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WO/1998/030609A1 |
Selected olefins such as ethylene and $g(a)-olefins are polymerized by nickel [II] complexes of certain monoanionic ligands. The polyolefins are useful in many applications such as molding resins, film, fibers and others. Also described ...
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WO/1998/019512A2 |
A method for the preparation of citalopram is described comprising reaction of a compound of Formula (IV) wherein R?1� is H or C�1-6?alkylcarbonyl successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent ...
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WO/1998/017267A1 |
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond $i(per se) so as to space the aromatic systems at a distance 1.5-15�, are effec...
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WO/1998/013331A1 |
The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon mul...
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WO/1998/011046A2 |
This invention relates to processes for the preparation of aryl-$g(b)-diketones and aryl-pyrimidine ketones. In addition, this invention relates to the preparation of aryl-$g(b)-triketones and dimethyl aminomethylene $g(b)-diketones, whi...
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WO/1998/006692A1 |
Cyano and carboxy derivatives of substituted styrenes of formula (I), in which Y is -COZ, -C$m(Z)N, or lower alkyl of 1 to 5 carbon atoms; Z is -OH, -NR?6�R?6�, -R?7�, or -OR?7�; X, R?1�, R?2�, R?3�, R?4�, R?5�, R?6�,...
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WO/1998/005623A1 |
A process for the preparation of meta-substituted arylalkanoic acids starting from m-aryl-olefins followed by the Claisen rearrangement and an oxidative cleavage of the formed compound.
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WO/1998/002413A1 |
The compounds of formula (I) wherein R�1?, R�2?, R�3? and A are as defined herein are useful, via potassium channel modulation, in the treatment of disorders associated with smooth muscle contraction. Such disorders include, but ar...
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WO/1998/000390A1 |
Disclosed are racemates and optically active isomers of substituted aminobutyl derivatives of cyclohexylphenylglycolic acid, including esters, amides and keto isosteres, which possess smooth muscle spaxmolytic properties with reduced ant...
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WO/1997/049433A1 |
Compounds of formula (A), wherein R1, R2, R3, Y and Z are organic substituents, are useful in the diagnosis of amyloidosis; some of the compounds of formula (A) are novel. Processes for their preparation, and pharmaceutical compositions ...
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WO/1997/045397A1 |
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase...
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WO/1997/045551A1 |
A method of preparing optically active methadones comprises an enzymatic process for the resolution of 1-dialkyl-amino-2-propanol and conversion of the enantiomers to the optically active methadones in high enantiomeric purity.
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WO/1997/043244A1 |
The invention relates to an improved process for the separation of racemic 2-)o-chlorophenyl)-2-methyl aminocyclohexanone (ketamine).
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WO/1997/033855A1 |
The invention relates to cinnamylidene camphor derivatives of the formula (1) in which the diene system is in the configuration Z,Z; Z,E; E,Z or E, E and R1 is H, CH3, R2 is C1-C6 alkyl, C1-C6 alkoxy, halogen, NR3H, NR32, R3 is C1-C4 alk...
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WO/1997/031904A1 |
The invention concerns compounds of formula (I) and their salts which are suitable as herbicides and plant growth regulators, R1 to R6, Y1, Y2, Y3, m and n being defined as in claim 1. These compounds can be prepared in similar manner to...
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WO/1997/028136A1 |
The invention relates to 4-benzoylisoxazole derivatives of formula (Ia), 5-phenylisoxazole derivatives of formula (Ib) and 2-cyano-1,3-dione derivatives of formula (Ic), wherein R1, R2, R3, X and n are as defined in the description, and ...
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WO/1997/021684A1 |
The therapeutical use of tricyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), for treating diseases related to venous function deficiency and/or inflammatory oedema, is disclosed. In general for...
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WO/1997/021432A1 |
The therapeutical use of bicyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), wherein each of X1, X2, X3 and X4 is independently a carbon atom or a nitrogen atom, with n being 0 or 1; A is select...
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WO/1997/020805A1 |
Indane dimer compounds of general formula 5, 6 or 9 and their pharmaceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or antiinflammatory activity are described, wherein in fo...
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WO/1997/020806A1 |
Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or anti-inflammatory activity as described, wherein in formul...
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WO/1997/020802A1 |
Indame dimer compounds and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or anti-inflammatory activity are described.
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WO/1997/019675A2 |
Cationic lipids, having a derivated quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for negatively charged macromolecules. The lipids comprise a linker having functional gro...
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WO/1997/016544A1 |
A chemical linking agent formed of a di- or higher functional photoactivatable compound and providing at least one group that is charged under the conditions of use in order to provide improved water solubility. The linking agent further...
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WO/1997/016406A1 |
A compound of the formula (I): A-L-D where A is a moiety which absorbs radiation and enters an excited state in which it accepts an electron; L is a linking group which tethers an electron acceptor moiety A to the electron donor moiety D...
