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JP4196572B2 |
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JP4194761B2 |
The compounds of formula 1 wherein R and R2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN leukocytes) at the inflammator...
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JP4193198B2 |
A process for producing alpha-aminohalomethyl ketones or N-protected alpha-aminohalomethyl ketones from specified 3-oxazolidin-5-one derivatives via 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. By this process, alpha-aminohalomethyl...
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JP2008543823A |
Synthesis of 2,5-bis-diamine-[1,4]benzoquinonic derivatives having the general formula (I), products and intermediates of said synthesis; the synthesis involves the use of p-benzoquinones having the general formula (IX) and diamines havi...
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JP4187274B2 |
The invention relates to novel compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers,...
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JP4176411B2 |
1-Amino-4-hydroxyanthraquinones are prepared by reacting 1,4-dihydroxyanthraquinone with aliphatic or aromatic amine in the presence of N-methyl-2-pyrrolidone. Preparation of 1-amino-4-hydroxyanthraquinones of formula (I) involves reacti...
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JP4176153B2 |
This invention is directed to polymeric hydroxylamine resin compounds and to processes for the solid-phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds useful thereof.
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JP4174104B2 |
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JP4172660B2 |
The present invention discloses a process for the preparation of a compound having formula 4: The process comprises the step of reacting an enolate having the formula: with a Grignard reagent. The enolate salt is formed in situ from the ...
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JP2008255105A |
To provide a method for producing an aromatic carbonyl compound that can produce easily and in a high yield an aromatic carbonyl compound having a substituent introduced in an aromatic ring adjacent to a carbonyl group.The method for pro...
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JP4155603B2 |
This invention relates to alpha -ammonium ketones, iminium ketones or amidinium ketones in the form of their tetraaryl- or triarylalkylborate salts which can be photochemically converted into amines, imines or amidines as well as to a pr...
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JP2008214194A |
To provide a catalytic reduction method and a coupling method useful for the synthesis of organic compounds and giving little load on the environment.A substrate and a heterogeneous platinum-group catalyst are mixed and stirred in a hydr...
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JP4151988B2 |
PCT No. PCT/EP97/02360 Sec. 371 Date Nov. 10, 1998 Sec. 102(e) Date Nov. 10, 1998 PCT Filed May 7, 1997 PCT Pub. No. WO97/43244 PCT Pub. Date Nov. 20, 1997The present invention is concerned with an improved process for the resolution of ...
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JP2008531761A |
A pro-odorant or pro-flavorant having the formula: the substituents being such that the compound is an odorant or flavorant; or the formula: R9R10C-NR11 the substituents being such that a compound of formula R9R10C-O is an odorant or fla...
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JP2008526821A |
Use of ionic liquids as solvents in base-catalysed chemical reactions wherein the ionic liquid is composed of at least one species of cation and at least one species of anion, characterised in that a cation of the ionic liquid comprises ...
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JP2008526822A |
The present invention relates to novel base stable ionic liquids and uses thereof as solvents in chemical reactions, especially base catalysed chemical reactions and reactions comprising the use of strong basis.
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JP2008526790A |
Novel squaric acid compounds of the formula (I), in which R, R1, R1', R2 and X have the meanings indicated in Claim ( 1 ), are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obe...
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JP2008156631A |
To provide a process for preparing a substituted aminoanthraquinone from which such uses as a dye for plastics and synthetic fibers, and further a precursor for preparing a dye for wool, are obtained.The process for preparing the substit...
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JP4116778B2 |
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JP2008115116A |
To provide a method for efficiently producing an -hydroxy--trifluoromethyl--lactam derivative.The method for producing an -hydroxy--trifluoromethyl--lactam derivative comprises subjecting an enamine compound and a trifluoropyruvic acid e...
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JP2008514554A |
A method for the chemoselective hydrogenation of alpha, beta unsaturated carbonyl compounds is disclosed, in which compounds of the formula R4R3C-CR2-C(O)R1, wherein R1-R4 are as defined herein, are reacted with a hybrid donor to form a ...
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JP2008501653A |
Compounds of formula I and a process for the preparation of such compounds are disclosed.
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JP2007314365A |
To provide a method for forming a large-size organic single crystal excellent in crystallinity and to provide the organic single crystal. Gel 3 is formed by charging a gelling agent 2 into a solution 1 in which organic matter constitutin...
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JP4001321B2 |
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JP2007529569A |
Methods and intermediates for the preparation of Fenoldopam mesylate and intermediates thereof are provided.
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JP3978229B2 |
The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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JP3974656B2 |
N-protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates which can b...
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JPWO2005070875A1 |
In the present invention, an imine compound and a nucleophilic compound (excluding trialkylsilyl vinyl ethers) are subjected to the general formula (1) [Chemical formula 1].(In the formula, A1Indicates a spacer, X1And X2Independently ind...
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JP3958851B2 |
To obtain the subject new compound, useful as an intermediate for crop-selective herbicides, e.g. 1-{[o-(cyclopropylcarbonyl)phenyl]-sulfamoyl}-3-(4,6- dimethoxy-2-pyrimidinyl)urea. This compound is shown by formula I [R is a 1-6C alkyl ...
