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WO/2018/167264A1 |
The present invention relates to a phenalene-1-one compound, a photosensitizer composition comprising said phenalene-1-one compound, an article comprising said phenalene-1-one compound and/or photosensitizer composition and the use thereof.
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WO/2018/159834A1 |
Provided are a donor-acceptor type compound having a novel structure and an application of the donor-acceptor type compound. This enamine compound is represented by general formula (1) (in the formula: R1 represents an electron-accepting...
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WO/2018/153212A1 |
The present invention relates to the technical field of medicinal chemistry, and in particular relates to colchicine derivatives (I), a preparation method therefor, and pharmaceutical compositions comprising the compounds. Pharmacodynami...
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WO/2018/136792A1 |
The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.
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WO/2018/109192A1 |
The present invention relates to novel cationic azomethine direct dyes of formula (I) and the leuco forms thereof of formula (II), and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair...
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WO/2018/103239A1 |
Disclosed is a preparation method for a compound shown by formula (E), a Velpatasvir intermediate shown by formula (K) and an analogue thereof. The method of the present invention uses inexpensive and easily available materials, and a si...
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WO/2018/102488A1 |
The present invention features methods, compositions, and kits for the treatment of all forms of emotional and painful symptoms related to the menstrual cycle, including symptoms characteristic of menstrual cycle-related disorders, such ...
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WO/2018/100556A1 |
Several compounds have been discovered that modulate signal transduction through the PD-1 receptor. In certain embodiments, the compounds promote or induce an activating signal through the PD-1 receptor that activates a T cell. The compo...
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WO/2018/076107A1 |
In one aspect, there is provided a method of treating, prophylaxis, or amelioration of a neurological disease by administering to a subject in need thereof minocycline, or a functional derivative thereof, and hydroxychloroquine, or a fun...
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WO/2018/076108A1 |
ABSTRACT In one aspect, there is provided a method of treating, prophylaxis, or amelioration of a neurological disease by administering to a subject in need thereof one or more compounds described herein. In a specific example, the neuro...
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WO/2018/074411A1 |
Provided is an efficient and economical method for producing a nitrogen-containing compound. In this method for producing a compound represented by the formula R3C(O)CH=CHNR1R2, a six-fold molar excess of a compound represented by the fo...
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WO/2018/053221A1 |
Disclosed are novel ketamine prodrugs, pharmaceutical preparations containing such prodrugs of ketamine and methods of treating, bipolar depression, neuropathic and chronic pain, including complex regional pain synthetic pain syndrome (C...
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WO/2018/025259A1 |
Naphthoquinone compounds that induce the formation of reactive oxygen species (ROS) are disclosed. Process of preparing the naphthoquinone compounds are also disclosed. Uses of the compounds for treating a disease or disorder are also di...
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WO/2017/067497A9 |
Disclosed are a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, preparation method therefor, and uses thereof. In the present invention, the amphiphilic hypocrellin derivative having substituted functional groups s...
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WO/2018/013682A1 |
Covalent organic frameworks (COFs) usually crystallize as insoluble powders and their processing for suitable devices has been thought to be limited. Here, it is demonstrated that COFs can be mechanically pressed into shaped objects havi...
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WO/2017/220969A1 |
The present invention provides di-substituted acetalanthraquinone- based compounds of the Formulae (l)-(IV) that are useful for cellular staining and for light-based detection of biological material, e.g. fluorescence-based detection of ...
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WO/2017/205795A1 |
The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.
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WO/2017/184752A1 |
The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococc...
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WO/2017/180589A1 |
The present disclosure provides compounds of Formula I and/or Formula II, or pharmaceutically acceptable salts thereof: wherein D is deuterium and each deuterium has deuterium enrichment of no less than about 10%, compositions containing...
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WO/2017/165878A1 |
The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine ...
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WO/2017/149052A1 |
The invention pertains to a process for producing a compound of formula (11) wherein R7 and R8 are each independently selected from H, halogen, alkyl, aryl, or alkylaryl, R42 is H or a protective group, R43 is H or R3, wherein R3 is a pr...
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WO/2017/145022A1 |
Described herein are UV-absorbing vinylic monomers conjugated to 2-aminobenzophenone derivatives and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and violet radiation with waveleng...
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WO/2017/147386A1 |
The present disclosure is directed to, e.g., 3-substituted, 5-amine-substituted-cyclohex-2-en-1-one compounds, and method of treatment and making associated with the same compounds.
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WO/2017/138838A1 |
The invention relates to salts and hydrates of arylcycloalkylamine derivatives of general formula (I) and formula (II), where in formula (I), R1 and R2 signify H, a linear or branched alkyl (C1, C4), a linear or branched alkoxy (C1, C4),...
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WO/2017/138363A1 |
The present invention provides an organic photoelectric conversion element (1) which comprises an electron collecting electrode (13), a hole collecting electrode (14), and a photoelectric conversion part arranged between the electron col...