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WO/1997/007101A1 |
A method of treating neoplastic disease which comprises the steps of: (a) administering to a patient in need of such treatment an effective amount of a radiation-activated cytotoxin prodrug (RACP) which has low toxicity, which can be red...
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WO/1997/006200A1 |
Controlled molecular weight imide oligomers and co-oligomers containing pendent phenylethynyl groups (PEPIs) and endcapped with nonreactive or phenylethynyl groups have been prepared by the cyclodehydration of the precursor amide acid ol...
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WO/1997/006135A1 |
A process for producing carbamoylmethylurea derivatives represented by general formula (I), characterized by reacting a compound represented by general formula (II) with a compound represented by general formula (III).
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WO/1996/038150A1 |
The present invention relates to novel 4.4-(disubstituted)cyclohexan-1-ols monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhib...
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WO/1996/032370A1 |
4-Amino-5-oxy-2,6,6-trimethyl-2-cycloheptene compounds represented by general formula (I), pharmacologically acceptable salts thereof, or solvates of these wherein R1 and R2 independently represent each hydrogen, optionally substituted a...
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WO/1996/021354A1 |
Pesticidal as a pesticide against whitefly, Lepidoptera and certain fungi is provided of compound of general formula (I) or a salt thereof is provided, in which n represents an integer from 0 to 4; m represents an integer 0 or 1; each R ...
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WO/1996/020795A1 |
The invention concerns NCO-terminated vinyl telomers which are particularly suitable for use as surface-modifying agents and as coating materials, but also in the production of polymerizable compounds or block copolymers which react to g...
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WO/1996/020964A1 |
The invention concerns a cross-linked polymer built up from a polymerization product of a highly unsaturated polymer (a) and a polysiloxane (b) with terminal or pendentive hydrosilane groups in such a way that numerous unsaturated carbon...
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WO/1996/021167A1 |
The invention concerns cross-linked polymers which are the polymerization products of a polymerizable mixture containing the following components: a) a macromer of formula (C) in which Macro is an m-valent macromer group from which m of ...
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WO/1996/019995A1 |
This invention relates to derivatives of 4,4-(disubstituted)cyclohexan-1-ones and related compounds which are useful for treating allergic and inflammatory diseases.
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WO/1996/019988A1 |
The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhib...
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WO/1996/020158A1 |
This invention relates to derivatives of 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds which are useful for treating allergic and inflammatory diseases.
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WO/1996/014300A1 |
The compounds of formula (I), wherein R1 is hydrogen, C1-10 straight or branched chain alkyl, C3-10 cyclic or bicyclic alkyl, alkanoyl of 2 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms, aroyl of 7 to 12 carbon atoms, arylalken...
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WO/1996/011894A1 |
Proposed is a process for separating enantiomers from a racemic mixture by countercurrent extraction using at least two substances, one of them a liquid in which the racemic mixture to be separated is present, the other containing a chir...
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WO/1996/009807A1 |
The invention concerns the use of 2-hydroxy-1-ethanone derivatives for dyeing keratin-containing fibres, in particular human hair.
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WO/1996/009297A1 |
Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of in...
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WO/1996/006068A1 |
A benzene compound represented by general formula (I) (wherein each symbol is as defined in the specification), an optical isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same ...
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WO/1996/004895A1 |
The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4 and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their ...
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WO/1996/004230A1 |
Terpene-quinone with antitumor activity defined from a cyclocondensation reaction of Diels-Alder, used to obtain families or series of said compounds having a new structure and presenting a cytotoxic activity to cellular cultures P-388, ...
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WO/1996/003476A1 |
The present invention is directed to stable liquid-crystalline glasses which have a high Tg and are readily orientable. Such glasses are suitable for use in optical applications. The glasses according to the invention are obtained by rea...
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WO/1996/003364A1 |
A benzoylethylene derivative represented by general formula (I) and a salt thereof wherein R1 to R5 represent each hydrogen, -OR9 (R9 being hydrogen, C1-C5 alkyl, etc.), etc.; R6 represents hydrogen, C1-C5 alkyl, etc.; R7 represents hydr...
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WO/1996/000725A1 |
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to their use in the treatment of hypertensi...
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WO/1995/033455A1 |
Novel meta substituted arylalkylamine compounds are disclosed. These compounds can be administered as small molecule drugs to treat diseases or conditions associated with insufficient serotonin mediated nerve transmission (e.g. depressio...
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WO/1995/030641A1 |
New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A-X1-NO2 or their salts, wherein: A is R(COXu)t, wherein t is zero or 1 and u is zero or 1; and X is O, NH o...
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WO/1995/030646A1 |
The present invention relates to compounds which are useful as sunscreens. The compounds persists on the skin for much longer than conventional sunscreens because they comprise a Michael acceptor linked directly or indirectly to a chromo...
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WO/1995/029167A1 |
The invention relates to novel substituted cyclopropylcarbonyl-phenylaminosulphonyl ureas of formula (I) in which the constituents R1, R2, R3 and R4 have the meanings given in the description and R5 is optionally halogen or C1-C4 alkyl-s...
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