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JP2007522194A |
A process for the preparation of compound AQ4N of formula (2) or a salt or solvate thereof wherein the said process includes the reaction step: Formula (1), Formula (2), where compound AQ4 of formula (1) is oxidised to compound AQ4N of f...
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JP2007126460A |
To provide a compound and a composition effective for inhibiting the activity of a CETP [cholesterol ester transfer protein (plasma lipid transfer protein-1)] and useful for treating especially atherosclerosis and other coronary arterial...
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JP2007070300A |
To provide a process for producing 2,5-diamino-1,4-benzenediol and/or a salt thereof as a monomer of high performance fibers.A process for producing 2,5-diamino-1,4-benzoquinone comprises allowing 2,5-dialkoxy-1,4-benzoquinone and ammoni...
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JP3893180B2 |
To provide a method for producing a (3-alkoxyphenyl)magnesium chloride, and to provide a method for using this compound in the reaction of a specific carbonyl compound. This (3-C1-5alkoxyphenyl)magnesium chloride is obtained by reaction ...
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JP3871448B2 |
To obtain a p-N-substituted aminobenzaldehyde in a high yield by reacting a Vilsmeier complex with an N-substituted aniline in an organic solvent, hydrolyzing the reaction product and subsequently extracting off an o-substituted isomer w...
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JP3871005B2 |
To obtain a new aldehyde compound satisfying an electrophotographic characteristic and useful as an intermediate for synthesis of a triarylamine compound which is a raw material monomer for a polymer-type charge transport material. This ...
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JP2006342060A |
To provide a stilbene derivative exhibiting sufficient solubility to a predetermined solvent even in the case of being relatively high in average molecular weight owing to having a specific substituent on an intramolecular predetermined ...
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JP2006335661A |
To provide a method for producing a distyryl derivative, by which the highly pure distyryl derivative can be produced in a high yield, while effectively inhibiting the production of monostyryl derivatives, even when the distyryl derivati...
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JP3856850B2 |
PURPOSE: To obtain the subject compounds useful as synthetic intermediates for medicines, agrichemicals, etc., or as optical resolving agents under mild conditions by a new one step method comprising directly reacting an α-amino acid de...
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JP3855323B2 |
To obtain a compound as an equivalent material of α-aminoalcohol derivative important as an intermediate for HIV protease inhibitor as a sort of enzyme-inhibitor and convertible into 3-amino-1,2-epoxypropanes. A compound of formula I (R...
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JP3843152B2 |
To obtain a 4-alkoxy-1,1,1-trifluoro-3-buten-2-one useful as an active ingredient of an agrochemical, etc., by a short and simple reaction process in high yield. A halide of the formula, CF3COHal (Hal is a halogen atom) such as trifluoro...
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JP3839551B2 |
To obtain the subject new compound having an excellent antifungal activity. This amine derivative is a compound of formula I [R1 is a 1-4C alkyl; R2 is a 1-4C alkyl or phenyl; R3 is a 1-3C alkyl, a 1-5C acyl, a halogen, etc.; (k), (l), a...
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JP3833471B2 |
Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below or salts thereof are provided. Äin the formula (1), R<1> represents a C1-5 alkyl group which may be halogenated, R<2> represents 4-(...
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JP2006248952A |
To provide a method for simply producing a ketone containing a nitrogen atom at the α-position such as an α-aminoketone in a high yield.The production method comprises reacting an alcohol represented by formula (1) (R1 is a hydrogen at...
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JP3824735B2 |
To obtain the new subject compound having an excellent antifungal activity. This amine derivative is a compound of formula I [R1 is a 1-4C alkyl; R2 is formula II, etc.; R3 is a 1-4C alkyl, a 1-5C acyl, etc.; (k), (l) and (m) are each 1-...
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JP2006232730A |
To provide a new substituted aminoaryladamantane derivative capable of being simply produced from an easily available compound and capable of being easily induced into an aminoaryladamantane derivative useful as a raw material, etc., for...
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JP2006520328A |
The present invention provides a combinatorial approach to a library of novel compounds having four diversity points. The compounds provide for the mapping of urotensin II and somatostatin 5 receptors by differential binding of said rece...
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JP3806260B2 |
To obtain the subject compound, useful as a stock for synthesizing a monomer for high-molecular-weight charge-transfer material which satisfies all of the basic electrophotographic characteristics. This compound is an aldehyde compound s...
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JP3786834B2 |
The present invention refers to new derivatives of the 6-(4-phenylbutoxy)hexylamine of the general formula (I): wherein: R1 is CHO or CHOR3OR4, where R3 and R4 independently are C1-C6 alkyl, aralkyl, or they form 5 or 6 membered cyclic a...
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JP3778527B2 |
To obtain the subject composition while suppressing the crystal growth of 2-amino-3-chloro-1,4-naphthoquinone during the storage over a long period by using the naphthoquinone compound in combination with a specific surfactant and a synt...
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JP2006104208A |
To obtain an agent for the prevention and treatment of urinary disturbance exhibiting excellent improving action on urinary function of the bladder (action to improve urine flow rate and urination efficiency) and free from influence on u...
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