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WO/2017/129759A1 |
The present invention concerns new halogen substituted diketone compounds, new pyrazole compounds, processes for the manufacture of pyrazole compounds and processes for the manufacture of agrochemical or pharmaceutical compounds.
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WO/2017/101791A1 |
Disclosed are a compound and a use thereof in preparing a drug, and in particular, provided in the present invention are: the compound as shown in formula (I) or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitroxide, a ...
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WO/2017/087607A1 |
Compounds are provided as chemokine inhibitors having the structure: Formula (A).
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WO/2017/087388A1 |
Phenyl cyclohexanone based active agents, pharmaceutical preparations containing such active agents, methods of modifying cellular activity by contacting cells with such active agents, and methods of treating various conditions by admini...
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WO/2017/082144A1 |
The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt or prodrug thereof. The present invention also provides: a composition which includes the compound represented by formula (I), or...
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WO/2017/081590A1 |
The present invention provides a process for preparing omarigliptin.
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WO/2017/077550A1 |
The present invention discloses a novel metal free process for the regioselective synthesis of α-substituted carbonyl compounds of formula I from alkene, X is selected from the following compounds (A, B).
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WO/2017/078332A1 |
The present invention relates to a method for forming a three-dimensional object. According to the present invention, when the three-dimensional object is manufactured by an inkjet method, a support can be removed without damage to a str...
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WO/2017/067634A1 |
The invention relates to the use of hydrophilic compounds of formula (I) as photopolymerization initiators of polymerizable substance mixtures, which contain unsaturated compounds, or to the photochemical cross-linking of linear polymers...
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WO/2017/057460A1 |
Provided is a method for producing an organic compound, wherein the organic compound is an industrially useful compound, and a deodorization step, for removing from a reaction solution odorants that are generated in or remaining after a ...
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WO/2017/054112A1 |
The present invention relates to a method of preparing a 3-fluoroalkyl-1-methylpyrazole-4-carboxylic acid comprising the following steps: Step 1, performing a condensation reaction on the fluoroacetyl halide derivative shown in formula I...
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WO/2017/043175A1 |
Provided is a near-infrared absorbing curable composition which is capable of forming a cured film that has excellent infrared light shielding properties and visible light transparency, while exhibiting excellent heat resistance and ligh...
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WO/2017/035665A1 |
The present application is directed to transdermal formulations for the delivery of doxycycline compounds to a subject for the treatment of doxycycline-responsive diseases. In particular, the transdermal formulation is an emulsion compri...
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WO/2017/035224A1 |
Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are ...
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WO/2016/207252A1 |
A method of preparing a compound represented by general formula (3) : Formula (3). R1 and R2 are each independently an alkyl group. The method includes reacting a compound represented by general formula (2) : Formula (2) with an alkylami...
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WO/2016/202254A1 |
Provided are a preparation method for synthesizing a pyrazolecarboxylic acid derivative of the following formula (I), which is suitable for industrial production, and an intermediate as shown by the following formula (II). The method is ...
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WO/2016/197730A1 |
The present invention relates to an organic electroluminescent material, which has a structure as represented by formula (I). Compounds as represented by formula (I) have highly stable electron acceptor groups and electron donor groups, ...
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WO/2016/180984A1 |
The present invention is directed to processes for the preparation of esketamine. The present invention is further directed to processes for the resolution of S-ketamine from a racemic or enantiomerically enriched mixture of ketamine. Th...
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WO/2016/150208A1 |
Disclosed are a pharmaceutical composition and dosage form containing a glaucocalyxin A derivative as represented by the formula (I) or salt thereof, and a preparation method and use of said composition and dosage form; the anti-autoimmu...
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WO/2016/150206A1 |
Disclosed is a glaucocalyxin A derivative -- dimethylamino glaucocalyxin A hydrochloride salt -- and two crystalline forms thereof. The dimethylamino glaucocalyxin A hydrochloride salt provided by the present invention has good water sol...
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WO/2016/150207A1 |
Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fig...
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WO/2016/152886A1 |
The present invention provides a novel method for producing pyrazole derivatives useful as intermediates of pharmaceuticals and agricultural chemicals, as well as novel intermediate compounds in this method. The present invention pertain...
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WO/2016/136963A1 |
Provided is a method for producing, through chemical synthesis, kakeromycin and derivatives thereof which exhibit antifungal activity and cytotoxicity, and are expected to serve as novel antifungal agents or anticancer agents. Said metho...
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WO/2016/113763A1 |
A novel antileishmanial formulation containing compounds belonging to the series of (2Z,2'Z)-3,3'-(alkane-1,2-diylbis(azanediyl))bis(6-hydroxy-1
- aryl/fluorenyl hex-2-en-1-ones) or their salts thereof showing antileishmanial activity un...
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WO/2016/103274A1 |
The present invention discloses an improved process for preparing pure (dimethylarnino)-4,4-diphenyl-3-heptanone and its hydrochloride salt.
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