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WO/2003/037846A1 |
An improved method of producing keto acids having the formula (I), wherein R¿1? and R¿2? independently represent (a) hydrogen, wherein at least one of R¿1? and R¿2? do not stand for hydrogen, (b) branched or unbranched alkyl of 1-18 ...
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WO/2003/033447A1 |
Compounds represented by the following general formula (I): R−Y−(−X−Phe−COCH2COCnF2n&plus 1)m (I) wherein R represents hydrogen, alkyl, phenyl or a group capable of binding to a protein, a peptide, an amino acid, a nucleic acid...
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WO/2003/029186A1 |
Compositions comprising (±)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods ofpreparing (±)-cis-2-((dimethylamino)methyl)-l-(aryl)cyclohexanols, in particular (±)-cis-2-((dimethylami...
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WO/2003/022818A1 |
The invention relates to a method for producing 4-haloalkylnicotinic acid esters of formula (I), wherein R?F¿ represents (C¿1?-C¿4?) alkyl halide and R represents (C¿1?-C¿6?) alkyl; whereby: a) an amino ketone of formula (II), R?F¿...
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WO/2003/018535A2 |
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compo...
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WO/2003/017955A1 |
The invention concerns dyeing agents for keratinous fibers based on a developer-coupler combination, characterized in that they contain at least a 3-aminophenol derivative of formula (I) or a salt thereof, water-soluble and physiological...
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WO/2003/018536A1 |
The invention provides 1,2-substituted cyclic compounds useful for treatment of diseases or disorders arising from abnormal or inappropriate cell proliferation, such as tumour growth, tumour metastasis and associated angiogenesis, as wel...
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WO/2003/015761A1 |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...
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WO/2003/006420A1 |
The present invention is directed to a method of converting an aryl compound to an aniline compound, comprising the steps of (1)providing an aryl compound containing a halide group or a sulfur-containing group; (2) reacting the aryl comp...
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WO/2003/002511A1 |
(−)−3−[3−[(1R,2R,4S)−bicyclo[2.2.1]hept−2−ylox
y]−4−methoxyanilino]−2−methyl−2−cyclopenten−1â
ˆ’one or a hydrate or solvate thereof&semi or a medicinal composition containing any of these.
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WO/2002/102782A2 |
Use of compound of formula (I), wherein (a) is (b) or (c) and wherein the symbols are as defined, or a pharmaceutically-acceptable and-cleavable ester, or acid addition salt thereof, for the preparation of a medicament for promoting the ...
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WO/2002/098400A1 |
Arylaminopropane analogues are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more ...
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WO/2002/096850A1 |
The present invention refers to compounds of formula (I) as precursors for a ketone of formula (II), an aldehyde or ketone of formula (III), and an aldehyde or ketone of formula (IV). These compounds are useful in perfumery, especially i...
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WO2001047866A9 |
The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments.
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WO2001098265B1 |
The present invention describes a new process for obtainment of the cetamine enantiomers, form the racemic cetamine resolution with the aid of an agent of chiral resolution, which provides the selective crystallization of its enantiomers...
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WO/2002/083624A1 |
There are disclosed compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
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WO/2002/081483A2 |
The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention comp...
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WO/2002/078693A2 |
The present invention provides compounds of formula (I), which are antagonists of the 5-HT¿6? receptor.
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WO/2002/076939A2 |
Compounds having quinone and quinone analogs useful for pharmaceutical preparations have now been found which inhibit cysteine proteases, in particular, caspases and 3C-cysteine proteases. The cysteine protease inhibitors of the present ...
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WO/2002/076926A1 |
There are disclosed compounds of formula (I) wherein the variables A and B are an aryl or heteroaryl group as defined in the claims, or a prodrug thereof, or a pharmaceutically acceptable salt, solvate or isomer of said compound or of sa...
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WO/2002/076995A2 |
Compounds of formula (I), wherein m, R, R¿1? and R¿3? to R¿6? are as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compounds have interesting properties, e.g. immunosu...
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WO/2002/076447A1 |
Compounds of formula I and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof wherein the symbols are as defined are MAP kinase inhibitors, useful pharmaceutically for treating TNF$g(a) and IL-1 med...
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WO/2002/072620A1 |
A compound is of general formula (I) wherein (A) is a moiety comprising one of more of a heterocylcic ring, a carbocyclic ring and a fused ring system, the ring or ring system being essential for a biological activity of the compound by ...
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WO/2002/066416A1 |
To more efficiently provide CPT, which is a starting compound for irinotecan hydrochloride and various camptothecin derivatives, by a practically usable total synthesis, a means whereby 2'-amino-5'-hydroxypropiophenone corresponding to t...
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WO/2002/064136A2 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
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WO/2002/064130A1 |
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipo-protein-cholesterol and to lower certain plasma lipid levels, ...
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WO/2002/062307A1 |
The invention relates to colouring agents for keratin fibres containing [1.1'-biphenyl]-2.4-diamine derivatives of general formula (I) or physiologically acceptable, water soluble salts thereof in addition to novel [1.1'-biphenyl]-2.4-di...
