorene oxime esters, a photocurable composition comprising the photoinitiator, and application of the photoinitiator. The photoinitiator has a structure represented by...
|
JP6980269B2 |
To provide a chiral complex which, when used as a catalyst, can make an aromatic boronic acid undergo asymmetric 1,4-addition to a conjugated enone in an aqueous solvent under relatively mild conditions and can be recovered by filtration...
|
JP2021527038A |
A process for the preparation of (2R, 6R) -hydroxynorketamine is provided. The process does not require chromatographic purification and gives (2R, 6R) -hydroxynorketamine in 8 steps with a total yield of 26% and a purity greater than 97%.
|
JP6922924B2 |
Provided is an efficient and economical production method of a nitrogen-containing compound. A method for producing a compound represented by the formula RC(O)CH=CHNRR, including reacting a compound represented by the following formula (...
|
JP6911197B2 |
The present invention discloses a hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by f...
|
JP6888550B2 |
Provided is a method for producing an organic compound, wherein the organic compound is an industrially useful compound, and a deodorization step, for removing from a reaction solution odorants that are generated in or remaining after a ...
|
JP6886206B1 |
To provide an anthraquinone compound having a maximum absorption in the vicinity of 740 to 800 nm and having excellent solvent solubility. An anthraquinone-based compound represented by the following formula (1). In the formula, R1~ R4Re...
|
JP6882990B2 |
The present invention is directed to processes for the preparation of esketamine. The present invention is further directed to processes for the resolution of S-ketamine from a racemic or enantiomerically enriched mixture of ketamine. Th...
|
JP6781596B2 |
To provide a method for producing an onium compound which can produce a specific onium compound with a simple method and a high yield.There is provided a method for producing an onium compound which is any of the following methods (A), (...
|
JP6758669B2 |
An object of the present invention is to provide a novel ascochlorin derivative which activates adenosine monophosphate-activated protein kinase (AMPK), and is useful in the treatment or prevention of diseases or conditions that involve ...
|
JP6694894B2 |
Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fig...
|
JP6610905B2 |
Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound ...
|
JP6511864B2 |
|
JP2019510768A |
The present disclosure provides methods for synthesizing the free base forms of (2R, 6R) -hydroxynorketamine (HNK) and (2S, 6S) -hydroxynorketamine. In certain embodiments, the synthesis of (2R, 6R) -hydroxynorketamine (HNK) prepares (R)...
|
JP2019504840A |
The present invention relates to a novel halogen-substituted diketone compound, a novel pyrazole compound, a method for producing a pyrazole compound, and a method for producing a pesticide or a pharmaceutical compound. [Selection diagra...
|
JP6471481B2 |
|
JP6450678B2 |
An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent ca...
|
JP2018536643A |
The present invention discloses mono- or poly-substituted oil-water amphipathic hypoclerin derivatives and methods and uses thereof. The oil-water amphipathic hypoclerin derivative produced in the present invention containing group subst...
|
JP6417419B2 |
Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowin...
|
JP6399540B2 |
An object of the present invention is to provide a method for directly performing arylation (particularly α-arylation) of carbonyl or thiocarbonyl compounds using a more inexpensive phenol derivative and nickel catalyst. Another object ...
|
JP6360549B2 |
Catalyst systems and methods for making and using the same are provided. A method for forming a polymer catalyst includes reacting a bromoketone compound with an aryl amine compound to form an amide compound. The amide compound is reacte...
|
JP2018516948A |
A method for preparing a compound represented by the general formula (3): formula (3) :. [Chemical 25]R1And R2However, each is an independently alkyl group. The method is a compound represented by the general formula (2): formula (2) :. ...
|
JP6334173B2 |
Objects are to provide efficient methods for producing hydrogen or heavy hydrogens and for hydrogenating (protiating, deuterating or tritiating) an organic compound, and to provide an equipment and the like used therefor. A method for pr...
|
JP2018054434A |
To provide a method for detecting a compound containing a formyl dehydro piperidine structure such as an acrolein amine-added body, for example, which functions as an oxidation stress marker.The present invention relates to a method for ...
|
JPWO2016199789A1 |
In order to produce various functional trifluoromethyl compounds, it is an object of the present invention to synthesize trifluoromethyl-substituted semisquarates in a short process and efficiently. Using squalate as a starting material,...
|
JP2018008928A |
To provide a generally applicable and economically viable process which can be implemented on the industrial scale for preparing novel pyrazole derivatives.The present invention provides a process for preparing enaminoketones represented...
|
JP6225358B2 |
The present invention provides a method for producing a benzaldehyde in which an amino group is bonded in the 2 position, a halogeno group or an alkoxy group is bonded in the 3 position, and a hydrogen atom, an alkyl group, a halogeno gr...
|
JP2017531635A |
The present disclosure describes a method of coupling a first compound to a second compound, wherein the method provides a first compound having a fluorosulfonic acid substituent and a second compound containing an amine. The first compo...
|