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WO/2002/058630A2 |
Primary intermediate for hair coloring compositions for oxidative dyeing of hair is 4-amino-2-(1-hydroxy-ethyl)-phenol.
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WO/2002/057211A1 |
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is al...
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WO/2002/057199A1 |
The invention relates to a process for carrying out a homogeneously catalyzed C-C coupling reaction between an optionally substituted (hetero)aromatic bromide compound and a second reactant, which is chosen from the group of olefins in w...
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WO2001040188A9 |
The present invention is directed to curcumin analogs (I), wherein Y is OH, halogen, or CF3; Z is H, OH, OR1, halogen, or CF3; X1 and X2 are independently C or N; and A is as defined in the application; exhibiting anti-tumor and anti-ang...
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WO/2002/053523A1 |
A tropolone derivative represented by the formula (I) which has retinoid activity and is useful as an active ingredient for medicines [R?1¿ to R?4¿ each represents hydrogen, alkyl, or alkoxy; ring Ar represents an aryl ring or heteroar...
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WO/2002/053537A1 |
The present invention relates to a process for preparing (±)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidi
ne of formula (I). The present invention also relates to novel intermediates of the formula (IX) and (IX') methods for ...
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WO/2002/044144A2 |
Radiolabeled fluorinated compounds useful for imaging in the diagnosis of Parkinson's Disease are disclosed. Methods and kits for their synthesis are also disclosed.
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WO/2002/044139A1 |
The invention concerns compounds of formula (I), wherein: A is a group of formula (a) or (b), their salts or solvates, pharmaceutical compositions containing them, a method for preparing them and intermediates used in said method. The co...
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WO/2002/042248A2 |
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)¿2?, S(O)¿2?NH, P(O)OCH¿3?, P(O)OH, NH, N(CH¿3?), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH¿2?NH, C(=NH); R?1¿ is aryl ...
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WO/2002/042254A1 |
The present invention relates to a process of producing carbonyl a-substituted nitrogen-containing compounds, which comprises reacting a-halo-ketone or a-halo-aldehyde with primary amine, secondary amine or heterocycle compound containin...
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WO/2002/038120A1 |
The present invention relates to photo-labile pro-fragrance conjugates comprising: a) a photo-labile unit which upon exposure to electromagnetic radiation is capable of releasing a pro-fragrance unit; and b )a pro-fragrance unit, which w...
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WO/2002/034708A2 |
The invention involves a methods and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and methods of treatment using these composition...
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WO/2002/028815A1 |
A compound of the formula in which R?1¿ and R?2¿ are each hydrogen or C¿1-4? alkyl, or R1 and R2 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholino group...
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WO/2002/028808A1 |
This invention provides analogs of triptycene which are useful as anticancer drugs, as well as for other uses. The potency of these compounds is in a similar magnitude as daunomycin, a currently used anticancer drug. Each compound of the...
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WO/2002/020460A1 |
Novel arylamine compounds of the general formula (1), and an organic electroluminescent device whose organic compound layer contains a novel arylamine compound described above: (1) (wherein R?1¿ and R?2¿ are each independently alkyl, a...
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WO/2002/018319A1 |
The present invention relates to a process for the preparation of N-arylanthranilic acids, and a process for the preparation of N-aryl anthranilic esters, amides, and hydroxamic esters.
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WO/2002/010103A1 |
A method for the synthesis of an $g(a),$g(b)-unsaturated ketone useful for making substituted 1,4-dihydropyridines is described by reacting an aldehyde with pyrrolidine and then adding a ketone followed by trifluoroacetic acid at low tem...
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WO/2002/008170A1 |
A process for producing optically active $g(a)-hydroxy-$g(b)-aminocarboxylic acid derivatives. $g(a)-Aminoketone derivatives (4) are successively halogenated, reduced and hydrolyzed to thereby efficiently produce $g(a)-amino-$g(a)', $g(a...
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WO/2002/008197A1 |
The invention relates to novel biphenyl carboxamides of formula (I), wherein A, R, Z, X, Y, m and n have the meanings given in the description, to multiple methods for producing these substances, to their use for combating unwanted micro...
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WO/2002/006210A1 |
This invention provides compounds of Formula (I) having the structure wherein, B is a, b, or c; or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance o...
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WO/2002/002516A2 |
The present invention is a series of novel and effective inhibitors of integrase, an essential in the life cycle of retroviruses. These compounds were designed to have a restricted conformation for the determination of the integrase bind...
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WO/2002/002507A1 |
The invention relates to an oxidative colouring agent for keratin fibres, in particular hair, based on a developing agent-coupling agent combination, which contains as a developing agent, at least one 2-hydroxy-5-amino-biphenyl derivativ...
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WO/2002/000586A1 |
The present invention relates to propanedione derivatives represented by general formular (A), and their use as UV-absorbent. Wherein R?1¿ is substituted aromatic ring, optionally substituted heteroaromatic ring, or optionally substitut...
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